MicroRNA-92a Negatively Regulates Toll-like Receptor (TLR)-triggered Inflammatory Response in Macrophages by Targeting MKK4 Kinase
Open accessAbstract
Toll-like receptors (TLRs) play a critical role in the initiation of immune responses against invading pathogens. MicroRNAs have been shown to be important regulators of TLR signaling. In this study, we have found that the stimulation of multiple TLRs rapidly reduced the levels of microRNA-92a (miRNA-92a) and some other members of the miRNA-92a family in macrophages. miR-92a mimics significantly decreased, whereas miR-92a knockdown increased, the activation of the JNK/c-Jun pathway and the production of inflammatory cytokines in macrophages when stimulated with ligands for TLR4. Furthermore, mitogen-activated protein kinase kinase 4 (MKK4), a kinase that activates JNK/stress-activated protein kinase, was found to be directly targeted by miR-92a. Similar to the effects of the miR-92a mimics, knockdown of MKK4 inhibited the activation of JNK/c-Jun signaling and the production of TNF-α and IL-6. In conclusion, we have demonstrated that TLR-mediated miR-92a reduction feedback enhances TLR-triggered production of inflammatory cytokines in macrophages, thus outlining new mechanisms for fine-tuning the TLR-triggered inflammatory response.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Silencing miR-92a increases JNK/c-Jun activation and pro-inflammatory cytokine production in macrophages.
“silencing of miR-92a increases the activation of the JNK/c-Jun pathway and stimulates the production of pro-inflammatory cytokines in macrophages [134]”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [134]
The miR-92a Regulates TLR-triggered Inflammatory Response section reports that miR-92a inhibitors increased JNK and c-Jun phosphorylation and LPS-induced TNFα and IL-6 production in macrophages (Figs. 4C and 3E–F). The citing sentence omits the LPS/TLR-stimulation condition under which these effects were shown. (LLM, conf=0.82)
Experimental — accuracy not yet measuredTLR stimulation downregulates miR-92a, which targets MKK4.
“Stimulation of different TLRs downregulates miR-92a, which targets mitogen-activated protein kinase 4 (MKK4).”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [134]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304 · see citing works
Pattern Recognition Receptors and Inflammation
Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895 · see citing works
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
Kawai, T., & Akira, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.006 · Cited by 3,658 · see citing works
Seger, R., & Krebs, E. G. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.9.7601337 · Cited by 3,631 · see citing works
A microRNA polycistron as a potential human oncogene
He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,520 · see citing works
MicroRNAs Modulate Hematopoietic Lineage Differentiation
Chen, C.-Z., Li, L., Lodish, H. F., & Bartel, D. P. (2004) · Science · doi:10.1126/science.1091903 · Cited by 3,257 · see citing works
Kawai, T., & Akira, S. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401850 · Cited by 1,817 · see citing works
MAP Kinases in the Immune Response
Dong, C., Davis, R. J., & Flavell, R. A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.091301.131133 · Cited by 1,660 · see citing works
Ventura, A., Young, A. G., Winslow, M. M., Lintault, L., Meissner, A., Erkeland, S. J., Newman, J. J., Bronson, R. T., Crowley, D. G., Stone, J. R., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.019 · Cited by 1,592 · see citing works
Differential regulation and properties of MAPKs
Raman, M., Chen, W., & Cobb, M. H. (2007) · Oncogene · doi:10.1038/sj.onc.1210392 · Cited by 1,430 · see citing works
Self-citationTili, E., Michaille, J.-J., Cimino, A., Costinean, S., Dumitru, C. D., Adair, B., Fabbri, M., Alder, H., Liu, C. G., Calin, G. A., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5082 · Cited by 1,304 · see citing works
MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice
Bonauer, A., Carmona, G., Iwasaki, M., Mione, M., Koyanagi, M., Fischer, A., Burchfield, J. S., Fox, H., Doebele, C., Ohtani, K., et al. (2009) · Science · doi:10.1126/science.1174381 · Cited by 1,214 · see citing works
Sheedy, F. J., Palsson-McDermott, E., Hennessy, E. J., Martin, C., O'Leary, J. J., Ruan, Q., Johnson, D. S., Chen, Y., & O'Neill, L. A. J. (2010) · Nature Immunology · doi:10.1038/ni.1828 · Cited by 1,005 · see citing works
MicroRNAs: the fine-tuners of Toll-like receptor signalling
O'Neill, L. A. J., Sheedy, F. J., & McCoy, C. E. (2011) · Nature reviews. Immunology · doi:10.1038/nri2957 · Cited by 851 · see citing works
Hou, J., Wang, P., Lin, L., Liu, X., Ma, F., An, H., Wang, Z., & Cao, X. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900707 · Cited by 739 · see citing works
Self-citationCeppi, M., Pereira, P. M., Dunand-Sauthier, I., Barras, E., Reith, W., Santos, M. A. S., & Pierre, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811073106 · Cited by 713 · see citing works
MAPK phosphatases — regulating the immune response
Liu, Y., Shepherd, E. G., & Nelin, L. D. (2007) · Nature reviews. Immunology · doi:10.1038/nri2035 · Cited by 679 · see citing works
Liu, G., Friggeri, A., Yang, Y., Park, Y.-J., Tsuruta, Y., & Abraham, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901216106 · Cited by 438 · see citing works
Wang, P., Hou, J., Lin, L., Wang, C., Liu, X., Li, D., Ma, F., Wang, Z., & Cao, X. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000491 · Cited by 431 · see citing works
Self-citationPetrocca, F., Vecchione, A. M., & Croce, C. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1768 · Cited by 386 · see citing works
Jang, S., Kelley, K. W., & Johnson, R. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802865105 · Cited by 365 · see citing works
The estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response
Castellano, L., Giamas, G., Jacob, J., Coombes, R. C., Lucchesi, W., Thiruchelvam, P. T. R., Barton, G. R., Jiao, L. R., Wait, R., Waxman, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906947106 · Cited by 329 · see citing works
The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma
Mestdagh, P., Boström, A.-K., Impens, F., Fredlund, E., Van Peer, G., De Antonellis, P., von Stedingk, K., Ghesquière, B., Schulte, S., Dews, M., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.11.038 · Cited by 314 · see citing works
Smith, A., Iwanaga, R., Drasin, D. J., Micalizzi, D. S., Vartuli, R. L., Tan, A. C., & Ford, H. L. (2012) · Oncogene · doi:10.1038/onc.2012.11 · Cited by 293 · see citing works
c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia
Waetzig, V., Czeloth, K., Hidding, U., Mielke, K., Kanzow, M., Brecht, S., Goetz, M. E., Lucius, R., Herdegen, T., & Hanisch, U. (2005) · Glia · doi:10.1002/glia.20173 · Cited by 291 · see citing works
Low levels of miR‐92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma
Pal, S., Baiocchi, R. A., Byrd, J. C., Grever, M. R., Jacob, S. T., & Sif, S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601794 · Cited by 286 · see citing works
mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer
Lanza, G., Ferracin, M., Gafà, R., Veronese, A., Spizzo, R., Pichiorri, F., Liu, C., Calin, G. A., Croce, C. M., & Negrini, M. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-54 · Cited by 285 · see citing works
Xiao, B., Liu, Z., Li, B., Tang, B., Li, W., Guo, G., Shi, Y., Wang, F., Wu, Y., Tong, W., et al. (2009) · The Journal of Infectious Diseases · doi:10.1086/605443 · Cited by 278 · see citing works
Liu, Y., Lai, L., Chen, Q., Song, Y., Xu, S., Ma, F., Wang, X., Wang, J., Yu, H. C., Cao, X., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103505 · Cited by 272 · see citing works
Self-citationOncogenic Potential of the miR-106-363 Cluster and Its Implication in Human T-Cell Leukemia
Landais, S., Landry, S., Legault, P., & Rassart, É. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4478 · Cited by 242 · see citing works
Development of the human cancer microRNA network
Bandyopadhyay, S., Mitra, R., Maulik, U., & Zhang, M. Q. (2010) · Silence · doi:10.1186/1758-907x-1-6 · Cited by 228 · see citing works
Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer
Jalava, S. E., Urbanucci, A., Latonen, L., Waltering, K. K., Sahu, B., Jänne, O. A., Seppälä, J., Lähdesmäki, H. J., Tammela, T. L. J., & Visakorpi, T. (2012) · Oncogene · doi:10.1038/onc.2011.624 · Cited by 221 · see citing works
Nahid, M. A., Satoh, M., & Chan, E. K. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002311 · Cited by 206 · see citing works
Tang, B., Xiao, B., Liu, Z., Li, N., Zhu, E., Li, B., Xie, Q., Zhuang, Y., Zou, Q., & Mao, X. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.063 · Cited by 202 · see citing works
Ganiatsas, S., Kwee, L., Fujiwara, Y., Perkins, A. C., Ikeda, T., Labow, M., & Zon, L. I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6881 · Cited by 193 · see citing works
Zhou, R., Hu, G., Gong, A.-Y., & Chen, X. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq056 · Cited by 191 · see citing works
Razumilava, N., Bronk, S. F., Smoot, R. L., Fingas, C. D., Werneburg, N. W., Roberts, L. R., & Mott, J. L. (2011) · Hepatology · doi:10.1002/hep.24698 · Cited by 191 · see citing works
Liu, X., Yao, M., Li, N., Wang, C., Zheng, Y., & Cao, X. (2008) · Blood · doi:10.1182/blood-2008-03-144022 · Cited by 180 · see citing works
Self-citationMicroRNAs Regulate Dendritic Cell Differentiation and Function
Turner, M. L., Schnorfeil, F. M., & Brocker, T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101137 · Cited by 165 · see citing works
Liu, Y., Chen, Q.-Y., Song, Y., Lai, L.-H., Wang, J.-L., Yu, H., Cao, X.-T., & Wang, Q.-Q. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.029 · Cited by 157 · see citing works
Self-citationCremer, T. J., Ravneberg, D. H., Clay, C. D., Piper-Hunter, M. G., Marsh, C. B., Elton, T. S., Gunn, J. S., Amer, A. O., Kanneganti, T., Schlesinger, L. S., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008508 · Cited by 157 · see citing works
MicroRNA function in myeloid biology
O’Connell, R. M., Zhao, J. L., & Rao, D. S. (2011) · Blood · doi:10.1182/blood-2011-03-291971 · Cited by 155 · see citing works
Chen, Z.-L., Zhao, X., Wang, J., Li, B.-Z., Wang, Z., Sun, J., Tan, F., Ding, D., Xu, X., Zhou, F., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.165654 · Cited by 153 · see citing works
MicroRNA-101 targets MAPK phosphatase-1 to regulate the activation of MAPKs in macrophages
Zhu, Q.-Y., Liu, Q., Chen, J.-X., Lan, K., & Ge, B.-X. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000798 · Cited by 137 · see citing works
MiR-25 regulates apoptosis by targeting Bim in human ovarian cancer
Zhu, Z. (2011) · Oncology Reports · doi:10.3892/or.2011.1530 · Cited by 134 · see citing works
Nishina, H., Bachmann, M. F., Oliveira-dos-Santos, A., Kozieradzki, I., Fischer, K., Odermatt, B., Wakeham, A. C., Shahinian, A., Takimoto, H., Bernstein, A., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.6.941 · Cited by 126 · see citing works
MAP kinase kinase kinases and innate immunity
Symons, A., Beinke, S., & Ley, S. C. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.11.007 · Cited by 125 · see citing works
Hu, G., Zhou, R., Liu, J., Gong, A., Eischeid, A. N., Dittman, J. W., & Chen, X. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804362 · Cited by 119 · see citing works
Mitogen-Activated Protein Kinase Kinase 4 (MKK4)
Cuenda, A. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00003-0 · Cited by 119 · see citing works
MicroRNAs and the resolution phase of inflammation in macrophages
Alam, M. M., & O'Neill, L. A. J. (2011) · European Journal of Immunology · doi:10.1002/eji.201141740 · Cited by 106 · see citing works
Ebi, H., Sato, T., Sugito, N., Hosono, Y., Yatabe, Y., Matsuyama, Y., Yamaguchi, T., Osada, H., Suzuki, M., & Takahashi, T. (2009) · Oncogene · doi:10.1038/onc.2009.201 · Cited by 104 · see citing works
Manni, I., Artuso, S., Careccia, S., Rizzo, M. G., Baserga, R., Piaggio, G., & Sacchi, A. (2009) · The FASEB Journal · doi:10.1096/fj.09-131847 · Cited by 88 · see citing works
Preferential activation of the p46 isoform of JNK/SAPK in mouse macrophages by TNFα
Chan, E. D., Winston, B. W., Jarpe, M. B., Wynes, M. W., & Riches, D. W. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13169 · Cited by 82 · see citing works
Marasa, B. S., Srikantan, S., Masuda, K., Abdelmohsen, K., Kuwano, Y., Yang, X., Martindale, J. L., Rinker-Schaeffer, C. W., & Gorospe, M. (2009) · Science Signaling · doi:10.1126/scisignal.2000442 · Cited by 78 · see citing works
miR-32 and its target SLC45A3 regulate the lipid metabolism of oligodendrocytes and myelin
Shin, D., Howng, S. Y. B., Ptáček, L. J., & Fu, Y. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.054 · Cited by 68 · see citing works
Swat, W., Fujikawa, K., Ganiatsas, S., Yang, D., Xavier, R. J., Harris, N. L., Davidson, L., Ferrini, R., Davis, R. J., Labow, M., et al. (1998) · Immunity · doi:10.1016/s1074-7613(00)80567-1 · Cited by 67 · see citing works
Wada, T., Nakagawa, K., Watanabe‐Asaka, T., Nishitai, G., Seo, J., Kishimoto, H., Kitagawa, D., Sasaki, T., Penninger, J. M., Nishina, H., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011780200 · Cited by 67 · see citing works
Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis.
Yashar, B. M., Kelley, C. M., Yee, K. O., Errede, B., & Zon, L. I. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5738 · Cited by 65 · see citing works
microRNAs: critical regulators in Th17 cells and players in diseases
Wei, B. K., & Pei, G. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.19 · Cited by 63 · see citing works
Integrin β1 Regulates Phagosome Maturation in Macrophages through Rac Expression
Wang, Q., Li, H., Oliver, T., Glogauer, M., Guo, J., & He, Y.-W. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2419 · Cited by 53 · see citing works
Self-citationRegulation of JNK by MKK‐7 in fibroblast‐like synoviocytes
Inoue, T., Hammaker, D. R., Boyle, D. L., & Firestein, G. S. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21919 · Cited by 50 · see citing works
CCR7-mediated c-Jun N-terminal kinase activation regulates cell migration in mature dendritic cells
Iijima, N., Yanagawa, Y., Clingan, J. M., & Onoé, K. (2005) · International Immunology · doi:10.1093/intimm/dxh297 · Cited by 44 · see citing works
Novel Role for Aldose Reductase in Mediating Acute Inflammatory Responses in the Lung
Ravindranath, T. M., Mong, P. Y., Ananthakrishnan, R., Li, Q., Quadri, N., Schmidt, A. M., Ramasamy, R., & Wang, Q. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900720 · Cited by 44 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment
Tahamtan, A., Teymoori‐Rad, M., Nakstad, B., & Salimi, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01377 · Cited by 355 · see citing works
Wang, X., Li, J., Dong, K., Fang, L., Long, M., Ouyang, Y., Wei, J., Chen, X., Weng, Y., He, T., et al. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.12.003 · Cited by 313 · see citing works
MicroRNAs: New Regulators of Toll-Like Receptor Signalling Pathways
He, X., Jing, Z., & Cheng, G. (2014) · BioMed Research International · doi:10.1155/2014/945169 · Cited by 238 · see citing works
Chandan, K., Gupta, M., & Sarwat, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03081 · Cited by 213 · see citing works
The Interleukin-10 Family of Cytokines and Their Role in the CNS
Burmeister, A. R., & Marriott, I. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00458 · Cited by 208 · see citing works
Cellular and molecular mechanisms of inflammation‐induced angiogenesis
Szade, A., Grochot‐Przeczek, A., Florczyk, U., Józkowicz, A., & Dulak, J. (2015) · IUBMB Life · doi:10.1002/iub.1358 · Cited by 199 · see citing works
Inflammatory response of macrophages in infection
Zhang, L., & Wang, C.-C. (2014) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(14)60024-2 · Cited by 188 · see citing works
MicroRNAs as Molecular Switches in Macrophage Activation
Curtale, G., Rubino, M., & Locati, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00799 · Cited by 182 · see citing works
The Clinical Application of MicroRNAs in Infectious Disease
Drury, R. E., O’Connor, D., & Pollard, A. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01182 · Cited by 169 · see citing works
Follistatin-like 1 in development and human diseases
Mattiotti, A., Prakash, S., Barnett, P., & van den Hoff, M. J. B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2805-0 · Cited by 174 · see citing works
Hsu, C., Hsieh, T., Tsai, C., Tsai, H., Chen, H., Chang, Y., Chuang, H., Lee, J.-N., Hsu, Y., & Tsai, E. (2013) · The Journal of Pathology · doi:10.1002/path.4295 · Cited by 157 · see citing works
Lipoprotein carriers of microRNAs
Michell, D. L., & Vickers, K. C. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.01.011 · Cited by 135 · see citing works
Mao, G., Huang, Z., Huang, Z., Chen, W., Huang, G., Meng, F., Zhang, Z., & Kang, Y. Q. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.11.006 · Cited by 119 · see citing works
Self-citationVergadi, E., Vaporidi, K., & Tsatsanis, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02705 · Cited by 117 · see citing works
Li, S., Yue, Y., Xu, W., & Xiong, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081438 · Cited by 113 · see citing works
Murata, K., Ito, H., Yoshitomi, H., Yamamoto, K., Fukuda, A., Yoshikawa, J., Moritoshi, F., Ishikawa, M., Shibuya, H., & Matsuda, S. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2040 · Cited by 112 · see citing works
MiR-17-92 cluster and immunity
Kuo, G. C., Wu, C., & Yang, H. (2018) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2018.04.013 · Cited by 100 · see citing works
MicroRNA-Let-7a regulates the function of microglia in inflammation
Cho, K., Song, J., Oh, Y., & Lee, J. E. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.07.004 · Cited by 99 · see citing works
The cellular origin and malignant transformation of Waldenström macroglobulinemia
Paiva, B., Corchete, L. A., Vídriales, M., García‐Sánz, R., Pérez, J. J., Aires‐Mejía, I., Sánchez, M.-L., Bárcena, P., Alignani, D., Jiménez, C., et al. (2015) · Blood · doi:10.1182/blood-2014-09-602565 · Cited by 97 · see citing works
Xu, G., Zhang, Z., Xing, Y., Wei, J., Ge, Z., Liu, X., Zhang, Y., & Huang, X. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24734 · Cited by 95 · see citing works
Self-citationCorrea, B. L., Harane, N. E., Gomez, I., Hocine, H. R., Vilar, J., Desgres, M., Bellamy, V., Kamaleswaran, K., Guillas, C., Perotto, M., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa028 · Cited by 88 · see citing works
Ma, J., Wang, C., Long, K., Zhang, H., Zhang, J., Jin, L. G., Tang, Q., Jiang, A., Wang, X., Tian, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03707-8 · Cited by 85 · see citing works
Rehfeldt, S. C. H., Laufer, S., & Goettert, M. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073701 · Cited by 85 · see citing works
Rusek, A. M., Abba, M. L., Eljaszewicz, A., Moniuszko, M., Nikliński, J., & Allgayer, H. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0302-8 · Cited by 81 · see citing works
Zhao, L., Zhu, J., Zhou, H., Zhao, Z., Zou, Z., Liu, X., Lin, X., Zhang, X., Deng, X., Wang, R., et al. (2015) · Scientific Reports · doi:10.1038/srep14991 · Cited by 80 · see citing works
Involvement of MicroRNA in Microglia-Mediated Immune Response
Guedes, J. R., Cardoso, A. L., & de Lima, M. C. P. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/186872 · Cited by 79 · see citing works
Shakespear, N., Ogura, M., Yamaki, J., & Homma, Y. (2020) · Neurochemical Research · doi:10.1007/s11064-020-02977-5 · Cited by 72 · see citing works
Pope, S. M., & Lässer, C. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.22484 · Cited by 70 · see citing works
miR‐148a suppresses inflammation in lipopolysaccharide‐induced endometritis
Jiang, K., Yang, J., Yang, C., Zhang, T., Shaukat, A., Yang, X., Dai, A., Wu, H., & Deng, G. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14744 · Cited by 69 · see citing works
Yu, H., Wang, X., Xu, J., Ma, Y., Zhang, S.-Z., Yu, D., Fei, D.-Q., & Muhammad, A. (2017) · Journal of Proteomics · doi:10.1016/j.jprot.2017.06.007 · Cited by 66 · see citing works
Zhang, P., Li, C., Shao, Y., Chen, X., Li, Y., Su, X., & Li, T. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.04.007 · Cited by 64 · see citing works
Caplan, I. F., & Maguire‐Zeiss, K. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00417 · Cited by 65 · see citing works
Malherbe, D. C., & Messaoudi, I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.911951 · Cited by 64 · see citing works
Zhang, Z., Zhang, A.-R., Xu, M., Lou, J., & Qiu, W. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.02.025 · Cited by 62 · see citing works
Ohayon, L., Zhang, X., & Dutta, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105692 · Cited by 62 · see citing works
Manoharan, P., Basford, J. E., Pilcher-Roberts, R., Neumann, J. C., Hui, D. Y., & Lingrel, J. B. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.579763 · Cited by 61 · see citing works
MicroRNAs in the Diagnosis and Treatment of Cancer
Mansoori, B., Mohammadi, A., Shirjang, S., & Baradaran, B. (2017) · Immunological Investigations · doi:10.1080/08820139.2017.1377407 · Cited by 57 · see citing works
MiRNAs at the Crossroads between Innate Immunity and Cancer: Focus on Macrophages
Curtale, G. (2018) · Cells · doi:10.3390/cells7020012 · Cited by 57 · see citing works
Role of innate immunity in the development of hepatocellular carcinoma
Aravalli, R. N. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i43.7500 · Cited by 57 · see citing works
miR-92a inhibits vascular smooth muscle cell apoptosis: role of the MKK4–JNK pathway
Zhang, L., Zhou, M., Wang, Y., Huang, W., Qin, G., Weintraub, N. L., & Tang, Y. (2014) · APOPTOSIS · doi:10.1007/s10495-014-0987-y · Cited by 56 · see citing works
Mao, G., Wu, P., Zhang, Z., Zhang, Z., Liao, W., Li, Y., & Kang, Y. Q. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000484579 · Cited by 49 · see citing works
microRNA-92a promotes CNS autoimmunity by modulating the regulatory and inflammatory T cell balance
Fujiwara, M., Raheja, R., Garo, L. P., Ajay, A. K., Kadowaki-Saga, R., Karandikar, S. H., Gabriely, G., Krishnan, R., Beynon, V., Paul, A., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci155693 · Cited by 47 · see citing works
Wang, J., Zheng, S., Xin, N., Dou, C., Fu, L., Zhang, X., Chen, J., Zhang, Y., Geng, D., Xiao, C., et al. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9498-9 · Cited by 46 · see citing works
Self-citationSun, Y., Qin, Z., Li, Q., Wan, J.-J., Cheng, M., Wang, P., Su, D., Yu, J., & Liu, X. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.16 · Cited by 47 · see citing works
HDL and microRNA therapeutics in cardiovascular disease
Michell, D. L., & Vickers, K. C. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.09.001 · Cited by 45 · see citing works
Targeted polyelectrolyte complex micelles treat vascular complications in vivo
Zhou, Z., Yeh, C., Mellas, M. J., Oh, M., Zhu, J., Li, J., Huang, R., Harrison, D. L., Shentu, T., Wu, D., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2114842118 · Cited by 45 · see citing works
Saba, E., Jeon, B. R., Jeong, D., Lee, K., Goo, Y., Kwak, D., Kim, S., Roh, S., Kim, S., Nah, S.-Y., et al. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/624132 · Cited by 44 · see citing works
Jahanbani, I., Al-Abdallah, A., Ali, R. H., Al-Brahim, N., & Mojiminiyi, O. A. (2018) · Thyroid · doi:10.1089/thy.2017.0127 · Cited by 44 · see citing works
Dong, Y., Lu, C.-W., Zhang, L., Yang, J. Y., Hameed, W., & Chen, W. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.10.015 · Cited by 43 · see citing works
Self-citationIdentification and Characterization of MicroRNAs in the Spleen of Common Carp Immune Organ
Li, G., Zhao, Y., Wen, L., Liu, Z., Yan, F., & Gao, C. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24843 · Cited by 42 · see citing works
Simionescu, N., Niculescu, L. S., Carnuta, M. G., Sanda, G. M., Stancu, C. S., Popescu, A. C., Popescu, M. R., Vlad, A., Dimulescu, D. R., Simionescu, M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161201 · Cited by 42 · see citing works
Sarkar, S. N., Russell, A. E., Engler-Chiurazzi, E. B., Porter, K. N., & Simpkins, J. W. (2018) · Aging and Disease · doi:10.14336/ad.2018.0409 · Cited by 42 · see citing works
Huang, W., Wu, X., Xue, Y., Zhou, Y., Xiang, H., Yang, W., & Wei, Y. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.09.045 · Cited by 42 · see citing works
RNA therapeutics for retinal diseases
Gemayel, M. C., Bhatwadekar, A. D., & Ciulla, T. A. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2021.1856365 · Cited by 42 · see citing works
MicroRNAs are involved in cadmium tolerance in Daphnia pulex
Chen, S., Nichols, K. M., Poynton, H. C., & Sepúlveda, M. S. (2016) · Aquatic Toxicology · doi:10.1016/j.aquatox.2016.03.023 · Cited by 41 · see citing works
Identifying miRNA/mRNA negative regulation pairs in colorectal cancer
Zhou, X., Xu, X., Wang, J., Lin, J., & Chen, W. (2015) · Scientific Reports · doi:10.1038/srep12995 · Cited by 37 · see citing works
Self-citationNeri, M., Fabbri, M., D’Errico, S., Paolo, M. D., Frati, P., Gaudio, R. M., Russa, R. L., Maiese, A., Marti, M., Pinchi, E., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-56682-7 · Cited by 37 · see citing works
MicroRNAs and their potential therapeutic applications in neural tissue engineering
Nguyen, L. H., Diao, H. J., & Chew, S. Y. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.05.007 · Cited by 35 · see citing works
Zhang, J., Xu, Z., Kong, L., Gao, H. T., Zhang, Y., Zheng, Y., & Yu, W. C. (2020) · International Journal of COPD · doi:10.2147/copd.s280614 · Cited by 35 · see citing works
Self-citationSmall RNA Sequencing of Aqueous Humor and Plasma in Patients With Primary Open-Angle Glaucoma
Hubens, W. H. G., Krauskopf, J., Beckers, H. J. M., Kleinjans, J. C. S., Webers, C. A. B., & Gorgels, T. G. M. F. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.7.24 · Cited by 35 · see citing works
Nie, L., Cai, S.-Y., Sun, J., & Chen, J. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.11.030 · Cited by 34 · see citing works
MicroRNAs and fracture healing: Pre-clinical studies
Komatsu, D. E., Duque, E., & Hadjiargyrou, M. (2020) · Bone · doi:10.1016/j.bone.2020.115758 · Cited by 32 · see citing works
Extracellular <scp>RNA</scp> in aging
Dluzen, D. F., Noren Hooten, N., & Evans, M. K. (2017) · WIREs RNA · doi:10.1002/wrna.1385 · Cited by 31 · see citing works
The role of endothelial miRNAs in myocardial biology and disease
Boen, J. R. A., Gevaert, A. B., Keulenaer, G. W. D., Craenenbroeck, E. M. V., & Segers, V. F. M. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.11.151 · Cited by 31 · see citing works
Ponticelli, M., Russo, D., Faraone, I., Sinisgalli, C., Labanca, F., Lela, L., & Milella, L. (2021) · Molecules · doi:10.3390/molecules26040954 · Cited by 31 · see citing works
Bhatwadekar, A. D., Yan, Y., Stepps, V., Hazra, S., Korah, M. M., Bartelmez, S. H., Chaqour, B., & Grant, M. B. (2015) · Diabetes · doi:10.2337/db15-0521 · Cited by 31 · see citing works
Circulating MicroRNAs in Serum from Cattle Challenged with Bovine Viral Diarrhea Virus‡
Taxis, T. M., Bauermann, F. V., Ridpath, J. F., & Casas, E. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00091 · Cited by 29 · see citing works
Li, Z., Li, L., Kang, L., & Wang, Y. (2018) · Cancer Medicine · doi:10.1002/cam4.1329 · Cited by 28 · see citing works
RetractedAssociation of MicroRNAs with Antibody Response to Mycoplasma bovis in Beef Cattle
Casas, E., Cai, G., Kuehn, L. A., Register, K. B., McDaneld, T. G., & Neill, J. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161651 · Cited by 25 · see citing works
MicroRNAs as Regulators of Phagocytosis
Gierlikowski, W., & Gierlikowska, B. (2022) · Cells · doi:10.3390/cells11091380 · Cited by 25 · see citing works
Tsai, C., Hsieh, S., Liu, C., Lu, C., Liao, H., Chen, M., Li, K., Wu, C.-H., Shen, C.-Y., Kuo, Y., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115689 · Cited by 25 · see citing works
MicroRNA-mediated immune modulation as a therapeutic strategy in host-implant integration
Ong, S., Biswas, S. K., & Wong, S. C. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.05.013 · Cited by 25 · see citing works
Yu, X., Chen, D., Wang, L., Li, J., Khan, K., Chen, H., Liang, Y., Luo, H., & Qiu, C. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.04.22 · Cited by 23 · see citing works
Ji, X., Zhang, Y., Ku, T., Yun, Y., Li, G., & Sang, N. (2016) · Toxicology Research · doi:10.1039/c6tx00257a · Cited by 24 · see citing works
Self-citationLv, M., Chen, H., Shao, Y., Li, C., Zhang, W., Zhao, X., Jin, C., & Xiong, J. (2017) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2017.08.033 · Cited by 23 · see citing works
Song, L., Zhou, J., Wang, S., Yang, Q., Nie, S., Ji, C., Zhang, X., Li, S., Zhou, X., Chu, J., et al. (2025) · 癌症:英文版 · doi:10.1002/cac2.70034 · Cited by 24 · see citing works
Self-citationJin, P., Li, S., Sun, L., Lv, C., & Ma, F. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2017.05.002 · Cited by 22 · see citing works
Liu, E., Sun, H., Wu, J., & Kuang, Y. (2020) · Experimental Physiology · doi:10.1113/ep088708 · Cited by 22 · see citing works
Ahmadi, A., & Moradi, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-89605-6 · Cited by 21 · see citing works
Liao, X., Liu, Y., Zhang, Q., & Chen, J. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2017.01.007 · Cited by 20 · see citing works
Self-citationKhowawisetsut, L., Vimonpatranon, S., Lekmanee, K., Sawasdipokin, H., Srimark, N., Chotivanich, K., & Pattanapanyasat, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032631 · Cited by 20 · see citing works
Wang, X., Zhu, Y., Xu, B., Wang, J., & Liu, X. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5197 · Cited by 18 · see citing works
The Estrogen-Induced miR-19 Downregulates Secretory Leucoprotease Inhibitor Expression in Monocytes
McKiernan, P. J., Smith, S. G. J., Durham, A. L., Adcock, I. M., McElvaney, N. G., & Greene, C. M. (2019) · Journal of Innate Immunity · doi:10.1159/000500419 · Cited by 16 · see citing works
MiR-367 alleviates inflammatory injury of microglia by promoting M2 polarization via targeting CEBPA
Pei, H., Peng, Q., Guo, S., Gu, Y., Sun, T., Xu, D., Jiang, Y., Xie, J., Zhang, L., & Zhu, Z. (2020) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-020-00519-5 · Cited by 15 · see citing works
Long, Y., Liu, X., Wang, N., Zhou, H., & Zheng, J. (2015) · PubMed Central · Cited by 15 · see citing works
Bros, M., Youns, M., Kollek, V., Buchmüller, D., Bollmann, F., Seo, E., Schupp, J., Montermann, E., Usanova, S., Kleinert, H., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00915 · Cited by 14 · see citing works
Carnino, J. M., Lee, H., Smith, L. C., Sunil, V. R., Rancourt, R. C., Vayas, K. N., Cervelli, J. A., Kwok, Z. H., Ni, K., Laskin, J. D., et al. (2022) · Toxicological Sciences · doi:10.1093/toxsci/kfac025 · Cited by 14 · see citing works
MicroRNA-92a-1-5p influences osteogenic differentiation of MC3T3-E1 cells by regulating β-catenin
Lin, Z., Tang, Y., Tan, H., & Cai, D. (2018) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-018-0935-y · Cited by 13 · see citing works
Ibrahim, A., Ciullo, A., Li, C., Akhmerov, A., Peck, K. A., Jones-Ungerleider, K. C., Morris, A. A., Marchevsky, A. M., Marbán, E., & Ibrahim, A. G.-E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.733158 · Cited by 12 · see citing works
Li, W., Guan, X., & Sun, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207725 · Cited by 12 · see citing works
Gu, L., Wu, Y., Hu, S., Chen, Q., Tan, J., Yan, Y., Liang, B., & Tang, N. (2016) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2015.12.035 · Cited by 11 · see citing works
Self-citationHou, J., Zhao, L. Q., Yan, J., Ren, X., Zhu, K., Gao, T., Du, X., Luo, H., Li, Z., & Xu, M. (2019) · Journal of International Medical Research · doi:10.1177/0300060519858900 · Cited by 11 · see citing works
Syed, A., Hew, K. M., Kohli, A., Knowlton, G., & Nadeau, K. C. (2013) · Journal of Environmental Protection · doi:10.4236/jep.2013.48a1014 · Cited by 11 · see citing works
Cui, J., Ding, H., Yao, Y., & Liu, W. (2020) · BioMed Research International · doi:10.1155/2020/9673284 · Cited by 10 · see citing works
Wu, J.-G., Yang, W., Huang, H.-Z., Tang, K., & Zheng, G.-D. (2022) · International Heart Journal · doi:10.1536/ihj.22-163 · Cited by 9 · see citing works
Yang, L., Zhu, X., Ni, Y., Wu, D., Tian, Y., Chen, Z., Li, M., Zhang, H., & Liang, D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00829 · Cited by 9 · see citing works
RetractedVillar-Lorenzo, A., Ardiles, A., Arroba, A. I., Hernández-Jiménez, E., Pardo, V., López‐Collazo, E., Jiménez, I. A., Bazzocchi, I. L., González‐Rodríguez, Á., & Valverde, Á. M. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.10.004 · Cited by 9 · see citing works
MicroRNA‐92a inhibits macrophage antiviral response by targeting retinoic acid inducible gene‐I
Sheng, Y., Wang, Y., Lu, W., Zhou, Y., Dong, G., Ge, X., Song, Y., & Zhang, Y. (2018) · Microbiology and Immunology · doi:10.1111/1348-0421.12640 · Cited by 8 · see citing works
Self-citationVerma, M., Asakura, Y., & Asakura, A. (2019) · Muscle & Nerve · doi:10.1002/mus.26433 · Cited by 8 · see citing works
miR-92a and integrin expression in fibrovascular membranes in proliferative diabetic retinopathy
Luo, Q., Hajrasouliha, A. R., & Bhatwadekar, A. D. (2023) · Frontiers in Ophthalmology · doi:10.3389/fopht.2023.1116838 · Cited by 7 · see citing works
- Authors
- Lai, L., Song, Y., Liu, Y., Chen, Q., Han, Q., Chen, W., Pan, T., Zhang, Y., Cao, X., & Wang, Q.
- Affiliations
- Zhejiang University (CN)
- Second Military Medical University (CN)
- Corresponding author
- Wang, Qingqing
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 288
- Issue
- 11
- Pages
- 7956-7967
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3597832
- OpenAlex
- W1982263285
- Cited by
- 126
- References
- 65
- Citations by year
- 2026: 2 · 2025: 5 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 16 · 2019: 8 · 2018: 16 · 2017: 14 · 2016: 13 · 2015: 13 · 2014: 7 · 2013: 10
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- microRNA-92a, TLR4, macrophages, MKK4, JNK/c-Jun signaling, inflammatory cytokines, TNF-α, interleukin-6
- MeSH terms
- Animals, Humans, Inflammation, Ligands, Macrophages, Mice, Inbred C57BL, Signal Transduction, Gene Expression Regulation, Enzymologic, Mice, Knockout, 3' Untranslated Regions, RNA, Small Interfering, MicroRNAs, MAP Kinase Kinase 4, Toll-Like Receptor 4, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review