The DOI matches its Crossref record; 250 of the 250 references it cites were found in a registry or an index.
The Aldo-Keto Reductase Superfamily and its Role in Drug Metabolism and Detoxification
Open accessAbstract
The aldo-keto reductase (AKR) superfamily comprises enzymes that catalyze redox transformations involved in biosynthesis, intermediary metabolism, and detoxification. Substrates of AKRs include glucose, steroids, glycosylation end-products, lipid peroxidation products, and environmental pollutants. These proteins adopt a (beta/alpha)(8) barrel structural motif interrupted by a number of extraneous loops and helixes that vary between proteins and bring structural identity to individual families. The human AKR family differs from the rodent families. Due to their broad substrate specificity, AKRs play an important role in the phase II detoxification of a large number of pharmaceuticals, drugs, and xenobiotics.
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Cites
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Farahyar, S., Zaini, F., Kordbacheh, P., Rezaie, S., Safara, M., Raoofian, R., & Heidari, M. (2013) · DARU Journal of Pharmaceutical Sciences · doi:10.1186/2008-2231-21-1 · Cited by 125
Metadata
- Authors
- Barski, O. A., Tipparaju, S. M., & Bhatnagar, A.
- Venue
- Drug Metabolism Reviews
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 40
- Issue
- 4
- Pages
- 553-624
- ISSN
- 0360-2532 (ISSN-L)
- 1097-9883
- OpenAlex
- W2138393164
- Cited by
- 542
- References
- 250
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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