Sex differences in mitochondrial (dys)function: Implications for neuroprotection

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., & Nagata, S. (1998) · Nature · doi:10.1038/34112 · Cited by 3,181 · see citing works

The prevalence of Parkinson's disease: a systematic review and meta-analysis

Pringsheim, T., Jette, N., Frolkis, A., & Steeves, T. D. L. (2014) · Movement Disorders · doi:10.1002/mds.25945 · Cited by 2,188 · see citing works

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

Scherz‐Shouval, R., Shvets, E., Fass, E., Shorer, H., Gil, L., & Elazar, Z. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601623 · Cited by 2,101 · see citing works

The Biologic Clock: The Mitochondria?

Harman, D. (1972) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1972.tb00787.x · Cited by 1,991 · see citing works

Policy: NIH to balance sex in cell and animal studies

Clayton, J. A., & Collins, F. S. (2014) · Nature · doi:10.1038/509282a · Cited by 1,816 · see citing works

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

Hailey, D. W., Rambold, A. S., Satpute‐Krishnan, P., Mitra, K., Sougrat, R., Kim, P. K., & Lippincott‐Schwartz, J. (2010) · Cell · doi:10.1016/j.cell.2010.04.009 · Cited by 1,419 · see citing works

Mitochondria and calcium: from cell signalling to cell death

Duchen, M. R. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00057.x · Cited by 1,261 · see citing works

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

Rambold, A. S., Kostelecky, B., Elia, N., & Lippincott‐Schwartz, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107402108 · Cited by 1,144 · see citing works

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

Chu, C. T., Ji, J., Dagda, R. K., Jiang, J. F., Tyurina, Y. Y., Kapralov, A. A., Tyurin, V. A., Yanamala, N., Shrivastava, I. H., Mohammadyani, D., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2837 · Cited by 1,083 · see citing works

Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase

Brown, G. C., & Cooper, C. E. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01290-3 · Cited by 1,055 · see citing works

Estradiol and the Developing Brain

McCARTHY, M. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00010.2007 · Cited by 885 · see citing works

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction

Keller, J. N., Kindy, M. S., Holtsberg, F. W., St. Clair, D. K., Yen, H.-C., Germeyer, A., Steiner, S. M., Bruce-Keller, A. J., Hutchins, J. B., & Mattson, M. P. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00687.1998 · Cited by 863 · see citing works

Mechanisms of Mitochondrial Fission and FusionPreprint

van der Bliek, A. M., Shen, Q., & Kawajiri, S. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a011072 · Cited by 861 · see citing works

Glutamate neurotoxicity in cortical cell culture is calcium dependent

Choi, D. W. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90069-2 · Cited by 810 · see citing works

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain

Mecocci, P., MacGarvey, U., Kaufman, A. E., Koontz, D., Shoffner, J. M., Wallace, D. C., & Beal, M. F. (1993) · Annals of Neurology · doi:10.1002/ana.410340416 · Cited by 757 · cited 1× · see citing works

Reframing sexual differentiation of the brain

McCarthy, M. M., & Arnold, A. P. (2011) · Nature Neuroscience · doi:10.1038/nn.2834 · Cited by 728 · see citing works

Sex Differences in the Brain: The Not So Inconvenient Truth

McCarthy, M. M., Arnold, A. P., Ball, G. F., Blaustein, J. D., & De Vries, G. J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5372-11.2012 · Cited by 724 · see citing works

Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species

Starkov, A. A., Fiskum, G. M., Chinopoulos, C., Lorenzo, B. J., Browne, S. E., Patel, M. S., & Beal, M. F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1899-04.2004 · Cited by 692 · see citing works

Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males

Borrás, C., Sastre, J., García-Sala, D., Lloret, A., Pallardó, F. V., & Viña, J. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01356-4 · Cited by 654 · see citing works

Nuclear activators and coactivators in mammalian mitochondrial biogenesis

Scarpulla, R. C. (2002) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(02)00343-3 · Cited by 631 · see citing works

Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase

Brown, G. C. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00238-3 · Cited by 602 · see citing works

Parthanatos: mitochondrial‐linked mechanisms and therapeutic opportunities

Fatokun, A. A., Dawson, V. L., & Dawson, T. M. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12416 · Cited by 594 · see citing works

Oxidative stress caused by mitochondrial calcium overload

Peng, T., & Jou, M. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05634.x · Cited by 569 · see citing works

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase

Brown, G. C. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00763-y · Cited by 540 · see citing works

Sex differences in Parkinson’s disease

Gillies, G. E., Pienaar, I. S., Vohra, S., & Qamhawi, Z. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.02.002 · Cited by 495 · see citing works

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

Koike, M., Shibata, M., Tadakoshi, M., Gotoh, K., Komatsu, M., Waguri, S., Kawahara, N., Kuida, K., Nagata, S., Kominami, E., et al. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070876 · Cited by 486 · see citing works

Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)

Wang, Y., Kim, N. S., Haince, J.-F., Kang, H. C., David, K. K., Andrabi, S. A., Poirier, G. G., Dawson, V. L., & Dawson, T. M. (2011) · Science Signaling · doi:10.1126/scisignal.2000902 · Cited by 476 · see citing works

Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death.

Zhu, J.-H., Horbinski, C., Guo, F.-L., Watkins, S. C., Uchiyama, Y., & Chu, C. T. (2007) · American Journal of Pathology · doi:10.2353/ajpath.2007.060524 · Cited by 469 · see citing works

Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency

Murakami, K., Kondo, T., 川瀬, 誠., Li, Y., Sato, S., Chen, S. F., & Chan, P. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00205.1998 · Cited by 467 · see citing works

NAD ⁺ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

Alano, C. C., Garnier, P., Ying, W., Higashi, Y., Kauppinen, T. M., & Swanson, R. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5552-09.2010 · Cited by 439 · see citing works

Immunocytochemical localization of TrkB in the central nervous system of the adult rat

Yan, Q., Radeke, M. J., Matheson, C. R., Talvenheimo, J., Welcher, A. A., & Felnstein, S. C. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970203)378:1 · Cited by 428 · see citing works

A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.

Djouadi, F., Weinheimer, C. J., Saffitz, J. E., Pitchford, C., Bastin, J., Gonzalez, F. J., & Kelly, D. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3949 · Cited by 410 · see citing works

Caspase‐3 Mediated Neuronal Death After Traumatic Brain Injury in Rats

Clark, R. S. B., Kochanek, P. M., Watkins, S. C., Chen, M., Dixon, C. E., Seidberg, N. A., Melick, J. A., Loeffert, J. E., Nathaniel, P. D., Jin, K. L., et al. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740740.x · Cited by 406 · see citing works

Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos

Wang, Y., Dawson, V. L., & Dawson, T. M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.020 · Cited by 405 · see citing works

The Neurosteroids Progesterone and Allopregnanolone Reduce Cell Death, Gliosis, and Functional Deficits after Traumatic Brain Injury in Rats

Djebaı̈li, M., Guo, Q., Pettus, E. H., Hoffman, S. W., & Stein, D. G. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.106 · Cited by 387 · see citing works

Mitochondrial and Nuclear Cross Talk in Cell Death

Andrabi, S. A., Dawson, T. M., & Dawson, V. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.014 · Cited by 378 · see citing works

Poly(ADP-ribose) Polymerase-1-mediated Cell Death in Astrocytes Requires NAD+ Depletion and Mitochondrial Permeability Transition

Alano, C. C., Ying, W., & Swanson, R. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313329200 · Cited by 374 · see citing works

Innate Gender-based Proclivity in Response to Cytotoxicity and Programmed Cell Death Pathway

Du, L., Bayır, H., Lai, Y., Zhang, X., Kochanek, P. M., Watkins, S. C., Graham, S. H., & Clark, R. S. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405461200 · Cited by 351 · see citing works

Mitochondrial Participation in Ischemic and Traumatic Neural Cell Death

Fiskum, G. M. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.843 · Cited by 348 · see citing works

Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation

Dewing, P., Shi, T., Horvath, S., & Vilain, E. J. N. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(03)00339-5 · Cited by 348 · see citing works

Calcium and Excitotoxic Neuronal Injury

Choi, D. W. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb44407.x · Cited by 344 · see citing works

Sex Differences in the Phosphorylation of Mitochondrial Proteins Result in Reduced Production of Reactive Oxygen Species and Cardioprotection in Females

Lagranha, C. J., Deschamps, A. M., Aponte, A. M., Steenbergen, C., & Murphy, E. (2010) · Circulation Research · doi:10.1161/circresaha.109.213645 · Cited by 328 · see citing works

Rapamycin is a neuroprotective treatment for traumatic brain injury

Erlich, S., Alexandrovich, A. G., Shohami, E., & Pinkas‐Kramarski, R. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.003 · Cited by 327 · see citing works

Ischemic Nitric Oxide and Poly (ADP-Ribose) Polymerase-1 in Cerebral Ischemia: Male Toxicity, Female Protection

McCullough, L. D., Zeng, Z., Blizzard, K. K., Debchoudhury, I., & Hurn, P. D. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600059 · Cited by 325 · see citing works

Mitochondria and Ca2+in cell physiology and pathophysiology

Duchen, M. R. (2000) · Cell Calcium · doi:10.1054/ceca.2000.0170 · Cited by 310 · see citing works

Intra-mitochondrial Poly(ADP-ribosylation) Contributes to NAD+ Depletion and Cell Death Induced by Oxidative Stress

Du, L., Zhang, X., Han, Y. Y., Burke, N. A., Kochanek, P. M., Watkins, S. C., Graham, S. H., Carcillo, J. A., Szabó, C., & Clark, R. S. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301295200 · Cited by 310 · see citing works

Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters.Preprint

Virbasius, J. V., Virbasius, C.-M. A., & Scarpulla, R. C. (1993) · Genes & Development · doi:10.1101/gad.7.3.380 · Cited by 291 · see citing works

TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP‐ribose) polymerase

Fonfría, E., Marshall, I. C. B., Benham, C. D., Boyfield, I., Brown, J. D., Hill, K., Hughes, J. P., Skaper, S. D., & McNulty, S. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705914 · Cited by 283 · see citing works

Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures.

Nicholls, D. (2004) · Current molecular medicine · doi:10.2174/1566524043479239 · Cited by 276 · see citing works

17β-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors

Weaver, C. E., Park-Chung, M., Gibbs, T. T., & Farb, D. H. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00449-6 · Cited by 274 · see citing works

Assessment of Antioxidant Reserves and Oxidative Stress in Cerebrospinal Fluid after Severe Traumatic Brain Injury in Infants and Children

Bayır, H., Kagan, V. E., Tyurina, Y. Y., Tyurin, V. A., Ruppel, R. A., Adelson, P. D., Graham, S. H., Janesko, K. L., Clark, R. S. B., & Kochanek, P. M. (2002) · Pediatric Research · doi:10.1203/00006450-200205000-00005 · Cited by 258 · see citing works

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

Hyman, B. T., & Yuan, J. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3228 · Cited by 249 · see citing works

The Glutathione System of Peroxide Detoxification Is Less Efficient in Neurons than in Astroglial Cells

Dringen, R., Kußmaul, L., Gutterer, J. M., Hirrlinger, J., & Hamprecht, B. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722523.x · Cited by 243 · see citing works

Rapidly Increased Neuronal Mitochondrial Biogenesis After Hypoxic-Ischemic Brain Injury

Yin, W., Signore, A. P., Iwai, M., Cao, G., Gao, Y., & Chen, J. (2008) · Stroke · doi:10.1161/strokeaha.108.520114 · Cited by 229 · see citing works

Mitochondrial mechanisms of estrogen neuroprotection

Simpkins, J. W., Yi, K. D., Yang, S., & Dykens, J. A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.11.013 · Cited by 205 · see citing works

Sex Differences in Mechanisms and Outcome of Neonatal Hypoxia-Ischemia in Rodent Models: Implications for Sex-Specific Neuroprotection in Clinical Neonatal Practice

Hill, C. A., & FITCH, R. H. (2012) · Neurology Research International · doi:10.1155/2012/867531 · Cited by 204 · see citing works

Immunocytochemical Evidence for a Mitochondrially Located Nitric Oxide Synthase in Brain and Liver

Bates, T. E., Loesch, A., Burnstock, G., & Clark, J. B. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2213 · Cited by 204 · see citing works

Starving Neurons Show Sex Difference in Autophagy

Du, L., Hickey, R. W., Bayir, H., Watkins, S. C., Tyurin, V. A., Guo, F., Kochanek, P. M., Jenkins, L. W., Ren, J., Gibson, G., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m804396200 · Cited by 204 · see citing works

Marked Gender Effect on Lipid Peroxidation after Severe Traumatic Brain Injury in Adult Patients

Bayir, H., Marion, D. W., Puccio, A. M., Wisniewski, S. R., Janesko, K. L., Clark, R. S. B., & Kochanek, P. M. (2004) · Journal of Neurotrauma · doi:10.1089/089771504772695896 · Cited by 194 · see citing works

Mitochondria: hub of injury responses in the developing brain

Hagberg, H., Mallard, C. E., Rousset, C. I., & Thornton, C. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70261-8 · Cited by 194 · see citing works

Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemia

Mehta, S. L., Kumari, S., Mendelev, N., & Li, P. A. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-79 · Cited by 183 · see citing works

Nitric oxide and mitochondria

Guy, C. B. (2006) · Frontiers in bioscience · doi:10.2741/2122 · Cited by 173 · see citing works

miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia

Siegel, C. S., Li, J., Liu, F., Benashski, S. E., & McCullough, L. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102635108 · Cited by 172 · see citing works

Loss of cardiolipin and mitochondria during programmed neuronal death: evidence of a role for lipid peroxidation and autophagy

Kirkland, R. A., Adibhatla, R. M., Hatcher, J. F., & Franklin, J. L. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00512-2 · Cited by 171 · see citing works

Closed Head Injury Induces Upregulation of Beclin 1 at the Cortical Site of Injury

Diskin, T., Tal‐Or, P., Erlich, S., Mizrachy, L., Alexandrovich, A. G., Shohami, E., & Pinkas‐Kramarski, R. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.750 · Cited by 169 · see citing works

Preconditioning limits mitochondrial Ca2+during ischemia in rat hearts: role of KATPchannels

Wang, L., Cherednichenko, G., Hernandez, L. A., Halow, J. M., Camacho, S. A., Figueredo, V. M., & Schaefer, S. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.5.h2321 · Cited by 169 · see citing works

Mitochondria as Therapeutic Targets of Estrogen Action in the Central Nervous System

Nilsen, J., & Brinton, R. D. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043337193 · Cited by 166 · see citing works

Mitochondrial Localization of PARP-1 Requires Interaction with Mitofilin and Is Involved in the Maintenance of Mitochondrial DNA Integrity

Rossi, M. N., Carbone, M., Mostocotto, C., Mancone, C., Tripodi, M., Maione, R., & Amati, P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.025882 · Cited by 163 · see citing works

LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons

Chu, C. T., Bayır, H., & Kagan, V. E. (2013) · Autophagy · doi:10.4161/auto.27191 · Cited by 159 · see citing works

Involvement of autophagy in hypoxic-excitotoxic neuronal death

Ginet, V., Spiehlmann, A., Rummel, C., Rudinskiy, N., Grishchuk, Y., Luthi‐Carter, R., Clarke, P. G., Truttmann, A. C., & Puyal, J. (2014) · Autophagy · doi:10.4161/auto.28264 · Cited by 159 · see citing works

Mitochondrial mechanisms of estrogen neuroprotection

Simpkins, J. W., & Dykens, J. A. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.04.007 · Cited by 145 · see citing works

Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death

Lin, C.-J., Chen, T.-H., Yang, L.-Y., & Shih, C.-M. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.123 · Cited by 142 · see citing works

Novel Mitochondrial Targets for Neuroprotection

Pérez‐Pinzón, M. A., Stetler, R. A., & Fiskum, G. M. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.32 · Cited by 142 · see citing works

Neuronal NOS‐mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury

Bayır, H., Kagan, V. E., Clark, R. S. B., Janesko‐Feldman, K. L., Rafikov, R., Huang, Z., Zhang, X., Vagni, V., Billiar, T. R., & Kochanek, P. M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04353.x · Cited by 140 · see citing works

Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats

Rao, V. L. R., Dog⫧an, A., Todd, K. G., Bowen, K. K., & Dempsey, R. J. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02617-8 · Cited by 135 · see citing works

Crosstalk between mitochondrial (dys)function and mitochondrial abundance

Michel, S., Wanet, A., Pauw, A. D., Rommelaere, G., Arnould, T., & Renard, P. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.23021 · Cited by 132 · see citing works

Sex Differences in Neuroprotection Provided by Inhibition of TRPM2 Channels following Experimental Stroke

Jia, J., Verma, S., Nakayama, S., Quillinan, N., Grafe, M. R., Hurn, P. D., & Herson, P. S. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.77 · Cited by 130 · see citing works

Traumatic Brain Injury in Adult Rats Causes Progressive Nigrostriatal Dopaminergic Cell Loss and Enhanced Vulnerability to the Pesticide Paraquat

Hutson, C. B., Lazo, C. R., Mortazavi, F., Giza, C. C., Hovda, D. A., & Chesselet, M. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2010.1723 · Cited by 129 · see citing works

Sex differences in cell death

Li, H., Pin, S., Zeng, Z., Wang, M. M., Andreasson, K. I., & McCullough, L. D. (2005) · Annals of Neurology · doi:10.1002/ana.20538 · Cited by 126 · see citing works

Gender differences in free radical homeostasis during aging: shorter‐lived female C57BL6 mice have increased oxidative stress

Ali, S. S., Xiong, C., Lucero, J. D., Behrens, M. M., Dugan, L. L., & Quick, K. L. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00252.x · Cited by 124 · see citing works

Mitochondria Play a Central Role in Estrogen-Induced Neuroprotection

Simpkins, J. W., Wang, J., Wang, X., Perez, E., Prókai, L., & Dykens, J. A. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007053005073 · Cited by 124 · see citing works

Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke

Yuan, M., Siegel, C. S., Zeng, Z., Li, J., Liu, F., & McCullough, L. D. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.02.012 · Cited by 123 · see citing works

PARP-1 Inhibition Attenuates Neuronal Loss, Microglia Activation and Neurological Deficits after Traumatic Brain Injury

Stoica, B. A., Loane, D. J., Zhao, Z., Kabadi, S. V., Hanscom, M., Byrnes, K. R., & Faden, A. I. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.3194 · Cited by 122 · see citing works

The response of the sexes to nutritional stress

Widdowson, E. M. (1976) · Proceedings of the Nutrition Society · doi:10.1079/pns19760030 · Cited by 115 · cited 2× · see citing works

The Mitochondrial Inner Membrane GTPase, Optic Atrophy 1 (Opa1), Restores Mitochondrial Morphology and Promotes Neuronal Survival following Excitotoxicity

Jahani‐Asl, A., Pilon‐Larose, K., Xu, W., MacLaurin, J. G., Park, D. S., McBride, H. M., & Slack, R. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.167155 · Cited by 115 · see citing works

Effect of N -Acetylcysteine on Mitochondrial Function Following Traumatic Brain Injury in Rats

Xiong, Y., Peterson, P. L., & Lee, C. P. (1999) · Journal of Neurotrauma · doi:10.1089/neu.1999.16.1067 · Cited by 114 · see citing works

An Ounce of Prevention Is a Ton of Work: Mass Antibiotic Prophylaxis for Anthrax, New York City, 2001

Blank, S., Moskin, L. C., & Zucker, J. R. (2003) · Emerging infectious diseases · doi:10.3201/eid0906.030118 · Cited by 114 · see citing works

N-Acetyl-Serotonin Offers Neuroprotection through Inhibiting Mitochondrial Death Pathways and Autophagic Activation in Experimental Models of Ischemic Injury

Zhou, H., Wang, J., Jiang, J., Stavrovskaya, I. G., Li, M., Li, W., Wu, Q., Zhang, X., Luo, C., Zhou, S., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1948-13.2014 · Cited by 113 · see citing works

Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression

Giordano, G., Tait, L. J., Furlong, C. E., Cole, T. B., Kavanagh, T. J., & Costa, L. G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.019 · Cited by 112 · see citing works

To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage

Huang, Q. B., & Shen, H. (2009) · Autophagy · doi:10.4161/auto.5.2.7640 · Cited by 108 · see citing works

The Dynamics of the Mitochondrial Organelle as a Potential Therapeutic Target

Stetler, R. A., Leak, R. K., Gao, Y., & Chen, J. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.158 · Cited by 106 · see citing works

Glutamate‐mediated excitotoxicity in neonatal hippocampal neurons is mediated by mGluR‐induced release of Ca++ from intracellular stores and is prevented by estradiol

Hilton, G. D., Nuñez, J. L., Bambrick, L. L., Thompson, S. M., & McCarthy, M. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05189.x · Cited by 101 · see citing works

Sex differences in Parkinson’s disease

Lubomski, M., Rushworth, R. L., Lee, W., Bertram, K., & Williams, D. R. (2014) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2013.12.016 · Cited by 101 · see citing works

Neuroprotection by estrogen in the brain: the mitochondrial compartment as presumed therapeutic target

Arnold, S., & Beyer, C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06133.x · Cited by 95 · see citing works

Neuroprotective effects of a novel NMDA antagonist, Gacyclidine, after experimental contusive spinal cord injury in adult rats

Gaviria, M., Privat, A., D’Arbigny, P., Kamenka, J. M., Haton, H., & Ohanna, F. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02581-6 · Cited by 95 · see citing works

Early-life sex-dependent vulnerability to oxidative stress: the natural twining model

Minghetti, L., Greco, A., Zanardo, V., & Suppiej, A. (2012) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2012.733751 · Cited by 95 · see citing works

Inhibition of Autophagy Contributes to Melatonin-Mediated Neuroprotection Against Transient Focal Cerebral Ischemia in Rats

Zheng, Y., Hou, J., Liu, J., Yao, M., Li, L., Zhang, B., Hua Zhu, C., & Wang, Z. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13220fp · Cited by 93 · see citing works

Autophagy in acute brain injury: Feast, famine, or folly?

Smith, C. M., Chen, Y., Sullivan, M. L. G., Kochanek, P. M., & Clark, R. S. B. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.09.014 · Cited by 93 · see citing works

Mitochondrial Nitric-Oxide Synthase: Enzyme Expression, Characterization, and Regulation

Haynes, V. L., Elfering, S. L., Traaseth, N. J., & Giulivi, C. (2004) · Journal of Bioenergetics and Biomembranes · doi:10.1023/b:jobb.0000041765.27145.08 · Cited by 92 · see citing works

Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection

Costa, L. G., de Laat, R., Dao, K., Pellacani, C., Cole, T. B., & Furlong, C. E. (2013) · NeuroToxicology · doi:10.1016/j.neuro.2013.08.011 · Cited by 91 · see citing works

MK-801 Prevents Hippocampal Neurodegeneration in Neonatal Hypoxic-Ischemic Rats

Ford, L. M., Sanberg, P. R., Norman, A. B., & Fogelson, M. H. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520460072016 · Cited by 87 · see citing works

The nature of the sex-linked differences in glutathione peroxidase activity and aerobic oxidation of glutathione in male and female rat liver

Pinto, R. E., & Bartley, W. (1969) · Biochemical Journal · doi:10.1042/bj1150449 · Cited by 86 · see citing works

F 2 -Isoprostane and Neuron-Specific Enolase in Cerebrospinal Fluid after Severe Traumatic Brain Injury in Infants and Children

Varma, S., Janesko, K. L., Wisniewski, S. R., Bayır, H., Adelson, P. D., Thomas, N. J., & Kochanek, P. M. (2003) · Journal of Neurotrauma · doi:10.1089/089771503767870005 · Cited by 86 · see citing works

Estrogen and neuroprotection: higher constitutive expression of glutaredoxin in female mice offers protection against MPTP‐mediated neurodegeneration

Kenchappa, R. S., Diwakar, L., Jayasree Annepu, B., & Ravindranath, V. (2004) · The FASEB Journal · doi:10.1096/fj.03-1075fje · Cited by 82 · see citing works

Early nuclear translocation of endonuclease G and subsequent DNA fragmentation after transient focal cerebral ischemia in mice

Lee, B. I., Lee, D. J., Cho, K. J., & Kim, G. W. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.05.058 · Cited by 81 · see citing works

Glutaredoxin is essential for maintenance of brain mitochondrial complex I: studies with MPTP

Kenchappa, R. S., & Ravindranath, V. (2003) · The FASEB Journal · doi:10.1096/fj.02-0771fje · Cited by 80 · see citing works

Autophagy in the brain of neonates following hypoxia-ischemia shows sex- and region-specific effects.

Weis, S. N., Toniazzo, A., Ander, B., Zhan, X.-H., Careaga, M., Ashwood, P., Wyse, A., Netto, C., & Sharp, F. R. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.046 · Cited by 78 · see citing works

A combination of four active compounds alleviates cerebral ischemia–reperfusion injury in correlation with inhibition of autophagy and modulation of AMPK/mTOR and JNK pathways

Guo, Z., Cao, G., Yang, H., Zhou, H., Li, L., Cao, Z., Yu, B., & Kou, J. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23400 · Cited by 77 · see citing works

A Calcineurin Docking Motif (LXVP) in Dynamin-related Protein 1 Contributes to Mitochondrial Fragmentation and Ischemic Neuronal Injury

Slupe, A. M., Merrill, R. A., Flippo, K. H., Lobas, M. A., Houtman, J. C. D., & Strack, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.459677 · Cited by 72 · see citing works

Gender modulation of Ca2+ uptake in cardiac mitochondria

ARIELI, Y. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.04.023 · Cited by 72 · see citing works

Gender associations with cerebrospinal fluid glutamate and lactate/pyruvate levels after severe traumatic brain injury

Wagner, A. K., Fabio, A., Puccio, A. M., Hirschberg, R. E., Li, W., ZAFONTE, R. D., & Marion, D. W. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000153931.23488.dd · Cited by 68 · see citing works

Novel Therapeutic Strategies for Traumatic Brain Injury: Acute Antioxidant Reinforcement

Fernández-Gajardo, R., Matamala, J. M., Carrasco, R. A., Gutiérrez, R., Melo, R., & Rodrigo, R. (2014) · CNS Drugs · doi:10.1007/s40263-013-0138-y · Cited by 68 · see citing works

Apoptosis and autophagy contribute to gender difference in cardiac ischemia–reperfusion induced injury in rats

Chen, C., Hu, L., Dong, T., Wang, G., Wang, L., Xi-ping, Z., Jiang, Y., Murao, K., Lu, S., Chen, J., et al. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.06.019 · Cited by 67 · see citing works

Sex differences in mitochondrial biogenesis determine neuronal death and survival in response to oxygen glucose deprivation and reoxygenation

Sharma, J., Johnston, M. V., & Hossain, M. A. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-9 · Cited by 67 · see citing works

The Potential Role of Mitochondria in Pediatric Traumatic Brain Injury

Robertson, C., Soane, L., Siegel, Z. T. G., & Fiskum, G. M. (2006) · Developmental Neuroscience · doi:10.1159/000094169 · Cited by 66 · see citing works

Inhibition of autophagy as a therapeutic strategy of iron-induced brain injury after hemorrhage

Chen, C.-W., Chen, T.-Y., Tsai, K.-L., Lin, C., Yokoyama, K. K., Lee, W., Chiueh, C. C., & Hsu, C. (2012) · Autophagy · doi:10.4161/auto.21289 · Cited by 65 · see citing works

Gender-specific regulation of mitochondrial fusion and fission gene transcription and viability of cortical astrocytes by steroid hormones

Arnold, S., de Araújo, G. W., & Beyer, C. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0085 · Cited by 65 · cited 1× · see citing works

The mitochondrial calcium regulator cyclophilin d is an essential component of oestrogen-mediated neuroprotection in amyotrophic lateral sclerosis

Kim, H. J., Magranè, J., Starkov, A. A., & Manfredi, G. (2012) · Brain · doi:10.1093/brain/aws208 · Cited by 64 · see citing works

Delayed increase of tyrosine hydroxylase expression in rat nigrostriatal system after traumatic brain injury

Yan, H. Q., Ma, X., Chen, X., Li, Y., Shao, L., & Dixon, C. E. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.087 · Cited by 63 · see citing works

Neurotoxicity of Dopamine and Protective Effects of the NMDA Receptor Antagonist AP-5 Differ between Male and Female Dopaminergic Neurons

Lieb, K., Andrae, J., Reisert, I., & Pilgrim, C. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1052 · Cited by 62 · see citing works

Amantadine Improves Cognitive Outcome and Increases Neuronal Survival after Fluid Percussion Traumatic Brain Injury in Rats

Wang, T., Huang, X.-J., Van, K. C., Went, G. T., Nguyen, J. T., & Lyeth, B. G. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.2917 · Cited by 61 · see citing works

ADP-ribosyl transferase and NAD glycohydrolase activities in rat liver mitochondria

Masmoudi, A. S., & Mandel, P. (1987) · Biochemistry · doi:10.1021/bi00381a027 · Cited by 61 · see citing works

TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death

Verma, S., Quillinan, N., Yang, Y., Nakayama, S., Cheng, J. G., Kelley, M. H., & Herson, P. S. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.09.044 · Cited by 61 · see citing works

Sex-specific responses to stroke

Turtzo, L. C., & McCullough, L. D. (2009) · Future Neurology · doi:10.2217/fnl.09.66 · Cited by 60 · see citing works

An update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stress

Starkov, A. A. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.07.005 · Cited by 60 · see citing works

Androgens predispose males to GABAA-mediated excitotoxicity in the developing hippocampus

Nuñez, J. L., & McCarthy, M. M. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.01.001 · Cited by 59 · see citing works

Mitochondrial fusion and fission after spinal sacord injury in rats

Cao, Y., Lv, G., Wang, Y., Fan, Z., Bi, Y., Zhao, L., & Guo, Z. (2013) · Brain Research · doi:10.1016/j.brainres.2013.05.033 · Cited by 57 · see citing works

Local Administration of the Poly(ADP-Ribose) Polymerase Inhibitor INO-1001 Prevents NAD + Depletion and Improves Water Maze Performance after Traumatic Brain Injury in Mice

Clark, R. S. B., Vagni, V., Nathaniel, P. D., Jenkins, L. W., Dixon, C. E., & Szabó, C. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2007.0305 · Cited by 56 · see citing works

NMDA receptor antagonist MK-801 reduces neuronal damage and preserves learning and memory in a rat model of traumatic brain injury

Rui-zhan, H., Hu, J. J., Weng, Y., Li, D., & Huang, Y. (2009) · Neuroscience Bulletin · doi:10.1007/s12264-009-0608-x · Cited by 55 · see citing works

Gender-specific role of mitochondria in the vulnerability of 6-hydroxydopamine-treated mesencephalic neurons

Misiak, M., Beyer, C., & Arnold, S. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.04.009 · Cited by 55 · see citing works

Neonatal hypoxia–ischemia induces sex-related changes in rat brain mitochondria

Weis, S. N., Pettenuzzo, L. F., Krolow, R., Valentim, L. M., Mota, C. S., Dalmaz, C., Wyse, Â. T. D. S., & Netto, C. A. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.10.002 · Cited by 55 · see citing works

Mitochondrial Dysfunction and NAD+ Metabolism Alterations in the Pathophysiology of Acute Brain Injury

Owens, K., Park, J. H., Schuh, R. A., & Kristián, T. (2013) · Translational Stroke Research · doi:10.1007/s12975-013-0278-x · Cited by 53 · see citing works

Sex differences in survival and mitochondrial bioenergetics during aging inDrosophila

Ballard, J. W. O., Melvin, R. G., Miller, J. T., & Katewa, S. D. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00331.x · Cited by 53 · see citing works

Depolarizing stimulation upregulates GA‐binding protein in neurons: a transcription factor involved in the bigenomic expression of cytochrome oxidase subunits

Zhang, C., & Wong‐Riley, M. T. T. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00997.x · Cited by 52 · see citing works

Glutamate-Mediated Excitotoxic Death of Cultured Striatal Neurons Is Mediated by Non-NMDA Receptors

Chen, Q., Harris, C. L., Brown, C. S., Howe, A. R., Surmeier, D. J., & Reiner, A. J. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1098 · Cited by 52 · see citing works

A new model for prenatal brain damage

Nuñez, J. L., Alt, J., & McCarthy, M. M. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00053-0 · Cited by 51 · see citing works

Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat

van Bregt, D. R., Thomas, T. C., Hinzman, J. M., Cao, T., Liu, M., Bing, G., Gerhardt, G. A., Pauly, J. R., & Lifshitz, J. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.12.003 · Cited by 49 · see citing works

Androgens and stroke: Good, bad or indifferent?

Quillinan, N., Deng, G., Grewal, H., & Herson, P. S. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.02.004 · Cited by 47 · see citing works

Inhibition of X-Linked Inhibitor of Apoptosis with Embelin Differentially Affects Male versus Female Behavioral Outcome following Neonatal Hypoxia-Ischemia in Rats

Hill, C. A., Alexander, M. L., McCullough, L. D., & FITCH, R. H. (2011) · Developmental Neuroscience · doi:10.1159/000331651 · Cited by 46 · see citing works

Sex‐ and brain region‐specific role of cytochrome c oxidase in 1‐methyl‐4‐phenylpyridinium‐mediated astrocyte vulnerability

Boyalla, S. S., Victor, M. B., Roemgens, A., Beyer, C., & Arnold, S. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22669 · Cited by 45 · see citing works

NAD+ and Nicotinamide: Sex Differences in Cerebral Ischemia

Siegel, C. S., & McCullough, L. D. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.068 · Cited by 42 · see citing works

Autophagy-mediated turnover of Dynamin-related Protein 1

Purnell, P. R., & Fox, H. S. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-86 · Cited by 41 · see citing works

Gemfibrozil Pretreatment Affecting Antioxidant Defense System and Inflammatory, but not Nrf-2 Signaling Pathways Resulted in Female Neuroprotection and Male Neurotoxicity in the Rat Models of Global Cerebral Ischemia–Reperfusion

Mohagheghi, F., Khalaj, L., Ahmadiani, A., & Rahmani, B. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9338-3 · Cited by 41 · see citing works

Sexual dimorphism in cerebral ischemia injury

Zuo, W., Zhang, W., & Chen, N. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.024 · Cited by 41 · see citing works

Thioltransferase (Glutaredoxin) Mediates Recovery of Motor Neurons from Excitotoxic Mitochondrial Injury

Kenchappa, R. S., Diwakar, L., Boyd, M. R., & Ravindranath, V. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08402.2002 · Cited by 40 · see citing works

Intra-mitochondrial poly(ADP-ribosyl)ation: Potential role for alpha-ketoglutarate dehydrogenase

Pankotai, E., Lacza, Z., Murányi, M., & Szabó, C. (2009) · Mitochondrion · doi:10.1016/j.mito.2009.01.013 · Cited by 39 · see citing works

Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: Implications in excitotoxicity

Diwakar, L., Kenchappa, R. S., Jayasree Annepu, B., & Ravindranath, V. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.03.008 · Cited by 37 · see citing works

Gender Differences in Amino Acid Use during Endurance Exercise

Lamont, L. S. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00116.x · Cited by 36 · see citing works

The neuroactive steroid 3-α-ol-5-β-pregnan-20-one hemisuccinate, a selective NMDA receptor antagonist improves behavioral performance following spinal cord ischemia

Lapchak, P. A. (2003) · Brain Research · doi:10.1016/j.brainres.2003.10.047 · Cited by 35 · see citing works

ADP‐Ribosylation of Highly Purified Rat Brain Mitochondria

Masmoudi, A., Islam, F., & Mandel, P. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb04854.x · Cited by 34 · see citing works

Sex-Specific Role of Thioredoxin in Neuroprotection Against Iron-Induced Brain Injury Conferred by Estradiol

Chen, T.-Y., Tsai, K.-L., Lee, T.-Y., Chiueh, C. C., Lee, W., & Hsu, C. (2009) · Stroke · doi:10.1161/strokeaha.109.562850 · Cited by 32 · see citing works

Induction of Mitochondrial Dysfunction by Poly(ADP-Ribose) Polymer: Implication for Neuronal Cell Death

Baek, S., Bae, O., Kim, E. K., & Yu, S.-W. (2013) · Molecules and Cells · doi:10.1007/s10059-013-0172-0 · Cited by 32 · see citing works

Sex differences in brain proteomes of neuron‐specific STAT3‐null mice after cerebral ischemia/reperfusion

Domenico, F. D., Casalena, G., Jia, J., Rukhsana Sultana, A., Barone, E., Cai, J., Pierce, W. M. J., Cini, C., Mancuso, C., Marzia Perluigi, A., et al. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07721.x · Cited by 31 · see citing works

Protection of cortical cells by equine estrogens against glutamate-induced excitotoxicity is mediated through a calcium independent mechanism

Perrella, J., & Bhavnani, B. R. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-34 · Cited by 30 · see citing works

Reperfusion Promotes Mitochondrial Biogenesis following Focal Cerebral Ischemia in Rats

Xie, Y., Li, J., Fan, G., Qi, S., & Li, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092443 · Cited by 28 · see citing works

Quantification of Poly(ADP-Ribose)-Modified Proteins in Cerebrospinal Fluid from Infants and Children after Traumatic Brain Injury

Fink, E. L., Lai, Y., Zhang, X., Janesko‐Feldman, K. L., Adelson, P. D., Szabó, C., Berger, R. P., Sarnaik, A., Kochanek, P. M., & Clark, R. S. B. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.52 · Cited by 24 · see citing works

Mitochondria as Generators and Targets of Nitric Oxide

Giulivi, C. (2007) · Novartis Foundation symposium · doi:10.1002/9780470725207.ch7 · Cited by 23 · see citing works

Evaluation of Autophagy Using Mouse Models of Brain Injury

Au, A. K., Bayır, H., Kochanek, P., & Clark, R. (2009) · Biochimica et Biophysica Acta · doi:10.1016/j.bbadis.2009.10.010 · Cited by 23 · see citing works

Sex differences in cerebral injury after severe haemorrhage and ventricular fibrillation in pigs

Semenas, E., Nozari, A., Sharma, H. S., BASU, S., Rubertsson, S., & Wiklund, L. (2009) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2009.02125.x · Cited by 22 · see citing works

Comparative analyses of the neurodegeneration induced by the non-competitive NMDA-receptor-antagonist drug MK801 in mice and rats

Bender, C. L., de Olmos, S., Bueno, A. M., de Olmos, J. S., & Lorenzo, A. (2010) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.05.002 · Cited by 21 · see citing works

Redox Activated MAP Kinase Death Signaling Cascade Initiated by ASK1 is not Activated in Female Mice Following MPTP: Novel Mechanism of Neuroprotection

Saeed, U., Karunakaran, S., Meka, D. P., Koumar, R. C., Ramakrishnan, S., Joshi, S. D., Nidadavolu, P., & Ravindranath, V. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9058-5 · Cited by 21 · see citing works

Effects of Nicotine Administration on Striatal Dopamine Signaling after Traumatic Brain Injury in Rats

Shin, S. S., Bray, E. R., & Dixon, C. E. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2011.1966 · Cited by 21 · see citing works

Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells

Zhang, C., Yuan, X., Li, H., Zhao, Z.-J., Liao, Y., Wang, X., Su, J., Sang, S., & Liu, Q. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.11.072 · Cited by 21 · see citing works

Gemfibrozil Pretreatment Resulted in a Sexually Dimorphic Outcome in the Rat Models of Global Cerebral Ischemia–Reperfusion via Modulation of Mitochondrial Pro-survival and Apoptotic Cell Death Factors as well as MAPKs

Mohagheghi, F., Ahmadiani, A., Rahmani, B., Moradi, F., Romond, N. B., & Khalaj, L. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9932-0 · Cited by 20 · see citing works

An Approach to Experimental Synaptic Pathology Using Green Fluorescent Protein-Transgenic Mice and Gene Knockout Mice to Show Mitochondrial Permeability Transition Pore-Driven Excitotoxicity in Interneurons and Motoneurons

Martin, L. J. (2010) · Toxicologic Pathology · doi:10.1177/0192623310389475 · Cited by 20 · see citing works

Effect of starvation on the survival of male and female mice.

Jikumaru, M., Hiramoto, K., Honma, T., Sato, E. F., Sekiyama, A., & Inoue, M. (2007) · PubMed · Cited by 14 · see citing works

17β‐estradiol does not protect cerebellar granule cells from excitotoxicity or apoptosis

Miñano-Molina, A. J., Cerbón, M. A., Xifró, X., Malagelada, C., Aguilera, J., & Rodrı́guez-Álvarez, J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04475.x · Cited by 10 · see citing works

Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know

Gupte, R. P., Brooks, W. M., Vukas, R. R., Pierce, J. D., & Harris, J. L. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6171 · Cited by 533 · see citing works

Sex differences in biological aging with a focus on human studies

Hägg, S., & Jylhävä, J. (2021) · eLife · doi:10.7554/elife.63425 · Cited by 442 · see citing works

Age and Sex Are Critical Factors in Ischemic Stroke Pathology

Roy-O’Reilly, M. A., & McCullough, L. D. (2018) · Endocrinology · doi:10.1210/en.2018-00465 · Cited by 475 · see citing works

Mechanisms of sex differences in Alzheimer’s disease

Lopez-Lee, C., Torres, E. R. S., Carling, G., & Gan, L. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.024 · Cited by 376 · see citing works

Mitochondria: A central target for sex differences in pathologies

Ventura-Clapier, R., Moulin, M., Piquereau, J., Lemaire, C., Mericskay, M., Veksler, V., & Garnier, A. (2017) · Clinical Science · doi:10.1042/cs20160485 · Cited by 371 · see citing works

The Role of Sex and Sex Hormones in Neurodegenerative Diseases

Vegeto, E., Villa, A. M., Torre, S. D., Crippa, V., Rusmini, P., Cristofani, R., Galbiati, M., Maggi, A. C., & Poletti, A. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz005 · Cited by 231 · see citing works

Dysregulation of mitochondrial dynamics, mitophagy and apoptosis in major depressive disorder: Does inflammation play a role?

Scaini, G., Mason, B. L., Díaz, A. P., Jha, M. K., Soares, J. C., Trivedi, M. H., & Quevedo, J. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01312-w · Cited by 184 · see citing works

Mitochondria, Estrogen and Female Brain Aging

Lejri, I., Grimm, A., & Eckert, A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00124 · Cited by 141 · see citing works

Sex-associated differences in mitochondrial function in human peripheral blood mononuclear cells (PBMCs) and brain

Silaidos, C., Pilatus, U., Grewal, R., Matura, S., Lienerth, B., Pantel, J., & Eckert, G. P. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0193-7 · Cited by 137 · see citing works

Sex differences in neuroinflammation and neuroprotection in ischemic stroke

Spychala, M. S., Honarpisheh, P., & McCullough, L. D. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23962 · Cited by 127 · see citing works

Impact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders

Ullah, M. F., Ahmad, A., Bhat, S. H., Abuduhier, F. M., Barreto, G. E., & Ashraf, G. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.003 · Cited by 113 · see citing works

Sex differences in ischaemic stroke: potential cellular mechanisms

Chauhan, A., Moser, H., & McCullough, L. D. (2017) · Clinical Science · doi:10.1042/cs20160841 · Cited by 105 · see citing works

Mitophagy Receptors and Mediators: Therapeutic Targets in the Management of Cardiovascular Ageing

Ajoolabady, A., Aslkhodapasandhokmabad, H., Aghanejad, A., Zhang, Y., & Ren, J. T. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101129 · Cited by 103 · see citing works

International society of sports nutrition position stand: nutritional concerns of the female athlete

Sims, S. T., Kerksick, C. M., Smith-Ryan, A. E., Janse de Jonge, X. A. K., Hirsch, K. R., Arent, S. M., Hewlings, S. J., Kleiner, S. M., Bustillo, E., Tartar, J. L., et al. (2023) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2023.2204066 · Cited by 91 · see citing works

Sex differences in the genetic architecture of depression

Kang, H., Park, Y., Yoo, K.-H., Kim, K. T., Kim, E.-S., Kim, J.-W., Kim, S., Shin, I., Yoon, J., Kim, J. H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-66672-9 · Cited by 89 · see citing works

Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease

Austad, S. N., Ballinger, S. W., Buford, T. W., Carter, C. S., Smith, D. L., Darley-Usmar, V. M., & Zhang, J. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.06.014 · Cited by 94 · see citing works

Sex‐dependent mitochondrial respiratory impairment and oxidative stress in a rat model of neonatal hypoxic‐ischemic encephalopathy

Demarest, T. G., Schuh, R. A., Waddell, J., McKenna, M. C., & Fiskum, G. M. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13590 · Cited by 86 · see citing works

Creatine target engagement with brain bioenergetics: a dose-ranging phosphorus-31 magnetic resonance spectroscopy study of adolescent females with SSRI-resistant depression

Kondo, D. G., Forrest, L. N., Shi, X., Sung, Y.-H., Hellem, T. L., Huber, R. S., & Renshaw, P. F. (2016) · Amino Acids · doi:10.1007/s00726-016-2194-3 · Cited by 79 · see citing works

Sex differences in frailty among older adults

Zeidan, R. S., McElroy, T., Rathor, L., Martenson, M. S., Lin, Y., & Mankowski, R. T. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112333 · Cited by 77 · see citing works

Curcumin-loaded polymeric nanoparticles for neuroprotection in neonatal rats with hypoxic-ischemic encephalopathy

Joseph, A., Wood, T. R., Chen, C., Corry, K. A., Snyder, J. M., Juul, S. E., Parikh, P., & Nance, E. A. (2018) · Nano Research · doi:10.1007/s12274-018-2104-y · Cited by 76 · see citing works

Transcriptional activation of antioxidant gene expression by Nrf2 protects against mitochondrial dysfunction and neuronal death associated with acute and chronic neurodegeneration

Goodfellow, M. J., Borcar, A., Proctor, J. L., Greco, T., Rosenthal, R. E., & Fiskum, G. M. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113247 · Cited by 74 · see citing works

Sex-dependent mitophagy and neuronal death following rat neonatal hypoxia–ischemia

Demarest, T. G., Waite, E. L., Kristián, T., Puché, A. C., Waddell, J., McKenna, M. C., & Fiskum, G. M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.08.026 · Cited by 70 · see citing works

Biological sex and DNA repair deficiency drive Alzheimer’s disease via systemic metabolic remodeling and brain mitochondrial dysfunction

Demarest, T. G., Varma, V. R., Estrada, D. J., Babbar, M., Basu, S., Mahajan, U. V., Moaddel, R., Croteau, D. L., Thambisetty, M., Mattson, M. P., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02152-8 · Cited by 70 · see citing works

Involvement of CXCL1/CXCR2 During Microglia Activation Following Inflammation-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal Rats

Serdar, M., Kempe, K., Herrmann, R., Picard, D. J., Remke, M., Herz, J., Bendix, I., Felderhoff‐Müser, U., & Sabir, H. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.540878 · Cited by 68 · see citing works

Ameliorating mitochondrial dysfunction restores carbon ion-induced cognitive deficits via co-activation of NRF2 and PINK1 signaling pathway

Liu, Y., Yan, J., Sun, C., Guo, L., Li, S., Zhang, L., Di, C., Gan, L., Wang, Y., Zhou, R., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.04.012 · Cited by 68 · see citing works

Bioenergetics and translational metabolism: implications for genetics, physiology and precision medicine

Hill, B. G., Shiva, S., Ballinger, S. W., Zhang, J., & Darley-Usmar, V. M. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0268 · Cited by 65 · see citing works

Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications

Torrens‐Mas, M., Pons, D. G., Sastre‐Serra, J., Oliver, J., & Roca, P. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101505 · Cited by 65 · see citing works

Precision medicine and drug development in Alzheimer’s disease: the importance of sexual dimorphism and patient stratification

Hampel, H., Vergallo, A., Giorgi, F. S., Kim, S. H., Depypere, H., Graziani, M., Saidi, A., Nisticò, R., & Lista, S. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.06.001 · Cited by 68 · see citing works

Sex, drugs and rock and roll: tales from preterm fetal life

Bennet, L. (2017) · The Journal of Physiology · doi:10.1113/jp272999 · Cited by 56 · see citing works

Sex difference of pre- and post-natal exposure to six developmental neurotoxicants on intellectual abilities: a systematic review and meta-analysis of human studies

Goodman, C. V., Green, R. R., DaCosta, A., Flora, D. B., Lanphear, B. P., & Till, C. (2023) · Environmental Health · doi:10.1186/s12940-023-01029-z · Cited by 52 · see citing works

Variability and sex-dependence of hypothermic neuroprotection in a rat model of neonatal hypoxic–ischaemic brain injury: a single laboratory meta-analysis

Wood, T. R., Gundersen, J. K., Falck, M., Maes, E., Osredkar, D., Løberg, E. M., Sabir, H., Walløe, L., & Thoresen, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-67532-2 · Cited by 52 · see citing works

Sex-Specific Differences in Redox Homeostasis in Brain Norm and Disease

Ruszkiewicz, J. A., Miranda‐Vizuete, A., Tinkov, A. A., Геннадиевна, С. М., Skalny, A. V., Tsatsakis, A. M., & Aschner, M. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1241-9 · Cited by 47 · see citing works

Developmental programming of peripheral diseases in offspring exposed to maternal obesity during pregnancy

Shrestha, N., Ezechukwu, H. C., Holland, O. J., & Hryciw, D. H. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00214.2020 · Cited by 48 · see citing works

Sex-specific stress response and HMGB1 release in pulmonary endothelial cells

Zemskova, M., Kurdyukov, S., James, J., McClain, N., Rafikov, R., & Rafikova, O. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231267 · Cited by 43 · see citing works

Sex-dependent mental illnesses and mitochondria

Shimamoto, A., & Rappeneau, V. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.02.025 · Cited by 41 · see citing works

The effect of mitochondrial transplantation therapy from different gender on inhibiting cell proliferation of malignant melanoma

Yu, Z., Hou, Y., Zhou, W., Zhao, Z., Liu, Z., & Fu, A. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.59581 · Cited by 41 · see citing works

Sex differences in the mitochondrial bioenergetics of astrocytes but not microglia at a physiologically relevant brain oxygen tension

Jaber, S. M., Bordt, E. A., Bhatt, N. M., Lewis, D. M., Gerecht, S., Fiskum, G., & Polster, B. M. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2017.09.003 · Cited by 40 · see citing works

Dynamics of enhanced mitochondrial respiration in female compared with male rat cerebral arteries

Rutkai, I., Dutta, S., Katakam, P. V., & Busija, D. W. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00231.2015 · Cited by 37 · see citing works

Cognitive performance of male and female C57BL/6J mice after repetitive concussive brain injuries

Velosky, A. G., Tucker, L. B., Fu, A. H., Liu, J., & McCabe, J. T. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.017 · Cited by 36 · see citing works

Effect of neuropsychiatric medications on mitochondrial function: For better or for worse

Emmerzaal, T. L., Nijkamp, G., Veldić, M., Rahman, S., Andreazza, A. C., Morava, É., Rodenburg, R. J., & Kozicz, T. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.001 · Cited by 33 · see citing works

Potential of PINK1 and PARKIN Proteins as Biomarkers for Active Multiple Sclerosis: A Japanese Cohort Study

Cossu, D., Yokoyama, K., Sechi, L. A., & Hattori, N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.681386 · Cited by 36 · see citing works

Epigenetic Blockade of Hippocampal SOD2 Via DNMT3b-Mediated DNA Methylation: Implications in Mild Traumatic Brain Injury-Induced Persistent Oxidative Damage

Balasubramanian, N., Sagarkar, S., Choudhary, A. G., Kokare, D. M., & Sakharkar, A. J. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02166-z · Cited by 34 · see citing works

DNA Damage Response and Repair, DNA Methylation, and Cell Death in Human Neurons and Experimental Animal Neurons Are Different

Martin, L. J., & Qing, C. (2018) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nly040 · Cited by 36 · see citing works

Depression and obesity among females, are sex specificities considered?

Baldini, I., Casagrande, B. P., & Estadella, D. (2021) · Archives of Women s Mental Health · doi:10.1007/s00737-021-01123-6 · Cited by 30 · see citing works

The influence of genetic and acquired factors on the vulnerability to develop depression: a review

Zhang, X., Qiao, Y., Wang, M., Liang, X., Zhang, M., Li, C., Cairang, J., Wang, J., Bi, H., & Gao, T. (2023) · Bioscience Reports · doi:10.1042/bsr20222644 · Cited by 31 · see citing works

NF-κB p65 directs sex-specific neuroprotection in human neurons

Ruiz-Perera, L. M., Schneider, L. V., Windmöller, B. A., Müller, J., Greiner, J. F. W., Kaltschmidt, C., & Kaltschmidt, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-34394-8 · Cited by 28 · see citing works

The Contribution of Plasma and Brain Vitamin C on Age and Gender-Related Cognitive Differences: A Mini-Review of the Literature

Travica, N., Ried, K., Hudson, I. L., Sali, A., Scholey, A. B., & Pipingas, A. (2020) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2020.00047 · Cited by 30 · see citing works

A myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice

Chernov, A. V., Hullugundi, S. K., Eddinger, K. A., Dolkas, J., Remacle, A. G., Angert, M., James, B. P., Yaksh, T. L., Strongin, A. Y., & Shubayev, V. I. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013696 · Cited by 28 · see citing works

Clinical impact of estradiol/testosterone ratio in patients with acute ischemic stroke

Choi, J. W., Ryoo, I. W., Hong, J. Y., Lee, K., Nam, H. S., Kim, W. C., Oh, S.-H., Kang, J., Lee, H. Y., Na, S.-J., et al. (2021) · BMC Neurology · doi:10.1186/s12883-021-02116-9 · Cited by 28 · see citing works

The Therapeutic Potential and Limitations of Ketones in Traumatic Brain Injury

Daines, S. A. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.723148 · Cited by 28 · see citing works

Mitochondrial health index correlates with plasma circulating cell-free mitochondrial DNA in bipolar disorder

Cordeiro, R. C., Lima, C. N. D. C., Fries, G. R., Zunta‐Soares, G. B., Soares, J. C., Quevedo, J., & Scaini, G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02249-y · Cited by 25 · see citing works

Prospective network analysis of proinflammatory proteins, lipid markers, and depression components in midlife community women

Zainal, N. H., & Newman, M. G. (2022) · Psychological Medicine · doi:10.1017/s003329172200232x · Cited by 27 · see citing works

Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination

Zhang, T., Feng, T., Wu, K., Guo, J. D., Nana, A. L., Yang, G., Seeley, W. W., & Hu, F. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02578-w · Cited by 25 · see citing works

Prenatal Exposure to Retrorsine Induces Developmental Toxicity and Hepatotoxicity of Fetal Rats in a Sex-Dependent Manner: The Role of Pregnane X Receptor Activation

Dai, Y., Luo, J., Xiang, E., Guo, Q., He, Z., Gong, Z., Sun, X., Kou, H., Xu, K., Fan, C., et al. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c06748 · Cited by 24 · see citing works

Oxidative injuries induced by maternal low-protein diet in female brainstem

de Sousa, S. M., Braz, G. R. F., Freitas, C. D. M., de Santana, D. F., Sellitti, D. F., Fernandes, M. P., & Lagranha, C. J. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1325974 · Cited by 24 · see citing works

Metabolic Sex Dimorphism of the Brain at the Gene, Cell, and Tissue Level

Lee, J. W., Profant, M. R., & Wang, C. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100853 · Cited by 23 · see citing works

Effects of estrogens and androgens on mitochondria under normal and pathological conditions

Mohajeri, M., Martín-Jiménez, C., Barreto, G. E., & Sahebkar, A. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.03.001 · Cited by 22 · see citing works

Role of Vitamin E in Neonatal Neuroprotection: A Comprehensive Narrative Review

Kolnik, S. E., & Wood, T. R. (2022) · Life · doi:10.3390/life12071083 · Cited by 22 · see citing works

Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer’s disease

Babygirija, R., Sonsalla, M. M., Mill, J., James, I., Han, J. H., Green, C. L., Calubag, M. F., Wade, G., Tobon, A., Michael, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49589-z · Cited by 20 · see citing works

Sex specific effects of buprenorphine on behavior, astrocytic opioid receptor expression and neuroinflammation after pediatric traumatic brain injury in mice

Hamood, Y., Abdullah, M., Ghoul, H. E., Saad, N., Dysko, R. C., & Zhang, Z. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100469 · Cited by 20 · see citing works

Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma

Song, M., Kim, J., Gorr, M. W., Miller, R. A., Karpurapu, M., Nguyen, J., Patel, D., Archer, K. J., Pabla, N., Shields, P. G., et al. (2023) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00033.2023 · Cited by 18 · see citing works

Disease-directed engineering for physiology-driven treatment interventions in neurological disorders

Wood, T. R., & Nance, E. A. (2019) · APL Bioengineering · doi:10.1063/1.5117299 · Cited by 20 · see citing works

Drosophila Exhibit Divergent Sex-Based Responses in Transcription and Motor Function After Traumatic Brain Injury

Shah, E. J., Gurdziel, K., & Ruden, D. M. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00511 · Cited by 21 · see citing works

Early Life Supraphysiological Levels of Oxygen Exposure Permanently Impairs Hippocampal Mitochondrial Function

Ramani, M., Miller, K., Brown, J. A., Kumar, R., Kadasamy, J., McMahon, L. L., Ballinger, S. W., & Ambalavanan, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-49532-z · Cited by 19 · see citing works

Sex differences in the behavioral and immune responses of mice to tumor growth and cancer therapy

Vichaya, E. G., Ford, B. G., Moltenkine, J. M., Taniguchi, C. M., West, A. P., & Dantzer, R. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.08.225 · Cited by 19 · see citing works

Mitochondrial-associated protein biomarkers in patients with attention-deficit/hyperactivity disorder

Lee, C., Wu, C., Chou, W., Lee, M., Chou, M., Lee, S.-Y., & Wang, L. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.07.007 · Cited by 18 · see citing works

Utility of specific amino acid ratios in screening for pyruvate dehydrogenase complex deficiencies and other mitochondrial disorders associated with congenital lactic acidosis and newborn screening prospects

Bedoyan, J. K., Hage, R., Shin, H. K., Linard, S. M., Ferren, E., Ducich, N. H., Wilson, K. A., Lehman, A. N., Schillaci, L.-A. P., Manickam, K., et al. (2020) · JIMD Reports · doi:10.1002/jmd2.12153 · Cited by 17 · see citing works

Vitamin E Decreases Cytotoxicity and Mitigates Inflammatory and Oxidative Stress Responses in a Ferret Organotypic Brain Slice Model of Neonatal Hypoxia-Ischemia

Kolnik, S. E., Corry, K. A., Hildahl, K., Filteau, J. R., White, O. R., Brandon, O. C., Farid, L., Shearlock, A., Moralejo, D. H., Juul, S. E., et al. (2022) · Developmental Neuroscience · doi:10.1159/000522485 · Cited by 18 · see citing works

Nanotherapeutics and the Brain

Joseph, A., & Nance, E. A. (2022) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-092220-030853 · Cited by 20 · see citing works

Mitochondrial transplantation against gentamicin-induced toxicity on rat renal proximal tubular cells: the higher activity of female rat mitochondria

Arjmand, A., Shiranirad, S., Ameritorzani, F., Kamranfar, F., Seydi, E., & Pourahmad, J. (2023) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-022-00743-1 · Cited by 18 · see citing works

Sex difference in monocrotaline-induced developmental toxicity and fetal hepatotoxicity in rats

Luo, J., Yang, X., Qiu, S., Li, X., Xiang, E., Fang, Y., Wang, Y., Zhang, L., Wang, H., Zheng, J., et al. (2019) · Toxicology · doi:10.1016/j.tox.2019.02.014 · Cited by 18 · see citing works

Sex may influence motor phenotype in a novel rodent model of cerebral palsy

Aravamuthan, B. R., Gandham, S., Young, A. B., & Rutkove, S. B. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104711 · Cited by 18 · see citing works

Female-specific activation of pregnane X receptor mediates sex difference in fetal hepatotoxicity by prenatal monocrotaline exposure

Xiang, E., Guo, Q., Dai, Y., Sun, X., Liu, J., Fan, C., Wang, Y., Qiu, S., Wang, H., & Guo, Y. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115137 · Cited by 18 · see citing works

Chronic hypoxia alters cardiac mitochondrial complex protein expression and activity in fetal guinea pigs in a sex-selective manner

Song, H., Polster, B. M., & Thompson, L. P. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00004.2021 · Cited by 18 · see citing works

Females Exhibit Better Cerebral Pressure Autoregulation, Less Mitochondrial Dysfunction, and Reduced Excitotoxicity after Severe Traumatic Brain Injury

Wettervik, T. S., Hånell, A., Howells, T. P., Enblad, P., & Lewén, A. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2022.0097 · Cited by 17 · see citing works

Formulation and Efficacy of Catalase-Loaded Nanoparticles for the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy

Joseph, A., Nyambura, C. W., Bondurant, D., Corry, K. A., Beebout, D., Wood, T. R., Pfaendtner, J., & Nance, E. A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081131 · Cited by 16 · see citing works

Inter-chromosomal contacts demarcate genome topology along a spatial gradient

Mokhtaridoost, M., Chalmers, J. J., Soleimanpoor, M., McMurray, B. J., Lato, D. F., Nguyen, S. C., Musienko, V., Nash, J. O., Espeso‐Gil, S., Ahmed, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53983-y · Cited by 17 · see citing works

Mitochondrial membrane potential and delayed graft function following kidney transplantation

Garonzik‐Wang, J., Lonze, B. E., Ruck, J. M., Luo, X., Massie, A. B., Melancon, K. P., Burdick, J. F., Segev, D. L., & Sun, Z. (2018) · American Journal of Transplantation · doi:10.1111/ajt.15174 · Cited by 16 · see citing works

Phenotype and energy metabolism differ between osteoarthritic chondrocytes from male compared to female patients: Implications for sexual dimorphism in osteoarthritis development?

Jain, L., Jardim, C. A., Yulo, P. R. J., Bolam, S. M., Monk, A. P., Munro, J. T., PITTO, R. P., Tamatea, J. A. U., Dalbeth, N., & Poulsen, R. C. (2023) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2023.09.013 · Cited by 15 · see citing works

Sex-Related Differences in the Pathophysiology, Cardiac Imaging, and Clinical Outcomes of Aortic Stenosis: A Narrative Review

Dahou, A., Awasthi, V., Bkhache, M., Djellal, M., Yang, X., Wang, H., & Bouchareb, R. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13216359 · Cited by 15 · see citing works

Neonatal Maternal Separation Modifies Proteostasis Marker Expression in the Adult Hippocampus

Sierra-Fonseca, J. A., Hamdan, J. N., Cohen, A. A., Cardenas, S. M., Saucedo, S., Lodoza, G. A., & Gosselink, K. L. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.661993 · Cited by 15 · see citing works

Cannabinol (CBN) alleviates age-related cognitive decline by improving synaptic and mitochondrial health

Dar, N. J., Currais, A. J. M., Taguchi, T., Andrews, N., & Maher, P. A. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103692 · Cited by 14 · see citing works

Inhibiting Mitochondrial Cytochrome c Oxidase Downregulates Gene Transcription After Traumatic Brain Injury in Drosophila

Shah, E. J., Hüttemann, M., Sanderson, T. H., Gurdziel, K., & Ruden, D. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.628777 · Cited by 14 · see citing works

Evaluation of Gender Differences in Response to Photobiomodulation Therapy, Including Laser Acupuncture: A Narrative Review and Implication to Precision Medicine

Liebert, A. D., Seyedsadjadi, N., Pang, V., Litscher, G., & Kiat, H. (2021) · Photobiomodulation Photomedicine and Laser Surgery · doi:10.1089/photob.2021.0066 · Cited by 13 · see citing works

The poorly conducted orchestra of steroid hormones, oxidative stress and inflammation in frailty needs a maestro: Regular physical exercise

Barros, M. P., Bachi, A. L. L., Santos, J. M. B., Lambertucci, R. H., Figueirôa, R. I., Polotow, T. G., Caldo‐Silva, A., Valente, P. A., Hogervorst, E., & Furtado, G. E. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111562 · Cited by 13 · see citing works

Sex-Specific Catabolic Metabolism Alterations in the Critically Ill following High Dose Vitamin D

Chary, S., Amrein, K., Mahmoud, S. H., Lasky-Su, J. A., & Christopher, K. B. (2022) · Metabolites · doi:10.3390/metabo12030207 · Cited by 13 · see citing works

Female and male C57BL/6J offspring exposed to maternal obesogenic diet develop altered hypothalamic energy metabolism in adulthood

Kulhanek, D., Abrahante, J. E., Buckley, L., Tkáč, I., Rao, R., & Paulsen, M. E. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00100.2022 · Cited by 13 · see citing works

Blood immune cells from people with HIV on antiviral regimens that contain tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) have differential metabolic signatures

Ritou, E., Satta, S., Petcherski, A., Δάσκου, Μ., Sharma, M. B., Vasilopoulos, H., Murakami, E., Shirihai, O. S., & Kelesidis, T. (2023) · Metabolism · doi:10.1016/j.metabol.2022.155395 · Cited by 15 · see citing works

Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension

Rafikov, R., James, J., McClain, N., Tofovic, S. P., & Rafikova, O. (2019) · Antioxidants · doi:10.3390/antiox8050135 · Cited by 12 · see citing works

Evaluation of heterogeneity in effect of therapeutic hypothermia by sex among infants with neonatal encephalopathy

Sewell, E., Shankaran, S., Natarajan, G., Laptook, A. R., Das, A., McDonald, S. A., Hamrick, S. E. G., Baack, M. L., Rysavy, M. A., Higgins, R. D., et al. (2023) · Pediatric Research · doi:10.1038/s41390-023-02586-2 · Cited by 12 · see citing works

Chronic fluoxetine or ketamine treatment differentially affects brain energy homeostasis which is not exacerbated in mice with trait suboptimal mitochondrial function

Emmerzaal, T. L., Jacobs, L., Geenen, B., Verweij, V. G. M., Morava, É., Rodenburg, R. J., & Kozicz, T. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14901 · Cited by 12 · see citing works

A ferret brain slice model of oxygen–glucose deprivation captures regional responses to perinatal injury and treatment associated with specific microglial phenotypes

Wood, T. R., Hildahl, K., Helmbrecht, H., Corry, K. A., Moralejo, D. H., Kolnik, S. E., Prater, K. E., Juul, S. E., & Nance, E. A. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10265 · Cited by 11 · see citing works

Male-specific behavioral and transcriptomic changes in aging C. elegans neurons

Weng, Y., & Murphy, C. T. (2024) · iScience · doi:10.1016/j.isci.2024.109910 · Cited by 10 · see citing works

Sex-specific associations of kynurenic acid with neopterin in Alzheimer’s disease

Knapskog, A., Edwin, T. H., Ueland, P. M., Ulvik, A., Fang, E. F., Eldholm, R. S., Halaas, N. B., Giil, L. M., Saltvedt, I. T., Watne, L. O., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01531-7 · Cited by 11 · see citing works

Air-Evacuation-Relevant Hypobaria Following Traumatic Brain Injury Plus Hemorrhagic Shock in Rats Increases Mortality and Injury to the Gut, Lungs, and Kidneys

Proctor, J. L., Medina, J. A., Rangghran, P., Tamrakar, P., Miller, C. H. T., Puché, A. C., Quan, W., Coksaygan, T., Drachenberg, C. B., Rosenthal, R. E., et al. (2021) · Shock · doi:10.1097/shk.0000000000001761 · Cited by 11 · see citing works

Further investigation of mitochondrial biogenesis and gene expression of key regulators in ascites- susceptible and ascites- resistant broiler research lines

Alzahrani, K., Licknack, T. J., Watson, D. L., Anthony, N. B., & Rhoads, D. D. (2019) · PLoS ONE · doi:10.1371/journal.pone.0205480 · Cited by 11 · see citing works

Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic Injury

Klöfers, M., Kohaut, J., Bendix, I., Herz, J., Boos, V., Felderhoff‐Müser, U., & Dzietko, M. (2017) · BioMed Research International · doi:10.1155/2017/2924848 · Cited by 11 · see citing works

Mitochondrial heterogeneity and crosstalk in aging: Time for a paradigm shift?

Hinton, A. O., Jr., Vue, Z., Scudese, E., Neikirk, K., Kirabo, A., & Montano, M. A. (2024) · Aging Cell · doi:10.1111/acel.14296 · Cited by 11 · see citing works

Pre and postnatal exposure to 900 MHz electromagnetic fields induce inflammation and oxidative stress, and alter renin-angiotensin system components differently in male and female offsprings

Kılıç, A., Üstünova, S., Bulut, H., & Meral, İ. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121627 · Cited by 10 · see citing works

The mitoepigenome responds to stress, suggesting novel mito-nuclear interactions in vertebrates

Lees, J. J., Pértille, F., Løtvedt, P. K., Jensen, P., & Guerrero‐Bosagna, C. (2023) · BMC Genomics · doi:10.1186/s12864-023-09668-9 · Cited by 10 · see citing works

Sex Differences in Mitochondrial Function Following a Controlled Cortical Impact Traumatic Brain Injury in Rodents

Kalimon, O. J., & Sullivan, P. G. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.753946 · Cited by 20 · see citing works

Mitochondria: A central target for sex differences in pathologies

Ventura-Clapier, R., Moulin, M., Piquereau, J., Lemaire, C., Mericskay, M., Veksler, V., & Garnier, A. (2017) · Clinical Science · doi:10.1042/cs20160485 · Cited by 371 · see citing works

Sex-associated differences in mitochondrial function in human peripheral blood mononuclear cells (PBMCs) and brain

Silaidos, C., Pilatus, U., Grewal, R., Matura, S., Lienerth, B., Pantel, J., & Eckert, G. P. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0193-7 · Cited by 137 · see citing works

Mitochondrial Dysfunction in Neural Injury

Zhao, X., Lu, M., Yuan, D., Xu, D.-E., Yao, P.-P., Ji, W., Chen, H., Liu, W., Yan, C.-X., Xia, Y., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00030 · Cited by 126 · see citing works

Detrimental effects of transient cerebral ischemia on middle cerebral artery mitochondria in female rats

Rutkai, I., Merdžo, I., Wunnava, S. V., McNulty, C. A., Chandra, P. K., Katakam, P. V. G., & Busija, D. W. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00346.2022 · Cited by 8 · see citing works