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Understanding Cullin-RING E3 Biology through Proteomics-based Substrate Identification
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They were unable to detect an interaction of SCAP and RNF145 in co-immunoprecipitation assays.
“We were unable to detect an interaction of SCAP and RNF145 in co-immunoprecipitation assays (Figure 6—figure supplement 1A), although this finding was not unexpected given the transient interactions between many E3 ubiquitin ligases and their substrates (Harper and Tan, 2012).”
From Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP (2017) · cites this paper as Harper and Tan, 2012
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RING Domain E3 Ubiquitin Ligases
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The SCF ubiquitin ligase: insights into a molecular machine
Cardozo, T., & Pagano, M. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1471 · Cited by 1,114
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Vashisht, A. A., Zumbrennen, K. B., Huang, X., Powers, D. N., Durazo, A., Sun, D., Bhaskaran, N., Persson, A., Uhlen, M., Sangfelt, O., et al. (2009) · Science · doi:10.1126/science.1176333 · Cited by 429
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Jin, L., Pahuja, K. B., Wickliffe, K. E., Gorur, A., Baumgärtel, C., Schekman, R., & Rape, M. (2012) · Nature · doi:10.1038/nature10822 · Cited by 330
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Metadata
- Authors
- Harper, J. W., & Tan, M.-K. M.
- Venue
- Molecular & Cellular Proteomics
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 11
- Issue
- 12
- Pages
- 1541-1550
- ISSN
- 1535-9476
- Cited by
- 66
- References
- 7
- Language
- en
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