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Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling
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During the progression of Alzheimer's disease, the β-amyloid protein can bind to the Frizzled receptor inhibiting downstream phosphorylation and preventing canonical Wnt signalling induction.
“During the progression of Alzheimer's disease, the β-amyloid protein can bind to the Frizzled receptor inhibiting downstream phosphorylation and preventing canonical Wnt signalling induction.16”
From Canonical Wnt pathway and the LDL receptor superfamily in neuronal cholesterol homeostasis and function (2024) · cites this paper as [16]
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Metadata
- Authors
- Magdesian, M. H., Carvalho, M. M. V. F., Mendes, F. A., Saraiva, L. M., Juliano, M. A., Juliano, L., Garcia-Abreu, J., & Ferreira, S. T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 283
- Issue
- 14
- Pages
- 9359-9368
- ISSN
- 0021-9258
- Cited by
- 221
- References
- 8
- Language
- en
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