The DOI matches its Crossref record.
TRANSLOCATION OF ULTRAFINE INSOLUBLE IRIDIUM PARTICLES FROM LUNG EPITHELIUM TO EXTRAPULMONARY ORGANS IS SIZE DEPENDENT BUT VERY LOW
Abstract
Recently it was speculated that ultrafine particles may translocate from deposition sites in the lungs to systemic circulation. This could lead to accumulation and potentially adverse reactions in critical organs such as liver, heart, and even brain, consistent with the hypothesis that ultrafine insoluble particles may play a role in the onset of cardiovascular diseases, as growing evidence from epidemiological studies suggests. Ultrafine (192)Ir radio-labeled iridium particles (15 and 80 nm count median diameter) generated by spark discharging were inhaled by young adult, healthy, male WKY rats ventilated for 1 h via an endotracheal tube. After exposure, excreta were collected quantitatively. At time points ranging from 6 h to 7 d, rats were sacrificed, and a complete balance of (192)Ir activity retained in the body and cleared by excretion was determined gamma spectroscopically. Thoracic deposition fractions of inhaled 15- and 80-nm (192)Ir particles were 0.49 and 0.28, respectively. Both batches of ultrafine iridium particles proved to be insoluble (<1% in 7 d). During wk 1 after inhalation particles were predominantly cleared via airways into the gastrointestinal tract and feces. This cleared fraction includes particles deposited in the alveolar region. Additionally, minute particle translocation of <1% of the deposited particles into secondary organs such as liver, spleen, heart, and brain was measured after systemic uptake from the lungs. The translocated fraction of th…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In contrast, only 20% of 20-nm-sized NPs and about 30% of 70-nm-sized NP deposited during inhalation or instillation can be lavaged – see Fig. 2 [54–59].”
From Particle toxicology and health - where are we? (2019) · cites this paper as [58]
In the citing paper
“Retention in secondary organs was followed up to six months after the inhalation of the IrNP aerosol showing no detectable clearance [55, 58].”
From Particle toxicology and health - where are we? (2019) · cites this paper as [58]
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 19
- 10.1006/faat.1995.1144 · DOI · Paper page
- Cooper J. R., 1979, Int. J. Radiat. Biol., 36, 453
- 10.1289/ehp.01109s4547 · DOI
- U.S. Environmental Protection Agency. (1996). Air quality criteria for particulate matter, Chapter 12, Epidemiology studies of health associated with exposure to airborne particles/acid particles. Washington, DC: U.S. Environmental Protection Agency, Office of Research and Development. EPA/600/P-95/001bF.
- 10.1098/rsta.2000.0682 · DOI
- 10.1201/b14423-11 · DOI
- 10.1089/jam.1988.1.351 · DOI
- 10.3109/01902149309064357 · DOI
- 10.1136/oem.58.3.211 · DOI
- Ferin J., 1990, Particle clearance, translocation, morphology. 7. Aerosol Sci., 21, 381
- 10.1089/jam.1991.4.57 · DOI
- 10.1165/ajrcmb/6.5.535 · DOI
- 10.1093/annhyg/38.inhaled_particles_VII.289 · DOI
- Kreyling W. G., 1984, Aerosols: Science, technology and industrial applications of air-borne particles, 985
- 10.1161/hc0402.104118 · DOI · Paper page
- 10.1080/00984100290071658 · DOI · Paper page
- 10.1006/faat.1997.2390 · DOI
- Stradling, G. N., Smith, H., and Cooper, J. R. 1980. Factors affecting the mobility of actinide oxides and their influence on radiological protection. In Pulmonary toxicology of respirable particles. 19th Annual Hanford Life Sciences Symposium, eds. C. L Sanders, F. T. Cross, G. E. Dagle, and J. A. Mahaffey, pp. 209-223. Washington, DC: Technical Information Center US DOE CONF-791002.
- 10.1016/S0002-8703(99)70002-5 · DOI
Cited by
Sorted by citations
Toxic potential of materials at the nanolevel
Nel, A., Xia, T., Mädler, L., & Li, N. (2006) · Science · doi:10.1126/science.1114397 · Cited by 9,324
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
Oberdörster, G., Oberdörster, E., & Oberdörster, J. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7339 · Cited by 7,891
Self-citationNanomaterials and nanoparticles: Sources and toxicity
Buzea, C., Pacheco, I. I., & Robbie, K. (2007) · Biointerphases · doi:10.1116/1.2815690 · Cited by 3,789
Plastic and Human Health: A Micro Issue?
Wright, S. L., & Kelly, F. J. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b00423 · Cited by 3,413
Oberdörster, G., Maynard, A., Donaldson, K., Castranova, V., Fitzpatrick, J., Ausman, K., Carter, J., Karn, B., Kreyling, W., Lai, D., et al. (2005) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-2-8 · Cited by 2,134
Self-citationThe Effect of Nanoparticle Size on In Vivo Pharmacokinetics and Cellular Interaction
Hoshyar, N., Gray, S., Han, H., & Bao, G. (2016) · Nanomedicine · doi:10.2217/nnm.16.5 · Cited by 1,990
Sharifi, S., Behzadi, S., Laurent, S., Laird Forrest, M., Stroeve, P., & Mahmoudi, M. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15188f · Cited by 1,460
Deposition and biokinetics of inhaled nanoparticles
Geiser, M., & Kreyling, W. G. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-2 · Cited by 747
Self-citationNanotechnology Safety Concerns Revisited
Stern, S. T., & McNeil, S. E. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfm169 · Cited by 560
Nanotoxicology: An Interdisciplinary Challenge
Krug, H. F., & Wick, P. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201001037 · Cited by 556
Particle toxicology and health - where are we?
Riediker, M., Zink, D., Kreyling, W., Oberdörster, G., Elder, A., Graham, U., Lynch, I., Duschl, A., Ichihara, G., Ichihara, S., et al. (2019) · Particle and Fibre Toxicology · doi:10.1186/s12989-019-0302-8 · Cited by 237
Self-citationMaternal exposure to fine particulate matter (PM2.5) and pregnancy outcomes: a meta-analysis
Zhu, X., Liu, Y., Chen, Y., Yao, C., Che, Z., & Cao, J. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-014-3458-7 · Cited by 195
Geraets, L., Oomen, A. G., Schroeter, J. D., Coleman, V. A., & Cassee, F. R. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs113 · Cited by 176
Newman, N. C., Ryan, P., LeMasters, G., Levin, L., Bernstein, D., Hershey, G. K. K., Lockey, J. E., Villareal, M., Reponen, T., Grinshpun, S., et al. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205555 · Cited by 160
Chen, J., Tan, M., Nemmar, A., Song, W., Dong, M., Zhang, G., & Li, Y. (2006) · Toxicology · doi:10.1016/j.tox.2006.02.016 · Cited by 132
Nakane, H. (2012) · Environmental Health and Preventive Medicine · doi:10.1007/s12199-011-0252-8 · Cited by 101
Safety and regulatory issues of nanomaterials in foods
Tarhan, Ö. (2020) · Handbook of Food Nanotechnology · doi:10.1016/b978-0-12-815866-1.00016-9 · Cited by 23
Emergency visits and hospital admissions in aged people living close to a gas-fired power plant
Di Ciaula, A. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2011.09.013 · Cited by 17
Metadata
- Authors
- Kreyling, W. G., Semmler, M., Erbe, F., Mayer, P., Takenaka, S., Schulz, H., Oberdörster, G., & Ziesenis, A.
- Venue
- Journal of Toxicology and Environmental Health, Part A
- Publisher
- Informa UK Limited
- Published
- 2002-10-12
- Volume
- 65
- Issue
- 20
- Pages
- 1513-1530
- ISSN
- 1528-7394
- 1087-2620
- Cited by
- 790
- References
- 0
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
