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The trans-Golgi network is a major site for α-secretase processing of amyloid precursor protein in primary neurons
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C83 is a preferential substrate of γ-secretase and the most abundant APP fragment in cultured neurons.
“consistent with C83 being a preferential substrate of γ-secretase [32] and the most abundant APP fragment in cultured neurons [15, 16]”
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Kuhn, P., Wang, H., Dislich, B., Colombo, A., Zeitschel, U., Ellwart, J. W., Kremmer, E., Roßner, S., & Lichtenthaler, S. F. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.167 · Cited by 621
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Self-citationPilat, D., Paumier, J.-M., García-González, L., Louis, L., Stephan, D., Manrique, C., Khrestchatisky, M., Di Pasquale, E., Baranger, K., & Rivera, S. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02407-z · Cited by 28
Metadata
- Authors
- Tan, J. Z. A., & Gleeson, P. A.
- ORCID
- Gleeson, Paul A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 294
- Issue
- 5
- Pages
- 1618-1631
- ISSN
- 0021-9258
- Cited by
- 56
- References
- 1
- Language
- en
- Funders
- Department of Health National Health and Medical Research Council (APP1082600)
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