Cited by 197Iron Metabolism and DisordersTrace Elements in HealthImmune Response and Inflammation

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Regulation of Reticuloendothelial Iron Transporter MTP1 (Slc11a3) by Inflammation

Open access

Yang, Funmei, Liu, Xiao-bing, Quinones, Marlon, Melby, Peter C., Ghio, Andrew, Haile, David J.·2002·Journal of Biological Chemistry

DOI 10.1074/jbc.m201485200

Open this paper in CoChat — free account

Abstract

Acute and chronic inflammation cause many changes in total body iron metabolism including the sequestration of iron in phagocytic cells of the reticuloendothelial system. This change in iron metabolism contributes to the development of the anemia of inflammation. MTP1, the duodenal enterocyte basolateral iron exporter, is also expressed in the cells of the reticuloendothelial system (RES) and is likely to be involved in iron recycling of these cells. In this study, we use a lipopolysaccharide model of the acute inflammation in the mouse and demonstrate that MTP1 expression in RES cells of the spleen, liver, and bone marrow is down-regulated by inflammation. The down-regulation of splenic expression of MTP1 by inflammation was also observed in a Leishmania donovani model of chronic infection. The response of MTP1 to lipopolysaccharide (LPS) requires signaling through the LPS receptor, Toll-like receptor 4 (TLR4). In mice lacking TLR4, MTP1 expression is not altered in response to LPS. In addition, mice lacking tumor necrosis factor-receptor 1a respond appropriately to LPS with down-regulation of MTP1, despite hyporesponsiveness to tumor necrosis factor-alpha signaling, suggesting that this cytokine may not be required for the LPS effect. We hypothesize that the iron sequestration in the RES system that accompanies inflammation is because of down-regulation of MTP1.

Integrity signals

Registry

Crossref · 10.1074/jbc.m201485200

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
Pfeffer, K., Matsuyama, T., Kündig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Krönke, M., & Mak, T. W. (1993) · Cell · doi:10.1016/0092-8674(93)90134-c · Cited by 1,677
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667
A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422
A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism
Abboud, S., & Haile, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000713200 · Cited by 1,267
Self-citation
Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene
Montosi, G., Donovan, A., Totaro, A., Garuti, C., Pignatti, E., Cassanelli, S., Trenor, C. C., Gasparini, P., Andrews, N. C., & Pietrangelo, A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13468 · Cited by 562
Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene
Montosi, G., Donovan, A., Totaro, A., Garuti, C., Pignatti, E., Cassanelli, S., Trenor, C. C., Gasparini, P., Andrews, N. C., & Pietrangelo, A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113468 · Cited by 557
A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis
Njajou, O. T., Vaessen, N., Joosse, M., Berghuis, B., van Dongen, J. W. F., Breuning, M. H., Snijders, P. J. L. M., Rutten, W. P. F., Sandkuijl, L. A., Oostra, B. A., et al. (2001) · Nature Genetics · doi:10.1038/90038 · Cited by 492
Iron, Infections, and Anemia of Inflammation
Jurado, R. L. (1997) · Clinical Infectious Diseases · doi:10.1086/515549 · Cited by 358
Ferritin Synthesis in Inflammation: I. PATHOGENESIS OF IMPAIRED IRON RELEASE
Konijn, A. M., & Hershko, C. (1977) · British Journal of Haematology · doi:10.1111/j.1365-2141.1977.tb08806.x · Cited by 247

Show all 44 references

Research works printed but not linked: 10

Means, 1999, Int. J. Hematol., 70, 7
Bertero, 1997, Haematologica, 82, 375
Tanaka, 1987, J. Biol. Respon. Modif., 6, 484
Alvarez-Hernandez, 1989, Lab. Invest., 61, 319
Raja, 1990, Int. J. Exp. Pathol., 71, 785
Kampschmidt, 1980, J. Lab. Clin. Med., 95, 616
Beguin, 1989, J. Lab. Clin. Med., 113, 346
Feldman, 1981, Am. J. Vet. Res., 42, 586
Feldman, 1981, Am. J. Vet. Res., 42, 583
Feldman, 1981, Am. J. Vet. Res., 42, 1109

Sorted by citations

Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Balancing Acts
Hentze, M. W., Muckenthaler, M. U., & Andrews, N. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00343-5 · Cited by 1,736
Ironing out Ferroportin
Drakesmith, H., Nemeth, E., & Ganz, T. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.006 · Cited by 638
MAMMALIAN ZINC TRANSPORTERS
Liuzzi, J. P., & Cousins, R. J. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132402 · Cited by 590
Intracellular iron transport and storage: from molecular mechanisms to health implications
Mackenzie, E. L., Iwasaki, K., & Tsuji, Y. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1893 · Cited by 526
Iron, anaemia, and inflammatory bowel diseases
Gasché, C., Lomer, M. C. E., Cavill, I., & Weiss, G. (2004) · Gut · doi:10.1136/gut.2003.035758 · Cited by 501
Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin
Knutson, M. D., Oukka, M., Koss, L. M., Aydemir, F., & Wessling-Resnick, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409409102 · Cited by 479
Iron Homeostasis and the Inflammatory Response
Wessling-Resnick, M. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104804 · Cited by 480
Differential regulation of iron homeostasis during human macrophage polarized activation
Recalcati, S., Locati, M., Marini, A., Santambrogio, P., Zaninotto, F., De Pizzol, M., Zammataro, L., Girelli, D., & Cairo, G. (2010) · European Journal of Immunology · doi:10.1002/eji.200939889 · Cited by 438
Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications
Theurl, I., Aigner, E., Theurl, M., Nairz, M., Seifert, M., Schroll, A., Sonnweber, T., Eberwein, L., Witcher, D. R., Murphy, A. T., et al. (2009) · Blood · doi:10.1182/blood-2008-12-195651 · Cited by 421
The struggle for iron - a metal at the host-pathogen interface: Iron at the host-pathogen interface
Nairz, M., Schroll, A., Sonnweber, T., & Weiss, G. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01529.x · Cited by 398
TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens
Peyssonnaux, C., Zinkernagel, A. S., Datta, V., Lauth, X., Johnson, R. S., & Nizet, V. (2006) · Blood · doi:10.1182/blood-2005-06-2259 · Cited by 379
The ferroportin disease
Pietrangelo, A. (2003) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2003.08.003 · Cited by 382
Iron Sequestration and Anemia of Inflammation
Ganz, T., & Nemeth, E. (2009) · Seminars in Hematology · doi:10.1053/j.seminhematol.2009.06.001 · Cited by 361
Iron in infection and immunity
Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359
Iron Metabolism in the Reticuloendothelial System
Knutson, M. D., & Wessling‐Resnick, M. (2003) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/713609210 · Cited by 360
Iron at the interface of immunity and infection
Nairz, M., Haschka, D., Demetz, E., & Weiss, G. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00152 · Cited by 325
“Macrophage iron content is further expanded via an inhibitory effect of IFN-γ and LPS on ferroportin transcription thereby reducing cellular iron egress (Yang et al., 2002; Ludwiczek et al., 2003).”
Background
Iron metabolism in the anemia of chronic disease
Weiss, G. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.08.006 · Cited by 322
Iron in Neurodegeneration – Cause or Consequence?
Ndayisaba, A., Kaindlstorfer, C., & Wenning, G. K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00180 · Cited by 304
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis
Muckenthaler, M. U., Roy, C. N., Custodio, Á. O., Miñana, B., DEGRAAF, J., Montross, L. K., Andrews, N. C., & Hentze, M. W. (2003) · Nature Genetics · doi:10.1038/ng1152 · Cited by 295
Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin
Delaby, C., Pilard, N., Gonçalves, A. S., Beaumont, C., & Canonne-Hergaux, F. (2005) · Blood · doi:10.1182/blood-2005-06-2398 · Cited by 283
A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression
Zhang, D.-L., Hughes, R. M., Ollivierre-Wilson, H., Ghosh, M. C., & Rouault, T. A. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.006 · Cited by 281
Autocrine formation of hepcidin induces iron retention in human monocytes
Theurl, I., Theurl, M., Seifert, M., Mair, S., Nairz, M., Rumpold, H., Zoller, H., Bellmann-Weiler, R., Niederegger, H., Talasz, H., et al. (2008) · Blood · doi:10.1182/blood-2007-05-090019 · Cited by 275
The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders
Urrutia, P. J., Mena, N. P., & NÃoÃ±ez, M. T. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00038 · Cited by 244
Cellular transport and homeostasis of essential and nonessential metals
Martinez‐Finley, E. J., Chakraborty, S., Fretham, S. J. B., & Aschner, M. (2012) · Metallomics · doi:10.1039/c2mt00185c · Cited by 243
Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages
Knutson, M. D., Vafa, M. R., Haile, D. J., & Wessling-Resnick, M. (2003) · Blood · doi:10.1182/blood-2003-04-1250 · Cited by 227
Self-citation
Nitric oxide–mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection
Nairz, M., Schleicher, U., Schroll, A., Sonnweber, T., Theurl, I., Ludwiczek, S., Talasz, H., Brandacher, G., Moser, P. L., Muckenthaler, M. U., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121946 · Cited by 204
Control of intracellular heme levels: Heme transporters and heme oxygenases
Khan, A., & Quigley, J. G. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.008 · Cited by 195
Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease
Theurl, I., Mattle, V., Seifert, M., Mariani, M., Marth, C., & Weiss, G. (2006) · Blood · doi:10.1182/blood-2005-08-3364 · Cited by 188
The co-ordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellular Salmonella typhimurium
Nairz, M., Theurl, I., Ludwiczek, S., Theurl, M., Mair, S. M., Fritsche, G., & Weiss, G. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00942.x · Cited by 182
Iron toxicity in neurodegeneration
Núñez, M. T., Urrutia, P. J., Mena, N. P., Aguirre, P., Tapia, V., & Salazar, J. (2012) · BioMetals · doi:10.1007/s10534-012-9523-0 · Cited by 183
Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages
Liu, X.-B., Nguyen, N.-B., Marquess, K. D., Yang, F., & Haile, D. J. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.04.006 · Cited by 177
Self-citation
The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease
Raha, A. A., Vaishnav, R., Friedland, R. P., Bomford, A. B., & Raha‐Chowdhury, R. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-55 · Cited by 182
Cell iron status influences macrophage polarization
Agoro, R., Taleb, M., Quesniaux, V. F. J., & Mura, C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196921 · Cited by 182
A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia
Guida, C., Altamura, S., Klein, F. A., Galy, B., Boutros, M., Ulmer, A. J., Hentze, M. W., & Muckenthaler, M. U. (2015) · Blood · doi:10.1182/blood-2014-08-595256 · Cited by 173
Fungal Strategies to Evade the Host Immune Recognition
Hernández-Chávez, M., Pérez-García, L., Niño-Vega, G., & Mora-Montes, H. (2017) · Journal of Fungi · doi:10.3390/jof3040051 · Cited by 173
Iron induces anti-tumor activity in tumor-associated macrophages
Costa da Silva, M., Breckwoldt, M. O., Vinchi, F., Correia, M. P., Stojanovic, A., Thielmann, C. M., Meister, M., Muley, T., Warth, A., Platten, M., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01479 · Cited by 164
The Regulation of Cellular Iron Metabolism
Chua, A. C. G., Graham, R. M., Trinder, D., & Olynyk, J. K. (2007) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360701428257 · Cited by 172
Modification of iron regulation by the inflammatory response
WEISS, G. (2005) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2004.09.001 · Cited by 161
Ferroportin is a manganese‐responsive protein that decreases manganese cytotoxicity and accumulation
Yin, Z., Jiang, H., Lee, E.-S., Ni, M., Erikson, K. M., Milatović, D., Bowman, A. B., & Aschner, M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06534.x · Cited by 162
Iron levels in polarized macrophages: regulation of immunity and autoimmunity
Recalcati, S., Locati, M., Gammella, E., Invernizzi, P., & Cairo, G. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.03.003 · Cited by 150
Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2
Nairz, M., Theurl, I., Schroll, A., Theurl, M., Fritsche, G., Lindner, E., Seifert, M., Crouch, M.-L. V., Hantke, K., Akira, S., et al. (2009) · Blood · doi:10.1182/blood-2009-05-223354 · Cited by 146
Mammalian iron transporters: Families SLC11 and SLC40
Montalbetti, N., Simonin, A., Kovács, G., & Hediger, M. A. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2013.01.002 · Cited by 151
Hepcidin Mitigates Renal Ischemia-Reperfusion Injury by Modulating Systemic Iron Homeostasis
Scindia, Y., Dey, P., Thirunagari, A., Liping, H., Rosin, D. L., Floris, M., Okusa, M. D., & Swaminathan, S. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014101037 · Cited by 141
Functional consequences of ferroportin 1 mutations
Liu, X.-B., Yang, F., & Haile, D. J. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.04.005 · Cited by 136
Self-citation
Role of HIF-1 and NF-κB Transcription Factors in the Modulation of Transferrin Receptor by Inflammatory and Anti-inflammatory Signals
Tacchini, L., Gammella, E., De Ponti, C., Recalcati, S., & Cairo, G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800365200 · Cited by 132
Localisation of proteins of iron metabolism in the human placenta and liver
Bastin, J. M., Drakesmith, H., REES, M. C. P., Sargent, I. L., & Townsend, A. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06216.x · Cited by 134
Non- HFE hemochromatosis
Pietrangelo, A. (2004) · Hepatology · doi:10.1002/hep.20007 · Cited by 128
Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin
Taniguchi, R., Kato, H. E., Font, J., Deshpande, C. N., Wada, M., Ito, K., Ishitani, R., Jormakka, M., & Nureki, O. (2015) · Nature Communications · doi:10.1038/ncomms9545 · Cited by 120
Comparative studies of duodenal and macrophage ferroportin proteins
Canonne-Hergaux, F., Donovan, A., Delaby, C., Wang, H.-J., & Gros, P. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00227.2005 · Cited by 124
Iron and innate antimicrobial immunity-depriving the pathogen, defending the host
Nairz, M., Dichtl, S., Schroll, A., Haschka, D., Tymoszuk, P., Theurl, I., & Weiss, G. (2018) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2018.03.007 · Cited by 123
Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat
Yeh, K., YEH, M. K. Y., & Glass, J. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00246.2003 · Cited by 118
Anemia of Inflammation
Roy, C. N. (2010) · Hematology · doi:10.1182/asheducation-2010.1.276 · Cited by 114
The Microbiota Shifts the Iron Sensing of Intestinal Cells
Deschemin, J., Noordine, M., Remot, A., Willemetz, A., Afif, C., Canonne‐Hergaux, F., Langella, P., Karim, Z., Vaulont, S., Thomas, M., et al. (2016) · The FASEB Journal · doi:10.1096/fj.15-276840 · Cited by 108
Ceruloplasmin-ferroportin system of iron traffic in vertebrates
Musci, G. (2014) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v5.i2.204 · Cited by 111
Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake
Kim, D., Kim, K., Choi, B., Youn, P., Ryu, D., Klaassen, C. D., & Park, J. (2006) · Archives of Toxicology · doi:10.1007/s00204-006-0160-7 · Cited by 106
A physiological model to study iron recycling in macrophages
Delaby, C., Pilard, N., Hetet, G., Driss, F., Grandchamp, B., Beaumont, C., & Canonne-Hergaux, F. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.07.002 · Cited by 103
Candida albicans specializations for iron homeostasis: from commensalism to virulence
Noble, S. M. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.09.006 · Cited by 104
Role of Ceruloplasmin in Macrophage Iron Efflux during Hypoxia
Sarkar, J., Seshadri, V., Tripoulas, N. A., Ketterer, M. E., & Fox, P. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304926200 · Cited by 101
The Ins and Outs of Iron Homeostasis
Donovan, A., Roy, C. N., & Andrews, N. C. (2006) · Physiology · doi:10.1152/physiol.00052.2005 · Cited by 101
Role of the Ferroportin Iron-Responsive Element in Iron and Nitric Oxide Dependent Gene Regulation
Liu, X., Hill, P., & Haile, D. J. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0572 · Cited by 95
Self-citation
Ceruloplasmin Protects Injured Spinal Cord from Iron-Mediated Oxidative Damage
Rathore, K. I., Kerr, B. J., Redensek, A., López‐Vales, R., Jeong, S. Y., Ponka, P., & David, S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3649-08.2008 · Cited by 98
Role of Hepcidin in the Setting of Hypoferremia during Acute Inflammation
Deschemin, J.-C., & Vaulont, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061050 · Cited by 89
The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1)
McKie, A. T., & Barlow, D. J. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1102-3 · Cited by 88
Molecular Mechanisms and Regulation of Iron Transport
Chung, J., & Wessling‐Resnick, M. (2003) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/713609332 · Cited by 86
Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients
Ghio, A. J., Roggli, V. L., Soukup, J. M., Richards, J. H., Randell, S. H., & Muhlebach, M. S. (2012) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2012.10.010 · Cited by 75
Self-citation
Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo
Theurl, I., Schroll, A., Nairz, M., Seifert, M., Theurl, M., Sonnweber, T., Kulaksiz, H., & Weiss, G. (2011) · Haematologica · doi:10.3324/haematol.2011.048926 · Cited by 77
The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome
Van Zandt, K. E., Sow, F. B., Florence, W. C., Zwilling, B. S., Satoskar, A. R., Schlesinger, L. S., & Lafuse, W. P. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1107781 · Cited by 74
Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice
Mok, H., Jelinek, J., Pai, S., Cattanach, B. M., Prchal, J. T., Youssoufian, H., & Schumacher, A. (2004) · Development · doi:10.1242/dev.01081 · Cited by 73
Hepcidin-mediated hypoferremic response to acute inflammation requires a threshold of Bmp6/Hjv/Smad signaling
Fillebeen, C., Wilkinson, N., Charlebois, E., Katsarou, A., Wagner, J., & Pantopoulos, K. (2018) · Blood · doi:10.1182/blood-2018-03-841197 · Cited by 73
The Macrophage: A Cellular Factory at the Interphase Between Iron and Immunity for the Control of Infections
Theurl, I., Fritsche, G., Ludwiczek, S., Garimorth, K., Bellmann-Weiler, R., & Weiss, G. (2005) · BioMetals · doi:10.1007/s10534-005-3710-1 · Cited by 72
Growth differentiation factor 15 in anaemia of chronic disease, iron deficiency anaemia and mixed type anaemia
Theurl, I., Finkenstedt, A., Schroll, A., Nairz, M., Sonnweber, T., Bellmann‐Weiler, R., Theurl, M., Seifert, M., Wroblewski, V. J., Murphy, A. T., et al. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07961.x · Cited by 72
Evidence for the multimeric structure of ferroportin.
De Domenico, I., Ward, D. M., Musci, G., & Kaplan, J. (2007) · Blood · doi:10.1182/blood-2006-06-032516 · Cited by 72
TLR4 Deficiency Impairs Oligodendrocyte Formation in the Injured Spinal Cord
Church, J. S., Kigerl, K. A., Lerch, J. K., Popovich, P. G., & McTigue, D. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0353-16.2016 · Cited by 75
Ferroportin 1 is expressed basolaterally in rat kidney proximal tubule cells and iron excess increases its membrane trafficking
Wolff, N. A., Liu, W., Fenton, R. A., Lee, W., Thévenod, F., & Smith, C. P. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00985.x · Cited by 71
Lactoferrin differently modulates the inflammatory response in epithelial models mimicking human inflammatory and infectious diseases
Frioni, A., Conte, M. P., Cutone, A., Longhi, C., Musci, G., di Patti, M. C. B., Natalizi, T., Marazzato, M., Lepanto, M. S., Puddu, P., et al. (2014) · BioMetals · doi:10.1007/s10534-014-9740-9 · Cited by 69
Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin
Krijt, J., Vokurka, M., Chang, K., & Nečas, E. (2004) · Blood · doi:10.1182/blood-2004-06-2422 · Cited by 69
Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE
Frazer, D. M., Wilkins, S. J., Millard, K. N., McKie, A. T., Vulpe, C. D., & Anderson, G. J. (2004) · British Journal of Haematology · doi:10.1111/j.1365-2141.2004.05044.x · Cited by 69
Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload†
Montosi, G., Corradini, E., Garuti, C., Barelli, S., Recalcati, S., Cairo, G., Valli, L., Pignatti, E., Vecchi, C., Ferrara, F., et al. (2005) · Hepatology · doi:10.1002/hep.20620 · Cited by 67
Hepcidin: a molecular link between inflammation and anaemia
Deicher, R., & Hörl, W. H. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg560 · Cited by 66
The ferroportin-ceruloplasmin system and the mammalian iron homeostasis machine: regulatory pathways and the role of lactoferrin
di Patti, M. C. B., Cutone, A., Polticelli, F., Rosa, L., Lepanto, M. S., Valenti, P., & Musci, G. (2018) · BioMetals · doi:10.1007/s10534-018-0087-5 · Cited by 66
Hepatic iron concentration does not predict response to standard and pegylated-IFN/ribavirin therapy in patients with chronic hepatitis C*1
HOFER, H. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.02.030 · Cited by 64
Lactoferrin prevents LPS-induced decrease of the iron exporter ferroportin in human monocytes/macrophages
Cutone, A., Frioni, A., Berlutti, F., Valenti, P., Musci, G., & di Patti, M. C. B. (2014) · BioMetals · doi:10.1007/s10534-014-9742-7 · Cited by 64
Specific Hemosiderin Deposition in Spleen Induced by a Low Dose of Cisplatin: Altered Iron Metabolism and Its Implication as an Acute Hemosiderin Formation Model
Wang, Y., Juan, L. V., Ma, X., Wang, D., Ma, H., Chang, Y., Nie, G., Jia, L., Duan, X., & Liang, X. (2010) · Current Drug Metabolism · doi:10.2174/138920010791636149 · Cited by 64
Therapeutic Advances in Regulating the Hepcidin/Ferroportin Axis
Hawula, Z. J., Wallace, D. F., Subramaniam, V. N., & Rishi, G. (2019) · Pharmaceuticals · doi:10.3390/ph12040170 · Cited by 62
Tumour necrosis factor alpha regulates iron transport and transporter expression in human intestinal epithelial cells
Johnson, D., Bayele, H. K., Johnston, K. L., Tennant, J. P., Srai, S. K., & Sharp, P. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.081 · Cited by 60
Hemochromatosis gene modifies course of hepatitis C viral infection
Pietrangelo, A. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00275-0 · Cited by 60
Recent advances in understanding haemochromatosis: a transition state
Robson, K., Merryweather-Clarke, A. T., Cadet, E., Viprakasit, V., Zaahl, M. G., Pointon, J. J., Weatherall, D. J., & Rochette, J. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2004.020644 · Cited by 62
For when bacterial infections persist: Toll-like receptor-inducible direct antimicrobial pathways in macrophages
Stocks, C. J., Schembri, M. A., Sweet, M. J., & Kapétanovic, R. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.4ri0917-358r · Cited by 58
Nutrient Transport in the Mammary Gland: Calcium, Trace Minerals and Water Soluble Vitamins
Montalbetti, N., Dalghi, M. G., Albrecht, C., & Hediger, M. A. (2014) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-014-9317-9 · Cited by 62
Ferroportin (Q248H) mutations in African families with dietary iron overload
McNamara, L., Gordeuk, V. R., & MacPhail, A. P. (2005) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2005.03930.x · Cited by 54
Molecular regulation of cellular iron balance
Recalcati, S., Gammella, E., Buratti, P., & Cairo, G. (2017) · IUBMB Life · doi:10.1002/iub.1628 · Cited by 55
Benefits and risks of iron therapy for chronic anaemias
Weiss, G., & Gordeuk, V. R. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01529.x · Cited by 54
Iron in intracellular infection: to provide or to deprive?
Silva-Gomes, S., Vale-Costa, S., Appelberg, R., & Gomes, M. S. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00096 · Cited by 51
Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice
Krijt, J., Čmejla, R., Sýkora, V., Vokurka, M., Vyoral, D., & Nečas, E. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.02.029 · Cited by 55
Erythrophagocytose et recyclage du fer héminique dans les conditions normales et pathologiques ; régulation par l'hepcidine
Beaumont, C., & Canonne‐Hergaux, F. (2005) · Transfusion Clinique et Biologique · doi:10.1016/j.tracli.2005.04.017 · Cited by 57
Supplemental Dietary Inulin Influences Expression of Iron and Inflammation Related Genes in Young Pigs
Yasuda, K., Dawson, H. D., Wasmuth, E. V., Roneker, C. A., Chen, C. Y., Urban, J. F., Welch, R. M., Miller, D. D., & Lei, X. G. (2009) · Journal of Nutrition · doi:10.3945/jn.109.110528 · Cited by 52
TNF, IFN-γ, and endotoxin increase expression of DMT1 in bronchial epithelial cells
Wang, X., Garrick, M. D., Yang, F., Dailey, L. A., Piantadosi, C. A., & Ghio, A. J. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00428.2003 · Cited by 51
Self-citation
Update on iron metabolism and molecular perspective of common genetic and acquired disorder, hemochromatosis
Yun, S., & Vincelette, N. D. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.02.006 · Cited by 52
Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron
Wang, X., Miller, D. S., & Zheng, W. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.02.024 · Cited by 49

Authors: Yang, F., Liu, X.-B., Quinones, M., Melby, P. C., Ghio, A., & Haile, D. J.
Affiliations: Audie L. Murphy Memorial VA Hospital (US)
The University of Texas at San Antonio Health Science Center (US)
Environmental Protection Agency (US)
Corresponding author: Haile, David J.
ORCID: Melby, Peter C.
Ghio, Andrew
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2002-10
Volume: 277
Issue: 42
Pages: 39786-39791
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m201485200
OpenAlex: W2044318447
Cited by: 197
References: 44
Citations by year: 2026: 1 · 2025: 4 · 2024: 1 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 9 · 2015: 9 · 2014: 12 · 2013: 9 · 2012: 14
FWCI: 7.87
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6590 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk053079-02)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK-53079)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: reticuloendothelial system, iron transport, inflammation, anemia of chronic disease, iron sequestration, lipopolysaccharide, TLR4, TNF-α, Leishmania donovani, spleen, liver, bone marrow, iron recycling
MeSH terms: Ferroportin, Animals, Immunohistochemistry, Inflammation, Iron, Kinetics, Lipopolysaccharides, Liver, Male, Membrane Glycoproteins, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Microscopy, Fluorescence, Oocytes, Protein Binding, Receptors, Cell Surface, RNA, Messenger, Spleen, Time Factors, Transfection, Tumor Necrosis Factor-alpha, Blotting, Western, Signal Transduction, Down-Regulation, Reverse Transcriptase Polymerase Chain Reaction, Cation Transport Proteins, Drosophila Proteins, Toll-Like Receptors, Toll-Like Receptor 4, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of Reticuloendothelial Iron Transporter MTP1 (Slc11a3) by Inflammation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks