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Early Growth Response 1 (Egr1) Regulates Cholesterol Biosynthetic Gene Expression

Gokey, Nolan G., Lopez-Anido, Camila, Gillian-Daniel, Anne Lynn, Svaren, John·2011·Journal of Biological Chemistry

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  • SREBP2 may maintain promoters of target genes in a receptive state for binding of those transcription factors.

    “SREBP2 may maintain promoters of target genes in a receptive state for binding of those transcription factors (Gokey et al., 2011; Liang et al., 2002).”

    From GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis (2019) · cites this paper as Gokey et al., 2011

  • Besides SREBP2, additional feeding-responsive transcription factors likely promote expression of cholesterol biosynthetic genes.

    “Moreover, there is longstanding evidence showing that, besides SREBP2, additional feeding-responsive transcription factors are likely to promote expression of cholesterol biosynthetic genes.”

    From GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis (2019) · cites this paper as Gokey et al., 2011

  • The early growth response gene family (EGR1, EGR2, EGR3) are ERK1/2 target genes and have been indicated as additional transcription factors that upregulate cholesterol biosynthetic gene expression upon feeding.

    “The early growth response gene family (EGR1, EGR2 and EGR3), which are ERK1/2 target genes, have previously been indicated as additional transcription factors to upregulate cholesterol biosynthetic gene expression upon feeding (Gokey et al., 2011).”

    From GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis (2019) · cites this paper as Gokey et al., 2011

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Metadata

Authors
Gokey, N. G., Lopez-Anido, C., Gillian-Daniel, A. L., & Svaren, J.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2011-08
Volume
286
Issue
34
Pages
29501-29510
ISSN
0021-9258
Cited by
51
References
0
Language
en

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