CoChat
Sign Up
Cited by 73

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Recycling of Apoprotein E Is Associated with Cholesterol Efflux and High Density Lipoprotein Internalization

Heeren, Joerg, Grewal, Thomas, Laatsch, Alexander, Rottke, Daniel, Rinninger, Franz, Enrich, Carlos, Beisiegel, Ulrike·2003·Journal of Biological Chemistry
DOI 10.1074/jbc.m209006200
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1074/jbc.m209006200

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Secreted ApoE is taken back up and transits through the recycling endosome pathway in multiple cell types, including astrocytes.

    “However, this interpretation is complicated by the fact that secreted ApoE is taken back up and transits through the recycling endosome pathway in multiple cell types, including astrocytes [32–36].”

    From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [36]

    The Results and Discussion (page unavailable) describe TRL-derived apoE entering endosomes and being recycled in human fibroblasts and hepatoma cells. They do not establish that secreted apoE is taken back up, or that this pathway occurs in astrocytes. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • The noxious propensity of apoE4 is due to an increase in isoelectric point compared to apoE3, resulting in unfolding of the protein in the acidic milieu of endosomes.

    “This noxious propensity of apoE4 is due to an increase in the isoelectric point, as compared to apoE3, resulting in unfolding of the protein in the acidic milieu of endosomes75–79.”

    From Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel (2025) · cites this paper as [77]

    The Experimental Procedures give an isoelectric point for apoE3 (pI 5.78), and the Discussion describes apoE in endosomes during recycling. Our copy does not compare apoE4 with apoE3 or say that acidic endosomes cause apoE4 to unfold (searched: isoelectric point, apoE4, unfolding). No page numbers were available for these passages. (LLM, conf=0.77)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 51

  1. Olivecrona, 1995, Curr. Opin. Lipidol., 6, 291, 10.1097/00041433-199510000-00009 · DOI
  2. Mahley, 1999, J. Lipid Res., 40, 1, 10.1016/S0022-2275(20)33334-4 · DOI · Paper page
  3. Goldberg, 2001, Front. Biosci., 6, D388
  4. Beisiegel, 1989, Nature, 341, 162, 10.1038/341162a0 · DOI
  5. Beisiegel, 1991, Proc. Natl. Acad. Sci. U. S. A., 88, 8342, 10.1073/pnas.88.19.8342 · DOI · Paper page
  6. Zhang, 1992, Science, 258, 468, 10.1126/science.1411543 · DOI · Paper page
  7. Heeren, 2001, Curr. Opin. Lipidol., 12, 255, 10.1097/00041433-200106000-00003 · DOI
  8. Tabas, 1990, J. Cell Biol., 111, 929, 10.1083/jcb.111.3.929 · DOI
  9. Tabas, 1991, J. Cell Biol., 115, 1547, 10.1083/jcb.115.6.1547 · DOI
  10. Myers, 1993, J. Cell Biol., 123, 1389, 10.1083/jcb.123.6.1389 · DOI
  11. Heeren, 1999, J. Cell Sci., 112, 349, 10.1242/jcs.112.3.349 · DOI · Paper page
  12. Enrich, 1999, Hepatology, 30, 1115, 10.1002/hep.510300505 · DOI
  13. Heeren, 2001, J. Biol. Chem., 276, 42333, 10.1074/jbc.M107461200 · DOI · Paper page
  14. Fazio, 1999, J. Biol. Chem., 274, 8247, 10.1074/jbc.274.12.8247 · DOI
  15. Swift, 2001, J. Biol. Chem., 276, 22965, 10.1074/jbc.M100172200 · DOI
  16. von Eckardstein, 2001, Arterioscler. Thromb. Vasc. Biol., 21, 13, 10.1161/01.ATV.21.1.13 · DOI
  17. Oram, 2002, Curr. Opin. Lipidol., 13, 373, 10.1097/00041433-200208000-00004 · DOI
  18. Fielding, 2001, Adv. Drug Delivery Rev., 49, 251, 10.1016/S0169-409X(01)00140-5 · DOI · Paper page
  19. Goldstein, 1983, Methods Enzymol., 98, 241, 10.1016/0076-6879(83)98152-1 · DOI
  20. Rinninger, 1994, Hepatology, 19, 1100, 10.1002/hep.1840190507 · DOI
  21. Niemeier, 1996, J. Lipid Res., 37, 1733, 10.1016/S0022-2275(20)39116-1 · DOI
  22. Handley, 1981, Proc. Natl. Acad. Sci. U. S. A., 78, 368, 10.1073/pnas.78.1.368 · DOI
  23. De Diego, 2002, J. Biol. Chem., 277, 32187, 10.1074/jbc.M205499200 · DOI
  24. Ortega, 1998, J. Cell Sci., 111, 261, 10.1242/jcs.111.2.261 · DOI
  25. Merkel, 2002, J. Biol. Chem., 277, 7405, 10.1074/jbc.M107914200 · DOI
  26. Holtta-Vuori, 2002, Mol. Biol. Cell, 13, 3107, 10.1091/mbc.e02-01-0025 · DOI · Paper page
  27. Mahlberg, 1992, J. Biol. Chem., 267, 4541, 10.1016/S0021-9258(18)42867-0 · DOI
  28. Silver, 2001, Curr. Opin. Lipidol., 12, 497, 10.1097/00041433-200110000-00004 · DOI
  29. Krieger, 2001, J. Clin. Invest., 108, 793, 10.1172/JCI14011 · DOI
  30. Schmitz, 2001, Curr. Opin. Lipidol., 12, 129, 10.1097/00041433-200104000-00006 · DOI
  31. Santamarina-Fojo, 2001, J. Lipid Res., 42, 1339, 10.1016/S0022-2275(20)30266-2 · DOI
  32. Neufeld, 2001, J. Biol. Chem., 276, 27584, 10.1074/jbc.M103264200 · DOI
  33. Chen, 2001, J. Biol. Chem., 276, 43564, 10.1074/jbc.M107938200 · DOI
  34. Takahashi, 1999, Proc. Natl. Acad. Sci. U. S. A., 96, 11358, 10.1073/pnas.96.20.11358 · DOI
  35. Bortnick, 2000, J. Biol. Chem., 275, 28634, 10.1074/jbc.M003407200 · DOI
  36. Zheng, 2001, Biochim. Biophys. Acta, 1534, 121, 10.1016/S1388-1981(01)00183-4 · DOI
  37. Oram, 2000, J. Biol. Chem., 275, 34508, 10.1074/jbc.M006738200 · DOI
  38. Babitt, 1997, J. Biol. Chem., 272, 13242, 10.1074/jbc.272.20.13242 · DOI
  39. Calvo, 2000, Electrophoresis, 21, 3386, 10.1002/1522-2683(20001001)21:16<3386::AID-ELPS3386>3.0.CO;2-L · DOI
  40. Silver, 2000, J. Clin. Invest., 105, 151, 10.1172/JCI8087 · DOI
  41. Silver, 2001, J. Biol. Chem., 276, 25287, 10.1074/jbc.M101726200 · DOI · Paper page
  42. Gu, 1998, J. Biol. Chem., 273, 26338, 10.1074/jbc.273.41.26338 · DOI
  43. Schmitz, 1985, EMBO J., 4, 613, 10.1002/j.1460-2075.1985.tb03674.x · DOI
  44. Garcia, 1996, Biochemistry, 35, 13064, 10.1021/bi952223l · DOI
  45. Klinger, 1997, Biochim. Biophys. Acta, 1345, 65, 10.1016/S0005-2760(96)00164-6 · DOI
  46. Rogler, 1991, Biochim. Biophys. Acta, 1095, 30, 10.1016/0167-4889(91)90041-U · DOI
  47. Rees, 1999, J. Biol. Chem., 274, 27925, 10.1074/jbc.274.39.27925 · DOI
  48. Bielicki, 1999, J. Lipid Res., 40, 85, 10.1016/S0022-2275(20)33342-3 · DOI
  49. Basu, 1982, J. Biol. Chem., 257, 9788, 10.1016/S0021-9258(18)34141-3 · DOI · Paper page
  50. Herscovitz, 1992, J. Lipid Res., 33, 791, 10.1016/S0022-2275(20)41505-6 · DOI
  51. Schwartz, 1978, Science, 200, 62, 10.1126/science.204996 · DOI

Cited by

Sorted by citations

Metadata

Authors
Heeren, J., Grewal, T., Laatsch, A., Rottke, D., Rinninger, F., Enrich, C., & Beisiegel, U.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2003-04
Volume
278
Issue
16
Pages
14370-14378
ISSN
0021-9258
DOI
10.1074/jbc.m209006200
Cited by
73
References
5
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review