Cited by 59Diabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Revisiting the diacylglycerol-induced insulin resistance hypothesis

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Amati, F.·2012·Obesity Reviews

Abstract

Obesity is associated with skeletal muscle insulin resistance, which is a crucial step in the development of type 2 diabetes. Among the mechanisms by which obesity may lead to insulin resistance, lipotoxicity is one of the hypotheses being explored; others include inflammation or the oxidative stress hypotheses. This review focuses on the role of diacylglycerols (DAG), a family of lipid metabolites implicated in the pathogenesis of lipotoxicity and insulin resistance. While recent studies report contradictory results in humans with regard to the importance of DAG-induced insulin resistance in skeletal muscle, other current literature highlight a potential role for DAG as signalling molecules. This review will discuss possible hypotheses explaining these contradictory results and the need to explore further the role of DAG in human metabolism.

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Crossref · 10.1111/j.1467-789x.2012.01036.x

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  • Experimental evidence relates lipid metabolism to the pathogenesis of type 2 diabetes via challenged mitochondrial metabolism, altered cellular signaling at the membrane, and modulation of gene expression.

    “In the literature, several lines of experimental evidence relate lipid metabolism to the pathogenesis of type 2 diabetes, among them a challenged mitochondrial metabolism, altered cellular signaling processes at the membrane, and modulation of gene expression (34,35).”

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Authors
Amati, F.
Affiliations
University of Lausanne (CH)
Corresponding author
Amati, F.
Venue
Obesity Reviews
Publisher
Wiley
Published
2012-10-29
Volume
13
Issue
S2
Pages
40-50
ISSN
  • 1467-7881 (ISSN-L)
  • 1467-789X
OpenAlex
W2082714335
Cited by
59
References
83
Citations by year
2025: 1 · 2024: 2 · 2023: 3 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 7 · 2015: 7 · 2014: 6 · 2013: 9
FWCI
0.98
Type
journal article
Language
en
Open access
Locations
  • Obesity Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
  • IRIS (submittedVersion)
Funders
National Research Foundation
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
diacylglycerol, insulin resistance, skeletal muscle, lipotoxicity, obesity, type 2 diabetes, lipid signaling, inflammation, oxidative stress
MeSH terms
Animals, Diglycerides, Humans, Insulin, Insulin Resistance, Signal Transduction, Muscle, Skeletal, Lipid Metabolism

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