Cited by 388Phytochemicals and Antioxidant ActivitiesFlavonoids in Medical ResearchBioactive natural compounds

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The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells

Hazafa, Abu, Rehman, Khalil-Ur-, Jahan, Nazish, Jabeen, Zara·2020·Nutrition and Cancer

DOI 10.1080/01635581.2019.1637006

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Abstract

Cancer remains a second leading cause of deaths and major public health problem. It occurs due to extensive DNA damage caused by ultraviolet radiations, ionizing radiations, environmental agents, therapeutic agents, etc. Among all cancers, the most frequently diagnosed cancers are lung (12.7%), breast (10.9%), colorectal (9.7%), and gastric cancer (7.81%). Natural compounds are most favorable against cancer on the count of their anti-cancerous ability, easy to avail and efficient. Among natural compounds, polyphenols (flavonoids, catechin, hesperetin, flavones, quercetin, phenolic acids, ellagic acid, lignans, stilbenes, etc.) represent a large and diverse group used in the prevention and treatment of cancer. Natural flavonoids are derived from different plant sources and from various medicinal plants including Petroselinum crispum, Apium graveolens, Flemingia vestita, Phyllanthus emblica, etc. Natural flavonoids possess antioxidant, anti-inflammation, as well as anti-cancerous activities through multiple pathways, they induce apoptosis in breast, colorectal, and prostate cancers, lower the nucleoside diphosphate kinase-B activity in lung, bladder and colon cancers, inhibit cell-proliferation and cell cycle arrest by suppressing the NF-kB pathway in various cancers, etc. The current review summarized the anticancer activities of natural polyphenols and their mechanisms of action.

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Background
Aglycone flavonoid brachydin A shows selective cytotoxicity and antitumoral activity in human metastatic prostate (DU145) cancer cells
de Oliveira, L. C. B., Nunes, H. L., Ribeiro, D. L., do Nascimento, J. R., da Rocha, C. Q., Cólus, I. M. D. S., & Serpeloni, J. M. (2021) · Cytotechnology · doi:10.1007/s10616-021-00495-y · Cited by 10
Modulatory Impact of Lamiaceae Metabolites on Apoptosis of Human Leukemia Cells
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Metabolites Profiling, In Vitro, In Vivo, Computational Pharmacokinetics and Biological Predictions of Aloe perryi Resins Methanolic Extract
Suliman, R. S., Alghamdi, S. S., Ali, R., Aljatli, D., Huwaizi, S. M., Suliman, R., Albadrani, G. M., Tolayyan, A. A., & Alghanem, B. (2021) · Plants · doi:10.3390/plants10061106 · Cited by 10
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Identification of Bcl2 as a Stably Expressed qPCR Reference Gene for Human Colon Cancer Cells Treated with Cottonseed-Derived Gossypol and Bioactive Extracts and Bacteria-Derived Lipopolysaccharides
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Antioxidant activity, phytochemical composition, and antitumor capacity of Amazonian fruits taperebá (Spondias mombin) and murici (Byrsonima crassifolia)
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NLRP3 inflammasome-based therapies by natural products: a new development in the context of cancer therapy
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Innovative approaches in breast cancer therapy: repurposing nanocarriers for enhanced outcomes
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“It occurs when cells divide uncontrollably, forming tumors, and includes types like carcinoma, leukemia, sarcoma, lymphoma, and CNS cancers (Hazafa et al. 2020).”
Targeted cancer therapy potential of quercetin-conjugated with folic acid-modified nanocrystalline cellulose nanoparticles: a study on AGS and A2780 cell lines
Soltani, M., Ahmadzadeh, N., Haghighi, H. N., Khatamian, N., & Tabrizi, M. H. (2025) · BMC Biotechnology · doi:10.1186/s12896-025-00962-w · Cited by 9
“Recent interest in natural compounds for cancer therapy has highlighted Quercetin, a polyphenolic flavonoid found in many fruits and vegetables [13].”
Ceiba pentandra ethyl acetate extract improves doxorubicin antitumor outcomes against chemically induced liver cancer in rat model: a study supported by UHPLC-Q-TOF-MS/MS identification of the bioactive phytomolecules
Orabi, M. A. A., Abouelela, M. E., Darwish, F., Abdelkader, M. S. A., Elsadek, B., Awadh, A. A. A., Alshahrani, M. M., Alhasaniah, A. H., Aldabaan, N. A., & Abdelhamid, R. A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1337910 · Cited by 9
Microbial Metabolites of Flavanols in Urine are Associated with Enhanced Anti-Proliferative Activity in Bladder Cancer Cells In Vitro
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The Employment of Genera Vaccinium, Citrus, Olea, and Cynara Polyphenols for the Reduction of Selected Anti-Cancer Drug Side Effects
Maiuolo, J., Musolino, V., Gliozzi, M., Carresi, C., Oppedisano, F., Nucera, S., Scarano, F., Scicchitano, M., Guarnieri, L., Bosco, F., et al. (2022) · Nutrients · doi:10.3390/nu14081574 · Cited by 10
The Impact of Genetic Mutations on the Efficacy of Immunotherapies in Lung Cancer
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Chlorella spp. as an Emerging Source for Anticancer Remedy and Nutraceuticals: An Advance Study
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“Good Wine Makes Good Blood”: An Integrated Approach to Characterize Autochthonous Apulian Grapevines as Promising Candidates for Healthy Wines
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Background
Adipose tissue angiogenesis genes are down-regulated by grape polyphenols supplementation during a human overfeeding trial
Delage, P., Segrestin, B., Seyssel, K., Chanon, S., Vieille‐Marchiset, A., Durand, A., Nemeth, A., Métairon, S., Charpagne, A., Descombes, P., et al. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109334 · Cited by 8
Plant Polyphenol Gossypol Induced Cell Death and Its Association with Gene Expression in Mouse Macrophages
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Attenuating Colorectal Cancer Using Nine Cultivars of Australian Lupin Seeds: Apoptosis Induction Triggered by Mitochondrial Reactive Oxygen Species Generation and Caspases-3/7 Activation
Mazumder, K., Aktar, A., Ramasamy, S., Biswas, B., Kerr, P. G., & BLANCHARD, C. L. (2023) · Cells · doi:10.3390/cells12212557 · Cited by 8
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Background
Phytochemical Profiling by UHPLC–Q-TOF/MS and Chemopreventive Effect of Aqueous Extract of Moringa oleifera Leaves and Benzyl Isothiocyanate on Murine Mammary Carcinogenesis
Rojas-Armas, J. P., Palomino-Pacheco, M., Arroyo-Acevedo, J. L., Ortiz-Sánchez, J. M., Justil-Guerrero, H. J., Martínez-Heredia, J. T., Castro-Luna, A., Flores, C. R., & Duxtan, A. J. G. (2024) · Molecules · doi:10.3390/molecules29061380 · Cited by 8
miR193a-5p Mediated ZNF746 and c-Myc Signaling Axis Is Critically Involved in Morusin Induced Apoptosis in Colorectal Cancer Cells
Park, W.-Y., Lee, H., Sim, D. Y., Im, E., Park, J.-E., Ahn, C., Shim, B., & Kim, S. (2021) · Cells · doi:10.3390/cells10082065 · Cited by 8
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Syringic acid, resveratrol and gallic acid compounds lipid metabolizing enzymes regulatory activity in isoproterenol-induced cardiac necrosis in rats
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Polyphenols From Morchella sextelata Induce Apoptosis of Colorectal Cancer Cells Through ROS‐Mediated Endogenous Mitochondrial Apoptosis Pathway In Vitro
Zhai, F., Wang, Y., & Yan, M. (2025) · Journal of Food Biochemistry · doi:10.1155/jfbc/7777790 · Cited by 7
Bee Pollen Phytochemicals and Nutrients as Unequaled Pool of Epigenetic Regulators: Implications for Age-Related Diseases
Kacemi, R., & Campos, M. G. (2025) · Foods · doi:10.3390/foods14030347 · Cited by 7
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Evaluation of the antiproliferative, cytotoxic and phytochemical properties of Zimbabwean medicinal plants used in cancer treatment
Mlilo, S., Sibanda, S., Sithole, S., Mukanganyama, S., & Naik, Y. S. (2025) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-025-04883-1 · Cited by 7
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Sakuranin represses the malignant biological behaviors of human bladder cancer cells by triggering autophagy via activating the p53/mTOR pathway
Hao, L., Mu, D., & Mu, H. (2023) · BMC Urology · doi:10.1186/s12894-023-01334-2 · Cited by 7
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Background
Effect of Malvidin on Induction of Apoptosis and Inhibition of Cell Proliferation on Myeloid and Lymphoid Leukemia
Dahlawi, H. A. (2022) · Scholars Journal of Applied Medical Sciences · doi:10.36347/sjams.2022.v10i01.025 · Cited by 7
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Exploration of the effect and mechanism of Scutellaria barbata D. Don in the treatment of ovarian cancer based on network pharmacology and in vitro experimental verification
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Background
Peruvian fava beans for health and food innovation: physicochemical, morphological, nutritional, and techno-functional characterization
Reyes, R. S., Furlan, L. C., Martínez‐Villaluenga, C., Paula, B. M. D., Nabeshima, E. H., Pinto, C. D. C., de Souza, S. M., Pallone, J. A. L., & Clerici, M. T. P. S. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114814 · Cited by 6
Research Progress on the Structure–activity Relationship and Mechanism of Flavonoid Derivatives in the Treatment of Lung Cancer
Yao, J., Zhu, F., Feng, Y., Gu, C., Wang, T., Li, X., Yang, H., Hu, X., Bonnet, P., & Meng, X. (2025) · Molecules · doi:10.3390/molecules30081827 · Cited by 6
Sweet lime pomace-peel powder as citrus tea: material balance and extraction kinetics
Shaik, L., & Chakraborty, S. (2023) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-023-05124-6 · Cited by 6
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Green Method Comparison and Optimization of Anthocyanin Recovery from “Sangiovese” Grape Pomace: A Critical Evaluation of the Design of Experiments Approach
Lianza, M., & Antognoni, F. (2024) · Molecules · doi:10.3390/molecules29112679 · Cited by 8
“…have been demonstrated, ranging from antimicrobial [25] to the prevention of chronic and degenerative diseases [26,27], as well as carcinogenic activity, largely based on evidence from in vitro cell-based assays [28–30], making these metabolites to be largely exploitable for different purposes.”
Background
Investigating the Anticancer Properties of the Essential Oil and Aqueous Extract of Moringa oleifera and its Biosynthesized Metal Nanoparticles on MCF-7 and BT-549 Cell Lines
Noruzpour, M., Zakaria, R. A., Zare, N., Ebrahimi, H. A., Khankandi, H. P., & Bourang, S. (2024) · Journal of Breast Disease · doi:10.61186/ijbd.17.1.59 · Cited by 6
Identification of 3-((4-Hydroxyphenyl)amino)propanoic Acid Derivatives as Anticancer Candidates with Promising Antioxidant Properties
Kavaliauskas, P., Grybaitė, B., Sapijanskaitė-Banevič, B., Anusevičius, K., Jonuškienė, I., Stankevičienė, R., Petraitienė, R., Petraitis, V., Grigalevičiūtė, R., Meškinytė, E., et al. (2024) · Molecules · doi:10.3390/molecules29133125 · Cited by 6
Anticancer effect and apoptosis induction by azaflavanone derivative in human prostate cancer cells
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Nutritional composition and antioxidant and cancer chemopreventive activities of fruits of Psidiummyrtoides (O. Berg)
Cassiano, C. Z. D. C., Soares, K. L., Berilli, P., Marques, S., Maróstica, M. R., Bogusz, S., Núñez, Ó., Fronza, M., Endringer, D. C., & Scherer, R. (2024) · Ciência Rural · doi:10.1590/0103-8478cr20230360 · Cited by 6
Isolation, NMR Characterization, and Bioactivity of a Flavonoid Triglycoside from Anthyllis henoniana Stems: Antioxidant and Antiproliferative Effects on MDA-MB-231 Breast Cancer Cells
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Background
Integrated transcriptomic and metabolomic analyses reveals anthocyanin biosynthesis in leaf coloration of quinoa (Chenopodium quinoa Willd.)
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Background
The impact of CYP3A4 genetic polymorphism on crizotinib metabolism and drug-drug interactions
Wang, J., Xu, X., Li, X., Luo, J.-C., Zhang, Z.-Y., Chen, J., Cai, J., Zhang, L., & Qian, J. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.117016 · Cited by 5
Unlocking Antioxidant–Anticancer Synergy: An Exploration of Therapeutic Bioactives from Methanolic Extracts of Rubus ellipticus and Boerhavia diffusa Using HeLa Cell Line
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“5,6 We are using two such plants for the present investigation.”
Chemical constituents and biological activities of endophytic fungi from Fagopyrum dibotrys
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“Their main effects include antioxidant ( Fu et al., 2017 ), hypoglycemic ( Mustafa et al., 2022 ), anticancer ( Hazafa et al., 2020 ), weight loss ( Montalbano et al., 2021 ), anti-inflammatory ( Maleki, Crespo & Cabanillas, 2019 ), and antimicrobial effects ( Shamsudin et al., 2022 ; Sunil & Xu,…”

Authors: Hazafa, A., Rehman, K.-U., Jahan, N., & Jabeen, Z.
Affiliations: University of Agriculture Faisalabad (PK)
Corresponding author: Hazafa, Abu
ORCID: Hazafa, Abu
Jahan, Nazish
Venue: Nutrition and Cancer
Publisher: Informa UK Limited
Published: 2019-07-09
Volume: 72
Issue: 3
Pages: 386-397
ISSN: 0163-5581 (ISSN-L)
1532-7914
DOI: 10.1080/01635581.2019.1637006
OpenAlex: W2961940793
Cited by: 388
References: 113
Citations by year: 2026: 42 · 2025: 61 · 2024: 99 · 2023: 66 · 2022: 76 · 2021: 29 · 2020: 15
FWCI: 2.89
Type: journal article
Language: en
Open access: closed
Locations: Nutrition and Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
Keywords: polyphenols, flavonoids, anticancer activity, natural compounds, apoptosis, NF-κB signaling, cell cycle arrest, DNA damage, antioxidant activity, anti-inflammatory activity, quercetin, catechins, ellagic acid, medicinal plants, cancer prevention
MeSH terms: Anthocyanins, Antineoplastic Agents, Antioxidants, Flavonoids, Humans, Neoplasms, Plants, Edible, Plants, Medicinal, Quercetin, Tea, Anticarcinogenic Agents, Apoptosis, Cell Line, Tumor, Cell Proliferation, Polyphenols

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The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells

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