Cited by 3,665Bioinformatics and Genomic NetworksGene expression and cancer classificationAdvanced Proteomics Techniques and Applications

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

Open access

Fagerberg, Linn, Hallström, Björn M., Oksvold, Per, Kampf, Caroline, Djureinovic, Dijana, Odeberg, Jacob, Habuka, Masato, Tahmasebpoor, Simin, Danielsson, Angelika, Edlund, Karolina, Asplund, Anna, Sjöstedt, Evelina, Lundberg, Emma, Szigyarto, Cristina Al-Khalili, Skogs, Marie, Takanen, Jenny Ottosson, Berling, Holger, Tegel, Hanna, Mulder, Jan, Nilsson, Peter, Schwenk, Jochen M., Lindskog, Cecilia, Danielsson, Frida, Mardinoglu, Adil, Sivertsson, Åsa, von Feilitzen, Kalle, Forsberg, Mattias, Zwahlen, Martin, Olsson, IngMarie, Navani, Sanjay, Huss, Mikael, Nielsen, Jens, Ponten, Fredrik, Uhlén, Mathias·2014·Molecular & Cellular Proteomics

DOI 10.1074/mcp.m113.035600PMC PMC3916642

Open this paper in CoChat — free account Open PDF

Abstract

Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease. Here, we used a quantitative transcriptomics analysis (RNA-Seq) to classify the tissue-specific expression of genes across a representative set of all major human organs and tissues and combined this analysis with antibody-based profiling of the same tissues. To present the data, we launch a new version of the Human Protein Atlas that integrates RNA and protein expression data corresponding to ∼80% of the human protein-coding genes with access to the primary data for both the RNA and the protein analysis on an individual gene level. We present a classification of all human protein-coding genes with regards to tissue-specificity and spatial expression pattern. The integrative human expression map can be used as a starting point to explore the molecular constituents of the human body.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1074/mcp.m113.035600

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cytoscape: A software Environment for integrated models of biomolecular interaction networks
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L., & Wold, B. (2008) · Nature Methods · doi:10.1038/nmeth.1226 · Cited by 13,696
TopHat: discovering splice junctions with RNA-Seq
Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,682
The cancer genome atlas pan-cancer analysis project
The Cancer Genome Atlas Research Network, Weinstein, J. N., Collisson, E. A., Mills, G. B., Shaw, K. R. M., Ozenberger, B. A., Ellrott, K., Shmulevich, I., Sander, C., & Stuart, J. M. (2013) · Nature Genetics · doi:10.1038/ng.2764 · Cited by 9,092
A gene atlas of the mouse and human protein-encoding transcriptomes
Su, A. I., Wiltshire, T., Batalov, S., Lapp, H., Ching, K. A., Block, D., Zhang, J., Soden, R., Hayakawa, M., Kreiman, G., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400782101 · Cited by 3,475
GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists
Eden, E., Navon, R., Steinfeld, I., Lipson, D., & Yakhini, Z. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-48 · Cited by 3,356
Towards a knowledge-based Human Protein Atlas
Uhlen, M., Oksvold, P., Fagerberg, L., Lundberg, E., Jonasson, K., Forsberg, M., Zwahlen, M., Kampf, C., Wester, K., Hober, S., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt1210-1248 · Cited by 2,440
Self-citation

Flagged first, then by citations

Show all 28 references

Sorted by citations

Items 701–800 of 1,006

Preclinical efficacy of a HER2 synNotch/CEA-CAR combinatorial immunotherapy against colorectal cancer with HER2 amplification
Cortese, M., Torchiaro, E., D'Andrea, A., Petti, C., Invrea, F., Franco, L., Donini, C., Leuci, V., Leto, S. M., Vurchio, V., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.06.023 · Cited by 35
Integrative analysis of human omics data using biomolecular networks
Robinson, J. L., & Nielsen, J. (2016) · Molecular BioSystems · doi:10.1039/c6mb00476h · Cited by 33
Self-citation
The Human Adrenal Gland Proteome Defined by Transcriptomics and Antibody-Based Profiling
Bergman, J., Botling, J., Fagerberg, L., Hallström, B. M., Djureinovic, D., Uhlén, M., & Pontén, F. (2016) · Endocrinology · doi:10.1210/en.2016-1758 · Cited by 32
Self-citation
KDM1A regulated the osteo/dentinogenic differentiation process of the stem cells of the apical papilla via binding with PLOD2
Wang, L., Yang, H., Lin, X., Cao, Y., Gao, P., Zheng, Y., & Fan, Z. (2018) · Cell Proliferation · doi:10.1111/cpr.12459 · Cited by 32
Novel rearrangements involving the RET gene in papillary thyroid carcinoma
Staubitz, J. I., Schad, A., Springer, E., Rajalingam, K., Lang, H., Roth, W., Hartmann, N., & Musholt, T. J. (2018) · Cancer Genetics · doi:10.1016/j.cancergen.2018.11.002 · Cited by 32
Drosophila Pif1A is essential for spermatogenesis and is the homolog of human CCDC157, a gene associated with idiopathic NOA
Yuan, X., Zheng, H., Su, Y., Guo, P., Zhang, X., Zhao, Q., Ge, W., Li, C., Xi, Y., & Yang, X. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1398-3 · Cited by 32
Targeted next generation sequencing in 112 Chinese patients with intellectual disability/developmental delay: novel mutations and candidate gene
Yan, H., Shi, Z., Wu, Y., Xiao, J., Gu, Q., Yang, Y., Li, M., Gao, K., Chen, Y., Yang, X., et al. (2019) · BMC Medical Genetics · doi:10.1186/s12881-019-0794-y · Cited by 35
Aldehyde oxidase; new approaches to old problems
Beedham, C. (2019) · Xenobiotica · doi:10.1080/00498254.2019.1626029 · Cited by 32
What “The Cancer Genome Atlas” database tells us about the role of ATP-binding cassette (ABC) proteins in chemoresistance to anticancer drugs
Briz, Ó., Perez‐Silva, L., Al‐Abdulla, R., Abete, L., Reviejo, M., Romero, M. R., & Marı́n, J. J. G. (2019) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2019.1631285 · Cited by 33
Development of anIn VitroHuman Thyroid Microtissue Model for Chemical Screening
Deisenroth, C., Soldatow, V. Y., Ford, J., Stewart, W. M., Brinkman, C. L., LeCluyse, E. L., MacMillan, D. K., & Thomas, R. S. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz238 · Cited by 33
Comparative gain-of-function effects of the KCNMA1-N999S mutation on human BK channel properties
Moldenhauer, H. J., Matychak, K. K., & Meredith, A. L. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00626.2019 · Cited by 32
Understanding the role of OXPHOS dysfunction in the pathogenesis of ECHS1 deficiency
Burgin, H. J., & McKenzie, M. (2020) · FEBS Letters · doi:10.1002/1873-3468.13735 · Cited by 32
Classification and signaling characteristics of 5-HT receptors: toward the concept of 5-HT receptosomes
Marin, P., Bécamel, C., Chaumont‐Dubel, S., Vandermoere, F., Bockaert, J., & Claeysen, S. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00005-0 · Cited by 36
De novo transcriptome assembly and sex-biased gene expression in the gonads of Amur catfish (Silurus asotus)
Shen, F., Long, Y., Li, F., Ge, G., Song, G., Li, Q., Qiao, Z., & Cui, Z. (2020) · Genomics · doi:10.1016/j.ygeno.2020.01.026 · Cited by 32
Kidney injury biomarkers in an academic hospital setting: where are we now?
van Duijl, T. T., Ruhaak, L. R., de Fijter, J. W., & Cobbaert, C. M. (2019) · Clinical Biochemist Reviews · doi:10.33176/aacb-18-00017 · Cited by 33
A meta-analysis of gene expression data highlights synaptic dysfunction in the hippocampus of brains with Alzheimer’s disease
Hosseinian, S., Arefian, E., Rakhsh-Khorshid, H., Eivani, M., Rezayof, A., Pezeshk, H., & Marashi, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-64452-z · Cited by 35
Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction
Banerjee, S., Ghoshal, S., Stevens, J. R., McCommis, K. S., Gao, S., Castro‐Sepúlveda, M., Mizgier, M. L., Clemence, G., Kumar, K. G., Galgani, J. E., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014381 · Cited by 36
The SNM1A DNA repair nuclease
Baddock, H. T., Yosaatmadja, Y., Newman, J. A., Schofield, C. J., Gileadi, O., & McHugh, P. J. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102941 · Cited by 36
A binding protein regulates myosin-7a dimerization and actin bundle assembly
Liu, R., Billington, N., Yang, Y., Bond, C. R., Hong, A., Siththanandan, V. B., Takagi, Y., & Sellers, J. R. (2021) · Nature Communications · doi:10.1038/s41467-020-20864-z · Cited by 32
Genetic Variability in Molecular Pathways Implicated in Alzheimer's Disease: A Comprehensive Review
Vogrinc, D., Goričar, K., & Dolžan, V. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.646901 · Cited by 32
α‐Synuclein antisense transcript SNCA‐AS1 regulates synapses‐ and aging‐related genes suggesting its implication in Parkinson's disease
Rey, F., Pandini, C., Messa, L., Launi, R., Barzaghini, B., Zangaglia, R., Raimondi, M. T., Gagliardi, S., Cereda, C., Zuccotti, G., et al. (2021) · Aging Cell · doi:10.1111/acel.13504 · Cited by 32
Neurofibromatosis Type 1 Gene Alterations Define Specific Features of a Subset of Glioblastomas
Scheer, M., Leisz, S., Sorge, E., Storozhuk, O. V., Prell, J., Ho, I. A. W., & Harder, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010352 · Cited by 32
MAX deficiency impairs human endometrial decidualization through down-regulating OSR2 in women with recurrent spontaneous abortion
Ma, W., Cao, M., Bi, S., Du, L., Chen, J., Wang, H., Jiang, Y., Wu, Y., Liao, Y., Kong, S., et al. (2022) · Cell and Tissue Research · doi:10.1007/s00441-022-03579-z · Cited by 33
Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension
Kelly, T. N., Sun, X., He, K., Brown, M. R., Taliun, S. A. G., Hellwege, J. N., Irvin, M. R., Mi, X., Brody, J. A., Franceschini, N., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19324 · Cited by 30
Self-citation
Protein glycosylation in urine as a biomarker of diseases
Xu, M., Yang, A., Xia, J., Jiang, J., Liu, C., Ye, Z., Ma, J., & Yang, S. (2022) · Translational research · doi:10.1016/j.trsl.2022.08.001 · Cited by 31
NHA1 is a cation/proton antiporter essential for the water-conserving functions of the rectal complex in Tribolium castaneum
Naseem, M. T., Beaven, R., Koyama, T., Naz, S., Su, S.-Y., Leader, D. P., Klaerke, D. A., Calløe, K., Denholm, B., & Halberg, K. A. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2217084120 · Cited by 32
The SLIT/ROBO Pathway in Liver Fibrosis and Cancer
Basha, S., Jin-Smith, B., Sun, C., & Pi, L. (2023) · Biomolecules · doi:10.3390/biom13050785 · Cited by 32
Clinical proteomics: Promises, challenges and limitations of affinity arrays
Betzen, C., Alhamdani, M. S. S., Lueong, S., Schröder, C., Stang, A., & Hoheisel, J. D. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400156 · Cited by 36
Binding and sequestration of poison frog alkaloids by a plasma globulin
Alvarez-Buylla, A., Fischer, M.-T., Moya Garzon, M. D., Rangel, A. E., Tapia, E. E., Tanzo, J. T., Soh, H. T., Coloma, L. A., Long, J. Z., & O'Connell, L. A. (2023) · eLife · doi:10.7554/elife.85096 · Cited by 32
CD98 heavy chain as a prognostic biomarker and target for cancer treatment
Pu, X., & Dubrovska, A. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1251100 · Cited by 35
Spatial transcriptomics and the anatomical pathologist: Molecular meets morphology
Pang, J., Byrne, D. J., Bergin, A. R. T., Caramia, F., Loi, S., Gorringe, K. L., & Fox, S. B. (2023) · Histopathology · doi:10.1111/his.15093 · Cited by 32
Differential Expression of Nuclear-Encoded Mitochondrial Protein Genes of ATP Synthase Across Different Tissues of Female Buffalo
Sadeesh, E. M., Lahamge, M. S., Malik, A., & Ampadi, A. N. (2024) · Molecular Biotechnology · doi:10.1007/s12033-024-01085-x · Cited by 31
Targeting FMS-like tyrosine kinase 3 (FLT3) in acute myeloid leukemia: Novel molecular approaches and therapeutic challenges
Rataj, J., Górecki, L., Muthná, D., Sorf, A., Kryštof, V., Klener, P., Čečková, M., Řezáčová, M., & Korábečný, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117788 · Cited by 32
Driver gene classification reveals a substantial overrepresentation of tumor suppressors among very large chromatin-regulating proteins
Waks, Z., Weissbrod, O., Carmeli, B., Norel, R., Utro, F., & Goldschmidt, Y. (2016) · Scientific Reports · doi:10.1038/srep38988 · Cited by 31
HMGB3 modulates ROS production via activating TLR cascade in Apostichopus japonicus
Lv, Z., Zhang, Z., Wei, Z., Li, C., Shao, Y., Zhang, W., Zhao, X., & Xiong, J. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2017.07.026 · Cited by 31
Recent developments in the genetics of attention‐deficit hyperactivity disorder
Grimm, O., Kittel‐Schneider, S., & Reif, A. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12673 · Cited by 36
Role of INSL4 Signaling in Sustaining the Growth and Viability of LKB1-Inactivated Lung Cancer
Yang, R., Li, S. W., Chen, Z., Zhou, X., Wei Min, N. I., Fu, D., Lu, J., Kaye, F. J., & Wu, L. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy166 · Cited by 28
CDK13-related disorder
Hamilton, M., & Suri, M. (2018) · Advances in genetics · doi:10.1016/bs.adgen.2018.11.001 · Cited by 30
Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1
Sabbir, M. G. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105376 · Cited by 33
Leveraging the Role of the Metastatic Associated Protein Anterior Gradient Homologue 2 in Unfolded Protein Degradation: A Novel Therapeutic Biomarker for Cancer
Alsereihi, R., Schulten, H.-J., Bakhashab, S., Saini, K. S., Al-Hejin, A. M., & Hussein, D. M. (2019) · Cancers · doi:10.3390/cancers11070890 · Cited by 31
Chronic Exposure to Chewing Tobacco Induces Metabolic Reprogramming and Cancer Stem Cell-Like Properties in Esophageal Epithelial Cells
Datta, K. K., Patil, S., Patel, K., Babu, N., Raja, R., Nanjappa, V., Mangalaparthi, K. K., Dhaka, B., Rajagopalan, P., Deolankar, S. C., et al. (2019) · Cells · doi:10.3390/cells8090949 · Cited by 31
Multiple roles and regulatory mechanisms of the transcription factor GATA6 in human cancers
Sun, Z., & Yan, B. (2019) · Clinical Genetics · doi:10.1111/cge.13630 · Cited by 36
Integration of IgA and IgG Autoantigens Improves Performance of Biomarker Panels for Early Diagnosis of Lung Cancer
Pan, J., Yu, L., Wu, Q., Lin, X., Liu, S., Hu, S., Rosa, C., Eichinger, D. J., Pino, I., Zhu, H., et al. (2020) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra119.001905 · Cited by 32
Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study
Alemany-Navarro, M., Cruz, R., Real, E., Segalàs, C., Bertolín, S., Rabionet, R., Carracedo, Á., Menchón, J. M., & Alonso, P. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0804-z · Cited by 31
Characterization of a pathogenic variant in GBA for Parkinson’s disease with mild cognitive impairment patients
Jiang, Z., Huang, Y., Zhang, P., Han, C., Lu, Y., Mo, Z., Zhang, Z., Li, X., Zhao, S., Cai, F., et al. (2020) · Molecular Brain · doi:10.1186/s13041-020-00637-x · Cited by 31
Male infertility and genitourinary birth defects: there is more than meets the eye
Punjani, N., & Lamb, D. J. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.06.042 · Cited by 34
Sepiapterin reductase: Characteristics and role in diseases
Wu, Y., Chen, P., Sun, L., Yuan, S., Cheng, Z., Lu, L., Du, H., & Zhan, M. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15608 · Cited by 30
Coronavirus genomes carry the signatures of their habitats
Wei, Y., Silke, J. R., Aris, P., & Xia, X. (2020) · PLoS ONE · doi:10.1371/journal.pone.0244025 · Cited by 31
Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase
Misiura, M., Guszczyn, T., Ościłowska, I., Baszanowska, W., Palka, J. A., & Miltyk, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020936 · Cited by 31
The Role of Single-Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Comorbidity of Arterial Hypertension and Tension-Type Headache
Shnayder, N. A., Петрова, М. М., Викторовна, М. П., Shesternya, P. A., Пожиленкова, Е. А., & Nasyrova, R. F. (2021) · Molecules · doi:10.3390/molecules26061556 · Cited by 31
Lung‐specific distant enhancer cis regulates expression ofFOXF1and lncRNAFENDRR
Szafrański, P., Gambin, T., Karolak, J. A., Popek, E. J., & Stankiewicz, P. (2021) · Human Mutation · doi:10.1002/humu.24198 · Cited by 31
Transcription factor AP ‐2beta in development, differentiation and tumorigenesis
Raap, M., Gierendt, L., Kreipe, H. H., & Christgen, M. (2021) · International Journal of Cancer · doi:10.1002/ijc.33558 · Cited by 31
The Transcriptional Co-factor IRF2BP2: A New Player in Tumor Development and Microenvironment
Pastor, T., Peixoto, B., & Viola, J. P. B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.655307 · Cited by 31
FAM209 associates with DPY19L2, and is required for sperm acrosome biogenesis and fertility in mice
Castaneda, J. M., Shimada, K., Satouh, Y., Yu, Z., Devlin, D. J., Ikawa, M., & Matzuk, M. M. (2021) · Journal of Cell Science · doi:10.1242/jcs.259206 · Cited by 31
Melanocortin-5 Receptor: Pharmacology and Its Regulation of Energy Metabolism
Ji, L., Hong, Y., & Tao, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158727 · Cited by 36
ATP6V0C variants impair V-ATPase function causing a neurodevelopmental disorder often associated with epilepsy
Mattison, K. A., Tossing, G., Mulroe, F., Simmons, C., Butler, K. M., Schreiber, A., Alsadah, A., Neilson, D., Naess, K., Wedell, A., et al. (2022) · Brain · doi:10.1093/brain/awac330 · Cited by 31
The epigenetic factor KDM2B regulates cell adhesion, small rho GTPases, actin cytoskeleton and migration in prostate cancer cells
Zacharopoulou, N., Tsapara, A., Kallergi, G., Schmid, E., Tsichlis, P. N., Kampranis, S. C., & Stournaras, C. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.01.009 · Cited by 31
Highly Specific Droplet-Digital PCR Detection of Universally Methylated Circulating Tumor DNA in Endometrial Carcinoma
Beinse, G., Borghese, B., Métairie, M., Just, P., Poulet, G., Garinet, S., Parfait, B., Didelot, A., Bourreau, C., Agueeff, N., et al. (2022) · Clinical Chemistry · doi:10.1093/clinchem/hvac020 · Cited by 30
PCSK9 Modulates Macrophage Polarization-Mediated Ventricular Remodeling after Myocardial Infarction
Wang, F., Li, M., Zhang, A., Li, H., Jiang, C., & Guo, J. (2022) · Journal of Immunology Research · doi:10.1155/2022/7685796 · Cited by 30
The potential roles of ATF family in the treatment of Alzheimer's disease
Yang, T., Zhang, Y., Chen, L., Thomas, E. R., Yu, W., Cheng, B., & Li, X. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114544 · Cited by 30
Heavy Metals in Umbilical Cord Blood: Effects on Epigenetics and Child Development
Dutta, S., & Ruden, D. M. (2024) · Cells · doi:10.3390/cells13211775 · Cited by 30
Mast Cells and Mas-related G Protein-coupled Receptor X2: Itching for Novel Pathophysiological Insights to Clinical Relevance
Castells, M., Madden, M., & Oskeritzian, C. A. (2024) · Current Allergy and Asthma Reports · doi:10.1007/s11882-024-01183-5 · Cited by 30
Sorting Nexin 31 Binds Multiple β Integrin Cytoplasmic Domains and Regulates β1 Integrin Surface Levels and Stability
Tseng, H.-Y., Thorausch, N., Ziegler, T., Meves, A., Fässler, R., & Böttcher, R. T. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.07.003 · Cited by 34
Variants WithinTSC2Exons 25 and 31 Are Very Unlikely to Cause Clinically Diagnosable Tuberous Sclerosis
Ekong, R., Nellist, M. D., Hoogeveen‐Westerveld, M., Wentink, M. W. J., Panzer, J. A., Sparagana, S. P., Emmett, W., Dawson, N. L., Malinge, M. C., Nabbout, R., et al. (2015) · Human Mutation · doi:10.1002/humu.22951 · Cited by 29
Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice
Luo, Y., Furuya, S., Soldatow, V. Y., Kosyk, O., Yoo, H. S., Fukushima, H., Lewis, L., Iwata, Y., & Rusyn, I. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy099 · Cited by 31
The Human Centrosomal Protein CCDC146 Binds Chlamydia trachomatis Inclusion Membrane Protein CT288 and Is Recruited to the Periphery of the Chlamydia-Containing Vacuole
Almeida, F., Luís, M. P., Pereira, I. S., Pais, S. V., & Mota, L. J. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00254 · Cited by 30
Transferrin isoforms in cerebrospinal fluid and their relation to neurological diseases
Murakami, Y., Saito, K., Ito, H., & Hashimoto, Y. (2019) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.95.015 · Cited by 30
Bioinformatics Methodologies to Identify Interactions Between Type 2 Diabetes and Neurological Comorbidities
Rahman, M. H., Peng, S., Hu, X., Chen, C., Uddin, S., Quinn, J. M. W., & Moni, M. A. (2019) · IEEE Access · doi:10.1109/access.2019.2960037 · Cited by 30
Tetraspanin 7 and its closest paralog tetraspanin 6: membrane organizers with key functions in brain development, viral infection, innate immunity, diabetes and cancer
Pérot, B. P., & Ménager, M. M. (2020) · Medical Microbiology and Immunology · doi:10.1007/s00430-020-00681-3 · Cited by 29
CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction†
Sun, J., Lu, Y., Nozawa, K., Xu, Z., Morohoshi, A., Castaneda, J. M., Noda, T., Miyata, H., Abbasi, F., Shawki, H. H., et al. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioaa083 · Cited by 31
Differentially expressed lnc‐NOS2P3‐miR‐939‐5p axis in chronic heart failure inhibits myocardial and endothelial cells apoptosis via iNOS/TNFα pathway
Chen, C., Zong, M., Lü, Y., Guo, Y., Lv, H., Xie, L., Fu, Z., Cheng, Y., Si, Y., Ye, B., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15740 · Cited by 30
Neuronal Glycoprotein M6a: An Emerging Molecule in Chemical Synapse Formation and Dysfunction
León, A., Aparicio, G. I., & Scorticati, C. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.661681 · Cited by 29
The RNA content of human sperm reflects prior events in spermatogenesis and potential post-fertilization effects
Corral-Vázquez, C., Blanco, J., Cigliano, R. A., Sarrate, Z., Rivera‐Egea, R., Vidal, F., Garrido, N., Daub, C. O., & Antón, E. (2021) · Molecular Human Reproduction · doi:10.1093/molehr/gaab035 · Cited by 31
The prognostic value of an autophagy-related lncRNA signature in hepatocellular carcinoma
Yang, S., Zhou, Y., Zhang, X., Wang, L., Fu, J., Zhao, X., & Liu, Y. (2021) · BMC Bioinformatics · doi:10.1186/s12859-021-04123-6 · Cited by 30
Proximal variants in CCND2 associated with microcephaly, short stature, and developmental delay: A case series and review of inverse brain growth phenotypes
Pirozzi, F., Lee, B., Horsley, N., Burkardt, D. D., Dobyns, W. B., Graham, J. M., Dentici, M. L., Cesario, C., Schallner, J., Porrmann, J., et al. (2021) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.62362 · Cited by 30
The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice
Nozawa, K., Fujihara, Y., Devlin, D. J., Deras, R. E., Kent, K., Larina, I. V., Umezu, K., Yu, Z., Sutton, C. M., Ye, Q., et al. (2022) · BMC Biology · doi:10.1186/s12915-022-01368-2 · Cited by 30
Whole-genome sequencing identifies a novel ABCB7 gene mutation for X-linked congenital cerebellar ataxia in a large family of Mongolian ancestry
Protasova, M., Grigorenko, A. P., Tyazhelova, T. V., Андреева, Т. В., Reshetov, D. A., Gusev, F. E., Laptenko, A. E., Kuznetsova, I. L., Goltsov, A. Y., Klyushnikov, S. A., et al. (2015) · European Journal of Human Genetics · doi:10.1038/ejhg.2015.139 · Cited by 30
Combining RNA and Protein Profiling Data with Network Interactions Identifies Genes Associated with Spermatogenesis in Mouse and Human1
Petit, F. G., Kervarrec, C., Jamin, S. P., Smagulova, F. O., Hao, C., Becker, E., Jégou, B., Chalmel, F., & Primig, M. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.114.126250 · Cited by 30
The Class IV human deacetylase, HDAC11, exhibits anti‐influenza A virus properties via its involvement in host innate antiviral response
Nutsford, A. N., Galvin, H. D., Ahmed, F., & Husain, M. (2018) · Cellular Microbiology · doi:10.1111/cmi.12989 · Cited by 31
Molecular signatures of chronic periodontitis in gingiva: A genomic and proteomic analysis
Guzeldemir-Akcakanat, E., Alkan, B., Akkoyunlu, D. S., Gürel, B., Balta‐Uysal, V. M., Kan, B., Akgün, E., Yılmaz, E. B., Baykal, A. T., Çine, N., et al. (2019) · Journal of Periodontology · doi:10.1002/jper.18-0477 · Cited by 30
Oncogenic SRSF3 in health and diseases
Jia, R., & Zheng, Z. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.83368 · Cited by 29
Antiviral responses in a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection
Hashimi, M., Sebrell, T. A., Hedges, J. F., Snyder, D. T., Lyon, K. N., Byrum, S. D., Mackintosh, S. G., Crowley, D. E., Cherne, M. D., Skwarchuk, D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42610-x · Cited by 28
Specificity of CRISPR-Cas9 Editing in Exagamglogene Autotemcel
Yen, A., Zappala, Z., Fine, R. S., Majarian, T. D., Sripakdeevong, P., & Altshuler, D. (2024) · New England Journal of Medicine · doi:10.1056/nejmc2313119 · Cited by 30
Single intramuscular injection of self-amplifying RNA of Nppa to treat myocardial infarction
Zhang, K., Tao, H., Zhu, D., Yue, Z., Hu, S., Wu, Y., Yan, N., Hu, Y., Liu, S., Liu, M., et al. (2026) · Science · doi:10.1126/science.adu9394 · Cited by 30
Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines
Chhibber, A., French, C. E., Yee, S. W., Gamazon, E. R., Theusch, E., Qin, X., Webb, A., Papp, A. C., Wang, A., Simmons, C. Q., et al. (2016) · The Pharmacogenomics Journal · doi:10.1038/tpj.2015.93 · Cited by 29
Linc02527 promoted autophagy in Intrahepatic cholestasis of pregnancy
Hu, J., Liu, L., Gong, Y., Zhang, L., Gan, X., Luo, X., Yu, T., Zhong, X., Deng, X., Hu, L., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1013-z · Cited by 29
DNA methylation among firefighters
Zhou, J., Jenkins, T. G., Jung, A. M., Jeong, K. S., Zhai, J., Jacobs, E. T., Griffin, S. C., Dearmon-Moore, D., Littau, S. R., Peate, W. F., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214282 · Cited by 30
Identification of differentially expressed genes in small and non-small cell lung cancer based on meta-analysis of mRNA
Shriwash, N., Singh, P. K., Arora, S., Ali, S. M., Ali, S., & Dohare, R. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e01707 · Cited by 29
Can trophectoderm RNA analysis predict human blastocyst competency?
Ntostis, P., Kokkali, G., Iles, D., Huntriss, J., Tzetis, M., Picton, H. M., Pantos, K., & Miller, D. (2019) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2019.1625085 · Cited by 29
Long non-coding RNA NNT-AS1 functions as an oncogenic gene through modulating miR-485/BCL9 in cholangiocarcinoma
Huang, L., Jiang, X., Kang, P., Wang, Z., Leng, K., Ji, D., Xu, Y., Wang, H., & Cui, Y. (2019) · Cancer Management and Research · doi:10.2147/cmar.s207801 · Cited by 29
The structure of the colorectal cancer-associated enzyme GalNAc-T12 reveals how nonconserved residues dictate its function
Fernandez, A. J., Daniel, E. J. P., Mahajan, S. P., Gray, J. J., Gerken, T. A., Tabak, L. A., & Samara, N. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902211116 · Cited by 29
Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence
Meng, W., Sjöholm, L. K., Kononenko, O., Tay, N., Zhang, D., Sarkisyan, D., Geske, J. R., Ing, A., Qiu, W., Watanabe, H., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0588-9 · Cited by 30
The association between genome‐wide polymorphisms and chronic postoperative pain: a prospective observational study
van Reij, R. R. I., Hoofwijk, D. M. N., Rutten, B. P. F., Weinhold, L., Leber, M., Joosten, E. A. J., Ramı́rez, A., van den Hoogen, N. J., & the Italian Pain Group (2020) · Anaesthesia · doi:10.1111/anae.14832 · Cited by 29
Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer
Xing, M., Ooi, W. F., Tan, J. Y., Qamra, A., Lee, P.-H., Li, Z., Xu, C., Padmanabhan, N., Lim, J. Q., Guo, Y. A., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci126726 · Cited by 30
Whole-Exome Sequencing Analysis of Alzheimer’s Disease in Non-APOE*4 Carriers
Fan, K.-H., Feingold, E., Rosenthal, S. L., Demirci, F. Y., Ganguli, M., López, O. L., & Kamboh, M. I. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200037 · Cited by 27
Genomic adaptations to cereal‐based diets contribute to mitigate metabolic risk in some human populations of East Asian ancestry
Landini, A., Yu, S., Gnecchi‐Ruscone, G. A., Abondio, P., Ojeda‐Granados, C., Sarno, S., Fanti, S. D., Gentilini, D., Blasio, A. M. D., Jin, H., et al. (2020) · Evolutionary Applications · doi:10.1111/eva.13090 · Cited by 33
Severe delayed pulmonary toxicity following PD‐L1–specific CAR‐T cell therapy for non‐small cell lung cancer
Liu, H., Ma, Y., Yang, C., Xia, S., Pan, Q., Zhao, H., Fang, W., Chen, X., Zhang, Y., Zou, B., et al. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1154 · Cited by 31
Distinct circular RNA expression profiles in pediatric ependymomas
Ahmadov, U., Bendikas, M. M., Ebbesen, K. K., Sehested, A. M., Kjems, J., Broholm, H., & Kristensen, L. S. (2020) · Brain Pathology · doi:10.1111/bpa.12922 · Cited by 30
Induction of aryl hydrocarbon receptor in granulosa cells by endoplasmic reticulum stress contributes to pathology of polycystic ovary syndrome
Kunitomi, C., Harada, M., Kusamoto, A., Azhary, J. M. K., Nose, E., Koike, H., Xu, Z., Urata, Y., Takahashi, N., Wada‐Hiraike, O., et al. (2021) · Molecular Human Reproduction · doi:10.1093/molehr/gaab003 · Cited by 29
Enhancer Pleiotropy, Gene Expression, and the Architecture of Human Enhancer–Gene Interactions
Singh, D., & Yi, S. V. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab085 · Cited by 29

Authors: Fagerberg, L., Hallström, B. M., Oksvold, P., Kampf, C., Djureinovic, D., Odeberg, J., Habuka, M., Tahmasebpoor, S., Danielsson, A., Edlund, K., Asplund, A., Sjöstedt, E., Lundberg, E., Szigyarto, C. A.-K., Skogs, M., Takanen, J. O., Berling, H., Tegel, H., Mulder, J., Nilsson, P., Schwenk, J. M., Lindskog, C., Danielsson, F., Mardinoglu, A., Sivertsson, Å., von Feilitzen, K., Forsberg, M., Zwahlen, M., Olsson, I., Navani, S., Huss, M., Nielsen, J., Ponten, F., & Uhlén, M.
Affiliations: Science for Life Laboratory (SE)
Uppsala University (SE)
KTH Royal Institute of Technology (SE)
Corresponding author: Uhlén, Mathias
ORCID: Fagerberg, Linn
Oksvold, Per
Djureinovic, Dijana
Odeberg, Jacob
Habuka, Masato
Edlund, Karolina
Sjöstedt, Evelina
Lundberg, Emma
Szigyarto, Cristina Al-Khalili
Tegel, Hanna
Mulder, Jan
Nilsson, Peter
Schwenk, Jochen M.
Lindskog, Cecilia
Sivertsson, Åsa
Zwahlen, Martin
Huss, Mikael
Nielsen, Jens
Uhlén, Mathias
Venue: Molecular & Cellular Proteomics
Publisher: Elsevier BV
Published: 2014-02
Volume: 13
Issue: 2
Pages: 397-406
ISSN: 1535-9476 (ISSN-L)
DOI: 10.1074/mcp.m113.035600
PMC: PMC3916642
OpenAlex: W2167898988
Cited by: 3,665
References: 28
Citations by year: 2026: 163 · 2025: 292 · 2024: 458 · 2023: 422 · 2022: 438 · 2021: 474 · 2020: 528 · 2019: 387 · 2018: 255 · 2017: 105 · 2016: 43 · 2015: 64 · 2014: 28
FWCI: 20.19
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 2434 d)
Locations: Molecular & Cellular Proteomics (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Chalmers Research (Chalmers University of Technology) (submittedVersion)
Chalmers Publication Library (Chalmers University of Technology) (submittedVersion)
Funders: Knut och Alice Wallenbergs Stiftelse
Science for Life Laboratory
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Keywords: tissue-specific gene expression, spatial expression patterns, Human Protein Atlas, RNA-seq, antibody-based proteomics, protein-coding genes, human organs, gene expression atlas
MeSH terms: Antibodies, Female, Humans, Male, Organ Specificity, Proteins, Gene Expression, Systems Integration, Proteome, Gene Expression Profiling, Genomics, Proteomics, Tissue Array Analysis, Gene Regulatory Networks, Transcriptome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks