Cited by 388Phytochemicals and Antioxidant ActivitiesFlavonoids in Medical ResearchBioactive natural compounds

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The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells

Hazafa, Abu, Rehman, Khalil-Ur-, Jahan, Nazish, Jabeen, Zara·2020·Nutrition and Cancer

DOI 10.1080/01635581.2019.1637006

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Abstract

Cancer remains a second leading cause of deaths and major public health problem. It occurs due to extensive DNA damage caused by ultraviolet radiations, ionizing radiations, environmental agents, therapeutic agents, etc. Among all cancers, the most frequently diagnosed cancers are lung (12.7%), breast (10.9%), colorectal (9.7%), and gastric cancer (7.81%). Natural compounds are most favorable against cancer on the count of their anti-cancerous ability, easy to avail and efficient. Among natural compounds, polyphenols (flavonoids, catechin, hesperetin, flavones, quercetin, phenolic acids, ellagic acid, lignans, stilbenes, etc.) represent a large and diverse group used in the prevention and treatment of cancer. Natural flavonoids are derived from different plant sources and from various medicinal plants including Petroselinum crispum, Apium graveolens, Flemingia vestita, Phyllanthus emblica, etc. Natural flavonoids possess antioxidant, anti-inflammation, as well as anti-cancerous activities through multiple pathways, they induce apoptosis in breast, colorectal, and prostate cancers, lower the nucleoside diphosphate kinase-B activity in lung, bladder and colon cancers, inhibit cell-proliferation and cell cycle arrest by suppressing the NF-kB pathway in various cancers, etc. The current review summarized the anticancer activities of natural polyphenols and their mechanisms of action.

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Additional file 1 of Integrated transcriptomic and metabolomic analyses reveals anthocyanin biosynthesis in leaf coloration of quinoa (Chenopodium quinoa Willd.)
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Additional file 2 of Sakuranin represses the malignant biological behaviors of human bladder cancer cells by triggering autophagy via activating the p53/mTOR pathway
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Additional file 2 of Integrated transcriptomic and metabolomic analyses reveals anthocyanin biosynthesis in leaf coloration of quinoa (Chenopodium quinoa Willd.)
Zhang, M., Li, Y., Wang, J., Shang, S., Wang, H., Yang, X., Lu, C., Wang, M., Sun, X., Liu, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26695653
Additional file 1 of Sakuranin represses the malignant biological behaviors of human bladder cancer cells by triggering autophagy via activating the p53/mTOR pathway
Hao, L., Mu, D., & Mu, H. (2023) · Figshare · doi:10.6084/m9.figshare.24431945
Additional file 5 of Integrated transcriptomic and metabolomic analyses reveals anthocyanin biosynthesis in leaf coloration of quinoa (Chenopodium quinoa Willd.)
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Additional file 8 of Integrated transcriptomic and metabolomic analyses reveals anthocyanin biosynthesis in leaf coloration of quinoa (Chenopodium quinoa Willd.)
Zhang, M., Li, Y., Wang, J., Shang, S., Wang, H., Yang, X., Lu, C., Wang, M., Sun, X., Liu, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26695671
Additional file 4 of Integrated transcriptomic and metabolomic analyses reveals anthocyanin biosynthesis in leaf coloration of quinoa (Chenopodium quinoa Willd.)
Zhang, M., Li, Y., Wang, J., Shang, S., Wang, H., Yang, X., Lu, C., Wang, M., Sun, X., Liu, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26695659
Additional file 7 of Integrated transcriptomic and metabolomic analyses reveals anthocyanin biosynthesis in leaf coloration of quinoa (Chenopodium quinoa Willd.)
Zhang, M., Li, Y., Wang, J., Shang, S., Wang, H., Yang, X., Lu, C., Wang, M., Sun, X., Liu, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26695668
Additional file 4 of Sakuranin represses the malignant biological behaviors of human bladder cancer cells by triggering autophagy via activating the p53/mTOR pathway
Hao, L., Mu, D., & Mu, H. (2024) · Figshare · doi:10.6084/m9.figshare.26630944
Additional file 5 of Sakuranin represses the malignant biological behaviors of human bladder cancer cells by triggering autophagy via activating the p53/mTOR pathway
Hao, L., Mu, D., & Mu, H. (2024) · Figshare · doi:10.6084/m9.figshare.26630947
Additional file 6 of Integrated transcriptomic and metabolomic analyses reveals anthocyanin biosynthesis in leaf coloration of quinoa (Chenopodium quinoa Willd.)
Zhang, M., Li, Y., Wang, J., Shang, S., Wang, H., Yang, X., Lu, C., Wang, M., Sun, X., Liu, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26695665
Additional file 3 of Sakuranin represses the malignant biological behaviors of human bladder cancer cells by triggering autophagy via activating the p53/mTOR pathway
Hao, L., Mu, D., & Mu, H. (2024) · Figshare · doi:10.6084/m9.figshare.26630941
Additional file 6 of Sakuranin represses the malignant biological behaviors of human bladder cancer cells by triggering autophagy via activating the p53/mTOR pathway
Hao, L., Mu, D., & Mu, H. (2024) · Figshare · doi:10.6084/m9.figshare.26630950
Additional file 3 of Integrated transcriptomic and metabolomic analyses reveals anthocyanin biosynthesis in leaf coloration of quinoa (Chenopodium quinoa Willd.)
Zhang, M., Li, Y., Wang, J., Shang, S., Wang, H., Yang, X., Lu, C., Wang, M., Sun, X., Liu, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26695656
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Authors: Hazafa, A., Rehman, K.-U., Jahan, N., & Jabeen, Z.
Affiliations: University of Agriculture Faisalabad (PK)
Corresponding author: Hazafa, Abu
ORCID: Hazafa, Abu
Jahan, Nazish
Venue: Nutrition and Cancer
Publisher: Informa UK Limited
Published: 2019-07-09
Volume: 72
Issue: 3
Pages: 386-397
ISSN: 0163-5581 (ISSN-L)
1532-7914
DOI: 10.1080/01635581.2019.1637006
OpenAlex: W2961940793
Cited by: 388
References: 113
Citations by year: 2026: 42 · 2025: 61 · 2024: 99 · 2023: 66 · 2022: 76 · 2021: 29 · 2020: 15
FWCI: 2.89
Type: journal article
Language: en
Open access: closed
Locations: Nutrition and Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
Keywords: polyphenols, flavonoids, anticancer activity, natural compounds, apoptosis, NF-κB signaling, cell cycle arrest, DNA damage, antioxidant activity, anti-inflammatory activity, quercetin, catechins, ellagic acid, medicinal plants, cancer prevention
MeSH terms: Anthocyanins, Antineoplastic Agents, Antioxidants, Flavonoids, Humans, Neoplasms, Plants, Edible, Plants, Medicinal, Quercetin, Tea, Anticarcinogenic Agents, Apoptosis, Cell Line, Tumor, Cell Proliferation, Polyphenols

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The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells

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