Cited by 1,216Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietAntioxidant Activity and Oxidative Stress

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Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands

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Hertog, Michaël G. L., Hollman, Peter C. H., Katan, Martijn B., Kromhout, Daan·1993·Nutrition and Cancer

DOI 10.1080/01635589309514267

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Abstract

Flavonoids are strong antioxidants that occur naturally in foods and can inhibit carcinogenesis in rodents. Accurate data on population-wide intakes of flavonoids are not available. Here, using data of the Dutch National Food Consumption Survey 1987-1988, we report the intake of the potentially anticarcinogenic flavonoids quercetin, kaempferol, myricetin, apigenin, and luteolin among 4,112 adults. The flavonoid content of vegetables, fruits, and beverages was determined by high-performance liquid chromatography. In all subjects, average intake of all flavonoids combined was 23 mg/day. The most important flavonoid was the flavonol quercetin (mean intake 16 mg/day). The most important sources of flavonoids were tea (48% of total intake), onions (29%), and apples (7%). Flavonoid intake did not vary between seasons; it was not correlated with total energy intake (r = 0.001), and it was only weakly correlated with the intake of vitamin A (retinol equivalents, r = 0.14), dietary fiber (r = 0.21), and vitamin C (r = 0.26). Our use of new analytic technology suggests that in the past flavonoid intake has been overestimated fivefold. However, on a milligram-per-day basis, the intake of the antioxidant flavonoids still exceeded that of the antioxidants beta-carotene and vitamin E. Thus flavonoids represent an important source of antioxidants in the human diet.

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Beyond Cholesterol
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425
Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence.
Block, G., Patterson, B. H., & Subar, A. (1992) · Nutrition and Cancer · doi:10.1080/01635589209514201 · Cited by 3,321
Prooxidant States and Tumor Promotion
Cerutti, P. (1985) · Science · doi:10.1126/science.2981433 · Cited by 2,513
Book ReviewAmbulatory Pediatric Care
Steinberg, J. B. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200122 · Cited by 2,105
Flavonoids are scavengers of superoxide anions
Robak, J., & Gryglewski, R. J. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90169-4 · Cited by 1,579
The Flavonoids. A Class of Semi-Essential Food Components: Their Role in Human Nutrition
K�hnau, J. (2015) · World review of nutrition and dietetics · doi:10.1159/000399407 · Cited by 1,491
Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands
Hertog, M. G. L., Hollman, P. C. H., & Katan, M. (1992) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00024a011 · Cited by 1,381
Self-citation
Chemoprevention of Cancer
Wattenberg, L. W. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6754-9_2795 · Cited by 1,244
Vegetables, fruit, and cancer. I. Epidemiology
Steinmetz, K. A., & Potter, J. D. (1991) · Cancer Causes and Control · doi:10.1007/bf00051672 · Cited by 1,118
Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices
Hertog, M. G. L., Hollman, P. C. H., & van de Putte, B. (1993) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00032a015 · Cited by 899
Self-citation

Show all 39 references

Research works printed but not linked: 8

Mukhtar H, 1988, Cancer Res, 48, 2361
Verma AK, 1988, Cancer Res, 48, 5754
Wei H, 1990, Cancer Res, 50, 499
Pamucku AM, 1980, Cancer Res, 40, 3468
Hertog MGL, J Agric Food Chem.
1984, Nationwide Food Consumption Survey
1988, SAS/STAT User's Guide. Release 6.03
Balestieri, F, Flori, A and Marini, D. 1991. “Strategies for Food Quality Control and Analytical Methods in Europe”. Proc 6th Cur Conf Food Chem Lebensmittelchemische Gesellschaft. 1991, Frankfurt am Main. pp.369–378.

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Self-citation
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Anhê, F. F., Desjardins, Y., Pilon, G., Dudonné, S., Genovese, M. I., Lajolo, F. M., & Marette, A. (2013) · PharmaNutrition · doi:10.1016/j.phanu.2013.07.004 · Cited by 150
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Antioxidant properties of commercial alcoholic and nonalcoholic beverages
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Consumption of quercetin and kaempferol in free-living subjects eating a variety of diets
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Self-citation
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Veldink, J. H., Kalmijn, S., Groeneveld, G. J., Wunderink, W., Koster, A., de Vries, J. H. M., van der Luyt, J., Wokke, J. H. J., & van den Berg, L. H. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.083378 · Cited by 139
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Variation in the Quercetin Content in Different Colored Onions (Allium cepa L.)
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Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells
Cai, X., Ye, T., Liu, C., Lu, W., Lu, M., Zhang, J., Wang, M., & Cao, P. (2011) · Toxicology in Vitro · doi:10.1016/j.tiv.2011.05.009 · Cited by 137
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Cooke, D. N., Schwarz, M., Boocock, D. J., Winterhalter, P., Steward, W. P., Gescher, A. J., & Marczylo, T. H. (2006) · International Journal of Cancer · doi:10.1002/ijc.22090 · Cited by 137
The medicinal chemistry of tea
Wheeler, D. S., & Wheeler, W. J. (2004) · Drug Development Research · doi:10.1002/ddr.10341 · Cited by 137
Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention
Thomasset, S. C., Berry, D. P., Cai, H., West, K., Marczylo, T. H., Marsden, D. A., Brown, K., Dennison, A. R., Garcea, G., Miller, A. M., et al. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0201 · Cited by 136
Dietary Anthocyanins as Nutritional Therapy for Nonalcoholic Fatty Liver Disease
Valenti, L. V. C., Riso, P., Mazzocchi, A., Porrini, M., Fargion, S. R., & Agostoni, C. V. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/145421 · Cited by 136
The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells
Verbeek, R., Plomp, A. C., van Tol, E. A. F., & van Noort, J. M. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.05.012 · Cited by 136
QTL and candidate gene mapping for polyphenolic composition in apple fruit
Chagné, D., Krieger, C., Rassam, M., Sullivan, M., Fraser, J. A., André, C. M., Pindo, M., Troggio, M., Gardiner, S. E., Henry, R. A., et al. (2012) · BMC Plant Biology · doi:10.1186/1471-2229-12-12 · Cited by 135
Black Raspberry-Derived Anthocyanins Demethylate Tumor Suppressor Genes Through the Inhibition of DNMT1 and DNMT3B in Colon Cancer Cells
Wang, L., Kuo, C., Cho, S.-J., Seguin, C. M., Siddiqui, J. H., Stoner, K., Weng, Y., Huang, T. H. ‐., Tichelaar, J. W., Yearsley, M., et al. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2013.741759 · Cited by 135
Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity
Lee, K., Lee, K., Jung, S., Lee, E. J., Heo, Y., Bode, A., Lubet, R., Lee, H., & Dong, Z.-G. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.042 · Cited by 130
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats
Bishayee, A., Mbimba, T., Thoppil, R. J., Háznagy‐Radnai, E., Sipos, P., Darvesh, A. S., Folkesson, H. G., & Hohmann, J. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.09.001 · Cited by 134
Differences in dietary intakes, food sources and determinants of total flavonoids between Mediterranean and non-Mediterranean countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Zamora‐Ros, R., Knaze, V., Luján‐Barroso, L., Romieu, I., Scalbert, A., Slimani, N., Hjartåker, A., Engeset, D., Skeie, G., Overvad, K., et al. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003273 · Cited by 141
A New Database Facilitates Characterization of Flavonoid Intake, Sources, and Positive Associations with Diet Quality among US Adults ,
Sebastian, R. S., Enns, C. W., Goldman, J. D., Martin, C., Steinfeldt, L. C., Murayi, T., & Moshfegh, A. J. (2015) · Journal of Nutrition · doi:10.3945/jn.115.213025 · Cited by 133
Consumption of flavonoids in onions and black tea: lack of effect on F2-isoprostanes and autoantibodies to oxidized LDL in healthy humans
O’Reilly, J. D., Mallet, A. I., McAnlis, G. T., Young, I. S., Halliwell, B. B., Sanders, T. A. B., & Wiseman, H. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.6.1040 · Cited by 133
Inhibitory effect of albendazole and its metabolites on cytochromes P450 activities in rat and mouflon in vitro.
Baliharová, V., Velík, J., Fimanová, K., Lamka, J., Szotáková, B., Savlík, M., & Skálová, L. (2005) · PubMed · Cited by 132
Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells
Tribolo, S., Lodi, F., Connor, C., Suri, S., Wilson, V. G., Taylor, M. A., Needs, P. W., Kroon, P. A., & Hughes, D. A. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.07.040 · Cited by 131
Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver
Santi, C. D., Pietrabissa, A., Mosca, F., & Pacifici, G. M. (2000) · Xenobiotica · doi:10.1080/00498250010002487 · Cited by 131
Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries
Walda, I., Tabak, C., Smit, H., Räsänen, L., Fidanza, F., Menotti, A., Nissinen, A. M., Feskens, E. J. M., & Kromhout, D. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601370 · Cited by 131
Self-citation
The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells
Rodgers, E. H., & Grant, M. H. (1998) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(98)00092-1 · Cited by 131
Flavonoid transport across RBE4 cells: A blood-brain barrier model
Faria, A., Pestana, D., Teixeira, D., Azevedo, J., de Freitas, V. A. P., Mateus, N. F. D. C. B., & Calhau, C. (2010) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-010-0006-4 · Cited by 132
Antioxidant Properties of the Major Polyphenolic Compounds in Broccoli
Plumb, G. W., PRICE, K. R., Modes, M. J. C., & Williamson, G. (1997) · Free Radical Research · doi:10.3109/10715769709065782 · Cited by 130
Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS
Anselm, E., Chataigneau, M., NDIAYE, M., Chataigneau, T., & Schini‐Kerth, V. B. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.08.004 · Cited by 130
Falvonole, Flavone und Anthocyane als natürliche Antioxidantien der Nahrung und ihre mögliche Rolle bei der Prävention chronischer Erkrankungen
Böhm, H., Boeing, H., Hempel, J., RAAB, B., & Kroke, A. (1998) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/pl00007376 · Cited by 130
Naringin, a citrus flavonone, protects against radiation-induced chromosome damage in mouse bone marrow
Jagetia, G. C. (2003) · Mutagenesis · doi:10.1093/mutage/geg001 · Cited by 130
Age-related variations in flavonoid intake and sources in the Australian population
Johannot, L., & Somerset, S. (2006) · Public Health Nutrition · doi:10.1017/phn2006971 · Cited by 128
Food Composition Databases for Bioactive Food Components
Pennington, J. A. T. (2002) · Journal of Food Composition and Analysis · doi:10.1006/jfca.2002.1073 · Cited by 129
Simulated intestinal digestion of green and black teas
Record, I. R., & Lane, J. M. (2001) · Food Chemistry · doi:10.1016/s0308-8146(01)00131-5 · Cited by 129
Protective Effects of Grape Seed Proanthocyanidins Against Oxidative Stress Induced by Lipopolysaccharides of Periodontopathogens
Houde, V. P., Grenier, D., & Chandad, F. (2006) · Journal of Periodontology · doi:10.1902/jop.2006.050419 · Cited by 128
Dietary sources of polyphenols in the Mediterranean healthy Eating, Aging and Lifestyle (MEAL) study cohort
Godos, J., Marventano, S., Mistretta, A., Galvano, F., & Grosso, G. (2017) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2017.1285870 · Cited by 127
Anti- and prooxidant effects of chronic quercetin administration in rats
Choi, E. J., Chee, K.-M., & Lee, B. H. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.09.067 · Cited by 127
Glucuronidated Quercetin Lowers Blood Pressure in Spontaneously Hypertensive Rats via Deconjugation
Galindo, P., Rodríguez‐Gómez, I., González‐Manzano, S., Dueñas, M., Jiménez, R., Menéndez, C., Vargas, F., Tamargo, J. L., Santos‐Buelga, C., Pérez‐Vizcaíno, F., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032673 · Cited by 127
Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds
Edenharder, R., & Tang, X. (1997) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(97)00125-7 · Cited by 126
7Phytoestrogens and inhibition of angiogenesis
Fotsis, T., Pepper, M. S., Montesano, R., Aktas, E., Breit, S., Schweigerer, L., Rasku, S., Wähälä, K., & Adlercreutz, H. (1998) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(98)80009-8 · Cited by 126

Authors: Hertog, M. G. L., Hollman, P. C. H., Katan, M. B., & Kromhout, D.
Affiliations: National Institute for Public Health and the Environment (NL)
ORCID: Hollman, Peter C. H.
Venue: Nutrition and Cancer
Publisher: Informa UK Limited
Published: 1993-01
Volume: 20
Issue: 1
Pages: 21-29
ISSN: 0163-5581 (ISSN-L)
1532-7914
DOI: 10.1080/01635589309514267
OpenAlex: W2153473625
Cited by: 1,216
References: 39
Citations by year: 2026: 2 · 2025: 11 · 2024: 9 · 2023: 20 · 2022: 18 · 2021: 18 · 2020: 17 · 2019: 29 · 2018: 27 · 2017: 32 · 2016: 28 · 2015: 52 · 2014: 52 · 2013: 60 · 2012: 76
FWCI: 12.72
Type: journal article
Language: en
Open access: green
research.wur.nl
Locations: Nutrition and Cancer (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: flavonoids, flavonoid intake, quercetin, kaempferol, myricetin, apigenin, luteolin, dietary antioxidants, tea, onion, apple, dietary assessment, vitamin C, dietary fiber, vitamin A, beta-carotene, vitamin E, Dutch adults
MeSH terms: Adult, Aged, Diet Surveys, Female, Flavonoids, Humans, Male, Middle Aged, Netherlands, Molecular Structure, Anticarcinogenic Agents, Flavonols

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Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands

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