Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods
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Estimation of dietary intake of polyphenols is difficult, due to limited availability of food composition data and bias inherent to dietary assessment methods. The aim of the present study was to evaluate the associations between the intake of polyphenol-rich foods and the urinary excretion of several phenolic compounds and therefore explore whether these phenolic compounds could be used as a biomarker of intake. Fifty-three participants of the SU.VI.MAX study (a randomised primary-prevention trial evaluating the effect of daily antioxidant supplementation on chronic diseases) collected a 24 h urine and a spot urine sample and filled a dietary record during a 2 d period. Thirteen polyphenols and metabolites, chlorogenic acid, caffeic acid, m-coumaric acid, gallic acid, 4-O-methylgallic acid, quercetin, isorhamnetin, kaempferol, hesperetin, naringenin, phloretin, enterolactone and enterodiol, were measured using HPLC-electrospray ionisation-MS-MS. In spot samples apple consumption was positively correlated to phloretin, grapefruit consumption to naringenin, orange to hesperetin, citrus fruit consumption to both naringenin and hesperetin, with r coefficients ranging from 0.31 to 0.57 (P < 0.05). The combination of fruits and/or fruit juices was positively correlated to gallic acid and 4-O-methylgallic acid, isorhamnetin, kaempferol, hesperetin, naringenin and phloretin (r 0.24-0.44, P < 0.05). Coffee consumption was positively correlated to caffeic and chlorogenic acids (r 0.29 and 0.63, P < 0.05 respectively). Black tea and wine consumption were positively correlated with gallic and 4-O-methylgallic acids (r 0.37-0.54, P < 0.001). The present results suggest that several polyphenols measured in a spot urine sample can be used as biomarkers of polyphenol-rich food intake.
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Polyphenols, carotenoids, and vitamin C have been used as surrogate biomarkers of fruit and vegetable intake.
“polyphenols, carotenoids, and vitamin C for fruit and vegetables (17,18)”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [18]
Polyphenols have been used as surrogate biomarkers of tea and wine intake.
“polyphenols for tea and wine (18,25)”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [18]
Vitamin C or the sum of carotenoids or flavonoids have been used as generic biomarkers for fruit and vegetable intake.
“Vitamin C or the sum of carotenoids or flavonoids have been used as generic biomarkers for fruit and vegetable intake (18,45).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [18]
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- Authors
- Mennen, L. I., Sapinho, D., Ito, H., Bertrais, S., Galan, P., Hercberg, S., & Scalbert, A.
- Affiliations
- Conservatoire National des Arts et Métiers (FR)
- Corresponding author
- Mennen, Louise I.
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2006-01
- Volume
- 96
- Issue
- 1
- Pages
- 191-198
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2054679532
- Cited by
- 174
- References
- 45
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 12 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 11 · 2017: 10 · 2016: 9 · 2015: 9 · 2014: 8 · 2013: 14 · 2012: 8
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- urinary biomarkers, dietary polyphenol intake, flavonoids, phenolic acids, chlorogenic acid, caffeic acid, m-coumaric acid, gallic acid, quercetin, isorhamnetin, kaempferol, hesperetin, naringenin, phloretin, enterolactone, enterodiol, apple consumption, citrus fruit consumption, coffee consumption, black tea, wine consumption, dietary assessment
- MeSH terms
- Adult, Antioxidants, Caffeic Acids, Chlorogenic Acid, Coffee, Diet, Female, Flavonoids, Food, Fruit, Gallic Acid, Humans, Male, Middle Aged, Phenols, Vegetables, Wine, 4-Butyrolactone, Cohort Studies, Biomarkers, Lignans, Kaempferols, Polyphenols, Hydroxybenzoates
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