Cited by 237Bone Metabolism and DiseasesProtease and Inhibitor MechanismsRheumatoid Arthritis Research and Therapies

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Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-κB ligand.

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Hikita, Atsuhiko, Yana, Ikuo, Wakeyama, Hidetoshi, Nakamura, Masaki, Kadono, Yuho, Oshima, Yasushi, Nakamura, Kozo, Seiki, Motoharu, Tanaka, Sakae·2006·Journal of Biological Chemistry

DOI 10.1074/jbc.m606656200

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Abstract

Receptor activator of NF-kappaB ligand (RANKL) is a transmembrane glycoprotein that has an essential role in the development of osteoclasts. The extracellular portion of RANKL is cleaved proteolytically to produce soluble RANKL, but definite RANKL sheddase(s) and the physiologic function of RANKL shedding have not yet been determined. In the present study, we found that matrix metalloproteinase (MMP) 14 and a disintegrin and metalloproteinase (ADAM) 10 have strong RANKL shedding activity. In Western blot analysis, soluble RANKL was detected as two different molecular weight products, and RNA interference of MMP14 and ADAM10 resulted in a reduction of both the lower and higher molecular weight products. Suppression of MMP14 in primary osteoblasts increased membrane-bound RANKL and promoted osteoclastogenesis in cocultures with macrophages. Soluble RANKL produced by osteoblasts from MMP14-deficient mice was markedly reduced, and their osteoclastogenic activity was promoted, consistent with the findings of increased osteoclastogenesis in vivo. RANKL shedding is an important process that down-regulates local osteoclastogenesis.

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Authors: Hikita, A., Yana, I., Wakeyama, H., Nakamura, M., Kadono, Y., Oshima, Y., Nakamura, K., Seiki, M., & Tanaka, S.
Affiliations: The University of Tokyo (JP)
Institute of Medical Science, The University of Tokyo (JP)
Corresponding author: Tanaka, Sakae
ORCID: Hikita, Atsuhiko
Nakamura, Masaki
Kadono, Yuho
Oshima, Yasushi
Seiki, Motoharu
Tanaka, Sakae
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2006-12
Volume: 281
Issue: 48
Pages: 36846-36855
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m606656200
OpenAlex: W1999201913
Cited by: 236
References: 41
Citations by year: 2026: 6 · 2025: 4 · 2024: 8 · 2023: 15 · 2022: 7 · 2021: 13 · 2020: 15 · 2019: 8 · 2018: 13 · 2017: 17 · 2016: 7 · 2015: 10 · 2014: 9 · 2013: 8 · 2012: 12
FWCI: 6.66
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 5056 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords: RANKL, ectodomain shedding, osteoclastogenesis, MMP-14, ADAM10, soluble RANKL, osteoblasts
MeSH terms: ADAM10 Protein, Animals, Binding Sites, Bone Diseases, Metabolic, Bone Marrow, Humans, Macrophages, Membrane Proteins, Mice, Inbred C57BL, Osteoblasts, Osteoclasts, Down-Regulation, Coculture Techniques, Mice, ADAM Proteins, RANK Ligand, Matrix Metalloproteinase 14, Amyloid Precursor Protein Secretases

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Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-κB ligand.

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