Lower Ventral Striatal Activation During Reward Anticipation in Adolescent Smokers
Abstract
OBJECTIVE: Adolescents are particularly vulnerable to addiction, and in the case of smoking, this often leads to long-lasting nicotine dependence. The authors investigated a possible neural mechanism underlying this vulnerability. METHOD: Functional MRI was performed during reward anticipation in 43 adolescent smokers and 43 subjects matched on age, gender, and IQ. The authors also assessed group differences in novelty seeking, impulsivity, and reward delay discounting. RESULTS: In relation to the comparison subjects, the adolescent smokers showed greater reward delay discounting and higher scores for novelty seeking. Neural responses in the ventral striatum during reward anticipation were significantly lower in the smokers than in the comparison subjects, and in the smokers this response was correlated with smoking frequency. Notably, the lower response to reward anticipation in the ventral striatum was also observed in smokers (N=14) who had smoked on fewer than 10 occasions. CONCLUSIONS: The present findings suggest that a lower response to reward anticipation in the ventral striatum may be a vulnerability factor for the development of early nicotine use.
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Attenuated motivation for non-drug rewards has been reported in younger populations at risk for substance abuse.
“Attenuated motivation for non-drug rewards has also been reported in younger populations at risk for substance abuse.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [160]
Adolescent smokers show reduced ventral striatal responses during the anticipation of food reward.
“Similarly, Peters and colleagues [160] reported reduced ventral striatal responses during the anticipation of food reward in adolescent smokers.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [160]
Several studies have examined reward systems in adolescent depression, anxiety and anxiety risk, substance use, and ADHD.
“A number of studies have already emerged, examining reward systems in different pathologies, such as depression (Forbes et al., 2010a), anxiety and risk for anxiety disorders (Guyer et al., 2012), substance use (Peters et al., 2011), and ADHD (Rubia et al., 2009) in adolescence.”
From A systematic review of fMRI reward paradigms used in studies of adolescents vs. adults: The impact of task design and implications for understanding neurodevelopment (2013) · cites this paper as Peters et al., 2011
Adolescent smokers show lower ventral striatal activation in response to reward anticipation than controls, even when they have smoked fewer than 10 occasions.
“Another IMAGEN study using the same fMRI task showed that activation of the ventral striatum in response to reward anticipation was lower in adolescent smokers compared to controls, even in subjects who had smoked less than 10 occasions, suggesting that blunted activation occurs beyond an effect that could be attributed just to nicotine exposure (Peters et al., 2011).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Peters et al., 2011
Adolescent smokers have smaller neural responses in the ventral striatum and midbrain to anticipation of financial reward compared with matched nonsmoking controls.
“Peters et al. examined neural responses to anticipation of financial reward in adolescent smokers (age 14 years)(262) and found that they had smaller neural responses in the ventral striatum and midbrain compared to matched non-smoking controls.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [262]
The reduced neural response in adolescent smokers shows a clear relationship with smoking frequency.
“Moreover, the reduced response showed a clear-cut relationship with the frequency of smoking.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [262]
Anhedonia and lower ventral striatum reward responses predict smoking initiation and escalation, and weaker reward system responsivity may raise early nicotine use and dependence severity.
“anhedonia is higher in adolescents who have smoked a cigarette in the past month compared to those who have not, suggesting that anhedonia could be involved in smoking initiation.116”
From Early life adversity and health-risk behaviors: Proposed psychological and neural mechanisms (2018) · cites this paper as [117]
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- Authors
- Peters, J., Bromberg, U., Schneider, S., Brassen, S., Menz, M., Banaschewski, T., Conrod, P. J., Flor, H., Gallinat, J., Garavan, H., Heinz, A., Itterman, B., Lathrop, M., Martinot, J.-L., Paus, T., Poline, J.-B., Robbins, T. W., Rietschel, M., Smolka, M., Ströhle, A., Struve, M., Loth, E., Schumann, G., Büchel, C., & IMAGEN Consortium
- Affiliations
- Central Institute of Mental Health (DE)
- Bristol-Myers Squibb (United States) (US)
- From the Department of Systems Neuroscience, Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany; the Department of Child and Adolescent Psychiatry, the Department of Genetic Epidemiology in Psychiatry, and the Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Germany; the Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité—Universitaetsmedizin Berlin; the Physikalisch-Technische Bundesanstalt, Berlin; the Department of Psychiatry...
- King's College London (GB)
- ORCID
- Peters, Jan
- Bromberg, Uli
- Schneider, Sophia
- Brassen, Stefanie
- Menz, Mareike
- Banaschewski, Tobias
- Conrod, Patricia J.
- Flor, Herta
- Garavan, Hugh
- Heinz, Andreas
- Lathrop, Mark
- Martinot, Jean-Luc
- Poline, Jean-Baptiste
- Robbins, Trevor W.
- Rietschel, Marcella
- Smolka, Michael
- Ströhle, Andreas
- Struve, Maren
- Loth, Eva
- Büchel, Christian
- Venue
- American Journal of Psychiatry
- Published
- 2011-05
- Volume
- 168
- Issue
- 5
- Pages
- 540-549
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2071245860
- Cited by
- 218
- References
- 33
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 4 · 2023: 9 · 2022: 4 · 2021: 9 · 2020: 13 · 2019: 16 · 2018: 6 · 2017: 13 · 2016: 27 · 2015: 17 · 2014: 34 · 2013: 36 · 2012: 17
- FWCI
- 20.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- adolescent smoking, nicotine dependence, reward anticipation, ventral striatum, novelty seeking, impulsivity, delay discounting, addiction vulnerability, smoking frequency
- MeSH terms
- Adolescent, Basal Ganglia, Marijuana Abuse, Exploratory Behavior, Female, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Personality Assessment, Reward, Smoking, Case-Control Studies, Anticipation, Psychological
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