Revisiting the diacylglycerol-induced insulin resistance hypothesis
Open accessAbstract
Obesity is associated with skeletal muscle insulin resistance, which is a crucial step in the development of type 2 diabetes. Among the mechanisms by which obesity may lead to insulin resistance, lipotoxicity is one of the hypotheses being explored; others include inflammation or the oxidative stress hypotheses. This review focuses on the role of diacylglycerols (DAG), a family of lipid metabolites implicated in the pathogenesis of lipotoxicity and insulin resistance. While recent studies report contradictory results in humans with regard to the importance of DAG-induced insulin resistance in skeletal muscle, other current literature highlight a potential role for DAG as signalling molecules. This review will discuss possible hypotheses explaining these contradictory results and the need to explore further the role of DAG in human metabolism.
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Experimental evidence relates lipid metabolism to the pathogenesis of type 2 diabetes via challenged mitochondrial metabolism, altered cellular signaling at the membrane, and modulation of gene expression.
“In the literature, several lines of experimental evidence relate lipid metabolism to the pathogenesis of type 2 diabetes, among them a challenged mitochondrial metabolism, altered cellular signaling processes at the membrane, and modulation of gene expression (34,35).”
From Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes (2015) · cites this paper as [35]
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Retracted
- Authors
- Amati, F.
- Affiliations
- University of Lausanne (CH)
- Corresponding author
- Amati, F.
- ORCID
- Amati, F.
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2012-10-29
- Volume
- 13
- Issue
- S2
- Pages
- 40-50
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W2082714335
- Cited by
- 59
- References
- 83
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 7 · 2015: 7 · 2014: 6 · 2013: 9
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- green
- serval.unil.ch
- Licence
- Locations
- Obesity Reviews (publishedVersion)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
- IRIS (submittedVersion)
- Funders
- National Research Foundation
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- diacylglycerol, insulin resistance, skeletal muscle, lipotoxicity, obesity, type 2 diabetes, lipid signaling, inflammation, oxidative stress
- MeSH terms
- Animals, Diglycerides, Humans, Insulin, Insulin Resistance, Signal Transduction, Muscle, Skeletal, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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