The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics
Open accessAbstract
Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease. Here, we used a quantitative transcriptomics analysis (RNA-Seq) to classify the tissue-specific expression of genes across a representative set of all major human organs and tissues and combined this analysis with antibody-based profiling of the same tissues. To present the data, we launch a new version of the Human Protein Atlas that integrates RNA and protein expression data corresponding to ∼80% of the human protein-coding genes with access to the primary data for both the RNA and the protein analysis on an individual gene level. We present a classification of all human protein-coding genes with regards to tissue-specificity and spatial expression pattern. The integrative human expression map can be used as a starting point to explore the molecular constituents of the human body.
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“We found that a set of 2,647 genes expressed specifically in brain tissue23 was strongly enriched for dURVs (OR=1.17; 95% CI=1.11–1.23; P = 1.2 × 10−4), whereas sets of genes with expression specific to other tissues (including immune cells) were not (Fig. 3a and Supplementary Fig. 7).”
From Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia (2016) · cites this paper as [23]
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Towards a knowledge-based Human Protein Atlas
Uhlen, M., Oksvold, P., Fagerberg, L., Lundberg, E., Jonasson, K., Forsberg, M., Zwahlen, M., Kampf, C., Wester, K., Hober, S., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt1210-1248 · Cited by 2,440
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“POR is expressed in all tissues, showing ubiquitous expression in the liver, adrenal glands, gonads, and others [8].”
BackgroundMethodMiranda, J. P., Lardone, M. C., Rodríguez, F., Cutler, G. B., Santos, J. L., Corvalán, C., Pereira, A., & Mericq, V. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab814 · Cited by 10
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“LRP1 is expressed in certain cell types, such as hepatocytes, fibroblasts, macrophages, smooth muscle cells, neurons, and astrocytes, making it present in most tissues of the body [64,89].”
BackgroundParrado, A. (2020) · Antibodies · doi:10.3390/antib9030027 · Cited by 7
Li, G., Huo, D., Guo, N., Li, Y., Ma, H., Liu, L., Xie, H., Zhang, D., Qu, B., & Chen, X. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1106724 · Cited by 5
Metadata
- Authors
- Fagerberg, L., Hallström, B. M., Oksvold, P., Kampf, C., Djureinovic, D., Odeberg, J., Habuka, M., Tahmasebpoor, S., Danielsson, A., Edlund, K., Asplund, A., Sjöstedt, E., Lundberg, E., Szigyarto, C. A.-K., Skogs, M., Takanen, J. O., Berling, H., Tegel, H., Mulder, J., Nilsson, P., Schwenk, J. M., Lindskog, C., Danielsson, F., Mardinoglu, A., Sivertsson, Å., von Feilitzen, K., Forsberg, M., Zwahlen, M., Olsson, I., Navani, S., Huss, M., Nielsen, J., Ponten, F., & Uhlén, M.
- Affiliations
- Science for Life Laboratory (SE)
- Uppsala University (SE)
- KTH Royal Institute of Technology (SE)
- Corresponding author
- Uhlén, Mathias
- ORCID
- Venue
- Molecular & Cellular Proteomics
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 13
- Issue
- 2
- Pages
- 397-406
- ISSN
- 1535-9476 (ISSN-L)
- PMC
- PMC3916642
- OpenAlex
- W2167898988
- Cited by
- 3,665
- References
- 28
- Citations by year
- 2026: 163 · 2025: 292 · 2024: 458 · 2023: 422 · 2022: 438 · 2021: 474 · 2020: 528 · 2019: 387 · 2018: 255 · 2017: 105 · 2016: 43 · 2015: 64 · 2014: 28
- FWCI
- 20.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular & Cellular Proteomics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Chalmers Research (Chalmers University of Technology) (submittedVersion)
- Chalmers Publication Library (Chalmers University of Technology) (submittedVersion)
- Funders
- Knut och Alice Wallenbergs Stiftelse
- Science for Life Laboratory
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Keywords
- tissue-specific gene expression, spatial expression patterns, Human Protein Atlas, RNA-seq, antibody-based proteomics, protein-coding genes, human organs, gene expression atlas
- MeSH terms
- Antibodies, Female, Humans, Male, Organ Specificity, Proteins, Gene Expression, Systems Integration, Proteome, Gene Expression Profiling, Genomics, Proteomics, Tissue Array Analysis, Gene Regulatory Networks, Transcriptome
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