The Endoplasmic Reticulum Enzyme DGAT2 Is Found in Mitochondria-associated Membranes and Has a Mitochondrial Targeting Signal That Promotes Its Association with Mitochondria

Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein

Shaner, N. C., Campbell, R. E., Steinbach, P. A., Giepmans, B. N. G., Palmer, A. E., & Tsien, R. Y. (2004) · Nature Biotechnology · doi:10.1038/nbt1037 · Cited by 4,619

A monomeric red fluorescent protein

Campbell, R. E., Tour, O., Palmer, A. E., Steinbach, P. A., Baird, G. S., Zacharias, D. A., & Tsien, R. Y. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082243699 · Cited by 2,346

Biochemistry of Lipids, Lipoproteins and Membranes

(2021) · Elsevier eBooks · doi:10.1016/c2020-0-00089-7 · Cited by 1,402

Phospholipid synthesis in a membrane fraction associated with mitochondria.

Vance, J. E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39106-9 · Cited by 1,153

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

Cases, S., Smith, S. J., Zheng, Y.-W., Myers, H. M., Lear, S. R., Sande, E., Novak, S., Collins, C. C., Welch, C. L., Lusis, A. J., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13018 · Cited by 1,138

Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

Yen, C.-L. E., Stone, S. J., Koliwad, S., Harris, C., & Farese, R. V. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800018-jlr200 · Cited by 1,105

Enzymes of triacylglycerol synthesis and their regulation

Coleman, R. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00051-1 · Cited by 985

The lipid handbook

Gunstone, F. D., Harwood, J. L., & Padley, F. B. (1994) · Cited by 972

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.

Mootha, V. K., Bunkenborg, J., Olsen, J. V., Hjerrild, M., Wisniewski, J. R., Stahl, E., Bolouri, M. S., Ray, H. N., Sihag, S., Kamal, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00926-7 · Cited by 889

Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members

Cases, S., Stone, S. J., Zhou, P., Yen, E., Tow, B., Lardizabal, K. D., Voelker, T., & Farese, R. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106219200 · Cited by 818

Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes

Sahini, N., & Borlak, J. T. (2014) · Progress in Lipid Research · doi:10.1016/j.plipres.2014.02.002 · Cited by 117

Acyl-CoA:diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control

Chen, G., Harwood, J. L., Lemieux, M. J., Stone, S. J., & Weselake, R. J. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101181 · Cited by 121

Cytosolic lipid droplets: From mechanisms of fat storage to disease

Gross, D. A., & Silver, D. L. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2014.931337 · Cited by 117

Missense Mutation in APOC3 within the C-terminal Lipid Binding Domain of Human ApoC-III Results in Impaired Assembly and Secretion of Triacylglycerol-rich Very Low Density Lipoproteins

Qin, W., Sundaram, M., Wang, Y., Zhou, H., Zhong, S., Chang, C.-C., Manhas, S., Yao, E. F., Parks, R. J., McFie, P. J., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.203679 · Cited by 107

Mitochondrial oxidative function in NAFLD: Friend or foe?

Shum, M., Ngo, J., Shirihai, O. S., & Liesa, M. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101134 · Cited by 112

Protein Quality Control and Lipid Droplet Metabolism

Roberts, M. A., & Olzmann, J. A. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-031320-101827 · Cited by 112

Functional and Topological Analysis of Yeast Acyl-CoA:Diacylglycerol Acyltransferase 2, an Endoplasmic Reticulum Enzyme Essential for Triacylglycerol Biosynthesis

Liu, Q., Siloto, R. M. P., Snyder, C. L., & Weselake, R. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204412 · Cited by 105

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease

Prakash, P., Manchanda, P., Paouri, E., Bisht, K., Sharma, K., Rajpoot, J., Wendt, V., Hossain, A., Wijewardhane, P. R., Randolph, C. E., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.029 · Cited by 104

New Insights into the Role of Mitochondria-Associated Endoplasmic Reticulum Membrane

Fujimoto, M., & Hayashi, T. (2011) · International review of cytology · doi:10.1016/b978-0-12-386033-0.00002-5 · Cited by 106

Lipid Droplets as Organelles

Cohen, S. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2017.12.007 · Cited by 102

Organelle plasticity and interactions in cholesterol transport and steroid biosynthesis

Issop, L., Rone, M. B., & Papadopoulos, V. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.12.003 · Cited by 103

Endoplasmic reticulum–mitochondria crosstalk: from junction to function across neurological disorders

Veeresh, P., Kaur, H., Sarmah, D., Mounica, L., Verma, G., Kotian, V., Kesharwani, R., Kalia, K., Borah, A., Wang, X., et al. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14212 · Cited by 98

Lipid droplets lighting up: Insights from live microscopy

Digel, M., Ehehalt, R., & Füllekrug, J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.03.035 · Cited by 98

Lipid droplet formation on opposing sides of the endoplasmic reticulum

Sturley, S. L., & Hussain, M. M. (2012) · Journal of Lipid Research · doi:10.1194/jlr.r028290 · Cited by 96

ER-mitochondria contact sites; a multifaceted factory for Ca2+ signaling and lipid transport

Sassano, M. L., Felipe‐Abrio, B., & Agostinis, P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.988014 · Cited by 97

Obesity promotes gastric cancer metastasis via diacylglycerol acyltransferase 2-dependent lipid droplets accumulation and redox homeostasis

Li, S., Wu, T., Lu, Y., Wang, J., Yu, F.-H., Yang, M., Huang, Y., Li, Z.-J., Wang, S.-L., Huang, L., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101596 · Cited by 90

Influence of bovine serum albumin and fetal bovine serum supplementation during in vitro maturation on lipid and mitochondrial behaviour in oocytes and lipid accumulation in bovine embryos

del Collado, M., Saraiva, N. Z., Lopes, F. L., Gaspar, R. C., Padilha, L. C., Costa, R. R., Rossi, G. F., Vantini, R., & Garcia, J. M. (2015) · Reproduction Fertility and Development · doi:10.1071/rd15067 · Cited by 93

Retinyl Ester Storage Particles (Retinosomes) from the Retinal Pigmented Epithelium Resemble Lipid Droplets in Other Tissues

Orban, T., Palczewska, G., & Palczewski, K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.195198 · Cited by 89

Lipid remodeling of adipose tissue in metabolic health and disease

Cho, Y. K., Lee, S., Lee, J. R., Doh, J., Park, J., Jung, Y., & Lee, Y. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01071-4 · Cited by 103

The Molecular Mechanisms Underlying Mitochondria-Associated Endoplasmic Reticulum Membrane-Induced Insulin Resistance

Cheng, H., Gang, X., He, G., Liu, Y., Wang, Y., Zhao, X. Y., & Wang, G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.592129 · Cited by 89

Quantitative electron microscopy shows uniform incorporation of triglycerides into existing lipid droplets

Cheng, J., Fujita, A., Ohsaki, Y., Suzuki, M., Shinohara, Y., & Fujimoto, T. (2009) · Histochemistry and Cell Biology · doi:10.1007/s00418-009-0615-z · Cited by 89

Endoplasmic Reticulum–Mitochondria Contact Sites and Neurodegeneration

Xu, L., Wang, X., & Tong, C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00428 · Cited by 87

Diacylglycerol Acyltransferase-2 (DGAT2) and Monoacylglycerol Acyltransferase-2 (MGAT2) Interact to Promote Triacylglycerol Synthesis

Jin, Y., McFie, P. J., Banman, S. L., Brandt, C., & Stone, S. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.571190 · Cited by 87

The size matters: regulation of lipid storage by lipid droplet dynamics

Yu, J., & Li, P. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-0322-x · Cited by 91

A Thematic Review Series: Lipid droplet storage and metabolism: from yeast to man

Reue, K. (2011) · Journal of Lipid Research · doi:10.1194/jlr.e020602 · Cited by 85

Organelle interactions compartmentalize hepatic fatty acid trafficking and metabolism

Najt, C. P., Adhikari, S., Heden, T. D., Cui, W., Gansemer, E. R., Rauckhorst, A. J., Markowski, T. W., Higgins, L., Kerr, E. W., Boyum, M. D., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112435 · Cited by 86

Lipid metabolism, remodelling and intercellular transfer in the CNS

Vanherle, S., Loix, M., Miron, V. E., Hendriks, J. J. A., & Bogie, J. F. J. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00908-3 · Cited by 96

Mitochondrial lipids in neurodegeneration

Aufschnaiter, A., Kohler, V., Diessl, J., Peselj, C., Carmona‐Gutiérrez, D., Keller, W., & Büttner, S. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2463-1 · Cited by 91

Dgat1 and Dgat2 regulate enterocyte triacylglycerol distribution and alter proteins associated with cytoplasmic lipid droplets in response to dietary fat

Hung, Y.-H., Carreiro, A. L., & Buhman, K. K. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.02.014 · Cited by 84

Intestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity in Dgat1 mice

Lee, B., Fast, A. M., Zhu, J., Cheng, J., & Buhman, K. K. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m002311 · Cited by 82

Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson’s Disease

Rodríguez‐Arribas, M., Yakhine-Diop, S. M. S., Pedro, J. M. B., Gómez‐Suaga, P., Gómez‐Sánchez, R., Martínez-Chacón, G., Fuentes, J. M., González‐Polo, R. A., & Niso‐Santano, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0140-8 · Cited by 82

The olive DGAT2 gene is developmentally regulated and shares overlapping but distinct expression patterns with DGAT1

Μπανίλας, Γ. Π., Karampelias, M., Makariti, I., Kourti, A., & Hatzopoulos, P. (2010) · Journal of Experimental Botany · doi:10.1093/jxb/erq286 · Cited by 82

The biology of lipid droplet-bound mitochondria

Veliova, M., Petcherski, A., Liesa, M., & Shirihai, O. S. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.04.013 · Cited by 82

Maintaining social contacts: The physiological relevance of organelle interactions

Silva, B. S. C., DiGiovanni, L. F., Kumar, R., Carmichael, R. E., Kim, P. K., & Schrader, M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118800 · Cited by 84

Functional multi-organelle units control inflammatory lipid metabolism of macrophages

Zimmermann, J. A., Lucht, K., Stecher, M., Badhan, C., Glaser, K. M., Epple, M. W., Koch, L. R., Deboutte, W., Manke, T., Ebnet, K., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01457-0 · Cited by 79

Dysregulation of organelle membrane contact sites in neurological diseases

Kim, S., Coukos, R., Gao, F., & Krainc, D. (2022) · Neuron · doi:10.1016/j.neuron.2022.04.020 · Cited by 82

The ubiquitin-like (UBX)-domain-containing protein Ubx2/ Ubxd8 regulates lipid droplet homeostasis

Wang, C.-W., & Lee, S. (2012) · Journal of Cell Science · doi:10.1242/jcs.100230 · Cited by 76

Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic ReticulumPreprint

Farese, R. V., & Walther, T. C. (2022) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041246 · Cited by 76

ER membranes associated with mitochondria: Possible therapeutic targets in heart-associated diseases

Silva‐Palacios, A., Zazueta, C., & Pedraza‐Chaverrí, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104758 · Cited by 74

Mycobacterium marinum Degrades Both Triacylglycerols and Phospholipids from Its Dictyostelium Host to Synthesise Its Own Triacylglycerols and Generate Lipid Inclusions

Barisch, C., & Soldati, T. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006095 · Cited by 70

Of yeast, mice and men: MAMs come in two flavors

Herrera-Cruz, M. S., & Simmen, T. (2017) · Biology Direct · doi:10.1186/s13062-017-0174-5 · Cited by 73

Insulin Resistance, Obesity, and Lipotoxicity

Yazıcı, D., Demir, S. Ç., & Sezer, H. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_14 · Cited by 85

Overexpression of diacylglycerol acyltransferase inYarrowia lipolyticaaffects lipid body size, number and distribution

Gajdoš, P., Ledesma‐Amaro, R., Nicaud, J., Čertí­k, M., & Rossignol, T. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow062 · Cited by 71

Mitochondrial lipid transport at a glance

Scharwey, M., Tatsuta, T., & Langer, T. (2013) · Journal of Cell Science · doi:10.1242/jcs.134130 · Cited by 74

Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis

Johnson, J. M., Peterlin, A. D., Balderas, E., Sustarsic, E. G., Maschek, J. A., Lang, M. J., Jara-Ramos, A., Panic, V., Morgan, J. T., Villanueva, C. J., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade7864 · Cited by 79

The consequences of mitochondrial amyloid β-peptide in Alzheimer's disease

Muirhead, K. E. A., Borger, E., Aitken, L., Conway, S. J., & Gunn‐Moore, F. J. (2010) · Biochemical Journal · doi:10.1042/bj20091941 · Cited by 68

Over Six Decades of Discovery and Characterization of the Architecture at Mitochondria-Associated Membranes (MAMs)

Herrera-Cruz, M. S., & Simmen, T. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4567-7_2 · Cited by 68

Liver X Receptor: an oxysterol sensor and a major player in the control of lipogenesis

Ducheix, S., Lobaccaro, J. A., Martin, P. G. P., & Guillou, H. (2011) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2011.06.004 · Cited by 71

Modulation of myocellular fat stores: lipid droplet dynamics in health and disease

Meex, R. C. R., Schrauwen, P., & Hesselink, M. K. C. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.91053.2008 · Cited by 65

Specific activation of the integrated stress response uncovers regulation of central carbon metabolism and lipid droplet biogenesis

Labbè, K., LeBon, L., King, B., Vu, N., Stoops, E. H., Ly, N., Lefebvre, A. E. Y. T., Seitzer, P., Krishnan, S., Heo, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52538-5 · Cited by 62

Role of Endoplasmic Reticulum-Mitochondria Communication in Type 2 Diabetes

Rieusset, J. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4567-7_13 · Cited by 64

Overexpression of the active diacylglycerol acyltransferase variant transforms Saccharomyces cerevisiae into an oleaginous yeast

Kamisaka, Y., Kimura, K., Uemura, H., & Yamaoka, M. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-4915-9 · Cited by 63

Characterization and manipulation of a DGAT2 from the diatom Thalassiosira pseudonana: Improved TAG accumulation without detriment to growth, and implications for chloroplast TAG accumulation

Manandhar-Shrestha, K., & Hildebrand, M. (2015) · Algal Research · doi:10.1016/j.algal.2015.09.004 · Cited by 61

Perilipin 5 is protective in the ischemic heart

Drevinge, C., Dalen, K. T., Mannila, M. N., Täng, M. S., Ståhlman, M., Klevstig, M., Lundqvist, A., Mardani, I., Haugen, F., Fogelstrand, P., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.06.037 · Cited by 61

Moving out but keeping in touch: contacts between endoplasmic reticulum and lipid droplets

Salo, V. T., & Ikonen, E. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.11.002 · Cited by 62

Futile lipid cycling: from biochemistry to physiology

Sharma, A. K., Khandelwal, R., & Wolfrum, C. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01003-0 · Cited by 66

The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications

Deng, B., Kong, W., Shen, X., Han, C. Q., Zhao, Z., Chen, S., Zhou, C., & Bae-Jump, V. L. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05084-z · Cited by 63

Metabolic and functional connections between cytoplasmic and chloroplast triacylglycerol storage

Xu, C., Fan, J., & Shanklin, J. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101069 · Cited by 60

Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications

Rakotonirina-Ricquebourg, R., Costa, V., & Teixeira, V. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101141 · Cited by 63

Mitochondria-associated membrane-modulated Ca2+ transfer: A potential treatment target in cardiac ischemia reperfusion injury and heart failure

Gong, Y., Lin, J., Ma, Z., Yu, M., Wang, M., Lai, D., & Fu, G. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119511 · Cited by 58

Structure and function of lipid droplet assembly complexes

Walther, T. C., Kim, S., Arlt, H., Voth, G. A., & Farese, R. V. (2023) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2023.102606 · Cited by 58

Interorganelle communication, aging, and neurodegenerationPreprint

Petković, M., O’Brien, C. E., & Jan, Y. N. (2021) · Genes & Development · doi:10.1101/gad.346759.120 · Cited by 58

Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson’s Disease

Sironi, L., Restelli, L. M., Tolnay, M., Neutzner, A., & Frank, S. (2020) · Cells · doi:10.3390/cells9010233 · Cited by 56

Perspectives on Mitochondria–ER and Mitochondria–Lipid Droplet Contact in Hepatocytes and Hepatic Lipid Metabolism

Ma, X., Qian, H., Chen, A., Ni, H., & Ding, W. (2021) · Cells · doi:10.3390/cells10092273 · Cited by 61

From dysfunctional endoplasmic reticulum-mitochondria coupling to neurodegeneration

Erpapazoglou, Z., Mouton‐Liger, F., & Corti, O. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.03.021 · Cited by 59

Endoplasmic reticulum-mitochondria calcium signaling in hepatic metabolic diseases

Rieusset, J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.01.001 · Cited by 58

Mitochondria-Associated Endoplasmic Reticulum Membranes in the Pathogenesis of Type 2 Diabetes Mellitus

Yang, S. S., Zhou, R., Zhang, C., He, S., & Su, Z. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.571554 · Cited by 60

CARS based label‐free assay for assessment of drugs by monitoring lipid droplets in tumour cells

Steuwe, C., Patel, I. I., Ul‐Hasan, M., Schreiner, A., Boren, J., Brindle, K. M., Reichelt, S., & Mahajan, S. (2013) · Journal of Biophotonics · doi:10.1002/jbio.201300110 · Cited by 52

Possible Role of Mitochondrial Remodelling on Cellular Triacylglycerol Accumulation

Kita, T., Nishida, H., Shibata, H., Niimi, S., Higuti, T., & Arakaki, N. (2009) · The Journal of Biochemistry · doi:10.1093/jb/mvp124 · Cited by 55

Piecing together the puzzle of perilipin proteins and skeletal muscle lipolysis

MacPherson, R. E. K., & Peters, S. J. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0485 · Cited by 51

DGAT2Mutation in a Family with Autosomal-Dominant Early-Onset Axonal Charcot-Marie-Tooth Disease

Hong, Y. B., Kang, J., Kim, J. H., Lee, J., Kwak, G., Hyun, Y. S., Nam, S. H., Hong, H. D., Choi, Y., Jung, S., et al. (2016) · Human Mutation · doi:10.1002/humu.22959 · Cited by 50

Modeling type 2 diabetes-like hyperglycemia in C. elegans on a microdevice

Zhu, G., Yin, F., Wang, L., Wei, W., Jiang, L., & Qin, J. (2015) · Integrative Biology · doi:10.1039/c5ib00243e · Cited by 52

Mitochondria in complex psychiatric disorders: Lessons from mouse models of 22q11.2 deletion syndrome

Devaraju, P., & Zakharenko, S. S. (2017) · BioEssays · doi:10.1002/bies.201600177 · Cited by 51

Inhibition of Diacylglycerol Acyltransferase 2 Versus Diacylglycerol Acyltransferase 1: Potential Therapeutic Implications of Pharmacology

Amin, N. B., Saxena, A. R., Somayaji, V., & Dullea, R. (2023) · Clinical Therapeutics · doi:10.1016/j.clinthera.2022.12.008 · Cited by 48

YPR139c/LOA1encodes a novel lysophosphatidic acid acyltransferase associated with lipid droplets and involved in TAG homeostasis

Ayciriex, S., Guédard, M. L., Camougrand, N. M., Velours, G., Schoene, M., Sébastien Léon, A., Wattelet‐Boyer, V., Dupuy, J., Shevchenko, A., Schmitter, J., et al. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-07-0650 · Cited by 48

Mitochondria‐associated endoplasmic reticulum membrane: Overview and inextricable link with cancer

Yang, X., Zhuang, J., Song, W., Shen, W., Wu, W., Shen, H., & Han, S. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17696 · Cited by 55

Regulation of diacylglycerol acyltransferase 2 protein stability by gp78‐associated endoplasmic‐reticulum‐associated degradation

Choi, K., Kim, H., Kang, H., Lee, S., Lee, S. J., Back, S. H., Lee, S. H., Kim, M. S., Lee, J. E., Park, J. Y., et al. (2014) · FEBS Journal · doi:10.1111/febs.12841 · Cited by 47

DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion

Long, M., Sánchez-Martínez, Á., Longo, M., Suomi, F., Stenlund, H. C., Johansson, A. I., Ehsan, H., Salo, V. T., Montava‐Garriga, L., Naddafi, S., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2021109390 · Cited by 48

Lipid Metabolism in Microalgae

Khozin‐Goldberg, I. (2016) · Springer eBooks · doi:10.1007/978-3-319-24945-2_18 · Cited by 49

The Retinol Dehydrogenase Rdh10 Localizes to Lipid Droplets during Acyl Ester Biosynthesis

Jiang, W., & Napoli, J. L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.402883 · Cited by 45

Therapeutic Strategies for Metabolic Diseases: Small‐Molecule Diacylglycerol Acyltransferase (DGAT) Inhibitors

Naik, R., Brice, O.-O., Kim, M., Choi, Y., Lee, H. S., & Lee, K. (2014) · ChemMedChem · doi:10.1002/cmdc.201402069 · Cited by 44

A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases

Fernandes, T., Domingues, M. R., Moreira, P. I., & Pereira, C. (2023) · Biology · doi:10.3390/biology12030414 · Cited by 45

Multivalent niacin nanoconjugates for delivery to cytoplasmic lipid droplets

Sharma, A., Khatchadourian, A., Khanna, K., Sharma, R. B., Kakkar, A. K., & Maysinger, D. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.10.025 · Cited by 44

Lipid droplet - mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy

Yang, M., Luo, S., Yang, J., Chen, W., He, L., Liu, D., Zhao, L., & Wang, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1017387 · Cited by 46

Mitochondria-Endoplasmic Reticulum Crosstalk in Parkinson’s Disease: The Role of Brain Renin Angiotensin System Components

Sunanda, T., Ray, B., Mahalakshmi, A. M., Bhat, A., Rashan, L. J., Rungratanawanich, W., Song, B., Essa, M. M., Sakharkar, M. K., & Chidambaram, S. B. (2021) · Biomolecules · doi:10.3390/biom11111669 · Cited by 43

Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity

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The Structure and Function of Acylglycerophosphate Acyltransferase 4/ Lysophosphatidic Acid Acyltransferase Delta (AGPAT4/LPAATδ)

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Chemical Modulation of Mitochondria–Endoplasmic Reticulum Contact Sites

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Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells

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Mitochondria-Associated Membranes (MAMs): A Novel Therapeutic Target for Treating Metabolic Syndrome

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Diacylglycerol acyltransferase-2 contains a c-terminal sequence that interacts with lipid droplets

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Amyloid β Induces Lipid Droplet‐Mediated Microglial Dysfunction in Alzheimer’s Disease

­Prakash, P., Manchanda, P., Paouri, E., Bisht, K., Sharma, K. P., Rajpoot, J., Wendt, V., Hossain, A., Wijewardhane, P. R., Randolph, C. E., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.075938 · Cited by 38

Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies

Chen, C., Dai, G., Fan, M., Wang, X., Niu, K., & Gao, W. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06262-3 · Cited by 45

Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3

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Essential Biology of Lipid Droplets

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Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes

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The Mitochondrial‐Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy

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Lipotoxicity of palmitic acid is associated with DGAT1 downregulation and abolished by PPARα activation in liver cells

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Formation and characterization of lipid droplets of the bovine corpus luteum

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Emerging functions of the mitochondria–ER– lipid droplet three‐way junction in coordinating lipid transfer, metabolism, and storage in cells

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Murine Diacylglycerol Acyltransferase-2 (DGAT2) Can Catalyze Triacylglycerol Synthesis and Promote Lipid Droplet Formation Independent of Its Localization to the Endoplasmic Reticulum

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J. Biol. Chem.

Stone, S., Levin, M., Zhou, P., Han, J., Walther, T. C., & Farese, R. (2008) · MPG.PuRe (Max Planck Society)

Characterization of the interaction of diacylglycerol acyltransferase-2 with the endoplasmic reticulum and lipid droplets

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Diacylglycerol acyltransferase-2 contains a c-terminal sequence that interacts with lipid droplets

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Diacylglycerol Acyltransferase-2 (DGAT2) and Monoacylglycerol Acyltransferase-2 (MGAT2) Interact to Promote Triacylglycerol Synthesis

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