Nitroalkenes Confer Acute Cardioprotection via Adenine Nucleotide Translocase 1

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

Brookes, P. S., Yoon, Y., Robotham, J. L., Anders, M. W., & Sheu, S.-S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00139.2004 · Cited by 2,575 · see citing works

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., et al. (2005) · Nature · doi:10.1038/nature03434 · Cited by 2,280 · see citing works

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

Kokoszka, J. E., Waymire, K. G., Levy, S. E., Sligh, J. E., Cai, J., Jones, D. P., MacGregor, G. R., & Wallace, D. C. (2004) · Nature · doi:10.1038/nature02229 · Cited by 1,086 · see citing works

Lipids of mitochondria

Daum, G. (1985) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(85)90002-4 · Cited by 863 · see citing works

The permeability transition pore complex: another view

Halestrap, A. P., McStay, G. P., & Clarke, S. J. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01375-5 · Cited by 709 · see citing works

Mitochondrial Fusion in Human Cells Is Efficient, Requires the Inner Membrane Potential, and Is Mediated by Mitofusins

Legros, F., Lombès, A., Frachon, P., & Rojo, M. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-06-0330 · Cited by 676 · see citing works

The ADP and ATP transport in mitochondria and its carrier

Klingenberg, M. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.04.011 · Cited by 613 · see citing works

Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase

Halestrap, A. P., Woodfield, K.-Y., & Connern, C. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3346 · Cited by 592 · see citing works

Mitochondrial H + Leak and ROS Generation: An Odd Couple

Brookes, P. S. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.016 · Cited by 447 · see citing works

Nitrolinoleic acid. An endogenous peroxisome proliferator-activated receptor γ ligand

Schopfer, F. J., Lin, Y., Baker, P. R. S., Cui, T., Garcia-Barrio, M., Zhang, J., Chen, K., Chen, Y. E., & Freeman, B. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408384102 · Cited by 428 · see citing works

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca 2+

Brustovetsky, N., & Klingenberg, M. (1996) · Biochemistry · doi:10.1021/bi960833v · Cited by 423 · see citing works

The basal proton conductance of mitochondria depends on adenine nucleotide translocase content

Brand, M. D., Pakay, J. L., Ocloo, A., Kokoszka, J., Wallace, D. C., Brookes, P. S., & Cornwall, E. J. (2005) · Biochemical Journal · doi:10.1042/bj20050890 · Cited by 410 · see citing works

Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition

Woodfield, K., Rück, A., Brdiczka, D. G., & Halestrap, A. P. (1998) · Biochemical Journal · doi:10.1042/bj3360287 · Cited by 386 · see citing works

Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore

McSTAY, G. P., CLARKE, S. J., & HALESTRAP, A. P. (2002) · Biochemical Journal · doi:10.1042/bj20011672 · Cited by 367 · see citing works

Fatty Acid Transduction of Nitric Oxide Signaling

Baker, P. R. S., Lin, Y., Schopfer, F. J., Woodcock, S. R., Groeger, A. L., Batthyany, C., Sweeney, S., Long, M. H., Iles, K. E., Baker, L. M. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504212200 · Cited by 358 · see citing works

Nitrated Fatty Acids: Endogenous Anti-inflammatory Signaling Mediators

Cui, T., Schopfer, F. J., Zhang, J., Chen, K., Ichikawa, T., Baker Paul, R. S., Batthyany, C., Chacko, B. K., Feng, X., Patel, R. P., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603357200 · Cited by 351 · see citing works

Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1

Huang, C., Andres, A. M., Ratliff, E. P., Hernandez, G., Lee, P. P. W., & Gottlieb, R. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020975 · Cited by 344 · see citing works

Uncoupling Protein-2 Overexpression Inhibits Mitochondrial Death Pathway in Cardiomyocytes

Teshima, Y., Akao, M., Jones, S. P., & Marbán, E. (2003) · Circulation Research · doi:10.1161/01.res.0000085581.60197.4d · Cited by 318 · see citing works

Quantitative Microplate-Based Respirometry with Correction for Oxygen Diffusion

Gerencser, A. A., Neilson, A., Choi, S. W., Edman, U., Yadava, N., Oh, R. J., Ferrick, D. A., Nicholls, D. G., & Brand, M. D. (2009) · Analytical Chemistry · doi:10.1021/ac900881z · Cited by 312 · see citing works

A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection

Halestrap, A. P. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380841 · Cited by 307 · see citing works

Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria

Chen, Q., Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00211.2007 · Cited by 299 · see citing works

Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species

Brookes, P. S., Levonen, A.-L., Shiva, S., Sarti, P., & Darley-Usmar, V. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00901-2 · Cited by 298 · see citing works

Nitration of Unsaturated Fatty Acids by Nitric Oxide-Derived Reactive Nitrogen Species Peroxynitrite, Nitrous Acid, Nitrogen Dioxide, and Nitronium Ion

O'Donnell, V. B., Eiserich, J. P., Chumley, P. H., Jablonsky, M. J., Krishna, N. R., Kirk, M., Barnes, S., Darley-Usmar, V. M., & Freeman, B. A. (1999) · Chemical Research in Toxicology · doi:10.1021/tx980207u · Cited by 289 · see citing works

Reversible Post-translational Modification of Proteins by Nitrated Fatty Acids in Vivo

Batthyany, C., Schopfer, F. J., Baker, P. R. S., Durán, R., Baker, L. M. S., Huang, Y., Cerveñansky, C., Branchaud, B. P., & Freeman, B. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602814200 · Cited by 285 · see citing works

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

Costantini, P., Belzacq, A.-S., Vieira, H. L., Larochette, N., de Pablo, M. A., Zamzami, N., Susin, S. A., Brenner, C., & Kroemer, G. (2000) · Oncogene · doi:10.1038/sj.onc.1203299 · Cited by 284 · see citing works

4-Hydroxyhexenal Is a Potent Inducer of the Mitochondrial Permeability Transition

Kristal, B. S., Park, B. K., & Yu, B. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6033 · Cited by 253 · see citing works

Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation

BRENNAN, J., SOUTHWORTH, R., MEDINA, R., DAVIDSON, S., DUCHEN, M., & SHATTOCK, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.07.019 · Cited by 242 · see citing works

A pore way to die

Halestrap, A. P. (2005) · Nature · doi:10.1038/434578a · Cited by 240 · see citing works

Chemical nature of nitric oxide storage forms in rat vascular tissue

Rodriguez, J., Maloney, R. E., Rassaf, T., Bryan, N. S., & Feelisch, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0234600100 · Cited by 210 · see citing works

Red cell membrane and plasma linoleic acid nitration products: Synthesis, clinical identification, and quantitation

Baker, P. R. S., Schopfer, F. J., Sweeney, S., & Freeman, B. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402587101 · Cited by 201 · see citing works

Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion

Rudolph, V., Rudolph, T. K., Schopfer, F. J., Bonacci, G., Woodcock, S. R., Cole, M. P., Baker, P. R. S., Ramani, R., & Freeman, B. A. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvp275 · Cited by 188 · see citing works

Specific Modification of Mitochondrial Protein Thiols in Response to Oxidative Stress

Lin, T., Hughes, G., Muratovska, A., Blaikie, F. H., Brookes, P. S., Darley-Usmar, V. M., Smith, R. A. J., & Murphy, M. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110797200 · Cited by 180 · see citing works

Autophagy Induced by Ischemic Preconditioning is Essential for Cardioprotection

Huang, C., Yitzhaki, S., Perry, C. N., Liu, W., Giricz, Z., Mentzer, R. M., & Gottlieb, R. A. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9189-3 · Cited by 171 · see citing works

Simultaneous Measurement of Protein Oxidation and S -Nitrosylation During Preconditioning and Ischemia/Reperfusion Injury With Resin-Assisted Capture

Kohr, M. J., Sun, J., Aponte, A. M., Wang, G., Guček, M., Murphy, E., & Steenbergen, C. (2010) · Circulation Research · doi:10.1161/circresaha.110.232173 · Cited by 169 · see citing works

Redox Regulation of Mitochondrial ATP Synthase

Wang, S.-B., Foster, D. B., Rucker, J. J., O'Rourke, B. P., Kass, D. A., & Eyk, J. E. V. (2011) · Circulation Research · doi:10.1161/circresaha.111.246124 · Cited by 161 · see citing works

The cardioprotective effects elicited by p66Shc ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury

Carpi, A., Menabò, R., Kaludercic, N., Pelicci, P. G., Lisa, F. D., & Giorgio, M. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.04.001 · Cited by 153 · see citing works

The Mammalian Longevity-associated Gene Product p66 Regulates Mitochondrial Metabolism

Nemoto, S., Combs, C. A., French, S. A., Ahn, B., Fergusson, M. M., Balaban, R. S., & Finkel, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511626200 · Cited by 147 · see citing works

A CaPful of mechanisms regulating the mitochondrial permeability transition

Lisa, F. D., & Bernardi, P. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.03.006 · Cited by 137 · see citing works

Mitochondrial nitroalkene formation and mild uncoupling in ischaemic preconditioning. Implications for cardioprotection

Nadtochiy, S. M., Baker, P. R. S., Freeman, B. A., & Brookes, P. S. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvn323 · Cited by 131 · see citing works

Lysine deacetylation in ischaemic preconditioning: the role of SIRT1

Nadtochiy, S. M., Redman, E., Rahman, I., & Brookes, P. S. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq287 · Cited by 130 · see citing works

Characterization of cysteine residues of mitochondrial ADP/ATP carrier with the SH-reagents eosin 5-maleimide and N-ethylmaleimide.

Majima, E., Koike, H., Hong, Y. M., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80665-6 · Cited by 125 · see citing works

Convergence of nitric oxide and lipid signaling: Anti-inflammatory nitro-fatty acids

Baker, P. R. S., Schopfer, F. J., O’Donnell, V. B., & Freeman, B. Α. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.021 · Cited by 124 · see citing works

Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection

Nadtochiy, S. M., Tompkins, A. J., & Brookes, P. S. (2006) · Biochemical Journal · doi:10.1042/bj20051927 · Cited by 123 · see citing works

Review: Autophagy: Definition, Molecular Machinery, and Potential Role in Myocardial Ischemia-Reperfusion Injury

Dong, Y., Undyala, V. V. R., Gottlieb, R. A., Mentzer, R. M., & Przyklenk, K. (2010) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248410370327 · Cited by 115 · see citing works

Cardioprotection by Endoplasmic Reticulum Stress–Induced Autophagy

Petrovski, G., Das, S., Juhász, B., Kertesz, A., Tósaki, Á., & Das, D. K. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3486 · Cited by 112 · see citing works

Mitochondria and reperfusion injury of the heart—A holey death but not beyond salvation

Halestrap, A. P. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9206-x · Cited by 110 · see citing works

Nitrolinoleate, a nitric oxide-derived mediator of cell function: Synthesis, characterization, and vasomotor activity

Lim, D. G., Sweeney, S., Bloodsworth, A., White, C. R., Chumley, P. H., Krishna, N. R., Schopfer, F., O'Donnell, V. B., Eiserich, J. P., & Freeman, B. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232409599 · Cited by 110 · see citing works

Adenine nucleotide translocator isoforms 1 and 2 are differently distributed in the mitochondrial inner membrane and have distinct affinities to cyclophilin D

Vyssokikh, M. Y., Annette, K. A. T. Z., RUECK, A., Wuensch, C., Dörner, A., Zorov, D. B., & Brdiczka, D. G. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3580349 · Cited by 93 · see citing works

Expression and sequence analysis of the mouse adenine nucleotide translocase 1 and 2 genes

Levy, S., Chen, Y., Graham, B. H., & Wallace, D. C. (2000) · Gene · doi:10.1016/s0378-1119(00)00252-3 · Cited by 93 · see citing works

FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation

BRENNAN, J., BERRY, R., BAGHAI, M., DUCHEN, M., & SHATTOCK, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.08.006 · Cited by 92 · see citing works

Mitochondrial Protein Targets of Thiol-Reactive Electrophiles

Wong, H. L., & Liebler, D. C. (2008) · Chemical Research in Toxicology · doi:10.1021/tx700433m · Cited by 82 · see citing works

Activation of the lifespan regulator p66 Shc through reversible disulfide bond formation

Gertz, M., Fischer, F. F., Wolters, D. A., & Steegborn, C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800691105 · Cited by 82 · see citing works

Redox signaling in inflammation: interactions of endogenous electrophiles and mitochondria in cardiovascular disease

Koenitzer, J. R., & Freeman, B. Α. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05559.x · Cited by 80 · see citing works

Signaling Actions of Electrophiles: Anti-inflammatory Therapeutic Candidates

Groeger, A. L., & Freeman, B. Α. (2010) · Molecular Interventions · doi:10.1124/mi.10.1.7 · Cited by 71 · see citing works

Adenine nucleotide translocator isoforms 1 and 2 are differently distributed in the mitochondrial inner membrane and have distinct affinities to cyclophilin D

Vyssokikh, M. Y., Annette, K. A. T. Z., RUECK, A., et al. (2001) · Biochemical Journal · doi:10.1042/bj3580349 · Cited by 65 · see citing works

Induction of the permeability transition and cytochrome c release by 15-deoxy-Δ12,14-prostaglandin J2 in mitochondria

Landar, A. L., Shiva, S., Levonen, A., Oh, J., Zaragoza, C., Johnson, M. S., & Darley-Usmar, V. M. (2006) · Biochemical Journal · doi:10.1042/bj20051259 · Cited by 63 · see citing works

Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adduction

Chavez, J. D., Wu, J., Bisson, W. H., & Maier, C. S. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.03.031 · Cited by 60 · see citing works

AMP decreases the efficiency of skeletal-muscle mitochondria

Cadenas, S., Buckingham, J. A., St‐Pierre, J., Dickinson, K., Jones, R. B., & Brand, M. D. (2000) · Biochemical Journal · doi:10.1042/bj3510307 · Cited by 57 · see citing works

An Odd Couple: Domestic Crimes and International Responsibility in the Special Tribunal for Lebanon

Milanović, M. (2007) · Journal of International Criminal Justice · doi:10.1093/jicj/mqm074 · Cited by 57 · see citing works

Increased state 4 mitochondrial respiration and swelling in early post‐ischemic reperfusion of rat heart

Bosetti, F., Baracca, A., Lenaz, G., et al. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00294-7 · Cited by 46 · see citing works

Localization of the N-ethylmaleimide reactive cysteine in the beef heart mitochondrial ADP/ATP carrier protein

Boulay, F., & Vignais, P. V. (1984) · Biochemistry · doi:10.1021/bi00315a042 · Cited by 43 · see citing works

Adenine nucleotide translocase-1 induces cardiomyocyte death through upregulation of the pro-apoptotic protein Bax

Baines, C. P., & Molkentin, J. D. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.01.016 · Cited by 41 · see citing works

Effect of dietary hempseed intake on cardiac ischemia-reperfusion injury

Al-Khalifa, A., Maddaford, T. G., Chahine, M. N., et al. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00661.2006 · Cited by 41 · see citing works

Peroxidative Damage to Cardiac Mitochondria. II. Immunological Analysis of Modified Adenine Nucleotide Translocase

Girón‐Calle, J., Zwizinski, C. W., & Schmid, H. H. O. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1463 · Cited by 39 · see citing works

Ischemic Preconditioning Decreases Mitochondrial Proton Leak and Reactive Oxygen Species Production in the Postischemic Heart

Quarrie, R., Cramer, B., Lee, D. S., Steinbaugh, G. E., Erdahl, W. L., Pfeiffer, D. R., Zweier, J. L., & Crestanello, J. A. (2010) · Journal of Surgical Research · doi:10.1016/j.jss.2010.09.018 · Cited by 37 · see citing works

Fatty Acid Transduction of Nitric Oxide Signaling

Cole, M. P., & Freeman, B. Α. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00011-3 · Cited by 29 · see citing works

Effect of Dietary Sunflower Seed Oil on the Severity of Reperfusion-Induced Arrhythmias in Anesthetized Rats

Leprán, I., & Szekeres, L. (1992) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199201000-00006 · Cited by 21 · see citing works

Ischemic preconditioning preserves proton leakage from mitochondrial membranes but not oxidative phosphorylation during heart reperfusion

Muscari, C., Bonafè, F., Gamberini, C., et al. (2005) · Cell Biochemistry and Function · doi:10.1002/cbf.1294 · Cited by 8 · see citing works

Strategies to increase nitric oxide signalling in cardiovascular disease

Lundberg, J. O., Gladwin, M. T., & Weitzberg, E. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4623 · Cited by 576 · see citing works

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health

Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works

The role of nitrated fatty acids and peroxisome proliferator-activated receptor gamma in modulating inflammation

Narala, V. R., Subramani, P. A., Narasimha, V. R., Shaik, F. B., & Panati, K. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.09.009 · Cited by 33 · see citing works

Molecular Interactions of the Mitochondrial Tim12 Translocase Subunit

Baud, C., Lousa, C. D. M., & Tokatlidis, K. (2007) · Protein and Peptide Letters · doi:10.2174/092986607780990019 · Cited by 10 · see citing works

TIM29 is a subunit of the human carrier translocase required for protein transport

Callegari, S., Richter, F., Chojnacka, K., et al. (2016) · FEBS Letters · doi:10.1002/1873-3468.12450 · Cited by 75 · see citing works

SAT-347 Unfolding Generates an Active CYP11A1 for Mitochondrial Integration and Activity

Bose, H. S., Gebrail, F., Marshall, B., et al. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-sat-347

Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria

Tamura, Y., Endo, T., Iijima, M., & Sesaki, H. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200812018 · Cited by 181 · see citing works

Faculty Opinions recommendation of Protein insertion into the mitochondrial inner membrane by a twin-pore translocase.

Werner‐Washburne, M. (2003) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1012851.185923