Cited by 152Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and Work-Related Fatigue

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Thermoregulatory effects of melatonin in relation to sleepiness

Kräuchi, Kurt, Cajochen, Christian, Pache, Mona, Flammer, Josef, Wirz‐Justice, Anna·2006·Chronobiology International

DOI 10.1080/07420520500545854

Open this paper in CoChat — free account

Abstract

Thermoregulatory processes have long been implicated in the initiation of human sleep. In this paper, we review our own studies conducted over the last decade showing a crucial role for melatonin as a mediator between the thermoregulatory and arousal system in humans. Distal heat loss, via increased skin temperature, seems to be intimately coupled with increased sleepiness and sleep induction. Exogenous melatonin administration during the day when melatonin is essentially absent mimics the endogenous thermophysiological processes occurring in the evening and induces sleepiness. Using a cold thermic challenge test, it was shown that melatonin-induced sleepiness occurs in parallel with reduction in the thermoregulatory set-point (threshold); thus, melatonin may act as a circadian modulator of the thermoregulatory set-point. In addition, an orthostatic challenge can partially block the melatonin-induced effects, suggesting an important role of the sympathetic nervous system as a link between the thermoregulatory and arousal systems. A topographical analysis of finger skin temperature with infrared thermometry revealed that the most distal parts of the fingers, i.e., fingertips, represent the important skin regions for heat loss regulation, most probably via opening the arteriovenous anastomoses, and this is clearly potentiated by melatonin. Taken together, melatonin is involved in the fine-tuning of vascular tone in selective vascular beds, as circulating melatonin levels rise and fall throughout the night. Besides the role of melatonin as "nature's soporific", it can also serve as nature's nocturnal vascular modulator.

Integrity signals

Registry

Crossref · 10.1080/07420520500545854

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Principles and Practice of Sleep Medicine
Kryger, M. H., Roth, T. G., & Dement, W. C. (2011) · Elsevier eBooks · doi:10.1016/c2009-0-59875-3 · Cited by 5,118
Fatigue, alcohol and performance impairment
Dawson, D., & Reid, K. (1997) · Nature · doi:10.1038/40775 · Cited by 1,199
Human Sleep: Its Duration and Organization Depend on Its Circadian Phase
Czeisler, C. A., Weitzman, E. D., Moore-Ede, M. C., Zimmerman, J. C., & Knauer, R. S. (1980) · Science · doi:10.1126/science.7434029 · Cited by 903
The central autonomic nervous system: conscious visceral perception and autonomic pattern generation
Saper, C. B. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.032502.111311 · Cited by 837
Principles and Practice of Sleep Medicine
Stafford, R. S. (2001) · JAMA · doi:10.1001/jama.285.8.1074 · Cited by 612
Circadian rhythm of heat production, heart rate, and skin and core temperature under unmasking conditions in men
Krauchi, K., & Wirz-Justice, A. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.267.3.r819 · Cited by 558 · cited 2×
“However, the circadian pattern of heat loss and heat production is not represented by uniform sine waves; heat loss in the evening is more dominant than reduction in heat production, and vice versa in the morning (Kräuchi and Wirz-Justice, 1994).”
Background
Neural Organization and Evolution of Thermal Regulation in Mammals
Satinoff, E. (1978) · Science · doi:10.1126/science.351802 · Cited by 512
Warm feet promote the rapid onset of sleep
Kräuchi, K., Cajochen, C., Werth, E., & Wirz-Justice, A. (1999) · Nature · doi:10.1038/43366 · Cited by 398
Self-citation
Melatonin: a major regulator of the circadian rhythm of core temperature in humans
Cagnacci, A., Elliott, J. A., & Yen, S. S. C. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.2.1639946 · Cited by 396
The dependence of onset and duration of sleep on the circadian rhythm of rectal temperature
Zulley, J., Wever, R., & Aschoff, J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00581514 · Cited by 377

Show all 40 references

Research works printed but not linked: 11

Brown C. C, 1979, Waking Sleeping, 3, 353
Cagnacci A., 1992, J. Clin. Endocrinol. Metab., 75, 447
Dubocovich M., 2000, Melatonin After Four DecadesKluwer Academic Edition, 181
Grant R. T., 1931, Heart, 15, 385
Hales J. R.S, 1985, Cardiovascular Shunts. Alfred Benzon Symposium 21, 433
Kräuchi K., 1994, Am. J. Physiol., 267, R819
Kräuchi K., 1997, Sleep Res., 26, 79
Kräuchi K., 1999, Sleep, 22, 285
Kräuchi K., 2000, Am. J. Physiol., 278, R741
Kräuchi K., 2002, Chronobiol. Int., 19, 993
Szymusiak R., 2001, Arch. Ital. Biol., 139, 77

Sorted by citations

Melatonin: A Multitasking Molecule
Reiter, R. J., Tan, D. X., & Fuentes‐Broto, L. (2010) · Progress in brain research · doi:10.1016/s0079-6123(08)81008-4 · Cited by 642
Functional roles of melatonin in plants, and perspectives in nutritional and agricultural science
Tan, D. X., Hardeland, R., Manchester, L. C., Korkmaz, A., Ma, S., Rosales‐Corral, S., & Reiter, R. J. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/err256 · Cited by 627
A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases
Stehle, J. H., Saade, A., Rawashdeh, O., Ackermann, K., Jilg, A., Sebesteny, T., & Maronde, E. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00856.x · Cited by 405
Biological Rhythm and Chronotype: New Perspectives in Health
Montaruli, A., Castelli, L., Mulè, A., Scurati, R., Esposito, F., Galasso, L., & Roveda, E. (2021) · Biomolecules · doi:10.3390/biom11040487 · Cited by 400
Physiology and pharmacology of melatonin in relation to biological rhythms
Zawilska, J. B., Skene, D. J., & Arendt, J. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70081-7 · Cited by 348
The primary vascular dysregulation syndrome: implications for eye diseases
Flammer, J., Konieczka, K., & Flammer, A. J. (2013) · The EPMA Journal · doi:10.1186/1878-5085-4-14 · Cited by 320
Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions
Slominski, A. T., Hardeland, R., Zmijewski, M. A., Slominski, R. M., Reiter, R. J., & Paus, R. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.10.025 · Cited by 314
The Temperature Dependence of Sleep
Harding, E. C., Franks, N. P., & Wisden, W. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00336 · Cited by 261
“Under natural conditions, increased circulating melatonin also coincides with declining core temperature prior to sleep onset (Krauchi et al., 1997; Krauchi et al., 2006; Logan and McClung, 2019).”
Background
Circadian mechanisms of 24-hour blood pressure regulation and patterning
Smolensky, M. H., Hermida, R. C., & Portaluppi, F. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.02.003 · Cited by 237
A review of signals used in sleep analysis
Roebuck, A., Monasterio, V., Gederi, E., Osipov, M., Behar, J. A., Malhotra, A., Penzel, T., & Clifford, G. D. (2013) · Physiological Measurement · doi:10.1088/0967-3334/35/1/r1 · Cited by 234
Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair
Fischer, T. W., Slominski, A. T., Zmijewski, M. A., Reiter, R. J., & Paus, R. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00767.x · Cited by 192
Role of the Melatonin System in the Control of Sleep
Pandi-Perumal, S. R., Srinivasan, V., Spence, D. W., & Cardinali, D. P. (2007) · CNS Drugs · doi:10.2165/00023210-200721120-00004 · Cited by 180
The human sleep–wake cycle reconsidered from a thermoregulatory point of view
Kräuchi, K. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.09.005 · Cited by 173
Worldwide melatonin research: a bibliometric analysis of the published literature between 2015 and 2019
Zakaria, R., Ahmi, A., Ahmad, A. H., & Othman, Z. (2020) · Chronobiology International · doi:10.1080/07420528.2020.1838534 · Cited by 168
The interrelationship between sleep regulation and thermoregulation
Krauchi, K. (2010) · Frontiers in bioscience · doi:10.2741/3636 · Cited by 156
Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations
Huelsmann, M., Hecker, N., Springer, M. S., Gatesy, J., Sharma, V., & Hiller, M. (2019) · Science Advances · doi:10.1126/sciadv.aaw6671 · Cited by 161
The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature
Costello, R. B., Lentino, C. V., Boyd, C. C., O’Connell, M. L., Crawford, C. C., Sprengel, M. L., & Deuster, P. A. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-106 · Cited by 134
Repeated Melatonin Supplementation Improves Sleep in Hypertensive Patients Treated with Beta-Blockers: A Randomized Controlled Trial
Scheer, F. A. J. L., Morris, C. J., Garcia, J. I., Smales, C., Kelly, E. E., Marks, J., Malhotra, A., & Shea, S. A. (2012) · SLEEP · doi:10.5665/sleep.2122 · Cited by 119
Sleep and autonomic nervous system
Zoccoli, G., & Amici, R. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.01.002 · Cited by 116
Perspectives in affective disorders: Clocks and sleep
Wirz‐Justice, A., & Benedetti, F. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14362 · Cited by 111
The influence of light on thermal responses
te Kulve, M., Schellen, L., Schlangen, L. J. M., & van Marken Lichtenbelt, W. D. (2016) · Acta Physiologica · doi:10.1111/apha.12552 · Cited by 105
On the interaction between lighting and thermal comfort: An integrated approach to IEQ
Bellia, L., Alfano, F. R. D., Fragliasso, F., Palella, B. I., & Riccio, G. (2020) · Energy and Buildings · doi:10.1016/j.enbuild.2020.110570 · Cited by 112
Circadian Rhythms, Melatonin and Depression
A. Quera Salva, M., Hartley, S., Barbot, F., C. Alvarez, J., Lofaso, F., & Guilleminault, C. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211796197188 · Cited by 100
The discovery of the Flammer syndrome: a historical and personal perspective
Flammer, J., & Konieczka, K. (2017) · The EPMA Journal · doi:10.1007/s13167-017-0090-x · Cited by 90
Evening Alcohol Suppresses Salivary Melatonin in Young Adults
Rupp, T. L., Acebo, C., & Carskadon, M. A. (2007) · Chronobiology International · doi:10.1080/07420520701420675 · Cited by 81
Daytime melatonin and light independently affect human alertness and body temperature
Lok, R., van Koningsveld, M. J., Gordijn, M. C. M., Beersma, D. G. M., & Hut, R. A. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12583 · Cited by 81
Nocturnal melatonin plasma levels in patients with OSAS: the effect of CPAP
Hernández, C., Abreu, J., Abreu, P. M., Castro, A., & Jiménez, A. (2007) · European Respiratory Journal · doi:10.1183/09031936.00051906 · Cited by 76
Circadian profiles in young people during the early stages of affective disorder
Naismith, S. L., Hermens, D. F., Ip, T. K. C., Bolitho, S., Scott, E. M., Rogers, N. L., & Hickie, I. B. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.47 · Cited by 72
Jet lag syndrome: circadian organization, pathophysiology, and management strategies
Avidan, A. Y., & Colwell, C. S. (2010) · Nature and Science of Sleep · doi:10.2147/nss.s6683 · Cited by 67
Eat, Train, Sleep—Retreat? Hormonal Interactions of Intermittent Fasting, Exercise and Circadian Rhythm
Haupt, S., Eckstein, M. L., Wolf, A., Zimmer, R. T., Wachsmuth, N. B., & Moser, O. (2021) · Biomolecules · doi:10.3390/biom11040516 · Cited by 75
Preliminary Results: The Impact of Smartphone Use and Short-Wavelength Light during the Evening on Circadian Rhythm, Sleep and Alertness
Höhn, C., Schmid, S. R., Plamberger, C. P., Bothe, K., Angerer, M., Gruber, G., Pletzer, B., & Hoedlmoser, K. (2021) · Clocks & Sleep · doi:10.3390/clockssleep3010005 · Cited by 61
“As melatonin is known to initiate heat loss by distal vasodilation of the vessels [27,52], our findings of a higher DPG, indicating a stronger heat loss, around the middle of the night (i.”
Background
The impact of morning light intensity and environmental temperature on body temperatures and alertness
Kulve, M. T., Schlangen, L. J. M., Schellen, L., Frijns, A. A., & Lichtenbelt, W. D. V. M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.043 · Cited by 69
Optimizing the Time and Dose of Melatonin as a Sleep‐Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose−Response Meta‐Analysis
Sanabria, F. C., Bruno, S., Crippa, A., Frumento, P., Scarselli, M., Skene, D. J., & Faraguna, U. (2024) · Journal of Pineal Research · doi:10.1111/jpi.12985 · Cited by 63
Short-wavelength attenuated polychromatic white light during work at night: limited melatonin suppression without substantial decline of alertness
van de Werken, M., Giménez, M. C., de Vries, B., Beersma, D. G. M., & Gordijn, M. C. M. (2013) · Chronobiology International · doi:10.3109/07420528.2013.773440 · Cited by 59
Effects of feet warming using bed socks on sleep quality and thermoregulatory responses in a cool environment
Ko, Y., & Lee, J. (2018) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-018-0172-z · Cited by 51
Melatonin and Tryptophan Affect the Activity-Rest Rhythm, Core and Peripheral Temperatures, and Interleukin Levels in the Ringdove: Changes With Age
Paredes, S. D., Marchena, A. M., Bejarano, I., Espino, J., Barriga, C., Rial, R. V., Reiter, R. J., & Rodríguez, A. B. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln054 · Cited by 50
Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease
Rigat, L., Ouk, K., Kramer, A., & Priller, J. (2023) · Acta Physiologica · doi:10.1111/apha.13970 · Cited by 50
Effects of the Melatonin MT-1/MT-2 Agonist Ramelteon on Daytime Body Temperature and Sleep
Markwald, R. R., Lee-Chiong, T. L., Burke, T. M., Snider, J. A., & Wright, K. P. (2010) · SLEEP · doi:10.1093/sleep/33.6.825 · Cited by 47
Wrist Skin Temperature, Motor Activity, and Body Position as Determinants of the Circadian Pattern of Blood Pressure
Blazquez, A., Martínez-Nicolás, A., Salazar, F. J., Rol, M. A., & Madrid, J. A. (2012) · Chronobiology International · doi:10.3109/07420528.2012.679328 · Cited by 47
Circadian Disruption and Psychiatric Disorders: The Importance of Entrainment
Wirz‐Justice, A., Bromundt, V., & Cajochen, C. (2009) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2009.01.008 · Cited by 45
Skin Temperature Rhythms in Humans Respond to Changes in the Timing of Sleep and Light
Cuesta, M., Boudreau, P., Cermakian, N., & Boivin, D. B. (2017) · Journal of Biological Rhythms · doi:10.1177/0748730417702974 · Cited by 44
Melatonin and the Skin: Current Progress and Perspectives for Human Health
Slominski, A. T., Kim, T., Janjetović, Z., Slominski, R. M., Ganguli‐Indra, G., Athar, M., Indra, A. K., Reiter, R. J., & Kleszczyński, K. (2025) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.11.012 · Cited by 46
A review of subjective evaluation, physiological indicators and cognitive performance in indoor light environment: The role of illuminance and correlated color temperature
Liu, C., Li, J., Wang, X., Zang, Q., Wang, W., & Gao, W. (2024) · Journal of Building Engineering · doi:10.1016/j.jobe.2024.110224 · Cited by 42
The Effect of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Randomized, Placebo-Controlled Trial
Gögenür, I., Kücükakin, B., Bisgaard, T., Kristiansen, V. B., Hjortsø, N.-C., Skene, D. J., & Rosenberg, J. (2009) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31819a6cf0 · Cited by 40
Effects of phased sleeping thermal environment regulation on human thermal comfort and sleep quality
Song, C., Zhao, T., Song, Z., & Liu, Y. (2020) · Building and Environment · doi:10.1016/j.buildenv.2020.107108 · Cited by 39
THERMOREGULATORY EFFECT IN HUMANS OF SUPPRESSED ENDOGENOUS MELATONIN BY PRE-SLEEP BRIGHT-LIGHT EXPOSURE IN A COLD ENVIRONMENT
Ishibashi, K., Arikura, S., Kozaki, T., Higuchi, S., & Yasukouchi, A. (2010) · Chronobiology International · doi:10.3109/07420521003794069 · Cited by 37
Alterations in diurnal rhythmicity in patients treated for nonfunctioning pituitary macroadenoma: a controlled study and literature review
Joustra, S. D., Thijs, R. D., van den Berg, R., van Dijk, M., Pereira, A. M., Lammers, G. J., Someren, E. J. W. V., Romijn, J. A., & Biermasz, N. R. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0172 · Cited by 37
The Singularity of Cetacea Behavior Parallels the Complete Inactivation of Melatonin Gene Modules
Lopes‐Marques, M., Ruivo, R., Alves, L. Q., Sousa, N., Machado, A. M., & Castro, L. F. C. (2019) · Genes · doi:10.3390/genes10020121 · Cited by 34
Exogenous melatonin administration modifies cutaneous vasoconstrictor response to whole body skin cooling in humans
Aoki, K., Zhao, K., Yamazaki, F., Sone, R., Alvarez, G. E., Kosiba, W. A., & Johnson, J. M. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00501.x · Cited by 32
Ocular and Systemic Factors Associated with Glaucoma
Bhartiya, S., Sharma, N., Verma, S. M., Dada, T., Gagrani, M., Chauhan, N., & Satpute, K. (2023) · JOURNAL OF CURRENT GLAUCOMA PRACTICE · doi:10.5005/jp-journals-10078-1383 · Cited by 38
What do we really know about the safety and efficacy of melatonin for sleep disorders?
Kennaway, D. J. (2021) · Current Medical Research and Opinion · doi:10.1080/03007995.2021.2000714 · Cited by 33
Body Temperature, Sleep, and Hibernation
Kräuchi, K., & Boer, T. D. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6645-3.00028-1 · Cited by 31
Effects of different sleep restriction protocols on sleep architecture and daytime vigilance in healthy men
Wu, H., Stone, W., Hsi, X., Zhuang, J., Huang, L., Yin, Y., Zhang, L., & Zhao, Z. (2010) · Physiological Research · doi:10.33549/physiolres.931895 · Cited by 30
Chronobiological characterization of women with primary vasospastic syndrome: body heat loss capacity in relation to sleep initiation and phase of entrainment
Vollenweider, S., Wirz‐Justice, A., Flammer, J., Orgül, S., & Kräuchi, K. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00609.2007 · Cited by 29
Treatment of Early‐Onset Specified and Unspecified Bipolar Disorders: A Systematic Review and Strategies for Identifying and Managing a Thermally Dysregulated Subtype in Children
Papolos, D. F., Teicher, M. H., & Post, R. M. (2025) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13817 · Cited by 31
Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle
López-Canul, M., Min, S. H., Posa, L., Gregorio, D. D., Bedini, A., Spadoni, G., Gobbi, G., & Comai, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102452 · Cited by 31
Drugs Used in Circadian Sleep-Wake Rhythm Disturbances
Burgess, H. J., & Emens, J. S. (2018) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2018.02.006 · Cited by 25
Increased plasma melatonin in presymptomatic Huntington disease sheep (Ovis aries): Compensatory neuroprotection in a neurodegenerative disease?
Morton, A. J., Middleton, B., Rudiger, S. R., Bawden, C. S., Kuchel, T. R., & Skene, D. J. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12624 · Cited by 25
EFFECTS OF LIGHT AND MELATONIN TREATMENT ON BODY TEMPERATURE AND MELATONIN SECRETION DAILY RHYTHMS IN A DIURNAL RODENT, THE FAT SAND RAT
Schwimmer, H., Mursu, N., & Haim, A. (2010) · Chronobiology International · doi:10.3109/07420528.2010.505355 · Cited by 24
Precision Light for the Treatment of Psychiatric Disorders
Kaladchibachi, S., & Fernandez, F. (2018) · Neural Plasticity · doi:10.1155/2018/5868570 · Cited by 25
Exploring the Interplay between Thermal and Visual Perception: A Critical Review of Studies from 1926 to 2022
Rakotoarivelo, T., & Malet-Damour, B. (2023) · Buildings · doi:10.3390/buildings13040879 · Cited by 26
Older Poor-Sleeping Women Display a Smaller Evening Increase in Melatonin Secretion and Lower Values of Melatonin and Core Body Temperature Than Good Sleepers
Olbrich, D., & Dittmar, M. (2011) · Chronobiology International · doi:10.3109/07420528.2011.599904 · Cited by 22
Advances of Melatonin-Based Therapies in the Treatment of Disturbed Sleep and Mood
Alston, M. K., Cain, S. W., & Rajaratnam, S. M. W. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_139 · Cited by 22
Potential effects of shift work on skin autoimmune diseases
Stenger, S., Graßhoff, H., Hundt, J. E., & Lange, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1000951 · Cited by 22
Effects of a 20-Min Nap Post Normal and Jet Lag Conditions on P300 Components in Athletes
Petit, E., Bourdin, H., Tio, G., Yenil, O., Haffen, É., & Mougin, F. (2018) · International Journal of Sports Medicine · doi:10.1055/a-0599-0888 · Cited by 20
Melatonin Treatment for Pediatric Patients with Insomnia: Is There a Place for It?
Rolling, J., Rabot, J., & Schroder, C. M. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s340944 · Cited by 23
Core body temperature changes in school-age children with circadian rhythm sleep–wake disorder
Kimura, S., Takaoka, Y., Toyoura, M., Kohira, S., & Ohta, M. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.08.026 · Cited by 19
Sleep problems and circadian rhythm functioning in autistic children, autism with co-occurring attention deficit hyperactivity disorder, and typically developing children: A comparative study
Martínez‐Cayuelas, E., Vinués, B. M., Pérez-Sebastián, I., Gavela‐Pérez, T., Camacho, G. D. R., Garcés, C., & Soriano‐Guillén, L. (2024) · Autism · doi:10.1177/13623613241254594 · Cited by 18
Thermoregulatory Adaptation in Humans and Its Modifying Factors
Kondo, N., Taylor, N. A. S., Shibasaki, M., & Aoki, K. (2009) · Research Online (University of Wollongong) · Cited by 17
Gene Duplication and Loss ofAANATin Mammals Driven by Rhythmic Adaptations
Yin, D., Zhou, R., Yin, M., Chen, Y., Xu, S., & Yang, G. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab125 · Cited by 18
Melatonin attenuates light-at-night effects on systolic blood pressure and body temperature but does not affect diastolic blood pressure and heart rate circadian rhythms
Gubin, D. G., Weinert, D., Solovieva, S. V., Михайлович, Д. А., Литвинова, Н. С., Danilova, L. A., Prokopiev, N. Y., Trushnikov, D. Y., & Карташова, Е. А. (2019) · Biological Rhythm Research · doi:10.1080/09291016.2018.1564586 · Cited by 15
Dual orexin receptor antagonist induces changes in core body temperature in rats after exercise
Martin, T., Dauvilliers, Y. A., Koumar, O.-C., Bouët, V., Fréret, T., Besnard, S., Dauphin, F., & Bessot, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-54826-3 · Cited by 15
Circadian regulation of sleep in mammals
Deboer, T. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.12.015 · Cited by 15
Sleep and Chronobiology as a Key to Understand Cluster Headache
Pilati, L., Angelo, T., Alonge, P., Vassallo, L., Maccora, S., Gagliardo, A., Pignolo, A., Iacono, S., Ferlisi, S., Stefano, V. D., et al. (2023) · Neurology International · doi:10.3390/neurolint15010029 · Cited by 14
Periocular skin warming elevates the distal skin temperature without affecting the proximal or core body temperature
Ichiba, T., Suzuki, M., Aritake‐Okada, S., & Uchiyama, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-42116-x · Cited by 15
Drugs Used in Circadian Sleep-Wake Rhythm Disturbances
Burgess, H. J., & Emens, J. S. (2020) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2020.02.015 · Cited by 13
The Effect of Melatonin on Climacteric Symptoms in Menopausal Women; A Double-Blind, Randomized Controlled, Clinical Trial.
Parandavar, N., Abdali, K., Keshtgar, S., Emamghoreishi, M., & Amooee, S. (2014) · PubMed Central · Cited by 13
Lipopolysaccharide-induced changes in the kynurenine pathway and symptoms of sickness behavior in humans
Balter, L. J. T., Li, X., Schwieler, L., Erhardt, S., Axelsson, J., Olsson, M. J., Lasselin, J., & Lekander, M. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106110 · Cited by 13
Basic chronobiology: what do sleep physicians need to know?
Zaki, N. F. W., Spence, D. W., Subramanian, P., Bharti, V. K., Ramanujam, K., BaHammam, A. S., & Pandi-Perumal, S. R. (2020) · Europe PMC (PubMed Central) · doi:10.5935/1984-0063.20200026 · Cited by 12
Melatonin rhythms in renal transplant recipients with sleep–wake disturbances
Burkhalter, H., Geest, S. D., Wirz‐Justice, A., & Cajochen, C. (2016) · Chronobiology International · doi:10.3109/07420528.2016.1169192 · Cited by 12
Photoperiod-induced alterations in biomarkers of oxidative stress and biochemical pathways in rats of different ages: Focus on individual physiological reactivity
Kurhaluk, N., Ткаченко, Г. М., & Лукаш, О. В. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1939364 · Cited by 11
Metabolic footprint in young, middle-aged and elderly rats with melatonin deficit
Tchekalarova, J. D., Hrischev, P., Ivanova, P. P., Boyadjiev, N., & Georgieva, K. N. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113786 · Cited by 10
Functional links between thermoregulation and sleep in children with neurodevelopmental and chronic health conditions
McCabe, S., Abbiss, C. R., Libert, J., & Bach, V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.866951 · Cited by 11
Melatonin reduces arousal and startle responsiveness without influencing startle habituation or affective startle modulation in young women
Schächinger, H., Blumenthal, T. D., Richter, S., Savaskan, E., Wirz‐Justice, A., & Kräuchi, K. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.03.013 · Cited by 10
Afternoon to early evening bright light exposure reduces later melatonin production in adolescents
Lazar, R., Fazlali, F., Dourte, M., Epple, C., Stefani, O., Spitschan, M., & Cajochen, C. (2025) · npj Biological Timing and Sleep · doi:10.1038/s44323-025-00040-6 · Cited by 12
Diet-induced obesity reduces core body temperature across the estrous cycle and pregnancy in the rat
Crew, R. C., Waddell, B. J., Maloney, S. K., & Mark, P. J. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1458035 · Cited by 9
Sleep disruption in tetraplegia: a randomised, double-blind, placebo-controlled crossover trial of 3 mg melatonin
Spong, J., Kennedy, G. A., Tseng, J., Brown, D. J., Armstrong, S. M., & Berlowitz, D. J. (2014) · Spinal Cord · doi:10.1038/sc.2014.84 · Cited by 9
Melatonin Relations With Respiratory Quotient Weaken on Acute Exposure to High Altitude
Tapia, M., Wulff-Zottele, C., Gregorio, N. D., Lang, M., Varela, H., Serón‐Ferré, M., Vivaldi, E., Araneda, O. F., Silva‐Urra, J., Gunga, H., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00798 · Cited by 9
Ramadan et trouble bipolaire : exemple de perturbation du rythme circadien et son impact sur la maladie
Eddahby, S., Kadri, N., & Moussaoui, D. (2013) · L Encéphale · doi:10.1016/j.encep.2012.11.008 · Cited by 9
Dysfonctionnements de l’horloge biologique et leurs traitements
Touitou, Y. (2008) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2008.05.001 · Cited by 9
Thermoregulation in Sleep and Hibernation
Kräuchi, K., & Deboer, T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00021-0 · Cited by 9
Within-subject correlations between evening-related changes in body temperature and melatonin in the spinal cord injured
Jones, H., Eijsvogels, T. M. H., Nyakayiru, J., Verheggen, R. J. H. M., Thompson, A., Groothuis, J. T., Atkinson, G., Hopman, M. T. E., & Thijssen, D. H. J. (2013) · Chronobiology International · doi:10.3109/07420528.2013.833516 · Cited by 9
The Effect of Melatonin on Incretin Hormones: Results From Experimental and Randomized Clinical Studies
Lauritzen, E. S., Støy, J., Bæch‐Laursen, C., Grarup, N., Jessen, N., Hansen, T. F., Møller, N., Hartmann, B., Holst, J. J., & Kampmann, U. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab521 · Cited by 8
Circadian Rhythm of Distal Skin Temperature in Healthy Older and Young Women and Its Relationship with Sleep–Wake Rhythm and Environmental Factors under Natural Living Conditions
Dittmar, M., Stark, T., & Wedell, S. (2024) · Geriatrics · doi:10.3390/geriatrics9040102 · Cited by 7
Melatonin Supplementation in Patients with Complete Tetraplegia and Poor Sleep
Spong, J., Kennedy, G. A., Brown, D. J., Armstrong, S. M., & Berlowitz, D. J. (2013) · Sleep Disorders · doi:10.1155/2013/128197 · Cited by 7
The Biological Clock and Its Resetting by Light
Johnsson, A., & Engelmann, W. (2007) · Springer eBooks · doi:10.1007/978-0-387-72655-7_14 · Cited by 7
Overview of Physiological Processes During Sleep
Amici, R., Cerri, M., & Parmeggiani, P. L. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-378610-4.00086-3 · Cited by 9
Photoperiod Impact on a Sailor’s Sleep-Wake Rhythm and Core Body Temperature in Polar Environment
de Blasiis, K., Mauvieux, B., Elsworth-Edelsten, C., Pezé, T., Jouffroy, R., & Hurdiel, R. (2019) · Wilderness and Environmental Medicine · doi:10.1016/j.wem.2019.06.001 · Cited by 6
Estimation of melatonin level and core body temperature: heart rate and heart rate variability as circadian rhythm markers
Eo, Y. J., Park, J., Kim, S., Lee, K. N., Lee, S. M., Kim, D. H., Kim, C., & Rag, Y. (2022) · Biological Rhythm Research · doi:10.1080/09291016.2021.2024408 · Cited by 6
How Light Resets Circadian Clocks
Johnsson, A., Helfrich‐Förster, C., & Engelmann, W. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1468-5_18 · Cited by 5

Authors: Kräuchi, K., Cajochen, C., Pache, M., Flammer, J., & Wirz‐Justice, A.
Affiliations: Universitäre Psychiatrische Kliniken Basel (CH)
University Hospital of Basel (CH)
Corresponding author: Kräuchi, Kurt
ORCID: Cajochen, Christian
Wirz‐Justice, Anna
Venue: Chronobiology International
Publisher: Informa UK Limited
Published: 2006-01
Volume: 23
Issue: 1-2
Pages: 475-484
ISSN: 0742-0528 (ISSN-L)
1525-6073
DOI: 10.1080/07420520500545854
OpenAlex: W2112943789
Cited by: 152
References: 40
Citations by year: 2026: 8 · 2025: 8 · 2024: 7 · 2023: 8 · 2022: 10 · 2021: 12 · 2020: 9 · 2019: 16 · 2018: 8 · 2017: 5 · 2016: 4 · 2015: 1 · 2014: 6 · 2013: 12 · 2012: 6
FWCI: 2.38
Type: journal article
Language: en
Open access: closed
Locations: Chronobiology International (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: melatonin, thermoregulation, sleepiness, sleep induction, thermoregulatory set point, circadian rhythm, arousal system, skin temperature, heat loss, orthostatic challenge, sympathetic nervous system, finger temperature, arteriovenous anastomoses
MeSH terms: Adult, Body Temperature Regulation, Circadian Rhythm, Hot Temperature, Humans, Male, Melatonin, Models, Biological, Skin Temperature, Sleep, Sleep Stages, Temperature, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Thermoregulatory effects of melatonin in relation to sleepiness

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks