Phenolic acid metabolites as biomarkers for tea- and coffee-derived polyphenol exposure in human subjects
Open accessAbstract
Tea and coffee are rich in polyphenols with a variety of biological activities. Many of the demonstrated activities are consistent with favourable effects on the risk of chronic diseases. 4-O-methylgallic acid (4OMGA) and isoferulic acid are potential biomarkers of exposure to polyphenols derived from tea and coffee respectively. 4OMGA is derived from gallic acid in tea, and isoferulic acid is derived from chlorogenic acid in coffee. Our major objective was to explore the relationships of tea and coffee intake with 24 h urinary excretion of 4OMGA and isoferulic acid in human subjects. The relationships of long-term usual (111 participants) and contemporaneously recorded current (344 participants) tea and coffee intake with 24 h urinary excretion of 4OMGA and isoferulic acid were assessed in two populations. 4OMGA was related to usual (r 0.50, P<0.001) and current (r 0.57, P<0.001) tea intake, and isoferulic acid was related to usual (r 0.26, P=0.008) and current (r 0.18, P<0.001) coffee intake. Overall, our present results are consistent with the proposal that 4OMGA is a good biomarker for black tea-derived polyphenol exposure, but isoferulic acid may be of limited usefulness as a biomarker for coffee-derived polyphenol exposure.
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Polyphenols have been used as surrogate biomarkers of tea and wine intake.
“polyphenols for tea and wine (18,25)”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [25]
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- Authors
- Hodgson, J. M., Yee Chan, S., Puddey, I. B., Devine, A., Wattanapenpaiboon, N., Wahlqvist, M. L., Lukito, W., Burke, V., Ward, N. C., Prince, R. L., & Croft, K. D.
- Affiliations
- The University of Western Australia (AU)
- Monash University (AU)
- Corresponding author
- Hodgson, Jonathan M.
- ORCID
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2004-02
- Volume
- 91
- Issue
- 2
- Pages
- 301-305
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2149853290
- Cited by
- 73
- References
- 28
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2020: 2 · 2018: 4 · 2017: 5 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 11
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Australasian Journal of Paramedicine (submittedVersion)
- Funders
- Healthway
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Keywords
- biomarkers of exposure, tea polyphenols, coffee polyphenols, isoferulic acid, urinary excretion, black tea, chlorogenic acid, gallic acid, dietary intake
- MeSH terms
- Cinnamates, Coffee, Cross-Sectional Studies, Drinking, Female, Flavonoids, Gallic Acid, Humans, Male, Middle Aged, Phenols, Tea, Biomarkers, Case-Control Studies, Polyphenols, Hydroxybenzoates
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