ZIP2 protein, a zinc transporter, is associated with keratinocyte differentiation
Open accessAbstract
Zinc is essential for the proper functioning of various enzymes and transcription factors, and its homeostasis is rigorously controlled by zinc transporters (SLC39/ZIP, importers; SLC30/ZnT, exporters). Skin disease is commonly caused by a zinc deficiency. Dietary and inherited zinc deficiencies are known to cause alopecia and the development of vesicular or pustular dermatitis. A previous study demonstrated that zinc played crucial roles in the survival of keratinocytes and their unique functions. High levels of zinc have been detected in the epidermis. Epidermal layers are considered to use a mechanism that preferentially takes in zinc, which is involved with the unique functions of keratinocytes. However, few studies have investigated the ZIP (Zrt- and Irt-like protein) proteins specifically expressed in keratinocytes and their functions. We explored the ZIP proteins specifically expressed in the epidermis and analyzed their functions. Gene expression analysis showed that the expression of ZIP2 was consistently higher in the epidermis than in the dermis. Immunohistochemistry analysis confirmed the expression of ZIP2 in differentiating keratinocytes. The expression of ZIP2 was found to be up-regulated by the differentiation induction of cultured keratinocytes. Intracellular zinc levels were decreased in keratinocytes when ZIP2 was knocked down by siRNA, and this subsequently inhibited the differentiation of keratinocytes. Moreover, we demonstrated that ZIP2 knockdown inhibited the normal formation of a three-dimensional cultured epidermis. Taken together, the results of this study suggest that ZIP2, a zinc transporter expressed specifically in the epidermis, and zinc taken up by ZIP2 are necessary for the differentiation of keratinocytes.
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The ZIP2 protein, a zinc transporter, is essential for the differentiation of keratinocytes.
“The ZIP2 protein, a zinc transporter, is essential for the differentiation of keratinocytes [103].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [103]
Cites
Trace Elements in Human and Animal Nutrition
UNDERWOOD, E. J. (1963) · Soil Science · doi:10.1097/00010694-196304000-00029 · Cited by 4,511 · see citing works
Trace Elements in Human and Animal Nutrition
(1977) · Elsevier eBooks · doi:10.1016/b978-0-12-709065-8.x5001-9 · Cited by 1,181 · see citing works
Counting the Zinc-Proteins Encoded in the Human Genome
Andreini, C., Banci, L., Bertini, I., & Rosato, A. (2006) · Journal of Proteome Research · doi:10.1021/pr050361j · Cited by 1,109 · see citing works
Zinc transporters and the cellular trafficking of zinc
Eide, D. J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.03.005 · Cited by 874 · see citing works
Klf4 is a transcription factor required for establishing the barrier function of the skin
Segre, J. A., Bauer, C., & Fuchs, E. V. (1999) · Nature Genetics · doi:10.1038/11926 · Cited by 793 · see citing works
Coordination Dynamics of Zinc in Proteins
Maret, W., & Li, Y. (2009) · Chemical Reviews · doi:10.1021/cr800556u · Cited by 644 · see citing works
Zinc homeostasis and signaling in health and diseases
Fukada, T., Yamasaki, S., Nishida, K., Murakami, M., & Hirano, T. (2011) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-011-0797-4 · Cited by 600 · see citing works
Keratin cytoskeletons in epithelial cells of internal organs
Sun, T., Shih, C., & Green, H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.6.2813 · Cited by 483 · see citing works
Overview of mammalian zinc transporters
Kambe, T., Yamaguchi‐Iwai, Y., Sasaki, R., & Nagao, M. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3148-y · Cited by 406 · see citing works
Molecular and genetic features of zinc transporters in physiology and pathogenesis
Fukada, T., & Kambe, T. (2011) · Metallomics · doi:10.1039/c1mt00011j · Cited by 295 · see citing works
Effect of Iron Deficiency and Desferrioxamine on DNA Synthesis in Human Cells
Hoffbrand, A. V., GANESHAGURU, K., Hooton, J. W. L., & Tattersall, M. H. N. (1976) · British Journal of Haematology · doi:10.1111/j.1365-2141.1976.tb03570.x · Cited by 240 · see citing works
Kambe, T., & Andrews, G. K. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00963-08 · Cited by 130 · see citing works
Xue, M., Thompson, P., Kelso, I. M., & Jackson, C. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.05.015 · Cited by 92 · see citing works
Cao, J., Bobo, J. A., Liuzzi, J. P., & Cousins, R. J. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.4.559 · Cited by 91 · see citing works
Peters, J. L., Dufner‐Beattie, J., Xu, W., Geiser, J., Lahner, B., Salt, D. E., & Andrews, G. K. (2007) · genesis · doi:10.1002/dvg.20297 · Cited by 72 · see citing works
Zinc in epidermis and dermis in healthy subjects
Michaëlsson, G., Ljunghall, K., & Danielson, B. (1980) · Acta Dermato Venereologica · doi:10.2340/0001555560295299 · Cited by 61 · see citing works
Voorhees, J. J. (1977) · Annual Review of Medicine · doi:10.1146/annurev.me.28.020177.002343 · Cited by 58 · see citing works
Apoptosis may underlie the pathology of zinc‐deficient skin
Wilson, D., Varigos, G., & Ackland, M. L. (2005) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2005.01391.x · Cited by 51 · see citing works
Chew, Y. C., Adhikary, G., Xu, W., Wilson, G. M., & Eckert, R. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.477133 · Cited by 40 · see citing works
Differentiation Induction of Human Keratinocytes by Phosphatidylethanolamine-binding Protein
Yamazaki, T., Nakano, H., Hayakari, M., Tanaka, M., Mayama, J., & Tsuchida, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404029200 · Cited by 30 · see citing works
Self-citationEffects of Zinc Histidine and Zinc Sulfate on Natural Human Keratinocytes
Deters, A. M., Schnetz, E., Schmidt, M., & Hensel, A. (2003) · Complementary Medicine Research · doi:10.1159/000069903 · Cited by 19 · see citing works
Pinheiro, T., Silva, R., Fleming, R., Gonçalves, A., Barreiros, M. A., Silva, J. M., Morlière, P., Santus, R. C., & Filipe, P. (2014) · Acta Dermato Venereologica · doi:10.2340/00015555-1601 · Cited by 17 · see citing works
Modulation of Nrf2-dependent antioxidant functions in the RPE by Zip2, a zinc transporter protein.
Rezaei, K., Chen, Y., Cai, J.-Y., & Sternberg, P. (2008) · Investigative Ophthalmology and Visual Science · doi:10.1167/iovs.07-0959 · Cited by 16 · see citing works
Kodera, H., Nishioka, H., Muramatsu, Y., & Terada, Y. (2008) · Analytical Sciences · doi:10.2116/analsci.24.1545 · Cited by 15 · see citing works
Light-scattering studies of cation-stimulated filament assembly of newborn rat epidermal keratin
Sakamoto, M., Tzeng, S., Fukuyama, K., & Epstein, W. L. (1980) · Biochimica et Biophysica Acta (BBA) - Protein Structure · doi:10.1016/0005-2795(80)90239-1 · Cited by 10 · see citing works
PHYSIOLOGICALLY IMPORTANT TRACE ELEMENTS OF PARALESIONAL PSORIATIC SKIN
Werner-Linde, Y., Pallon, J., & Forslind, B. (1998) · Cited by 8 · see citing works
Hodge, L. A., & Comaish, J. S. (1977) · Drugs · doi:10.2165/00003495-197713040-00004 · Cited by 6 · see citing works
UVB radiation induces an increase in intracellular zinc in human epidermal keratinocytes
Li (2010) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000486 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kambe, T., Tsuji, T., Hashimoto, A., & Itsumura, N. (2015) · Physiological Reviews · doi:10.1152/physrev.00035.2014 · Cited by 1,158 · see citing works
Bioactive Compounds for Skin Health: A Review
Michalak, M., Pierzak, M., Kręcisz, B., & Suliga, E. (2021) · Nutrients · doi:10.3390/nu13010203 · Cited by 345 · see citing works
Ogawa, Y., Kinoshita, M., Shimada, S., & Kawamura, T. (2018) · Nutrients · doi:10.3390/nu10020199 · Cited by 214 · see citing works
Vollmer, D. L., West, V. A., & Lephart, E. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103059 · Cited by 132 · see citing works
Coger, V., Million, N., Rehbock, C., Sures, B., Nachev, M., Barcikowski, S., Wistuba, N., Strauß, S., & Vogt, P. M. (2018) · Biological Trace Element Research · doi:10.1007/s12011-018-1600-y · Cited by 125 · see citing works
Ogawa, Y., Kawamura, T., & Shimada, S. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.06.003 · Cited by 123 · see citing works
Baltacı, A. K., & Yüce, K. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2454-y · Cited by 117 · see citing works
Recent Advances in the Role of SLC39A/ZIP Zinc Transporters In Vivo
Takagishi, T., Hara, T., & Fukada, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122708 · Cited by 95 · see citing works
Drosophila melanogaster Models of Metal-Related Human Diseases and Metal Toxicity
Calap-Quintana, P., González-Fernández, J., Sebastiá-Ortega, N., Llorens, J. V., & Moltó, M. D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071456 · Cited by 97 · see citing works
Zinc transporters as potential therapeutic targets: An updated review
Hara, T., Yoshigai, E., Ohashi, T., & Fukada, T. (2021) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2021.11.007 · Cited by 89 · see citing works
Xiao, J., Zhou, Y., Ye, M., An, Y., Wang, K., Wu, Q., Song, L., Zhang, J., He, H., Zhang, Q., et al. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202001591 · Cited by 87 · see citing works
Bengalli, R. D., Colantuoni, A., Perelshtein, I., Gedanken, A., Collini, M., Mantecca, P., & Fiandra, L. (2020) · NanoImpact · doi:10.1016/j.impact.2020.100282 · Cited by 76 · see citing works
Constantino, V. R. L., Figueiredo, M. P., Magri, V. R., Eulálio, D., Cunha, V. R. R., Alcântara, A. C. S., & Perotti, G. F. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020413 · Cited by 73 · see citing works
Han, Z., Deng, L., Chen, S., Wang, H., & Huang, Y. (2022) · Burns & Trauma · doi:10.1093/burnst/tkac048 · Cited by 73 · see citing works
Zinc and its binding proteins: essential roles and therapeutic potential
Kiouri, D. P., Chasapis, C. T., Mavromoustakos, T., Spiliopoulou, C., & Stefanidou, M. E. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03891-3 · Cited by 56 · see citing works
Zinc and Zinc Transporters in Dermatology
Al-Khafaji, Z., Brito, S., & Bin, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416165 · Cited by 47 · see citing works
Bin, B.-H., Bhin, J., Kim, N.-H., Lee, S.-H., Jung, H.-S., Seo, J., Kim, D., Hwang, D., Fukada, T., Lee, A., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.11.028 · Cited by 43 · see citing works
Zinc in Dog Nutrition, Health and Disease: A Review
Pereira, A. M., Maia, M. R. G., Fonseca, A. J. M., & Cabrita, A. R. J. (2021) · Animals · doi:10.3390/ani11040978 · Cited by 42 · see citing works
Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis
Ogawa, Y., Kinoshita, M., Shimada, S., & Kawamura, T. (2018) · Journal of Immunology Research · doi:10.1155/2018/5404093 · Cited by 40 · see citing works
Gene Expression Linked to Reepithelialization of Human Skin Wounds
Ågren, M. S., Litman, T., Eriksen, J. O., Schjerling, P., Bzorek, M., & Gjerdrum, L. M. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415746 · Cited by 39 · see citing works
Kamei, S., Fujikawa, H., Nohara, H., Ueno-Shuto, K., Maruta, K., Nakashima, R., Kawakami, T., Matsumoto, C., Sakaguchi, Y., Ono, T., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.12.025 · Cited by 38 · see citing works
Hara, T., Yoshigai, E., Ohashi, T., & Fukada, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087152 · Cited by 36 · see citing works
Laminin-332 regulates differentiation of human interfollicular epidermal stem cells
Yamada, T., Hasegawa, S., Miyachi, K., Date, Y., Inoue, Y., Yagami, A., Arima, M., Iwata, Y., Yamamoto, N., Nakata, S., et al. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.03.007 · Cited by 35 · see citing works
Self-citationBin, B., Lee, S. ‐., Bhin, J., Irié, T., Kim, S., Seo, J., Mishima, K., Lee, T. R., Hwang, D., Fukada, T., et al. (2018) · British Journal of Dermatology · doi:10.1111/bjd.17339 · Cited by 32 · see citing works
Differential expression of zinc transporters accompanies the differentiation of C2C12 myoblasts
Paskavitz, A. L., Quintana, J., Cangussu, D., Tavera‐Montañez, C., Xiao, Y., Ortiz‐Miranda, S., Navea, J. G., & Padilla‐Benavides, T. (2018) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2018.04.024 · Cited by 31 · see citing works
The Role of the Slc39a Family of Zinc Transporters in Zinc Homeostasis in Skin
Bin, B.-H., Hojyo, S., Seo, J., Hara, T., Takagishi, T., Mishima, K., & Fukada, T. (2018) · Nutrients · doi:10.3390/nu10020219 · Cited by 30 · see citing works
Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2
Franz, M.-C., Pujol‐Giménez, J., Montalbetti, N., Fernández-Tenorio, M., DeGrado, T. R., Ernst Niggli, A., Romero, M. F., & Hediger, M. A. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00511 · Cited by 29 · see citing works
Optically Induced Nanostructures
Ostendorf, A., & König, K. (2015) · De Gruyter eBooks · doi:10.1515/9783110354324 · Cited by 27 · see citing works
Larsen, H., Ahlström, M. G., Gjerdrum, L. M. R., Mogensen, M., Ghathian, K. S. A., Calum, H., Sørensen, A. L., Forman, J. L., Vandeven, M. H., Holerca, M. N., et al. (2017) · Wound Repair and Regeneration · doi:10.1111/wrr.12605 · Cited by 27 · see citing works
Dietrich, N., Schneider, D. L., & Kornfeld, K. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx762 · Cited by 26 · see citing works
Maita, K. C., Ávila, F. R., Torres‐Guzman, R. A., Garcia, J. P., Eldaly, A. S., Serrano, L. P., Emam, O. S., Ho, O. A., & Forte, A. J. (2022) · Journal of Clinical and Translational Research · doi:10.18053/jctres.08.202206.007 · Cited by 25 · see citing works
Gyimesi, G., Albano, G. D., Fuster, D. G., Hediger, M. A., & Pujol‐Giménez, J. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006113 · Cited by 25 · see citing works
Risk factors for claw disorders in intensively finished Charolais beef cattle
Magrin, L., Brščić, M., Armato, L., Contiero, B., Lotto, A., Cozzi, G., & Gottardo, F. (2019) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2019.104864 · Cited by 24 · see citing works
Zinc Deficiency and Zinc Supplementation in Allergic Diseases
Maywald, M., & Rink, L. (2024) · Biomolecules · doi:10.3390/biom14070863 · Cited by 23 · see citing works
Gao, L., Zhang, H., Yu, B., Li, W., Gao, F., Zhang, K., Zhang, H., Shen, Y., & Cong, H. (2020) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36952 · Cited by 22 · see citing works
Ågren, M. S., Chafranska, L., Eriksen, J. O., Forman, J. L., Bjerrum, M. J., Schjerling, P., Larsen, H., Cottarelli, E., Jørgensen, L. N., & Gjerdrum, L. M. R. (2020) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2020.151147 · Cited by 20 · see citing works
Kohlmeier, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-387784-0.00011-0 · Cited by 20 · see citing works
Lu, C., Pang, J. S., Ko, Y., Chang, C., Wang, C., Chen, W., Chen, C., Hui, R. C., Chung, W., Lu, L., et al. (2022) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18703 · Cited by 17 · see citing works
Tohyama, M., Sakaguchi, C., Nishina, T., & Hyodo, I. (2021) · The Journal of Dermatology · doi:10.1111/1346-8138.16049 · Cited by 16 · see citing works
Wang, H., Wang, X., Yang, Y., Zhu, Y., Wang, S., Chen, Q., Yan, D., Dong, X., Li, M., & Lu, S. (2024) · BMC Genomics · doi:10.1186/s12864-024-10484-y · Cited by 13 · see citing works
Senescent cell removal via JAG1‐NOTCH1 signalling in the epidermis
Yoshioka, H., Yamada, T., Hasegawa, S., Miyachi, K., Ishii, Y., Hasebe, Y., Inoue, Y., Tanaka, H., Iwata, Y., Arima, M., et al. (2021) · Experimental Dermatology · doi:10.1111/exd.14361 · Cited by 13 · see citing works
Self-citationRichards, C. D., & Burke, R. (2015) · BioMetals · doi:10.1007/s10534-015-9881-5 · Cited by 13 · see citing works
A Topical Zinc Ionophore Blocks Tumorigenic Progression in UV‐exposed SKH‐1 High‐risk Mouse Skin
Justiniano, R., Perer, J., Hua, A., Fazel, M., Krajisnik, A., Cabello, C. M., & Wondrak, G. T. (2017) · Photochemistry and Photobiology · doi:10.1111/php.12794 · Cited by 13 · see citing works
Wei, Y., Zhu, X., Lin, S., Yang, W., Wang, T., Nie, X., Shi, Z., Liu, Z., Zhang, R., & Li, D. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117129 · Cited by 12 · see citing works
Becares, E. R., Pedersen, P. A., Gourdon, P. E., & Gotfryd, K. (2021) · Cells · doi:10.3390/cells10020213 · Cited by 12 · see citing works
dos Santos, F. M., Piffer, A. C., Schneider, R., Ribeiro, N. S., Garcia, A. W. A., Schrank, A., Kmetzsch, L., Vainstein, M. H., & Staats, C. C. (2017) · Future Microbiology · doi:10.2217/fmb-2016-0160 · Cited by 10 · see citing works
Biochemical Markers of Zinc Nutrition
Wang, X., Zhang, M. H., Ma, J., Tie, Y., & Wang, S. (2024) · Biological Trace Element Research · doi:10.1007/s12011-024-04091-x · Cited by 9 · see citing works
Shaw, P., Sharma, A. K., Kalonia, A., Kirti, Kumar, R., Yashavarddhan, M. H., Surya, P., Singh, S., & Shukla, S. K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138679 · Cited by 9 · see citing works
Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review
Abadie, M. A., Sharara, Z., Abadie, M., Ball, P., & Morrissey, H. (2022) · Dermatology Reports · doi:10.4081/dr.2022.9512 · Cited by 8 · see citing works
Otsuka, M., Saito, H., & Sasaki, T. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102105 · Cited by 8 · see citing works
Combined Metallomics/Transcriptomics Profiling Reveals a Major Role for Metals in Wound Repair
Wilkinson, H. N., Guinn, B., & Hardman, M. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.788596 · Cited by 8 · see citing works
Influence of dietary zinc on the claw and interdigital skin of sheep
Bauer, B. U., Rapp, C., Mülling, C. K. W., Meissner, J., Vogel, C., & Humann-Ziehank, E. (2018) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2018.07.026 · Cited by 7 · see citing works
Xu, J., Gu, H., Zhou, K., Wu, L. L., Zhang, Y., Bian, C., Huang, Z., Chen, G., Cheng, X., & Yin, X. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70431 · Cited by 7 · see citing works
Correlation between psoriasis and ZIP2 and ZIP3 Zinc transporters
Kiliç, S. O., & Şehitoğlu, H. (2020) · Turkish Journal of Dermatology · doi:10.4103/tjd.tjd_29_20 · Cited by 7 · see citing works
Zinc has a role in pathogenesis of pityriasis alba
Akl, E. M., Elesawy, F. M., & Halim, W. A. A. (2020) · Indian Journal of Paediatric Dermatology · doi:10.4103/ijpd.ijpd_109_19 · Cited by 7 · see citing works
Yeh, C., Huang, W., Lu, C., Chen, C., Lin, S., Pan, Y., & Wu, C. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03618-y · Cited by 7 · see citing works
Nishito, Y., Hashimoto, A., & Kambe, T. (2023) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2023.04.017 · Cited by 5 · see citing works
Epidermal turnover and iron metabolism in senile lentigo
Odawara, M., Mezaki, M., Yoshimura, T., Takaoka, A., Oda, F., Saeki, H., & Funasaka, Y. (2024) · The Journal of Dermatology · doi:10.1111/1346-8138.17034 · Cited by 5 · see citing works
Inoue, Y., Hasegawa, S., Miyachi, K., Yamada, T., Nakata, S., Ipponjima, S., Hibi, T., Nemoto, T., Tanaka, M., Suzuki, R., et al. (2018) · Experimental Dermatology · doi:10.1111/exd.13672 · Cited by 5 · see citing works
Self-citationÜnal, Ö., Baltacı, A. K., Moğulkoç, R., & Avunduk, M. C. (2021) · Biotechnic & Histochemistry · doi:10.1080/10520295.2021.1885738 · Cited by 5 · see citing works
Million, N., Coger, V., Wilke, P., Rehbock, C., Vogt, P. M., Pich, A., & Barcikowski, S. (2017) · BioNanoMaterials · doi:10.1515/bnm-2017-0004 · Cited by 5 · see citing works
Zinc transporters in physiology and pathophysiology
Fukada, T., Bin, B., Hara, T., Takagishi, T., Yoshigai, E., & Lian, X. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-805378-2.00004-8 · Cited by 3 · see citing works
3. Laser-generated bioactive hydrogels as ion-release systems for burn wound therapy
Coger, V., Million, N., Wilke, P., Pich, A., Vogt, P. M., Reimers, K., & Barcikowski, S. (2015) · De Gruyter eBooks · doi:10.1515/9783110354324-014 · Cited by 3 · see citing works
Tsukui, K., Suzuki, M., Amma, M., Kawaguchi, S.-I., & Tokudome, Y. (2025) · Molecules · doi:10.3390/molecules30234592 · Cited by 2 · see citing works
Effect of Zinc-Deficient Diet on Two Strains of Mice
Tadokoro, K., Ohta, M., KAKUNO, Y., Iida, A., & Nakamura, T. (2023) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.69.444 · Cited by 2 · see citing works
Dysregulated zinc homeostasis in rare skin disorders
Hojyo, S., Bin, B.-H., & Fukada, T. (2017) · Expert Opinion on Orphan Drugs · doi:10.1080/21678707.2017.1394184 · Cited by 2 · see citing works
Zinc transporters in the epidermis
Ogawa, Y., Kinoshita, M., Shimada, S., Kambe, T., & Kawamura, T. (2019) · The Journal of Dermatology · doi:10.1111/1346-8138.14797 · Cited by 2 · see citing works
Otsuka, M., Saito, H., Hattori, Y., & Sasaki, T. (2025) · Next Materials · doi:10.1016/j.nxmate.2025.100642 · Cited by 1 · see citing works
Age-related redistribution of zinc and copper within human skin
Zakaria, N., Griffiths, A., Gânier, C., Lynch, M., Messenger, D. J., Bhogal, R. K., & Maret, W. (2026) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2026.127837 · Cited by 2 · see citing works
Skin carcinogenesis: the pathogenetic and therapeutic role of zinc
Emri, G., Emri, E., Boros, G., Janka, E. A., & Remenyik, É. (2015) · University of Debrecen Electronic Archive (University of Debrecen) · Cited by 1 · see citing works
Epidermal keratinocytes need zinc
Ogawa, Y. (2019) · British Journal of Dermatology · doi:10.1111/bjd.17496 · Cited by 1 · see citing works
Takagishi, T., Hara, T., & Fukada, T. (2019) · Folia Pharmacologica Japonica · doi:10.1254/fpj.154.327 · Cited by 1 · see citing works
Ardi, D. A., Candra, A., & Dieny, F. F. (2020) · Media Gizi Mikro Indonesia · doi:10.22435/mgmi.v11i2.1212 · Cited by 1 · see citing works
Aminoácidos, minerais, vitaminas e a saúde do casco dos bovinos
Queiroz, P. J. B., Assis, B. M., Silva, D. C., Dantas, A. V. E., Rabelo, R. E., & da Silva, L. A. F. (2018) · Revista Acadêmica Ciência Animal · doi:10.7213/1981-4178.2018.163102
Ogawa, Y., & Kawamura, T. (2019) · The Nishinihon Journal of Dermatology · doi:10.2336/nishinihonhifu.81.165
Zinc Transporters and Zinc Signaling in Skin Formation and Diseases
Bin, B., Lee, M., Hara, T., Takagishi, T., & Fukada, T. (2019) · Springer eBooks · doi:10.1007/978-981-15-0557-7_15
Bangash, S. U. K., McNeill, F. E., Farquharson, M., Wainman, B. C., & Zeller, M. P. (2025) · Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms · doi:10.1016/j.nimb.2025.165696
Syahputra, G., Louisa, M., Putra, M. Y., Wijayanti, R., Gustini, N., & Rosyidah, A. (2025) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2025v17i6.55054
wang, H., Wang, X., Yang, Y., Zhu, Y., Wang, S., Chen, Q., Yan, D., Dong, X., li, M., & Lu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26732083
wang, H., Wang, X., Yang, Y., Zhu, Y., Wang, S., Chen, Q., Yan, D., Dong, X., li, M., & Lu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26732080
Wang, H., Wang, X., Yang, Y., Zhu, Y., Wang, S., Chen, Q., Yan, D., Dong, X., li, M., & Lu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26732098
wang, H., Wang, X., Yang, Y., Zhu, Y., Wang, S., Chen, Q., Yan, D., Dong, X., li, M., & Lu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26732101
wang, H., Wang, X., Yang, Y., Zhu, Y., Wang, S., Chen, Q., Yan, D., Dong, X., li, M., & Lu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26011981
wang, H., Wang, X., Yang, Y., Zhu, Y., Wang, S., Chen, Q., Yan, D., Dong, X., li, M., & Lu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26732092
wang, H., Wang, X., Yang, Y., Zhu, Y., Wang, S., Chen, Q., Yan, D., Dong, X., li, M., & Lu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26732086
wang, H., Wang, X., Yang, Y., Zhu, Y., Wang, S., Chen, Q., Yan, D., Dong, X., li, M., & Lu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26011739
wang, H., Wang, X., Yang, Y., Zhu, Y., Wang, S., Chen, Q., Yan, D., Dong, X., li, M., & Lu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26732089
wang, H., Wang, X., Yang, Y., Zhu, Y., Wang, S., Chen, Q., Yan, D., Dong, X., li, M., & Lu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26732104
wang, H., Wang, X., Yang, Y., Zhu, Y., Wang, S., Chen, Q., Yan, D., Dong, X., Li, M., & Lu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26732095
Zinc transporters and cardiac pathophysiology
Cheng, X., Zhao, H., Zhang, Q., & Xu, Z. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.02.045
The Zinc–Senescence Axis in Skin Aging and Wound Healing: A Narrative Review
Mutig, K., Singh, P. B., Azhibek, D., & Lebedeva, S. A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177713
Spiniello, S., Termini, D., Tavoletti, G., Avallone, G., Violetti, S. A., Marzano, A. V., & Nazzaro, G. (2026) · Nutrients · doi:10.3390/nu18172865
- Authors
- Inoue, Y., Hasegawa, S., Ban, S., Yamada, T., Date, Y., Mizutani, H., Nakata, S., Tanaka, M., & Hirashima, N.
- Affiliations
- Nagoya City University (JP)
- Fujita Health University (JP)
- Nippon Menard Cosmetic (Japan) (JP)
- Corresponding author
- Inoue, Yu
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 289
- Issue
- 31
- Pages
- 21451-21462
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC4118108
- OpenAlex
- W2081337005
- Cited by
- 87
- References
- 28
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 11 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 12 · 2017: 10 · 2016: 2 · 2015: 6
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (25430040)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
- Keywords
- ZIP2, zinc transporters, keratinocyte differentiation, zinc homeostasis, epidermis, zinc deficiency, hair loss, pustular dermatitis, epidermal differentiation, siRNA knockdown
- MeSH terms
- Epidermal Cells, Animals, Base Sequence, Cell Differentiation, Cells, Cultured, Epidermis, Humans, Keratinocytes, DNA Primers, Cation Transport Proteins, RNA, Small Interfering, Mice, Gene Knockdown Techniques, Real-Time Polymerase Chain Reaction
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