Ginkgo biloba leaves extract’s cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation
Abstract
BACKGROUND: (GB) leaves extract is known to possess potent antioxidants and other bioactivities such as improved skin conditions and rejuvenation. OBJECTIVE: This study aimed to develop a cosmeceutical preparation to utilize the strong antioxidant potential of GB leaves as part of the skincare formulation. METHODS: Cream incorporated GB (GBC) was prepared by mixing the obtained extract with stearic acid-sodium hydroxide components in an emulsion format. The obtained GBC was characterized for GB contents, uniformity, pH, compatibility, stability, and skin's human application. RESULTS: A homogeneous, physically, and chemically stable, with pH near the skin pH and shiny cream, was obtained. The prepared cream was easy to rub and pearly in appearance. It was effective and safe during the two-week trial conducted on human volunteers according to clinical trial registry protocols. The cream scavenged free radicals in DPPH assay tests. The cream incorporated GB made the skin more spirited and tauter. Furthermore, the wrinkles were reduced and the skin was renewed vigor. CONCLUSION: The GBC worked at the topical level and provided benefits when applied daily for the trial duration. The formulation also provided visually observable anti-wrinkle effects on the skin, with visible improvements in the skin's shape and texture. The prepared cream can be used to rejuvenate the skin.
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Abdellatif et al. study on Ginkgo biloba leaf extract was classified as Level D evidence and had methodological flaws including small sample size, absence of a control group, and failure to address adverse effects.
“According to the Oxford evidence hierarchy, this study would be classified as level D evidence, which relies on expert opinion or observational studies with a high risk of bias.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [9]
Cites
Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378 · see citing works
Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion
Shimada, K., Fujikawa, K., Yahara, K., & Nakamura, T. (1992) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00018a005 · Cited by 3,208 · see citing works
Do, Q.-D., Angkawijaya, A. E., Tran‐Nguyen, P. L., Huynh, L. H., Soetaredjo, F. E., Ismadji, S., & Ju, Y. (2013) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2013.11.001 · Cited by 1,920 · see citing works
Kleijnen, J., & Knipschild, P. G. (1992) · The Lancet · doi:10.1016/0140-6736(92)93158-j · Cited by 464 · see citing works
Natural phenolics in the prevention of UV-induced skin damage. A review
Svobodová, A. R., Psotová, J., & Daniela Walterová, B. (2003) · Biomedical Papers · doi:10.5507/bp.2003.019 · Cited by 452 · see citing works
Ginkgo BilobaLeave Extract: Biological, Medicinal, and Toxicological Effects
Chan, P., Xia, Q., & Fu, P. P. (2007) · Journal of Environmental Science and Health Part C · doi:10.1080/10590500701569414 · Cited by 286 · see citing works
Smith, P. F., Maclennan, K., & Darlington, C. L. (1996) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(96)01379-7 · Cited by 262 · see citing works
Ghanbarzadeh, S., & Arami, S. (2013) · BioMed Research International · doi:10.1155/2013/616810 · Cited by 207 · see citing works
Sastre, J., Millan, A., de la Asunción, J. G., Plá, R. C. I., Juan, G., Pallardó, F. V., O’Connor, E., Martín, J. A., Droy‐Lefaix, M., & Viña, J. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00228-1 · Cited by 206 · see citing works
Liu, X., Hao, W., Qin, Y., Decker, Y., Wang, X., Burkart, M., Schötz, K., Menger, M. D., Fassbender, K., & Liu, Y. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.01.011 · Cited by 149 · see citing works
Ginkgo Biloba Leaf Extract: Review of Biological Actions and Clinical Applications
Yoshikawa, T., Naito, Y., & Kondo, M. (1999) · Antioxidants and Redox Signaling · doi:10.1089/ars.1999.1.4-469 · Cited by 147 · see citing works
Phospholipids affect stratum corneum lipid bilayer fluidity and drug partitioning into the bilayers
Kirjavainen, M., Mönkkönen, J., Saukkosaari, M., Valjakka-Koskela, R., Kiesvaara, J., & Urtti, A. O. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00152-7 · Cited by 145 · see citing works
Shim, S. H., Kim, J. M., Choi, C. Y., et al. (2012) · Journal of Medicinal Food · doi:10.1089/jmf.2012.2241 · Cited by 140 · see citing works
Woelk, H., Arnoldt, K., Kieser, M., & Hoerr, R. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.05.004 · Cited by 120 · see citing works
An overview of in vitro dissolution/release methods for novel mucosal drug delivery systems
Jug, M., Hafner, A., Lovrić, J., Kregar, M. L., Pepić, I., Vanić, Ž., Cetina‐Čižmek, B., & Filipović‐Grčić, J. (2017) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2017.06.072 · Cited by 112 · see citing works
Transfersomal Nanoparticles for Enhanced Transdermal Delivery of Clindamycin
Abdellatif, A. A. H., & Tawfeek, H. M. (2015) · AAPS PharmSciTech · doi:10.1208/s12249-015-0441-7 · Cited by 102 · see citing works
Self-citationGargouri, B., Carstensen, J., Bhatia, H. S., Hüell, M., Dietz, G. P. H., & Fiebich, B. L. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.04.009 · Cited by 97 · see citing works
Clinical efficacy comparison of anti-wrinkle cosmetics containing herbal flavonoids
Chuarienthong, P., Lourith, N., & Leelapornpisid, P. (2010) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2010.00522.x · Cited by 95 · see citing works
Antioxidant properties evaluation of topical astaxanthin formulations as anti‐aging products
Eren, B., Tanrıverdi, S. T., Köse, F. A., & Özer, Ö. (2018) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12665 · Cited by 94 · see citing works
Kotakadi, V. S., Yu, J. H., Hofseth, A. B., Ying, L., Cui, X., Volate, S. R., Chumanevich, A. A., Wood, P. A., Price, R. L., McNeal, A., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn143 · Cited by 93 · see citing works
Belo, S. E. D., Gaspar, L. R., Campos, P. M. B. G. M., & Marty, J.-P. (2009) · Skin Pharmacology and Physiology · doi:10.1159/000241299 · Cited by 87 · see citing works
Molecular Mechanisms Involved in the Aging of the T-cell Immune Response
Moro‐García, M. A., Alonso‐Arias, R., & López‐Larrea, C. (2012) · Current Genomics · doi:10.2174/138920212803759749 · Cited by 85 · see citing works
Mohammed, H. A., Qureshi, K. A., Ali, H. M., Al-Omar, M. S., Khan, O. F., & Mohammed, S. A. A. (2022) · Antioxidants · doi:10.3390/antiox11020332 · Cited by 83 · see citing works
Self-citationRažná, K., Sawinska, Z., Ivanišová, E., Vuković, N. L., Terentjeva, M., Stričík, M., Kowalczewski, P. Ł., Hlavačková, L., Rovná, K., Žiarovská, J., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093087 · Cited by 79 · see citing works
Biologically Active Secondary Metabolites from Ginkgo biloba
Bedіr, E., Tatlı, I. İ., Khan, R. A., Zhao, J., Takamatsu, S., Walker, L., Goldman, P., & Khan, I. A. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf011682s · Cited by 74 · see citing works
Self-citationHibatallah, J., Carduner, C., & Poelman, M.-C. (1999) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357991777083 · Cited by 74 · see citing works
Environmental effects and skin disease
English, J., Dawe, R., & Ferguson, J. (2003) · British Medical Bulletin · doi:10.1093/bmb/ldg026 · Cited by 73 · see citing works
Tampucci, S., Guazzelli, L., Burgalassi, S., Carpi, S., Chetoni, P., Mezzetta, A., Nieri, P., Polini, B., Pomelli, C. S., Terreni, E., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111078 · Cited by 73 · see citing works
&NA; (2003) · Drugs in R&D · doi:10.2165/00126839-200304030-00009 · Cited by 68 · see citing works
Kim, Y. S., Pyo, M. K., Park, K. M., Park, P. H., Hahn, B.-S., Wu, S. J., & Yun‐Choi, H. S. (1998) · Thrombosis Research · doi:10.1016/s0049-3848(98)00075-9 · Cited by 66 · see citing works
Inhibitory effect of Ginkgo biloba extract on human platelet aggregation
Dutta-Roy, M. J. G. A. K. (1999) · Platelets · doi:10.1080/09537109975933 · Cited by 62 · see citing works
Qureshi, K. A., Mohammed, S. A. A., Khan, O. F., Ali, H. M., El-Readi, M. Z., & Mohammed, H. A. (2022) · Molecules · doi:10.3390/molecules27165225 · Cited by 62 · see citing works
Self-citationHeinonen, T., & Gaus, W. (2014) · Toxicology · doi:10.1016/j.tox.2014.10.013 · Cited by 58 · see citing works
Marcilhac, A., Dakine, N., Bourhim, N., Guillaume, V., Grino, M., Drieu, K., & Oliver, C. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00214-8 · Cited by 58 · see citing works
Spiegel, R., Kalla, R., Mantokoudis, G., Maire, R., Mueller, H., Hoerr, R., & Ihl, R. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s157877 · Cited by 55 · see citing works
Tawfeek, H. M., Abdellatif, A. A. H., Dennison, T. J., et al. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.08.069 · Cited by 53 · see citing works
Self-citationAnthocyanins rich pomegranate cream as a topical formulation with anti-aging activity
Abdellatif, A. A. H., Alawadh, S. H., Bouazzaoui, A., Alhowail, A. H., & Mohammed, H. A. (2020) · Journal of Dermatological Treatment · doi:10.1080/09546634.2020.1721418 · Cited by 46 · see citing works
Self-citationAbdellatif, A. A. H., Aldosari, B. N., Al-Subaiyel, A., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010022 · Cited by 43 · see citing works
Self-citationMohammed, H. A., Mohammed, S. A. A., Khan, O. F., & Ali, H. M. (2022) · Journal of Oleo Science · doi:10.5650/jos.ess22214 · Cited by 40 · see citing works
Self-citationHerbals in the control of ageing
Kapoor, V. K., Dureja, J., & Chadha, R. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2009.06.014 · Cited by 38 · see citing works
Anti‐Aging Data and Support Claims – Consensus Statement
Elsner, P. L., Fluhr, J. W., Gehring, W., Kerscher, M. J., Krutmann, J., Lademann, J. M., Makrantonaki, E., Wilhelm, K., & Zouboulis, C. C. (2011) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0379.2011.07746.x · Cited by 35 · see citing works
Park, Y. J., Ahn, H. Y., Kim, H. R., Chung, K. H., & Oh, S. M. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.12.007 · Cited by 35 · see citing works
In vitro anti-aging activities of ginkgo biloba leaf extract and its chemical constituents
Wang, X., Gong, X., Zhang, H., Zhu, W., JIANG, Z., Shi, Y., & Li, L. (2020) · Food Science and Technology · doi:10.1590/fst.02219 · Cited by 34 · see citing works
Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba
Fransen, H. P., Pelgrom, S. M. G. J., Stewart-Knox, B. J., de Kaste, D., & Verhagen, H. (2010) · Food & Nutrition Research · doi:10.3402/fnr.v54i0.5221 · Cited by 33 · see citing works
A Study of Identifying the Emulsion Type of Surfactant: Volume Balance Value
Ding-cong, W. (2002) · Journal of Colloid and Interface Science · doi:10.1006/jcis.2001.8152 · Cited by 25 · see citing works
Arıcıoğlu, A., Bozkurt, M., Balabanlı, B., Kilinç, M., NAZAROĞLU, N. K., & Türközkan, N. (2001) · Biological Trace Element Research · doi:10.1385/bter:80:2:175 · Cited by 24 · see citing works
Carneiro, R. L., & Poppi, R. J. (2013) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2013.08.104 · Cited by 23 · see citing works
Towards a unified and interdiciplinary model of ageing
Jameson, C. W. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.01.021 · Cited by 19 · see citing works
Ginkgo biloba (EGb 761) in arteriosclerosis prophylaxis
Siegel, G., Schäfer, P., Winkler, K., & Malmsten, M. (2007) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-007-0426-6 · Cited by 18 · see citing works
Onuki, Y., Machida, Y., Yokawa, T., et al. (2015) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c15-00192 · Cited by 15 · see citing works
Shukla, S., Lee, J. S., Bajpai, V. K., et al. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.04.018 · Cited by 10 · see citing works
Kim, D., Hwang, I., Ku, B., & Choi, E.-M. (2021) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-021-00088-4 · Cited by 10 · see citing works
Formulation, Optimization and Evaluation of Organogel for Topical Delivery of Acyclovir
Bonde, S., Mavani, N., & Bonde, C. G. (2017) · Current Drug Delivery · doi:10.2174/1567201814666171013150938 · Cited by 9 · see citing works
Logan, R. A., Hay, R. J., & Whitefield, M. (1987) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(87)80181-0 · Cited by 7 · see citing works
Chandrashekar, N. S., & Hiremath, S. R. R. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.656 · Cited by 7 · see citing works
Mentor, J. M., Etemadi, A. A., Patta, A. M., et al. (2015) · Dermatology Online Journal · doi:10.5070/d3214026285 · Cited by 6 · see citing works
Anti‐Aging Data and Support Claims: Consensus Statement
Schöpf, E. (2011) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0379.2011.07745.x · Cited by 5 · see citing works
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Cosmeceuticals in photoaging: A review.
Chan, L. K. W., Lee, K. W. A., Lee, C. H., Lam, K. W. P., Lee, K. F. V., Wu, R., Wan, J., Shivananjappa, S., Sky, W. T. H., Choi, H., et al. (2024) · Skin Research and Technology · doi:10.1111/srt.13730 · Cited by 23 · see citing works
- Authors
- Abdellatif, A. A. H., Mohammed, H. A., Al-Khalaf, A. M., Khan, O., Mostafa, M. A. H., Al Haidari, R. A., Taha, H. H., & Khan, R. A.
- Affiliations
- Qassim University (SA)
- Al-Azhar University (EG)
- Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Saudi Arabia
- Corresponding author
- Abdellatif, Ahmed A. H.
- Khan, Riaz A.
- Venue
- Drug Development and Industrial Pharmacy
- Publisher
- Informa UK Limited
- Published
- 2023-03-04
- Volume
- 49
- Issue
- 3
- Pages
- 281-292
- ISSN
- 0363-9045 (ISSN-L)
- 1520-5762
- OpenAlex
- W4366352649
- Cited by
- 8
- References
- 57
- Citations by year
- 2025: 4 · 2024: 4
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Development and Industrial Pharmacy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deputyship for Research and Innovation, Ministry of Education, Saudi Arabia (QU-IF-1-2-1)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Ginkgo biloba extract, cosmeceuticals, skin rejuvenation, anti-wrinkle effect, antioxidant activity, free radical scavenging, topical cream formulation, emulsion stability, skin texture
- MeSH terms
- Cosmeceuticals, Antioxidants, Humans, Plant Extracts, Rejuvenation, Skin Aging, Ginkgo biloba, Skin Cream, Healthy Volunteers
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