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Early Growth Response 1 (Egr1) Regulates Cholesterol Biosynthetic Gene Expression
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SREBP2 may maintain promoters of target genes in a receptive state for binding of those transcription factors.
“SREBP2 may maintain promoters of target genes in a receptive state for binding of those transcription factors (Gokey et al., 2011; Liang et al., 2002).”
From GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis (2019) · cites this paper as Gokey et al., 2011
Besides SREBP2, additional feeding-responsive transcription factors likely promote expression of cholesterol biosynthetic genes.
“Moreover, there is longstanding evidence showing that, besides SREBP2, additional feeding-responsive transcription factors are likely to promote expression of cholesterol biosynthetic genes.”
From GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis (2019) · cites this paper as Gokey et al., 2011
The early growth response gene family (EGR1, EGR2, EGR3) are ERK1/2 target genes and have been indicated as additional transcription factors that upregulate cholesterol biosynthetic gene expression upon feeding.
“The early growth response gene family (EGR1, EGR2 and EGR3), which are ERK1/2 target genes, have previously been indicated as additional transcription factors to upregulate cholesterol biosynthetic gene expression upon feeding (Gokey et al., 2011).”
From GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis (2019) · cites this paper as Gokey et al., 2011
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Cited by
Sorted by citations
GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis
Yu, H., Rimbert, A., Palmer, A. E., Toyohara, T., Xia, Y., Xia, F., Ferreira, L. M. R., Chen, Z., Chen, T., Loaiza, N., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.034 · Cited by 113
Kandror, K. V. (2017) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000352 · Cited by 8
Metadata
- Authors
- Gokey, N. G., Lopez-Anido, C., Gillian-Daniel, A. L., & Svaren, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 286
- Issue
- 34
- Pages
- 29501-29510
- ISSN
- 0021-9258
- Cited by
- 51
- References
- 0
- Language
- en
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