Cited by 300Sexual Differentiation and DisordersHypothalamic control of reproductive hormonesNeural and Behavioral Psychology Studies

Puberty-related influences on brain development

Giedd, Jay N., Clasen, Liv S., Lenroot, Rhoshel, Greenstein, Dede, Wallace, Gregory L., Ordaz, Sarah, Molloy, Elizabeth A., Blumenthal, Jonathan D. +7 more·2006·Molecular and Cellular Endocrinology

Abstract

Puberty is a time of striking changes in cognition and behavior. To indirectly assess the effects of puberty-related influences on the underlying neuroanatomy of these behavioral changes we will review and synthesize neuroimaging data from typically developing children and adolescents and from those with anomalous hormone or sex chromosome profiles. The trajectories (size by age) of brain morphometry differ between boys and girls, with girls generally reaching peak gray matter thickness 1-2 years earlier than boys. Both boys and girls with congenital adrenal hyperplasia (characterized by high levels of intrauterine testosterone), have smaller amygdala volume but the brain morphometry of girls with CAH did not otherwise significantly differ from controls. Subjects with XXY have gray matter reductions in the insula, temporal gyri, amygdala, hippocampus, and cingulate-areas consistent with the language-based learning difficulties common in this group.

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Crossref · 10.1016/j.mce.2006.04.016

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Authors
Giedd, J. N., Clasen, L. S., Lenroot, R., Greenstein, D., Wallace, G. L., Ordaz, S., Molloy, E. A., Blumenthal, J. D., Tossell, J. W., Stayer, C., Samango-Sprouse, C. A., Shen, D., Davatzikos, C., Merke, D., & Chrousos, G. P.
Affiliations
  • National Institutes of Health (US)
  • University of Pennsylvania (US)
Corresponding author
Giedd, Jay N.
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2006-07
Volume
254-255
Pages
154-162
ISSN
0303-7207 (ISSN-L)
OpenAlex
W2122741903
Cited by
300
References
55
Citations by year
2026: 3 · 2025: 2 · 2024: 11 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 13 · 2019: 11 · 2018: 45 · 2017: 6 · 2016: 21 · 2015: 11 · 2014: 23 · 2013: 28 · 2012: 20
FWCI
5.99
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
puberty, brain development, brain morphometry, gray matter thickness, sex differences, congenital adrenal hyperplasia, amygdala volume, Klinefelter syndrome, sex chromosome aneuploidy, neuroimaging
MeSH terms
Adolescent, Adrenal Hyperplasia, Congenital, Adult, Amygdala, Brain, Child, Child, Preschool, Female, Hippocampus, Humans, Klinefelter Syndrome, Male, Organ Size, Puberty

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