Cited by 1,216Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands

Open access

Hertog, Michaël G. L., Hollman, Peter C. H., Katan, Martijn B., Kromhout, Daan·1993·Nutrition and Cancer

DOI 10.1080/01635589309514267

Open this paper in CoChat — free account

Abstract

Flavonoids are strong antioxidants that occur naturally in foods and can inhibit carcinogenesis in rodents. Accurate data on population-wide intakes of flavonoids are not available. Here, using data of the Dutch National Food Consumption Survey 1987-1988, we report the intake of the potentially anticarcinogenic flavonoids quercetin, kaempferol, myricetin, apigenin, and luteolin among 4,112 adults. The flavonoid content of vegetables, fruits, and beverages was determined by high-performance liquid chromatography. In all subjects, average intake of all flavonoids combined was 23 mg/day. The most important flavonoid was the flavonol quercetin (mean intake 16 mg/day). The most important sources of flavonoids were tea (48% of total intake), onions (29%), and apples (7%). Flavonoid intake did not vary between seasons; it was not correlated with total energy intake (r = 0.001), and it was only weakly correlated with the intake of vitamin A (retinol equivalents, r = 0.14), dietary fiber (r = 0.21), and vitamin C (r = 0.26). Our use of new analytic technology suggests that in the past flavonoid intake has been overestimated fivefold. However, on a milligram-per-day basis, the intake of the antioxidant flavonoids still exceeded that of the antioxidants beta-carotene and vitamin E. Thus flavonoids represent an important source of antioxidants in the human diet.

Integrity signals

Registry

Crossref · 10.1080/01635589309514267

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Beyond Cholesterol
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425
Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence.
Block, G., Patterson, B. H., & Subar, A. (1992) · Nutrition and Cancer · doi:10.1080/01635589209514201 · Cited by 3,321
Prooxidant States and Tumor Promotion
Cerutti, P. (1985) · Science · doi:10.1126/science.2981433 · Cited by 2,513
Book ReviewAmbulatory Pediatric Care
Steinberg, J. B. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200122 · Cited by 2,105
Flavonoids are scavengers of superoxide anions
Robak, J., & Gryglewski, R. J. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90169-4 · Cited by 1,579
The Flavonoids. A Class of Semi-Essential Food Components: Their Role in Human Nutrition
K�hnau, J. (2015) · World review of nutrition and dietetics · doi:10.1159/000399407 · Cited by 1,491
Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands
Hertog, M. G. L., Hollman, P. C. H., & Katan, M. (1992) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00024a011 · Cited by 1,381
Self-citation
Chemoprevention of Cancer
Wattenberg, L. W. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6754-9_2795 · Cited by 1,244
Vegetables, fruit, and cancer. I. Epidemiology
Steinmetz, K. A., & Potter, J. D. (1991) · Cancer Causes and Control · doi:10.1007/bf00051672 · Cited by 1,118
Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices
Hertog, M. G. L., Hollman, P. C. H., & van de Putte, B. (1993) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00032a015 · Cited by 899
Self-citation

Show all 39 references

Research works printed but not linked: 8

Mukhtar H, 1988, Cancer Res, 48, 2361
Verma AK, 1988, Cancer Res, 48, 5754
Wei H, 1990, Cancer Res, 50, 499
Pamucku AM, 1980, Cancer Res, 40, 3468
Hertog MGL, J Agric Food Chem.
1984, Nationwide Food Consumption Survey
1988, SAS/STAT User's Guide. Release 6.03
Balestieri, F, Flori, A and Marini, D. 1991. “Strategies for Food Quality Control and Analytical Methods in Europe”. Proc 6th Cur Conf Food Chem Lebensmittelchemische Gesellschaft. 1991, Frankfurt am Main. pp.369–378.

Sorted by citations

Items 401–500 of 1,000

Bioavailability and molecular activities of anthocyanins as modulators of endothelial function
Speciale, A., Cimino, F., Saija, A., Canali, R., & Virgili, F. (2014) · Genes & Nutrition · doi:10.1007/s12263-014-0404-8 · Cited by 92
Human Red Blood Cells as A Natural Flavonoid Reservoir
Fiorani, M., Accorsi, A., & Cantoni, O. (2003) · Free Radical Research · doi:10.1080/10715760310001615998 · Cited by 88
Phenolic compounds and related enzymes as determinants of sorghum for food use
Dicko, M. H., Gruppen, H., Traore, A. S., Voragen, A. G. J., & van Berkel, W. J. H. (2006) · Socio-Environmental Systems Modeling · doi:10.5897/bmbr.9000008 · Cited by 88
Antioxidative Effects of Flavonols and Their Glycosides against the Free‐Radical‐Induced Peroxidation of Linoleic Acid in Solution and in Micelles
Zhou, B., Miao, Q., Li, Y., & Liu, Z. (2004) · Chemistry - A European Journal · doi:10.1002/chem.200400391 · Cited by 87
Black Raspberry Components Inhibit Proliferation, Induce Apoptosis, and Modulate Gene Expression in Rat Esophageal Epithelial Cells
Zikri, N. N., Riedl, K. M., Wang, L., Lechner, J. F., Schwartz, S. J., & Stoner, G. D. (2009) · Nutrition and Cancer · doi:10.1080/01635580903285148 · Cited by 87
Cocoa and Chocolate: Composition, Bioavailability, and Health Implications
Borchers, A. T., Keen, C. L., Hannum, S. M., & Gershwin, M. E. (2000) · Journal of Medicinal Food · doi:10.1089/109662000416285 · Cited by 88
In vitrotoxicity assessment of silver nanoparticles in the presence of phenolic compounds – preventive agents against the harmful effect?
Martirosyan, A. S., Bazes, A., & Schneider, Y. (2013) · Nanotoxicology · doi:10.3109/17435390.2013.812258 · Cited by 86
Modulation of drug transport by selected flavonoids: Involvement of P-gp and OCT?
Ofer, M., Wolffram, S., Koggel, A., Spahn-Langguth, H., & Langguth, P. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2005.03.001 · Cited by 86
Rutin Attenuates Vancomycin-Induced Nephrotoxicity by Ameliorating Oxidative Stress, Apoptosis, and Inflammation in Rats
Qu, S., Dai, C., Lang, F., Hu, L., Tang, Q., Wang, H., Zhang, Y., & Hao, Z. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01545-18 · Cited by 85
Flavonoids as nutraceuticals: Structural related antioxidant properties and their role on ascorbic acid preservation
Marín, F. R., Fernández, M. J. F., Pérez‐Álvarez, J. Á., Martinez-Sánchez, F., & del Rı́o, J. A. (2002) · Studies in natural products chemistry · doi:10.1016/s1572-5995(02)80018-7 · Cited by 85
Quantitative structure–activity relationship to predict differential inhibition of aldose reductase by flavonoid compounds
Fernández, M., Caballero, J., Helguera, A. M., Castro, E. A., & González, M. P. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.02.038 · Cited by 85
Transcriptome Profiling Using Single-Molecule Direct RNA Sequencing Approach for In-depth Understanding of Genes in Secondary Metabolism Pathways of Camellia sinensis
Xu, Q., Zhu, J., Zhao, S., Hou, Y., Li, F., Tai, Y., Wan, X., & Wei, C. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01205 · Cited by 85
Protection by Naringin and Some Other Flavonoids of Hepatocytic Autophagy and Endocytosis against Inhibition by Okadaic Acid
Gordon, P. B., Holen, I., & Seglen, P. O. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.11.5830 · Cited by 84
Antioxidant and Free Radical Scavenging Properties of Marennine, a Blue-Green Polyphenolic Pigment from the DiatomHaslea ostrearia(Gaillon/Bory) Simonsen Responsible for the Natural Greening of Cultured Oysters
Pouvreau, J., Taran, F., Rosa, P., Pin, S., Fleurence, J., & Pondaven, P. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf073187n · Cited by 83
Rutin and quercetin show greater efficacy than nifedipin in ameliorating hemodynamic, redox, and metabolite imbalances in sodium chloride-induced hypertensive rats
Olaleye, M., Crown, O., Akinmoladun, A. C., & Akindahunsi, A. A. (2013) · Human & Experimental Toxicology · doi:10.1177/0960327113504790 · Cited by 83
Protective effect of rutin on lipids, lipoproteins, lipid metabolizing enzymes and glycoproteins in streptozotocin-induced diabetic rats
Prince, P. S. M., & Kannan, N. K. (2006) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.58.10.0011 · Cited by 83
The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice
Cao, X., Liu, M., Tuo, J., Shen, D., & Chan, C. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.03.016 · Cited by 83
Structurally related flavonoids with antioxidative properties differentially affect cell cycle progression and apoptosis of human acute leukemia cells
Rusak, G., Gutzeit, H. O., & Müller, J. L. (2005) · Nutrition Research · doi:10.1016/j.nutres.2004.12.003 · Cited by 82
Evaluation of the total phenolics and quercetin content of foliage in mycorrhizal grape (Vitis vinifera L.) varieties and effect of postharvest drying on quercetin yield
Eftekhari, M. H., Alizadeh, M., & Ebrahimi, P. (2012) · Industrial Crops and Products · doi:10.1016/j.indcrop.2012.01.022 · Cited by 83
Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages
Lian, T.-W., Wang, L., Lo, Y., Huang, I., & Wu, M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.06.009 · Cited by 82
Apple Peel as a Contributor to Whole Fruit Quantity of Potentially Healthful Bioactive Compounds. Cultivar and Year Implication
Łata, B., & Tomala, K. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf072035p · Cited by 86
Dietary flavonoids and hypertension: is there a link?
Moline, J. M., Bukharovich, I. F., Wolff, M. S., & Phillips, R. A. (2000) · Medical Hypotheses · doi:10.1054/mehy.2000.1057 · Cited by 82
Influences of air and controlled atmosphere storage on the concentration of potentially healthful phenolics in apples and other fruits
Awad, M. A., & de Jager, A. (2002) · Postharvest Biology and Technology · doi:10.1016/s0925-5214(02)00189-8 · Cited by 82
Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis
Kang, N. J., Jung, S. K., Lee, K. W., & Lee, H. J. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06122.x · Cited by 81
Dietary Modifiers of Carcinogenesis
Kohlmeier, L., Simonsen, N., & Mottus, K. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103s8177 · Cited by 81
The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential
van Zanden, J. J., van der Woude, H., Vaessen, J., Usta, M., Wortelboer, H. M., Cnubben, N. H. P., & Rietjens, I. M. C. M. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.04.002 · Cited by 81
Physiologically-active compounds in plant foods: An overview
Rhodes, M. J. C. (1996) · Proceedings of The Nutrition Society · doi:10.1079/pns19960036 · Cited by 81
Development of a database of critically evaluated flavonoids data: application of USDA's data quality evaluation system
Holden, J. M., Bhagwat, S. A., Haytowitz, D. B., Gebhardt, S. E., Dwyer, J. T., Peterson, J. J., Beecher, G. R., Eldridge, A. L., & Balentine, D. A. (2005) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2004.07.002 · Cited by 80
Fasting plasma concentrations of selected flavonoids as markers of their ordinary dietary intake
Radtke, J. X. F. R., Linseisen, J., & Wolfram, G. (2002) · European Journal of Nutrition · doi:10.1007/s00394-002-0377-z · Cited by 80
The role of antioxidant phytonutrients in the prevention of diseases
Lugasi, A., Hóvári, J., Sági, K. V., & Bíró, L. (2003) · Acta Biologica Szegediensis · Cited by 79
Biomarkers of intake for coffee, tea, and sweetened beverages
Rothwell, J. A., Madrid-Gambín, F., Garcia‐Aloy, M., Andrés‐Lacueva, C., Logue, C., Gallagher, A. M., Mack, C. I., Kulling, S. E., Gao, Q., Praticò, G., et al. (2018) · Genes & Nutrition · doi:10.1186/s12263-018-0607-5 · Cited by 81
Quercetin, a potent and specific inhibitor of the human P-form phenolsulfotransferase
Walle, T., Eaton, E. A., & Walle, U. K. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00190-b · Cited by 79
Quercetin–iron chelates are transported via glucose transporters
Vlachodimitropoulou, E., Sharp, P., & Naftalin, R. J. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.005 · Cited by 78
Dietary Flavonol and Flavone Intakes and Their Major Food Sources in Chinese Adults
Zhang, Y., Li, Y., Cao, C., Cao, J., Chen, W., Zhang, Y., Wang, C., Wang, J., Zhang, X., & Zhao, X. (2010) · Nutrition and Cancer · doi:10.1080/01635581.2010.513800 · Cited by 78
Effect of protocatechuic acid on insulin responsiveness and inflammation in visceral adipose tissue from obese individuals: possible role for PTP1B
Ormazabal, P., Scazzocchio, B., Varı́, R., Santangelo, C., D’Archivio, M., Silecchia, G., Iacovelli, A., Giovannini, C., & Masella, R. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0075-4 · Cited by 77
Flavonoids and steroid hormone-dependent cancers
Zand, R. S. R., Jenkins, D. J. A., & Diamandis, E. P. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00213-1 · Cited by 77
Effects of Onion on Serum Uric Acid Levels and Hepatic Xanthine Dehydrogenase/Xanthine Oxidase Activities in Hyperuricemic Rats
Haidari, F., Rashidi, M., Keshavarz, S. A., Mahboob, S., Eshraghian, M. R., & Mohammadshahi, M. (2008) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2008.1779.1784 · Cited by 77
Insulinomimetic effects of myricetin on lipogenesis and glucose transport in rat adipocytes but not glucose transporter translocation
Ong, K. C., & Khoo, H. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)02195-7 · Cited by 77
Taxonomic Classification Helps Identify Flavonoid-Containing Foods on a Semiquantitative Food Frequency Questionnaire
Peterson, J. J., & Dwyer, J. T. (1998) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(98)00153-9 · Cited by 77
Graphene-Based Sensors for the Detection of Bioactive Compounds: A Review
Sainz-Urruela, C., Vera, S., Andrés, M. P. S., & Diez-Pascual, A. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073316 · Cited by 76
Anthocyanin-Rich Black Currant Extract Suppresses the Growth of Human Hepatocellular Carcinoma Cells
Bishayee, A., Háznagy‐Radnai, E., Mbimba, T., Sipos, P., Morazzoni, P., Darvesh, A. S., Bhatia, D., & Hohmann, J. (2010) · Natural Product Communications · doi:10.1177/1934578x1000501020 · Cited by 76
Anticancer and Antioxidant Activity of Bread Enriched with Broccoli Sprouts
Gawlik‐Dziki, U., Świeca, M., Dziki, D., Sęczyk, Ł., Złotek, U., Różyło, R., Kaszuba, K., Ryszawy, D., & Czyż, J. (2014) · BioMed Research International · doi:10.1155/2014/608053 · Cited by 76
Flavonoid Intake and Risk of Pancreatic Cancer in Male Smokers (Finland)
Bobe, G., Weinstein, S. J., Albanes, D., Hirvonen, T., Ashby, J., Taylor, P. R., Virtamo, J. R. K., & Stolzenberg‐Solomon, R. Z. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-2523 · Cited by 76
Quercitrin a bioflavonoid improves the antioxidant status in streptozotocin: induced diabetic rat tissues
Babujanarthanam, R., Kavitha, P., Rao, U. S. M., & Pandian, M. R. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0927-x · Cited by 76
Food flavonoid aryl hydrocarbon receptor-mediated agonistic/antagonistic/synergic activities in human and rat reporter gene assays
der Heiden, E. V., Bechoux, N., Müller, M., Sergent, T., Schneider, Y., Larondelle, Y., Maghuin‐Rogister, G., & Scippo, M. (2008) · Analytica Chimica Acta · doi:10.1016/j.aca.2008.09.054 · Cited by 76
A Study of Controlled Uptake and Release of Anthocyanins by Oxidized Starch Microgels
Wang, Z., Li, Y., Chen, L., Xin, X., & Yuan, Q. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400275m · Cited by 76
Diet, Helicobacter pylori Infection, Food Preservation and Gastric Cancer Risk: Are There New Roles for Preventative Factors?
Hwang, H., Dwyer, J. T., & Russell, R. M. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1994.tb01394.x · Cited by 76
Chemical and biological approaches on nine fruit tree leaves collected from the Mediterranean region of Turkey
Uysal, Ş., Zengin, G., Aktümsek, A., & Karataş, Ş. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.02.006 · Cited by 75
Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms
Giordano, R., Saii, Z., Fredsgaard, M., Hulkko, L. S. S., Poulsen, T. B. G., Thomsen, M. E., Henneberg, N. C., Zucolotto, S. M., Arendt‐Nielsen, L., Papenbrock, J., et al. (2021) · Molecules · doi:10.3390/molecules26113140 · Cited by 79
Putative Cancer Chemopreventive Agents of Dietary Origin—How Safe Are They?
Verschoyle, R. D., Steward, W. P., & Gescher, A. J. (2007) · Nutrition and Cancer · doi:10.1080/01635580701458186 · Cited by 75
Antioxidant properties of flavonol glycosides from tea
Plumb, G. W., PRICE, K. R., & Williamson, G. (1999) · Redox Report · doi:10.1179/135100099101534684 · Cited by 75
Influence of galangin on HL-60 cell proliferation and survival
Bestwick, C. S., & Milne, L. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.11.025 · Cited by 75
Improving the Nutritional Quality of Microwave-vacuum Dried Strawberries: A Preliminary Study
Böhm, V., Kühnert, S., Rohm, H., & Scholze, G. (2006) · Food Science and Technology International · doi:10.1177/1082013206062136 · Cited by 75
Content of Selected Flavonoids in 100 Edible Vegetables and Fruits
Cao, J., Chen, W., Zhang, Y., Zhang, Y., & Zhao, X. (2010) · Food Science and Technology Research · doi:10.3136/fstr.16.395 · Cited by 75
Kaempferol Promotes Apoptosis in Human Bladder Cancer Cells by Inducing the Tumor Suppressor, PTEN
Xie, F., Su, M., Qiu, W., Zhang, M., Guo, Z., Su, B., Liu, J., Li, X., & Zhou, L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141121215 · Cited by 75
Isolation and characterization of antioxidant and antibacterial compound from mango ginger (Curcuma amada Roxb.) rhizome
Policegoudra, R. S., Abiraj, K., Gowda, D. C., & Aradhya, S. M. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.12.036 · Cited by 75
Quercetin Enhances Chemosensitivity to Gemcitabine in Lung Cancer Cells by Inhibiting Heat Shock Protein 70 Expression
Lee, S. H., Lee, E. J., Min, K. H., Hur, G. Y., Lee, S. H., Lee, S. Y., Kim, J. H., Shin, C., Shim, J. J., In, K. H., et al. (2015) · Clinical Lung Cancer · doi:10.1016/j.cllc.2015.05.006 · Cited by 74
Discriminative protection against hydroxyl and superoxide anion radicals by quercetin in human leucocytes in vitro
Wilms, L. C., Kleinjans, J. C. S., Moonen, E. J. C., & Briedé, J. J. (2007) · Toxicology in Vitro · doi:10.1016/j.tiv.2007.09.002 · Cited by 74
Anthocyanin-rich Mulberry extract inhibit the gastric cancer cell growth in vitro and xenograft mice by inducing signals of p38/p53 and c-jun
Huang, H., Chang, Y., Wu, C., Hung, C.-N., & Wang, C. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.06.035 · Cited by 74
Heterocyclic Amines: Occurrence and Prevention in Cooked Food
Robbana‐Barnat, S., Rabache, M., Rialland, E., & Fradin, J. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104280 · Cited by 74
FLAVONOID AGLYCONS IN FOODS OF PLANT ORIGIN I. VEGETABLES
Lugast, A., & Hóvári, J. (2000) · Acta Alimentaria · doi:10.1556/aalim.29.2000.4.4 · Cited by 73
The Anti-apoptotic and Anti-oxidant Effect of Eriodictyol on UV-Induced Apoptosis in Keratinocytes
Lee, E.-R., Kim, J., Kang, Y.-J., & Cho, S. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.32 · Cited by 73
Determination of Post-Harvest Biochemical Composition, Enzymatic Activities, and Oxidative Browning in 14 Apple Cultivars
Serra, S., Anthony, B. M., Sesillo, F. B., Masia, A., & Musacchi, S. (2021) · Foods · doi:10.3390/foods10010186 · Cited by 72
Cruciferous phytoalexins: antiproliferative effects in T-Jurkat leukemic cells
Pilátová, M. B., Šarišský, M., Kutschy, P., Miroššay, A., Mezencev, R., Čurillová, Z., Suchý, M., Monde, K., Mirossay, L., & Mojžíš, J. (2004) · Leukemia Research · doi:10.1016/j.leukres.2004.09.003 · Cited by 72
Onion Flesh and Onion Peel Enhance Antioxidant Status in Aged Rats
Park, J., Kim, J., & Kim, M. K. (2007) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.53.21 · Cited by 72
Modulation of N-methyl-N-amylnitrosamine-induced rat oesophageal tumourigenesis by dietary feeding of diosmin and hesperidin, both alone and in combination
Tanaka, T. (1997) · Carcinogenesis · doi:10.1093/carcin/18.4.761 · Cited by 72
Quercitrin, a bioflavonoid improves glucose homeostasis in streptozotocin‐induced diabetic tissues by altering glycolytic and gluconeogenic enzymes
Babujanarthanam, R., Kavitha, P., & Pandian, M. R. (2009) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2009.00771.x · Cited by 71
Protective and detrimental effects of kaempferol in rat H4IIE cells: Implication of oxidative stress and apoptosis
Niering, P., Michels, G., Wätjen, W., Ohler, S., Steffan, B., Chovolou, Y., Kampkötter, A., Proksch, P., & Kahl, R. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.04.004 · Cited by 71
The modulating effects of quercetin and rutin on the mitomycin C induced DNA damage
Ündeğer, Ü., DİLSİZ, S. A., Başaran, A., & Başaran, N. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2003.12.071 · Cited by 71
Quercetin Administration During Chelation Therapy Protects Arsenic-Induced Oxidative Stress in Mice
Mishra, D., & Flora, S. J. S. (2008) · Biological Trace Element Research · doi:10.1007/s12011-007-8064-9 · Cited by 71
Hypolipidemic and Antioxidant Activity of Enoki Mushrooms ( Flammulina velutipes )
Yeh, M.-Y., Ko, W.-C., & Lin, L.-Y. (2014) · BioMed Research International · doi:10.1155/2014/352385 · Cited by 71
Distribution of quercetin content in different rings of various coloured onion (Allium cepaL.) cultivars
Patil, B. S., & Pike, L. M. (1995) · Journal of Horticultural Science · doi:10.1080/14620316.1995.11515338 · Cited by 71
Geroprotective and Radioprotective Activity of Quercetin, (-)-Epicatechin, and Ibuprofen in Drosophila melanogaster
Николаевна, П. Е., Lashmanova, E., Dobrovolskaya, E., Zemskaya, N. V., Kudryavtseva, A. V., Shaposhnikov, M. V., & Moskalev, A. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00505 · Cited by 71
Alcohol in the Mediterranean diet
Rimm, E. B., & Ellison, R. C. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.6.1378s · Cited by 71
Effect of mangiferin on radiation-induced micronucleus formation in cultured human peripheral blood lymphocytes
Jagetia, G. C., & Venkatesha, V. A. (2005) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20124 · Cited by 70
Anticancer Activity Test for Extracts of Sarang Semut Plant (Myrmecodya pendens) to HeLa and MCM-B2 Cells
Soeksmanto, A., Subroto, M. A., Wijaya, H., & Simanjunta, P. (2010) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2010.148.151 · Cited by 70
Antiproliferative activity of pentadeca-(8E, 13Z) dien-11-yn-2-one and (E)-1,8-pentadecadiene from Echinacea pallida (Nutt.) Nutt. roots
Yağlıoğlu, A. Ş., Akdulum, B., Erenler, R., Demirtaş, İ., Telci̇, İ., & Teki̇n, Ş. (2012) · Medicinal Chemistry Research · doi:10.1007/s00044-012-0297-2 · Cited by 70
Intact Anthocyanins and Metabolites in Rat Urine and Plasma After 3 Months of Anthocyanin Supplementation
He, J., Magnuson, B. A., Lala, G., Tian, Q., Schwartz, S. J., & Giusti, M. M. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5401_2 · Cited by 71
Intracellular Accumulation of Ascorbic Acid Is Inhibited by Flavonoids via Blocking of Dehydroascorbic Acid and Ascorbic Acid Uptakes in HL-60, U937 and Jurkat Cells
Park, J. B., & Levine, M. (2000) · Journal of Nutrition · doi:10.1093/jn/130.5.1297 · Cited by 69
Urinary metabolites of flavonoids and hydroxycinnamic acids in humans after application of a crude extract from Equisetum arvense
Graefe, E. U., & Veit, M. (1999) · Phytomedicine · doi:10.1016/s0944-7113(99)80015-4 · Cited by 69
Tea catechins modulate the glucose transport system in 3T3-L1 adipocytes
Ueda, M., Furuyashiki, T., Yamada, K., Aoki, Y., Sakane, I., Fukuda, I., Yoshida, K., & Ashida, H. (2010) · Food & Function · doi:10.1039/c0fo00105h · Cited by 69
The inhibition by flavonoids of 2-amino-3-methylimidazo[4,5-f]quinoline metabolic activation to a mutagen: a structure–activity relationship study
Edenharder, R., Rauscher, R., & Platt, K. L. (1997) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00085-7 · Cited by 69
Inhibitions of protein kinase C and proto-oncogene expressions in NIH 3t3 cells by apigenin
Huang, Y.-T., Kuo, M., Liu, J.-Y., Huang, S.-Y., & Lin, J. (1996) · European Journal of Cancer · doi:10.1016/0959-8049(95)00540-4 · Cited by 69
Influence of preharvest and postharvest methyl jasmonate treatments on flavonoid content and metabolomic enzymes in red raspberry
Flores, G., & del Castillo, M. L. R. (2014) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2014.06.009 · Cited by 68
Cyanidin suppresses ultraviolet B-induced COX-2 expression in epidermal cells by targeting MKK4, MEK1, and Raf-1
Kim, J., Kwon, J. Y., Seo, S. K., Son, J. E., Jung, S. K., Min, S. Y., Hwang, M. K., Heo, Y., Lee, K. W., & Lee, H. J. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.01.008 · Cited by 68
New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals:In VitroandIn VivoStudies and the Underlying Mechanisms
Singh, M., Suman, S., & Shukla, Y. (2014) · BioMed Research International · doi:10.1155/2014/243452 · Cited by 68
An Essential Difference between the Flavonoids MonoHER and Quercetin in Their Interplay with the Endogenous Antioxidant Network
Jacobs, H., Moalin, M., Bast, A., van der Vijgh, W. J. F., & Haenen, G. R. M. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013880 · Cited by 67
Specific localization of quercetin-3-O-glucuronide in human brain
Ishisaka, A., Mukai, R., Terao, J., Shibata, N., & Kawai, Y. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.025 · Cited by 67
Protective effect of rutin, a polyphenolic flavonoid against haloperidol‐induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes
Bishnoi, M., Chopra, K., & Kulkarni, S. K. (2007) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2007.00512.x · Cited by 67
Phenols, Flavors, and the Mediterranean Diet
Issaoui, M., Delgado, A. M., Caruso, G., Micali, M., Barbera, M., Atrous, H., Ouslati, A., & Chammem, N. (2020) · Journal of AOAC International · doi:10.1093/jaocint/qsz018 · Cited by 67
FLAVONOIDS: DIETARY OCCURRENCE AND HEALTH BENEFITS
Tanwar, B., & Modgil, R. (2012) · Spatula DD · doi:10.5455/spatula.20120328100506 · Cited by 66
Chemical Composition and Mammary Cancer Inhibitory Activity of Dry Bean
Thompson, M. D., Brick, M. A., McGinley, J. N., & Thompson, H. J. (2009) · Crop Science · doi:10.2135/cropsci2008.04.0218 · Cited by 66
Dietary phenolics as anti-mutagens and inhibitors of tobacco-related DNA adduction in the urothelium of smokers
MALAVEILLE, C., Hautefeuille, A., Pignatelli, B., Talaska, G., Vineis, P., & Bartsch, H. (1996) · Carcinogenesis · doi:10.1093/carcin/17.10.2193 · Cited by 66
Nutraceuticals in Cardiovascular Prevention: Lessons from Studies on Endothelial Function
Zuchi, C., Ambrosio, G., Lüscher, T. F., & Landmesser, U. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00165.x · Cited by 66
Pretreatment with quercetin ameliorates lipids, lipoproteins and marker enzymes of lipid metabolism in isoproterenol treated cardiotoxic male Wistar rats
Prince, P. S. M., & Sathya, B. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.02.019 · Cited by 65
Molecular and biochemical evidence on the protective effects of quercetin in isoproterenol‐induced acute myocardial injury in rats
Kumar, M., Kasala, E. R., Bodduluru, L. N., Kumar, V., & Lahkar, M. (2016) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21832 · Cited by 65
Quercetin: Critical Evaluation as an Antileishmanial Agent In Vivo in Hamsters Using Different Vesicular Delivery Modes
Sarkar, S., Mandal, S., Sinha, J., Mukhopadhyay, S., Das, N., & Basu, M. K. (2002) · Journal of drug targeting · doi:10.1080/106118021000072681 · Cited by 64
A dietary pattern rich in lignans, quercetin and resveratrol decreases the risk of oesophageal cancer
Lin, Y., Yngve, A., Lagergren, J., & Lu, Y. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514003055 · Cited by 64
Bioavailability of quercetin in humans and the influence of food matrix comparing quercetin capsules and different apple sources
Petersen, B., Egert, S., Bosy‐Westphal, A., Müller, M. J., Wolffram, S., Hubbermann, E. M., Rimbach, G. H., & Schwarz, K. (2016) · Food Research International · doi:10.1016/j.foodres.2016.02.013 · Cited by 64
Short Photoirradiation Induces Flavonoid Synthesis and Increases Its Production in Postharvest Vegetables
Kanazawa, K., Hashimoto, T., Yoshida, S., Sungwon, P., & Fukuda, S. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300107s · Cited by 63

Authors: Hertog, M. G. L., Hollman, P. C. H., Katan, M. B., & Kromhout, D.
Affiliations: National Institute for Public Health and the Environment (NL)
ORCID: Hollman, Peter C. H.
Venue: Nutrition and Cancer
Publisher: Informa UK Limited
Published: 1993-01
Volume: 20
Issue: 1
Pages: 21-29
ISSN: 0163-5581 (ISSN-L)
1532-7914
DOI: 10.1080/01635589309514267
OpenAlex: W2153473625
Cited by: 1,216
References: 39
Citations by year: 2026: 2 · 2025: 11 · 2024: 9 · 2023: 20 · 2022: 18 · 2021: 18 · 2020: 17 · 2019: 29 · 2018: 27 · 2017: 32 · 2016: 28 · 2015: 52 · 2014: 52 · 2013: 60 · 2012: 76
FWCI: 12.72
Type: journal article
Language: en
Open access: green
research.wur.nl
Locations: Nutrition and Cancer (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: flavonoids, flavonoid intake, quercetin, kaempferol, myricetin, apigenin, luteolin, dietary antioxidants, tea, onion, apple, dietary assessment, vitamin C, dietary fiber, vitamin A, beta-carotene, vitamin E, Dutch adults
MeSH terms: Adult, Aged, Diet Surveys, Female, Flavonoids, Humans, Male, Middle Aged, Netherlands, Molecular Structure, Anticarcinogenic Agents, Flavonols

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks