Cited by 388Phytochemicals and Antioxidant ActivitiesFlavonoids in Medical ResearchBioactive natural compounds

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The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells

Hazafa, Abu, Rehman, Khalil-Ur-, Jahan, Nazish, Jabeen, Zara·2020·Nutrition and Cancer

DOI 10.1080/01635581.2019.1637006

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Abstract

Cancer remains a second leading cause of deaths and major public health problem. It occurs due to extensive DNA damage caused by ultraviolet radiations, ionizing radiations, environmental agents, therapeutic agents, etc. Among all cancers, the most frequently diagnosed cancers are lung (12.7%), breast (10.9%), colorectal (9.7%), and gastric cancer (7.81%). Natural compounds are most favorable against cancer on the count of their anti-cancerous ability, easy to avail and efficient. Among natural compounds, polyphenols (flavonoids, catechin, hesperetin, flavones, quercetin, phenolic acids, ellagic acid, lignans, stilbenes, etc.) represent a large and diverse group used in the prevention and treatment of cancer. Natural flavonoids are derived from different plant sources and from various medicinal plants including Petroselinum crispum, Apium graveolens, Flemingia vestita, Phyllanthus emblica, etc. Natural flavonoids possess antioxidant, anti-inflammation, as well as anti-cancerous activities through multiple pathways, they induce apoptosis in breast, colorectal, and prostate cancers, lower the nucleoside diphosphate kinase-B activity in lung, bladder and colon cancers, inhibit cell-proliferation and cell cycle arrest by suppressing the NF-kB pathway in various cancers, etc. The current review summarized the anticancer activities of natural polyphenols and their mechanisms of action.

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“Additionally, they exhibit anticancer properties [50].”
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Hossain, C. M., Choudhuri, S., Ali, K. A., & Das, R. (2025) · Springer eBooks · doi:10.1007/978-981-97-9936-7_20-1 · Cited by 1
Alkali Lignin-Based Biopolymer Formulations for Electro-Assisted Drug Delivery of Natural Antioxidants in Breast Cancer Cells—A Preliminary Study
Semkova, S., Deneva, R., Antov, G., Ivanova, D., & Nikolova, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157481 · Cited by 1
“…of cell cycle signaling (MAPK, PI3K, NF-κ B pathways), the activation of intracellular antioxidant enzyme activities, the influencing of energy and redox-homeostasis, etc., have been identified as key characteristics for inducing apoptosis and/or decreasing cancer cell proliferation activity [35].”
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Hernández, P. E., Esparza‐González, S. C., Rodrı́guez-Herrera, R., Medina, M. D. D., Chávez‐González, M. L., Rúelas-Chácon, X., Ascacio-Valdés, J. A., Naveda, A. F., & Sepúlveda, L. (2025) · Food and Bioprocess Technology · doi:10.1007/s11947-025-04059-2 · Cited by 1
“Delphinidin has the highest anticancer activity and has been reported to suppress the NF-kB pathway to induce apoptosis and cell cycle arrest in various types of cancer (Hazafa et al., 2019).”
Corylin induces UGT1A1 via PPARs/AhR and exerts hepatoprotection in mice
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“Dietary phytochemicals, such as flavonoids, have the advantage of low toxicity, can reduce multidrug resistance 38,39 , and have significant therapeutic effects in various disease models 24 .”
Network pharmacology, bioinformatics and in vitro/in vivo validation elucidate the anti-lung cancer activities and potential targets of Rhoifolin
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Natural compounds in the treatment of osteosarcoma: just chemotherapy adjuvants? or is there much more?
Bellavia, D., Naselli, F., Russo, P. M., Costa, V., Luca, A. D., Raimondi, L., Caradonna, F., & Giavaresi, G. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04174-w · Cited by 1
“Currently, more than 3,000 species of plants have been accounted in the treatment of cancer and clinical trials so far [56].”
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“They have also been reported to play a role in regulating cell function and gene expression (Singh and Yadav 2022; Hazafa et al. 2020; Kopustinskiene et al. 2020; Zhang and Ma 2018).”
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“Phytochemicals present in fruits, such as flavonoids and other phenolic compounds, have been shown to exert anti-proliferative and chemoprotective effects (Hazafa et al. 2020; Samec et al. 2021).”
The biomedical applications of flavonoid-containing hydrogels
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“…observed in reducing cell proliferation at a concentration of 1000 µg/ ml are possibly due to the presence of phenolic compounds, which have antioxidant, anti-inflammatory and anticancer properties through various pathways, and induce apoptosis in different types of cancers (Hazafa et al. 2020).”
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“Senegalia modesta, a perennial tree found in Pakistan and India contains various phytochemicals and has been traditionally used to treat various ailments, but its potential in cancer therapy remains unexplored (Abid et al. 2022; Hazafa et al. 2020).”
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“A large number of scientific reports have also dealt with their potentially antineoplastic effects [17,18], although available data depict a rather heterogeneous and sometimes contradictory landscape, and no univocal conclusion can be drawn.”
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In vivo antioxidants, chemical characterization and biochemical and medicinal potential of Murraya koenigii in cisplatin-induced nephrotoxicity
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Authors: Hazafa, A., Rehman, K.-U., Jahan, N., & Jabeen, Z.
Affiliations: University of Agriculture Faisalabad (PK)
Corresponding author: Hazafa, Abu
ORCID: Hazafa, Abu
Jahan, Nazish
Venue: Nutrition and Cancer
Publisher: Informa UK Limited
Published: 2019-07-09
Volume: 72
Issue: 3
Pages: 386-397
ISSN: 0163-5581 (ISSN-L)
1532-7914
DOI: 10.1080/01635581.2019.1637006
OpenAlex: W2961940793
Cited by: 388
References: 113
Citations by year: 2026: 42 · 2025: 61 · 2024: 99 · 2023: 66 · 2022: 76 · 2021: 29 · 2020: 15
FWCI: 2.89
Type: journal article
Language: en
Open access: closed
Locations: Nutrition and Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
Keywords: polyphenols, flavonoids, anticancer activity, natural compounds, apoptosis, NF-κB signaling, cell cycle arrest, DNA damage, antioxidant activity, anti-inflammatory activity, quercetin, catechins, ellagic acid, medicinal plants, cancer prevention
MeSH terms: Anthocyanins, Antineoplastic Agents, Antioxidants, Flavonoids, Humans, Neoplasms, Plants, Edible, Plants, Medicinal, Quercetin, Tea, Anticarcinogenic Agents, Apoptosis, Cell Line, Tumor, Cell Proliferation, Polyphenols

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The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells

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