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Cited by 1,216Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands

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Hertog, Michaël G. L., Hollman, Peter C. H., Katan, Martijn B., Kromhout, Daan·1993·Nutrition and Cancer
DOI 10.1080/01635589309514267
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Abstract

Flavonoids are strong antioxidants that occur naturally in foods and can inhibit carcinogenesis in rodents. Accurate data on population-wide intakes of flavonoids are not available. Here, using data of the Dutch National Food Consumption Survey 1987-1988, we report the intake of the potentially anticarcinogenic flavonoids quercetin, kaempferol, myricetin, apigenin, and luteolin among 4,112 adults. The flavonoid content of vegetables, fruits, and beverages was determined by high-performance liquid chromatography. In all subjects, average intake of all flavonoids combined was 23 mg/day. The most important flavonoid was the flavonol quercetin (mean intake 16 mg/day). The most important sources of flavonoids were tea (48% of total intake), onions (29%), and apples (7%). Flavonoid intake did not vary between seasons; it was not correlated with total energy intake (r = 0.001), and it was only weakly correlated with the intake of vitamin A (retinol equivalents, r = 0.14), dietary fiber (r = 0.21), and vitamin C (r = 0.26). Our use of new analytic technology suggests that in the past flavonoid intake has been overestimated fivefold. However, on a milligram-per-day basis, the intake of the antioxidant flavonoids still exceeded that of the antioxidants beta-carotene and vitamin E. Thus flavonoids represent an important source of antioxidants in the human diet.

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Research works printed but not linked: 8

  1. Mukhtar H, 1988, Cancer Res, 48, 2361
  2. Verma AK, 1988, Cancer Res, 48, 5754
  3. Wei H, 1990, Cancer Res, 50, 499
  4. Pamucku AM, 1980, Cancer Res, 40, 3468
  5. Hertog MGL, J Agric Food Chem.
  6. 1984, Nationwide Food Consumption Survey
  7. 1988, SAS/STAT User's Guide. Release 6.03
  8. Balestieri, F, Flori, A and Marini, D. 1991. “Strategies for Food Quality Control and Analytical Methods in Europe”. Proc 6th Cur Conf Food Chem Lebensmittelchemische Gesellschaft. 1991, Frankfurt am Main. pp.369–378.

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Metadata

Authors
Hertog, M. G. L., Hollman, P. C. H., Katan, M. B., & Kromhout, D.
Affiliations
National Institute for Public Health and the Environment (NL)
ORCID
Hollman, Peter C. H.
Venue
Nutrition and Cancer
Publisher
Informa UK Limited
Published
1993-01
Volume
20
Issue
1
Pages
21-29
ISSN
  • 0163-5581 (ISSN-L)
  • 1532-7914
DOI
10.1080/01635589309514267
OpenAlex
W2153473625
Cited by
1,216
References
39
Citations by year
2026: 2 · 2025: 11 · 2024: 9 · 2023: 20 · 2022: 18 · 2021: 18 · 2020: 17 · 2019: 29 · 2018: 27 · 2017: 32 · 2016: 28 · 2015: 52 · 2014: 52 · 2013: 60 · 2012: 76
FWCI
12.72
Type
journal article
Language
en
Open access
Locations
  • Nutrition and Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
flavonoids, flavonoid intake, quercetin, kaempferol, myricetin, apigenin, luteolin, dietary antioxidants, tea, onion, apple, dietary assessment, vitamin C, dietary fiber, vitamin A, beta-carotene, vitamin E, Dutch adults
MeSH terms
Adult, Aged, Diet Surveys, Female, Flavonoids, Humans, Male, Middle Aged, Netherlands, Molecular Structure, Anticarcinogenic Agents, Flavonols

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