The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Extracellular Superoxide Dismutase Is a Major Antioxidant in Human Fibroblasts and Slows Telomere Shortening
Open accessAbstract
There is good evidence that telomere shortening acts as a biological clock in human fibroblasts, limiting the number of population doublings a culture can achieve. Oxidative stress also limits the growth potential of human cells, and recent data show that the effect of mild oxidative stress is mediated by a stress-related increased rate of telomere shortening. Thus, fibroblast strains have donor-specific antioxidant defense, telomere shortening rate, and growth potential. We used low-density gene expression array analysis of fibroblast strains with different antioxidant potentials and telomere shortening rates to identify gene products responsible for these differences. Extracellular superoxide dismutase was identified as the strongest candidate, a correlation that was confirmed by Northern blotting. Over-expression of this gene in human fibroblasts with low antioxidant capacity increased total cellular superoxide dismutase activity, decreased the intracellular peroxide content, slowed the telomere shortening rate, and elongated the life span of these cells under normoxia and hyperoxia. These results identify extracellular superoxide dismutase as an important antioxidant gene product in human fibroblasts, confirm the causal role of oxidative stress for telomere shortening, and strongly suggest that the senescence-like arrest under mild oxidative stress is telomere-driven.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“overexpressing the antioxidant enzyme superoxide dismutase (SOD3) in human fibroblasts, or reducing the levels of intracellular peroxide using antioxidants, are effective in reducing the rate of telomere shortening and extending replicative lifespan of these cells (von Zglinicki et al., 2000, Serra et al., 2003).”
From Telomeres and cell senescence—size matters not (2017) · cites this paper as Serra et al., 2003
Citations
Cites
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Oxidative stress shortens telomeres
von Zglinicki, T. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02110-2 · Cited by 2,524
Olovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847
Kirkwood, T. B. L., & Austad, S. N. (2000) · Nature · doi:10.1038/35041682 · Cited by 1,774
Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
Melov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P., Wallace, D. C., Malfroy, B., Doctrow, S. R., & Lithgow, G. J. (2000) · Science · doi:10.1126/science.289.5484.1567 · Cited by 913
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?
von Zglinicki, T., Saretzki, G., Döcke, W., & Lotze, C. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1305 · Cited by 856
Self-citationOxidative DNA damage and senescence of human diploid fibroblast cells.
Chen, Q., Fischer, A., Reagan, J. D., Yan, L. J., & Ames, B. N. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4337 · Cited by 720
Toussaint, O., Medrano, E. E., & von Zglinicki, T. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00180-7 · Cited by 713
Genetic analysis of ageing: role of oxidative damage and environmental stresses
Martin, G. M., Austad, S. N., & Johnson, T. E. (1996) · Nature Genetics · doi:10.1038/ng0596-25 · Cited by 646
Research works printed but not linked: 2
- Ludwig, 2001, Cancer Res., 61, 3053
- Sheng, 1999, Neurosci. Lett., 267
Cited by
Sorted by citations
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053
Oxidative Stress, Mitochondrial Dysfunction, and Aging
Cui, H., Kong, Y., & Zhang, H. (2011) · Journal of Signal Transduction · doi:10.1155/2012/646354 · Cited by 1,076
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
Passos, J. F., Saretzki, G., Ahmed, S., Nelson, G., Richter, T., Peters, H., Wappler, I., Birket, M. J., Harold, G., Schaeuble, K., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050110 · Cited by 796
“negative human somatic cells can be significantly modulated by either increasing oxidative stress [10] or by antioxidant protection [34,37].”
BackgroundMethodInfluentialSelf-citationA New Description of Cellular Quiescence
Coller, H. A., Sang, L., & Roberts, J. M. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040083 · Cited by 548
Demissie, S., Levy, D., Benjamin, E. J., Cupples, L. A., Gardner, J. P., Herbert, A., Kimura, M., Larson, M. G., Meigs, J. B., Keaney, J. F., et al. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00224.x · Cited by 508
DNA damage, cellular senescence and organismal ageing: causal or correlative?
Chen, J.-H., Hales, C. N., & Ozanne, S. E. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm681 · Cited by 507
Telomeres and cell senescence—size matters not
Victorelli, S., & Passos, J. F. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.027 · Cited by 413
Psychological and metabolic stress: A recipe for accelerated cellular aging?
Epel, E. S. (2009) · HORMONES · doi:10.14310/horm.2002.1217 · Cited by 424
Human cell senescence as a DNA damage response
Zglinicki, T. V., Saretzki, G., Ladhoff, J., Fagagna, F. D. D., & Jackson, S. P. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.09.034 · Cited by 419
Self-citationRedox Control of the Cell Cycle in Health and Disease
Sarsour, E. H., Kumar, M. G., Chaudhuri, L., Kalen, A. L., & Goswami, P. C. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2513 · Cited by 393
Changes in aqueous humor dynamics with age and glaucoma
Gabelt, B. T., & Kaufman, P. L. (2005) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.10.003 · Cited by 389
Rise in Insulin Resistance Is Associated With Escalated Telomere Attrition
Gardner, J. P., Li, S., Srinivasan, S. R., Chen, W., Kimura, M., Lu, X., Berenson, G. S., & Aviv, A. (2005) · Circulation · doi:10.1161/01.cir.0000163550.70487.0b · Cited by 359
The evolutionary ecology of senescence
Monaghan, P., Charmantier, A., Nussey, D. H., & Ricklefs, R. E. (2008) · Functional Ecology · doi:10.1111/j.1365-2435.2008.01418.x · Cited by 373
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
Passos, J. F., Saretzki, G., & von Zglinicki, T. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm893 · Cited by 344
Self-citationThe Cambridge Handbook of Age and Ageing
Bengtson, V. L., Coleman, P. G., & Kirkwood, T. B. L. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511610714 · Cited by 347
Lu, T., & Finkel, T. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.01.011 · Cited by 327
A continuous correlation between oxidative stress and telomere shortening in fibroblasts
Richter, T., & Zglinicki, T. V. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.08.005 · Cited by 321
Short Telomeres Are Associated With Increased Carotid Atherosclerosis in Hypertensive Subjects
Benetos, A., Gardner, J. P., Zureik, M., Labat, C., Xiaobin, L., Adamopoulos, C., Temmar, M., Bean, K. E., Thomas, F., & Aviv, A. (2004) · Hypertension · doi:10.1161/01.hyp.0000113081.42868.f4 · Cited by 313
Associations between diet, lifestyle factors, and telomere length in women
Cassidy, A., Vivo, I. D., Liu, Y., Han, J., Prescott, J., Hunter, D. J., & Rimm, E. B. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28947 · Cited by 312
Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy
Verzola, D., Gandolfo, M. T., Gaetani, G., Ferraris, A., Mangerini, R., Ferrario, F., Villaggio, B., Gianiorio, F., Tosetti, F., Weiss, U., et al. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90302.2008 · Cited by 302
Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2
Opresko, P. L. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki273 · Cited by 289
Cellular Senescence in Neurodegenerative Diseases
Martínez‐Cué, C., & Rueda, N. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00016 · Cited by 299
Factors contributing to the outcome of oxidative damage to nucleic acids
Evans, M. D., & Cooke, M. S. (2004) · BioEssays · doi:10.1002/bies.20027 · Cited by 279
Mesquita, A., Weinberger, M., Silva, A., Sampaio-Marques, B., Almeida, B., Leão, C., Costa, V., Rodrigues, F., Burhans, W. C., & Ludovico, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004432107 · Cited by 240
Telomere length predicts poststroke mortality, dementia, and cognitive decline
Martin-Ruiz, C. M., Dickinson, H. O., Keys, B., Rowan, E. N., Kenny, R. A., & von Zglinicki, T. (2006) · Annals of Neurology · doi:10.1002/ana.20869 · Cited by 257
Speakman, J. R., & Selman, C. (2011) · BioEssays · doi:10.1002/bies.201000132 · Cited by 266
Transcriptional responses to oxidative stress: Pathological and toxicological implications
Ma, Q. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.11.004 · Cited by 252
Telomere loss in relation to age and early environment in long-lived birds
Hall, M. E., Nasir, L., Daunt, F., Gault, E. A., Croxall, J. P., Wanless, S., & Monaghan, P. (2004) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2004.2768 · Cited by 255
A Life‐History Perspective on Short‐ and Long‐Term Consequences of Compensatory Growth
Mangel, M., & Munch, S. B. (2005) · The American Naturalist · doi:10.1086/444439 · Cited by 250
Cellular Senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations
Müller, M. K. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2104 · Cited by 243
Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues
Chen, M. B., Yang, A. C., Yousef, H., Lee, D., Chen, W., Schaum, N., Lehallier, B., Quake, S. R., & Wyss-Coray, T. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.012 · Cited by 233
“Interestingly, transcript levels of superoxide dismutase (Sod1)–an antioxidant shown to increase lifespan, decrease the rate of telomere shortening (Serra et al., 2003), protect AD model mice (Murakami et al.”
The association between stressors and telomeres in non‐human vertebrates: a meta‐analysis
Chatelain, M., Drobniak, S. M., & Szulkin, M. (2019) · Ecology Letters · doi:10.1111/ele.13426 · Cited by 232
Telomere Length Variations in Aging and Age-Related Diseases
Rizvi, S., Raza, S. T., & Mahdi, F. (2015) · Current Aging Science · doi:10.2174/1874609808666150122153151 · Cited by 220
Saretzki, G., Murphy, M. P., & Von Zglinicki, T. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00040.x · Cited by 203
Self-citationTelomeres and human aging: facts and fibs
Aviv, A. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.51.pe43 · Cited by 198
Carrero, J. J., Stenvinkel, P., Fellström, B., Qureshi, A. R., Lamb, K. J., Heimbürger, O., Barany, P. F., Radhakrishnan, K., Lindholm, B., Soveri, I., et al. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01890.x · Cited by 185
Telomere shortening occurs in Asian Indian Type 2 diabetic patients
Adaikalakoteswari, A., Balasubramanyam, M., & Mohan, V. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01574.x · Cited by 179
The evolution of senescence from a comparative perspective
Ricklefs, R. E. (2008) · Functional Ecology · doi:10.1111/j.1365-2435.2008.01420.x · Cited by 174
Collerton, J. C., Barrass, K., Bond, J., Eccles, M., Jagger, C., James, O., Martin-Ruiz, C. M., Robinson, L. A., von Zglinicki, T., & Kirkwood, T. B. L. (2007) · BMC Geriatrics · doi:10.1186/1471-2318-7-14 · Cited by 163
Telomere Length in Prospective and Retrospective Cancer Case-Control Studies
Pooley, K. A., Sandhu, M. S., Tyrer, J. P., Shah, M., Driver, K. E., Luben, R., Bingham, S. A., Ponder, B. A. J., Pharoah, P. D. P., Khaw, K., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4595 · Cited by 161
Mitochondria: Are they causal players in cellular senescence?
Correia-Melo, C., & Passos, J. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.017 · Cited by 160
Telomere attrition as ageing biomarker.
Bekaert, S., Meyer, T. D., & Oostveldt, P. V. (2005) · PubMed · Cited by 158
Hoxha, M., Dioni, L., Bonzini, M., Pesatori, A. C., Fustinoni, S., Cavallo, D. M., Carugno, M., Albetti, B., Marinelli, B., Schwartz, J. D., et al. (2009) · Environmental Health · doi:10.1186/1476-069x-8-41 · Cited by 156
Developmental differences in the immortalization of lung fibroblasts by telomerase
Forsyth, N. R., Evans, A., Shay, J. W., & Wright, W. E. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00057.x · Cited by 161
Redox Regulation in the Extracellular Environment
Ottaviano, F. G., Handy, D. E., & Loscalzo, J. (2007) · Circulation Journal · doi:10.1253/circj.72.1 · Cited by 158
Mitochondrial function as a determinant of life span
Lanza, I. R., & Nair, K. S. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0724-5 · Cited by 153
Telomerase, mitochondria and oxidative stress
Saretzki, G. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.05.004 · Cited by 128
Self-citationA new generation of proto-oncogenes: Cold-inducible RNA binding proteins
LLeonart, M. E. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.11.001 · Cited by 144
Kondoh, H., LLeonart, M. E., Bernard, D., & Gil, J. (2007) · PubMed · doi:10.14670/hh-22.85 · Cited by 143
Accelerated Telomere Shortening in Leukocyte Subpopulations of Patients With Coronary Heart Disease
Spyridopoulos, I., Hoffmann, J., Aicher, A., Brümmendorf, T. H., Doerr, H. W., Zeiher, A. M., & Dimmeler, S. (2009) · Circulation · doi:10.1161/circulationaha.109.854299 · Cited by 147
Telomere shortening in chronic obstructive pulmonary disease
Houben, J. M. J., Mercken, E. M., Ketelslegers, H. B., Bast, A., Wouters, E. F., Hageman, G. J., & Schols, A. M. W. J. (2009) · Respiratory Medicine · doi:10.1016/j.rmed.2008.09.003 · Cited by 141
Telomere dysfunction, genome instability and cancer
Annie, L. M. C. (2007) · Frontiers in bioscience · doi:10.2741/2825 · Cited by 137
Rai, P., Young, J. J., Burton, D. G. A., Giribaldi, M. G., Önder, T. T., & Weinberg, R. A. (2010) · Oncogene · doi:10.1038/onc.2010.520 · Cited by 138
Martin-Ruiz, C. M., Saretzki, G. C., Petrie, J., Ladhoff, J., Jeyapalan, J. C., Wei, W., Sedivy, J. M., & von Zglinicki, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311980200 · Cited by 134
Self-citationMitochondria, telomeres and cell senescence
Passos, J. F., & von Zglinicki, T. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.04.006 · Cited by 133
Oxygen free radicals in cell senescence: Are they signal transducers?
Passos, J. F., & Von Zglinicki, T. (2006) · Free Radical Research · doi:10.1080/10715760600917151 · Cited by 122
Chronic oxidative stress induces a tissue-specific reduction in telomere length in CAST/Ei mice
Cattan, V., Mercier, N., Gardner, J. P., Regnault, V., Labat, C., Mäki-Jouppila, J. H., Nzietchueng, R., Bénétos, A., Kimura, M., Aviv, A., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.01.007 · Cited by 120
The role of cold‐inducible RNA binding protein in cell stress response
Liao, Y., Tong, L., Tang, L., & Wu, S. (2017) · International Journal of Cancer · doi:10.1002/ijc.30833 · Cited by 117
Gorowiec, M. R., Borthwick, L. A., Parker, S., Kirby, J. A., Saretzki, G. C., & Fisher, A. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.12.020 · Cited by 117
Self-citationCardiomyocyte‐Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans
Sharifi‐Sanjani, M., Oyster, N. M., Tichy, E. D., Bedi, K. C., Harel, O., Margulies, K. B., & Mourkioti, F. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.005086 · Cited by 113
Redox Control of Signal Transduction, Gene Expression and Cellular Senescence
Esposito, F., Ammendola, R., Faraonio, R., Russo, T., & Cimino, F. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000014832.78725.1a · Cited by 113
Effect of Long-Term Hormone Therapy on Telomere Length in Postmenopausal Women
Lee, D., Im, J., Kim, J., Lee, H.-R., & Shim, J. (2005) · Yonsei Medical Journal · doi:10.3349/ymj.2005.46.4.471 · Cited by 114
Oxidative Stress, Mitochondrial Dysfunction and the Mitochondria Theory of Aging
Kong, Y., Trabucco, S. E., & Zhang, H. (2014) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000358901 · Cited by 117
Mitochondria, Telomeres and Telomerase Subunits
Zheng, Q., Huang, J., & Wang, G. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00274 · Cited by 118
Free Radical Theory of Aging: Implications in Male Infertility
Desai, N. R., Sabanegh, E., Kim, T. S., & Agarwal, A. K. (2009) · Urology · doi:10.1016/j.urology.2009.05.025 · Cited by 107
Nicotinamide extends replicative lifespan of human cells
Kang, H. T., Lee, H. I., & Hwang, E. S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00234.x · Cited by 105
Telomere length and cardiovascular aging
Fyhrquist, F., & Saijonmaa, O. J. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.660497 · Cited by 102
Tsitsimpikou, C., Tzatzarakis, M. N., Fragkiadaki, P., Kovatsi, L., Stivaktakis, P. D., Kalogeraki, A. M., Kouretas, D., & Tsatsakis, A. M. (2012) · Toxicology · doi:10.1016/j.tox.2012.11.002 · Cited by 101
Theurey, P., & Pizzo, P. (2018) · Genes · doi:10.3390/genes9010022 · Cited by 108
Involvement of the INK4a/Arf gene locus in senescence
Collins, C. J., & Sedivy, J. M. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00048.x · Cited by 113
Cellular life span and the Warburg effect
Kondoh, H. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.03.007 · Cited by 98
Short telomeres in short‐lived males: what are the molecular and evolutionary causes?
Jemielity, S., Kimura, M., Parker, K. M., Parker, J. D., Cao, X., Aviv, A., & Keller, L. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00279.x · Cited by 97
Starr, J. M., Shiels, P. G., Harris, S. E., Pattie, A., Pearce, M. S., Relton, C. L., & Deary, I. J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.09.020 · Cited by 96
Mitochondrial longevity pathways
Vendelbo, M. H., & Nair, K. S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.029 · Cited by 92
Epigenetic Mechanisms Impacting Aging: A Focus on Histone Levels and Telomeres
Song, S., & Johnson, F. B. (2018) · Genes · doi:10.3390/genes9040201 · Cited by 95
Bull, C. F., & Fenech, M. F. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108006988 · Cited by 91
Proteasome inhibition induces a senescence-like phenotype in primary human fibroblasts cultures
Chondrogianni, N., & Gonos, E. S. (2004) · Biogerontology · doi:10.1023/b:bgen.0000017687.55667.42 · Cited by 86
Stress-induced Premature Senescence in hTERT-expressing Ataxia Telangiectasia Fibroblasts
Naka, K., Tachibana, A., Ikeda, K., & Motoyama, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309457200 · Cited by 91
Cardiotoxicity in rabbits after a low-level exposure to diazinon, propoxur, and chlorpyrifos
Zafiropoulos, A., Tsarouhas, K., Tsitsimpikou, C., Fragkiadaki, P., Germanakis, I. E., Tsardi, M., Maravgakis, G., Goutzourelas, N., Vasilaki, F., Kouretas, D., et al. (2014) · Human & Experimental Toxicology · doi:10.1177/0960327114532384 · Cited by 83
Grahame, T. J., & Schlesinger, R. B. (2012) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-9-21 · Cited by 87
Integrated Multi-Omics for Novel Aging Biomarkers and Antiaging Targets
Wu, L., Xie, X., Liang, T., Ma, J., Yang, L., Yang, J., Li, L., Xi, Y., Li, H., Zhang, J., et al. (2021) · Biomolecules · doi:10.3390/biom12010039 · Cited by 87
Physical Activity and Telomere Biology: Exploring the Link with Aging-Related Disease Prevention
Ludlow, A. T., & Roth, S. M. (2011) · Journal of Aging Research · doi:10.4061/2011/790378 · Cited by 80
Reactive oxygen species, ageing and the hormesis police
Ludovico, P., & Burhans, W. C. (2013) · FEMS Yeast Research · doi:10.1111/1567-1364.12070 · Cited by 80
Leukocyte telomere length is associated with HDL cholesterol levels: The Bogalusa heart study
Chen, W., Gardner, J. P., Kimura, M., Brimacombe, M. B., Cao, X., Srinivasan, S. R., Berenson, G. S., & Aviv, A. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.01.021 · Cited by 78
Franco, S., Blasco, M. A., Siedlak, S. L., Harris, P. L. R., Moreira, P. I., Perry, G. L., & Smith, M. A. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.03.001 · Cited by 77
Diet-related telomere shortening and chromosome stability
Marcon, F., Siniscalchi, E., Crebelli, R., Saieva, C., Sera, F., Fortini, P., Simonelli, V., & Palli, D. (2011) · Mutagenesis · doi:10.1093/mutage/ger056 · Cited by 71
The intrinsic stiffness of human trabecular meshwork cells increases with senescence
Morgan, J. T., Raghunathan, V. K., Chang, Y.-R., Murphy, C. J., & Russell, P. (2015) · Oncotarget · doi:10.18632/oncotarget.3798 · Cited by 71
Zhao, F., Yang, Q., Shi, S., Luo, X., & Sun, Y. (2016) · Scientific Reports · doi:10.1038/srep39051 · Cited by 66
Replicative senescence and the art of counting
von Zglinicki, T. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.015 · Cited by 69
Telomeric aging: mitotic clock or stress indicator?
Koliada, A. K., Krasnienkov, D. S., & Vaiserman, A. M. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00082 · Cited by 67
Growth, telomere dynamics and successful and unsuccessful human aging
Aviv, A., Levy, D. A., & Mangel, M. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00143-x · Cited by 66
Caruso, C. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s72 · Cited by 68
Short telomeres in aggressive non-Hodgkin's lymphoma as a risk factor in lymphomagenesis
Widmann, T., Herrmann, M., Taha, N., König, J., & Pfreundschuh, M. G. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2007.03.009 · Cited by 64
Cardiotoxicity in rabbits after long-term nandrolone decanoate administration
Vasilaki, F., Tsitsimpikou, C., Tsarouhas, K., Germanakis, I. E., Tzardi, M., Kavvalakis, M. P., Özçağlı, E., Kouretas, D., & Tsatsakis, A. M. (2015) · Toxicology Letters · doi:10.1016/j.toxlet.2015.10.026 · Cited by 64
Shim, G., Ricoul, M., Hempel, W. M., Azzam, E. I., & Sabatier, L. (2014) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2014.01.001 · Cited by 66
Lin, S., Huo, X., Zhang, Q., Fan, X., Du, L., Xu, X., Qiu, S., Zhang, Y., Wang, Y., & Gu, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060815 · Cited by 65
Lawless, C., Jurk, D., Gillespie, C. S., Shanley, D., Saretzki, G., von Zglinicki, T., & Passos, J. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032117 · Cited by 62
Self-citationCellular senescence: unravelling complexity
Passos, J. F., Simillion, C., Hallinan, J. S., Wipat, A., & von Zglinicki, T. (2009) · AGE · doi:10.1007/s11357-009-9108-1 · Cited by 61
Richter, T., Saretzki, G. C., Nelson, G., Melcher, M., Olijslagers, S., & von Zglinicki, T. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.02.003 · Cited by 61
Self-citation
Metadata
- Authors
- Serra, V., von Zglinicki, T., Lorenz, M., & Saretzki, G.
- Affiliations
- Stiftung Charité (DE)
- Newcastle University (GB)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 278
- Issue
- 9
- Pages
- 6824-6830
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2128014750
- Cited by
- 278
- References
- 41
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 10 · 2021: 18 · 2020: 6 · 2019: 11 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 14 · 2014: 13 · 2013: 13 · 2012: 14
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- extracellular superoxide dismutase, telomere shortening, human fibroblasts, oxidative stress, antioxidant defense, cellular aging, replicative lifespan, hyperoxia, hydrogen peroxide, gene expression profiling, senescence
- MeSH terms
- Actins, Aging, Hypoxia, Antioxidants, Cells, Cultured, Cytoplasm, Fibroblasts, Humans, Superoxide Dismutase, Blotting, Northern, Gene Expression, Telomere, Oxidative Stress, Reverse Transcriptase Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
