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Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
Open accessAbstract
Both activating and null mutations of proteins required for canonical WNT signaling have revealed the importance of this pathway for normal skeletal development. However, tissue-specific transcriptional mechanisms through which WNT signaling promotes the differentiation of bone-forming cells have yet to be identified. Here, we address the hypothesis that canonical WNT signaling and the bone-related transcription factor RUNX2/CBFA1/AML3 are functionally linked components of a pathway required for the onset of osteoblast differentiation. Our findings show that, in bone of the SFRP1 (secreted frizzled-related protein-1)-null mouse, which exhibits activated WNT signaling and a high bone mass phenotype, there is a significant increase in expression of T-cell factor (TCF)-1, Runx2, and the RUNX2 target gene osteocalcin. We demonstrate by mutational analysis that a functional TCF regulatory element responsive to canonical WNT signaling resides in the promoter of the Runx2 gene (-97 to -93). By chromatin immunoprecipitation, recruitment of beta-catenin and TCF1 to the endogenous Runx2 gene is shown. Coexpression of TCF1 with canonical WNT proteins resulted in a 2-5-fold activation of Runx2 promoter activity and a 7-8-fold induction of endogenous mRNA in mouse pluripotent mesenchymal and osteoprogenitor cells. This enhancement was abrogated by SFRP1. Taken together, our results provide evidence for direct regulation of Runx2 by canonical WNT signaling and suggest that Runx2 is a target of beta-catenin/TCF1 for the stimulation of bone formation. We propose that WNT/TCF1 signaling, like bone morphogenetic protein/transforming growth factor-beta signaling, activates Runx2 gene expression in mesenchymal cells for the control of osteoblast differentiation and skeletal development.
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“Many studies have demonstrated that β-catenin is required for bone formation and is activated during multiple stages of osteoblast differentiation to regulate both osteoblast and osteoclast.40–43”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [43]
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The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246
Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80258-5 · Cited by 4,244
Otto, F., Thornell, A., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,813
LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development
Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235
Day, T. F., Guo, X., Garrett-Beal, L., & Yang, Y. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.016 · Cited by 1,616
High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., & Lifton, R. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013444 · Cited by 1,591
Secreted antagonists of the Wnt signalling pathway
Kawano, Y., & Kypta, R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00623 · Cited by 1,584
Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation.
Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.017 · Cited by 1,558
Antiretroviral-Drug Resistance among Patients Recently Infected with HIV
Little, S. J., Holte, S., Routy, J., Daar, E. S., Markowitz, M., Collier, A. C., Koup, R. A., Mellors, J. W., Connick, E., Conway, B., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013552 · Cited by 1,138
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Research works printed but not linked: 2
- Church, 2002, Int. J. Dev. Biol., 46, 927
- Hovanes, 2001, Nat. Genet., 28, 53
Cited by
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Items 801–900 of 1,000
Kornsuthisopon, C., Rochanavibhata, S., Nowwarote, N., Tompkins, K. A., Sukarawan, W., & Osathanon, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158676 · Cited by 12
Park, O., Kwon, Y., Kim, J., Park, C. Y., Yun, C., & Han, S. H. (2023) · The Journal of Pathology · doi:10.1002/path.6069 · Cited by 13
Molecular and cellular mechanisms of valve calcification
Chester, A. H. (2011) · Aswan Heart Centre Science & Practice Series · doi:10.5339/ahcsps.2011.4 · Cited by 12
Dickkopf-1 reduces hypertrophic changes in human chondrocytes derived from bone marrow stem cells
Rojas, A., MARDONES, R. M., Pritzker, K. P. H., van Wijnen, A. J., Galindo, M. A., & Heras, F. L. (2018) · Gene · doi:10.1016/j.gene.2018.11.037 · Cited by 12
Costa, M., Zhu, Y., & Ortiz, A. (2021) · Journal of Carcinogenesis · doi:10.4103/jcar.jcar_22_20 · Cited by 12
Deng, Z., Yan, W., Dai, X., Chen, M., Qu, Q., Wu, B., & Zhao, W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.661116 · Cited by 12
Zhang, Y., Hou, W., Liu, Y., Long, H., Zhang, L., Zhu, Z., & Yu, H. (2016) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2016.06.009 · Cited by 12
Xing, J., Li, H., Xia, H., Xia, L. H., & Zhao, H. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1698647 · Cited by 13
Yin, H. Y., Guan, Y., Zhang, X., Wei, Q., Ma, C., Ni, M., & Wang, Y. (2023) · Colloids and Interface Science Communications · doi:10.1016/j.colcom.2023.100714 · Cited by 11
Development of novel osteoarthritis therapy by targeting AMPK-β-catenin-Runx2 signaling
Zeng, D., Umar, M., Zhu, Z., Pan, H., Lu, W. W., Xiao, G., Chen, Y., Tong, L., & Chen, D. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101247 · Cited by 11
New calcification model for intact murine aortic valves
Kruithof, B. P. T., van de Pol, V., Los, T., Lodder, K., Gourabi, B. M., DeRuiter, M. C., Goumans, M., & Marsan, N. A. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.03.003 · Cited by 11
Regulation of Wnt signaling by non-coding RNAs during osteoblast differentiation
Saranya, I., Akshaya, R. L., & Selvamurugan, N. (2022) · Differentiation · doi:10.1016/j.diff.2022.10.003 · Cited by 11
Tailoring Biomaterials Ameliorate Inflammatory Bone Loss
Cheng, S., Wang, K., Zhou, L., Sun, Z., & Zhang, L. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304021 · Cited by 11
MC3T3 preosteoblast differentiation on bone morphogenetic protein-2 peptide ormosils
Przybylowski, C. J., Quinn, T., Callahan, A., Kaplan, M., Golding, A. S., Alesi, C., Ammar, M. M., LeBlon, C. E., Guo, Y. H., Zhang, X. H., et al. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm16490f · Cited by 11
Ko, B., Kim, D. S., Kang, S., Lee, N. R., Ryuk, J. A., & Park, S. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/367698 · Cited by 11
CHEN, S., Li, C., Wu, B., Zhang, C., LIU, C., LIN, X., WU, X., Sun, L., Liu, C., Chen, B., et al. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2501 · Cited by 11
Wen, Q., Zhang, S., Du, X., Wang, R., Li, Y., Liu, H., Hu, S., Zhou, C., Zhou, X., & Ma, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030734 · Cited by 11
Wang, T., Sun, C., Zhong, H., Gong, Y., Cui, Z., Xie, J., Wang, Y., Liang, C., Cao, H., Chen, X., et al. (2019) · Phytotherapy Research · doi:10.1002/ptr.6301 · Cited by 11
Wang, Q., Miao, Y., Qian, Z., Chen, L., Lu, T., Xu, Y., Jiang, X., & Shen, Y. (2021) · Bioengineered · doi:10.1080/21655979.2021.1977766 · Cited by 11
Legrand, M. A., Jourdan, M., & Pinieux, G. D. B. D. (2023) · PubMed · doi:10.14670/hh-18-532 · Cited by 11
Wnt3a enhances bone morphogenetic protein 9-induced osteogenic differentiation of C3H10T1/2 cells
ZHANG, X., Lin, L., Dao-jing, X., Chen, R., Tan, J., Liang, X., Hu, N., & Huang, W. H. (2013) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20120741 · Cited by 11
Dspp mutations disrupt mineralization homeostasis during odontoblast differentiation.
Jia, J., Bian, Z., & Song, Y. (2015) · PubMed Central · Cited by 11
Clough, B. H., Zeitouni, S., Krause, U., Chaput, C. D., Cross, L., Gaharwar, A. K., & Gregory, C. A. (2018) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0229 · Cited by 11
Shao, X., Yan, Z., Wang, D., Yang, Y., Ding, Y., Luo, E., Jing, D., & Cai, J. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7296 · Cited by 11
Targeting Ferroptosis: Emerging Insights into Osteoporosis Mechanisms
Yang, H., Ru, K., Liu, S., Zhu, C., Qian, A., & Chen, Z. (2025) · Biology · doi:10.3390/biology14081062 · Cited by 11
Vascular Calcification: Mechanisms, Models, and Therapies
Zhu, W., Yang, S., Chen, Z., Yang, X., Liang, Z., & Chen, Y. (2026) · iNew Medicine · doi:10.1002/inm3.70035 · Cited by 10
Yun, H., Kim, E., Kwon, Y.-J., & Park, K. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16040485 · Cited by 10
Vibration-based cell engineering
Johnson-Love, O., Salmerón‐Sánchez, M., Reid, S. D., Childs, P. G., & Dalby, M. J. (2025) · Nature Reviews Bioengineering · doi:10.1038/s44222-025-00273-x · Cited by 10
Yu, Z., Kawashima, N., Nara, K., Wang, S., Han, P., Kieu, T. Q., Ren, C., Noda, S., Tazawa, K., & Okiji, T. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06208-9 · Cited by 10
García‐Sánchez, D., González-González, A., García‐García, P., Reyes, R., Pérez‐Núñez, M. I., Riancho, J. A., Évora, C., Rodríguez-Rey, J. C., & Pérez-Campo, F. M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081277 · Cited by 10
Hsieh, C.-C., Yen, B. L., Chang, C., Hsu, P., Lee, Y., Yen, M., Yet, S., & Chen, L. (2022) · iScience · doi:10.1016/j.isci.2022.105713 · Cited by 10
Li, Y., Nie, J., Deng, C., & Li, H. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-03658-z · Cited by 10
Bu, T., Huang, J., Yu, Y., Sun, P., & Yang, K. (2023) · Nutrients · doi:10.3390/nu15132863 · Cited by 10
Lian, J. B., Gordon, J. A., & Stein, G. S. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2076 · Cited by 10
Self-citationChen, S., Ryan, D. A., Dwyer, M. A., & Cashman, J. R. (2014) · Bone · doi:10.1016/j.bone.2014.06.032 · Cited by 10
Katagiri, W., Osugi, M., Kawai, T., & Hibi, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161023250 · Cited by 10
Stimulatory effects of platycodin D on osteoblast differentiation
Han, Y., Jin, S. W., Lee, G. H., Choi, J. H., Lee, H. S., Chung, Y., Jeong, H. G., & Lee, K. Y. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28580 · Cited by 10
Akhtar, M., Woo, K. M., Tahir, M., Wu, W., Elango, J., Mirza, M. R., Khan, M., Shamim, S., Arany, P. R., & Rahman, S. U. (2021) · Clinical Oral Investigations · doi:10.1007/s00784-021-04230-x · Cited by 10
Yun, H., Lee, J. Y., Kim, S. H., Kwon, I. K., & Park, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158297 · Cited by 10
Rao, C., Guan, B., Luo, D., Deng, Q., Peng, Q., Lin, Z., Huang, M., Qi, M., Zhong, B., & Lu, X. (2020) · Human Mutation · doi:10.1002/humu.24054 · Cited by 10
“A Friend Among Strangers” or the Ambiguous Roles of Runx2
Azarkina, K., Gromova, E., & Malashicheva, A. (2024) · Biomolecules · doi:10.3390/biom14111392 · Cited by 10
Bone metastasis in endocrine-related cancer: unravelling invasion and destruction
Duong, H., Kafer, G. R., & Maugham, M. (2024) · Endocrine Related Cancer · doi:10.1530/erc-24-0294 · Cited by 10
Zeng, X., He, S., Yang, C., Yang, Y., Zheng, G., Wang, H., Liang, L., Xu, C., Cao, P., Wu, X., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107850 · Cited by 9
Cai, D., Shao, J., & Xiao, Y. (2026) · Dental Research · doi:10.1016/j.dtrs.2026.100025 · Cited by 9
Sakisaka, Y., Kanaya, S., Nakamura, T., Tamura, M., Shimauchi, H., & Nemoto, E. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.076 · Cited by 9
Lithium chloride attenuates suppressed differentiation induced by mechanical strain in cementoblasts
Ge, M., Zhou, C., Li, H., Li, Y., Yang, X., Wang, X., & Zou, S. (2019) · Connective Tissue Research · doi:10.1080/03008207.2019.1593390 · Cited by 9
Kimura, A., Toda, Y., Matsumoto, Y., Yamamoto, H., Yahiro, K., Shimada, E., Kanahori, M., Oyama, R., Fukushima, S., Nakagawa, M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-17728-5 · Cited by 9
Multiscale computational modeling of aortic valve calcification
Azimi-Boulali, J., Mahler, G. J., Murray, B. T., & Huang, P. (2023) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-023-01793-4 · Cited by 9
Pharmacological impacts of tanshinone on osteogenesis and osteoclastogenesis: a review
Sudha, S. S., Upmanyu, A., Saraswat, D., & Singh, M. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03351-w · Cited by 10
Choi, B., Chang, S., Cho, H. J., Kang, E., Shin, K., Song, Y., & Lee, Y. (2014) · Scandinavian Journal of Rheumatology · doi:10.3109/03009742.2014.905629 · Cited by 9
Li, N., Zhang, M., Drummen, G. P. C., Zhao, Y., Tan, Y. F., Luo, S. X., & Qu, X. B. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/2109204 · Cited by 9
Bonfim, D. C., Dias, R. B., Fortuna-Costa, A., Chicaybam, L., Lopes, D. V., Dutra, H. S., Borojević, R., Bonamino, M., Mermelstein, C., & Rossi, M. I. D. (2016) · Stem Cells International · doi:10.1155/2016/3865315 · Cited by 9
Ali, D., Chalisserry, E. P., Manikandan, M., Hamam, R., Alfayez, M. A., Kassem, M. S., Aldahmash, A. M., & Alajez, N. M. (2018) · Stem Cells International · doi:10.1155/2018/2379546 · Cited by 9
Ni, L., Tang, R., Yuan, C., Song, K., Wang, L., Wang, X., Zhang, Y., Zhang, X., Zhu, D., & Liu, B. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.05.44 · Cited by 9
Liu, D., Qin, H., Yang, J., Yang, L., He, S., Chen, S., Bao, Q., Zhao, Y., & Zhaowen, Z. (2020) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-020-3138-3 · Cited by 9
Nomura, K., Kimira, Y., Osawa, Y., Kataoka-Matsushita, A., Takao, K., Sugita, Y., Shimizu, J., Wada, M., & Mano, H. (2021) · Bioscience Reports · doi:10.1042/bsr20210304 · Cited by 9
Guo, Q., Ma, J., & Wu, J. (2021) · Regenerative Therapy · doi:10.1016/j.reth.2021.11.003 · Cited by 9
Wnt Proteins in Mineralized Tissue Development and Homeostasis
Tompkins, K. A. (2011) · Connective Tissue Research · doi:10.3109/03008207.2011.616610 · Cited by 10
Nkd2 promotes the differentiation of dental follicle stem/progenitor cells into osteoblasts
Chen, C., Zhan, J., Ling, J., Du, Y., & Hou, Y. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3822 · Cited by 9
WIF1 enhanced dentinogenic differentiation in stem cells from apical papilla
Wang, H., & Cao, Y. (2019) · BMC Oral Health · doi:10.1186/s12903-018-0700-6 · Cited by 9
Gustafson, J. A., Park, S. S., & Cunningham, M. L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221402 · Cited by 9
Molecular Mediators of Mesenchymal Stem Cell Biology
Alfaro, M. P., Saraswati, S., & Young, P. P. (2011) · Vitamins and hormones · doi:10.1016/b978-0-12-386015-6.00023-8 · Cited by 9
Abderrahmani, A., Niederhäuser, G., Lenain, V., Regazzi, R., & Waeber, G. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.09.093 · Cited by 9
Parathyroid Hormone and Parathyroid Hormone-Related Protein
Nissenson, R. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00012-1 · Cited by 10
Factors affecting the role of canonical Wnt inhibitor Dickkopf-1 in cancer progression
Doucet, D., Brubaker, C., Turner, D., & Gregory, C. A. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1114822 · Cited by 8
Relationship between arginine methylation and vascular calcification
Chen, C., Ding, Y., Huang, Q., Zhang, C., Zhao, Z., Zhou, H., Li, D., & Zhou, G. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111189 · Cited by 8
Cell-free bilayer functionalized scaffold for osteochondral tissue engineering
Khatami, S. M., Hanaee‐Ahvaz, H., Parivar, K., Soleimani, M., Dargoush, S. A., & Sohi, A. N. (2024) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2024.07.018 · Cited by 10
Tissue-specific mechanism of estrogen in osteoporosis and vascular calcification
Wu, W., Qiao, A., & Du, T. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177783 · Cited by 9
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Wragg, N. M., Mosqueira, D., Blokpeol‐Ferreras, L., Capel, A. J., Player, D. J., Martin, N. R. W., Liu, Y., & Lewis, M. P. (2019) · Biotechnology Journal · doi:10.1002/biot.201900106 · Cited by 8
Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice
Zhu, S., Song, H., Zhong, L., Huo, S., Fang, Y., Zhao, W., Yang, X., Dai, Z., He, R., Qiu, M. S., et al. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.07.006 · Cited by 8
Nakamura, K., Koide, M., Kobayashi, Y., Yamashita, T., Matsushita, M., Yasuda, H., Ishihara, Y., Yoshinari, N., & Udagawa, N. (2023) · Journal of Periodontal Research · doi:10.1111/jre.13134 · Cited by 8
Defects of the spliceosomal gene SNRPB affect osteo‐ and chondro‐differentiation
Knill, C., Henderson, E. J., Johnson, C. I., Wah, V. Y., Cheng, K., Forster, A. J., & Itasaki, N. (2023) · FEBS Journal · doi:10.1111/febs.16934 · Cited by 8
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Ungureanu, M.-C., Bilhă, Ş., Hogas, M. M., Velicescu, C., Leuștean, L., Teodoriu, L. C., & Preda, C. (2023) · Metabolites · doi:10.3390/metabo13090991 · Cited by 8
Zhu, Y., Cheng, Q., Liu, C., Wang, H., Zhu, C., Qian, J. W., Hu, H., Li, B., Guo, Q., & Shi, J. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.139835 · Cited by 8
Ling, Z., Wu, L., Shi, G., Chen, L., & Dong, Q. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4216 · Cited by 8
Ye, X., Cheng, S., Dong, Y., Ren, J., Su, L., Liu, J., Zhou, J., Liu, Q., & Zhu, N. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.06.028 · Cited by 8
Dhakad, U., Sahoo, R. R., Goel, A. P., Pradhan, S., Srivastava, R., & Das, S. (2019) · Indian Journal of Rheumatology · doi:10.4103/injr.injr_113_18 · Cited by 8
Expression of FBXW11 in normal and disease‐associated osteogenic cells
Carbonare, L. D., Gomez‐Lira, M., Minoia, A., Bertacco, J., Orsi, S., Lauriola, A., Vigni, V. L., Gandini, A., Antoniazzi, F., Zipeto, D., et al. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17767 · Cited by 8
Cellular and Molecular Aspects of Bone Repair
Bab, I., & Sela, J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-2059-0_2 · Cited by 8
Li, Y., Wang, Y., Yu, J., Ma, Z., Bai, Q., Wu, X., Bao, P., Li, L., Ma, D., Liu, J., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/127480 · Cited by 8
Matsuzaka, T., Matsugaki, A., Ishihara, K., & Nakano, T. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.12.017 · Cited by 7
Goovaerts, S., Naqvi, S., Hoskens, H., Herrick, N., Yuan, M., Shriver, M. D., Shaffer, J. R., Walsh, S., Weinberg, S. M., Wysocka, J., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07875-6 · Cited by 9
Liu, Y., Wang, L., Yang, Y., & Xiong, J. (2021) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/133495 · Cited by 7
TCF-1 participates in the occurrence of dedifferentiated chondrosarcoma
Xu, X., Tang, X., Guo, W., Yang, K., & Ren, T. (2016) · Tumor Biology · doi:10.1007/s13277-016-5235-3 · Cited by 7
Liu, Y., Su, D., & Song, T. (2017) · RSC Advances · doi:10.1039/c7ra02000g · Cited by 7
Mishra, R., Das, N., Varshney, R., Juneja, K., Sircar, D., & Roy, P. (2021) · Food & Function · doi:10.1039/d0fo02619k · Cited by 7
Yamadera, M., Shinto, E., Nagata, K., Shiraishi, T., Kajiwara, Y., Mochizuki, S., Okamoto, K., Kishi, Y., & Ueno, H. (2022) · International Journal of Clinical Oncology · doi:10.1007/s10147-021-02104-6 · Cited by 7
Chandra, A., Rosenzweig, A. B., & Pignolo, R. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-72228-3_1 · Cited by 6
Wang, N., Gan, G., Yang, J., & Wang, L. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220629150656 · Cited by 7
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Metadata
- Authors
- Gaur, T., Lengner, C. J., Hovhannisyan, H., Bhat, R. A., Bodine, P. V. N., Komm, B. S., Javed, A., van Wijnen, A. J., Stein, J. L., Stein, G. S., & Lian, J. B.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Wyeth (US)
- Corresponding author
- Lian, Jane B.
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 280
- Issue
- 39
- Pages
- 33132-33140
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2153720415
- Cited by
- 1,170
- References
- 70
- Citations by year
- 2026: 32 · 2025: 40 · 2024: 43 · 2023: 46 · 2022: 64 · 2021: 80 · 2020: 96 · 2019: 68 · 2018: 56 · 2017: 73 · 2016: 65 · 2015: 74 · 2014: 57 · 2013: 67 · 2012: 55
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK032520, P30-DK32520)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049069, P01 AR 48818, P01AR048818, AR 39588, R01AR039588)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- Wnt/β-catenin signaling, Runx2, bone formation, osteogenic differentiation, SFRP1, TCF1, β-catenin, osteocalcin, skeletal development, mesenchymal cells, osteoprogenitor cells
- MeSH terms
- Secreted Frizzled-Related Proteins, Animals, Cell Differentiation, Cells, Cultured, Fibroblasts, Membrane Proteins, Mice, Transgenic, Models, Biological, Osteoblasts, Osteogenesis, Promoter Regions, Genetic, RNA, Messenger, Signal Transduction, Gene Expression Regulation, Developmental, Intercellular Signaling Peptides and Proteins, Chromatin Immunoprecipitation, Core Binding Factor Alpha 1 Subunit, Mice, Hepatocyte Nuclear Factor 1-alpha, Mesenchymal Stem Cells
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