Tentative evidence for striatal hyperactivity in adolescent cannabis-using boys: a cross-sectional multicenter fMRI study
Open accessAbstract
Adolescents' risk-taking behavior has been linked to a maturational imbalance between reward ("go") and inhibitory-control ("stop")-related brain circuitry. This may drive adolescent drug-taking, such as cannabis use. In this study, we assessed the non-acute effects of adolescent cannabis use on reward-related brain function. We performed a two-site (United States and Netherlands; pooled data) functional magnetic resonance imaging (fMRI) study with a cross-sectional design. Twenty-one abstinent but frequent cannabis-using boys were compared with 24 non-using peers on reward-related brain function, using a monetary incentive delay task with fMRI. Focus was on anticipatory and response stages of reward and brain areas critically involved in reward processing like the striatum. Performance in users was normal. Region-of-interest analysis indicated striatal hyperactivity during anticipatory stages of reward in users. Intriguingly, this effect was most pronounced during non-rewarding events. Striatal hyperactivity in adolescent cannabis users may signify an overly sensitive motivational brain circuitry. Frequent cannabis use during adolescence may induce diminished ability to disengage the motivational circuit when no reward can be obtained. This could strengthen the search for reinforcements like drugs of abuse, even when facing the negative (non-rewarding) consequences.
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Across dozens of neuroimaging studies of human adolescents, alterations in ventral striatum activation have been linked to negative outcomes including drug and alcohol use, depression, anxiety, susceptibility to peer influence, and conduct and rule-breaking behaviors.
“across dozens of neuroimaging studies of human adolescents, alterations in ventral striatum activation have been linked to negative outcomes including drug and alcohol use (Jager et al., 2013), depression (Telzer et al., 2014, Silk et al., 2013), anxiety (Bar-Haim et al., 2009, Guyer et al., 2006), susceptibility to peer influence (Chein et al., 2010), and conduct and rule-breaking behaviors (Gal”
From Dopaminergic reward sensitivity can promote adolescent health: a new perspective on the mechanism of ventral striatum activation (2016) · cites this paper as Jager et al., 2013
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- Authors
- Jager, G., Block, R. I., Luijten, M., & Ramsey, N. F.
- Affiliations
- University Medical Center Utrecht (NL)
- University of Iowa (US)
- Erasmus University Rotterdam (NL)
- Corresponding author
- Block, Robert I.
- Venue
- Journal of Psychoactive Drugs
- Publisher
- Informa UK Limited
- Published
- 2013-04
- Volume
- 45
- Issue
- 2
- Pages
- 156-167
- ISSN
- 0279-1072 (ISSN-L)
- 2159-9777
- PMC
- PMC3733475
- OpenAlex
- W1998078057
- Cited by
- 66
- References
- 28
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 3 · 2022: 12 · 2021: 11 · 2020: 6 · 2019: 7 · 2018: 8 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 3
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Psychoactive Drugs (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- ZonMw (31100003)
- National Institute on Drug Abuse (R01DA019338)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- adolescent cannabis use, reward processing, monetary incentive delay task, inhibitory control, risk-taking, drug-seeking behavior, boys
- MeSH terms
- Adolescent, Adolescent Behavior, Age Factors, Basal Ganglia, Brain Mapping, Marijuana Abuse, Cross-Sectional Studies, Cues, Humans, Iowa, Magnetic Resonance Imaging, Male, Marijuana Smoking, Motivation, Netherlands, Reaction Time, Sex Factors, Task Performance and Analysis, Token Economy, Case-Control Studies, Behavior, Addictive, Young Adult
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