G-CSF: a key regulator of neutrophil production, but that's not all!
Abstract
G-CSF is a major extracellular regulator of haemopoiesis and the innate immune system. Named for its relatively specific stimulation of the growth of neutrophil progenitor cells in vitro in semi-solid cultures (Burgess and Metcalf 1980, Nicola et al. 1983), G-CSF influences the survival, proliferation and differentiation of all cells in the neutrophil lineage, from haemopoietic stem cell through to mature neutrophil. Further, G-CSF influences the function of mature neutrophils. These actions underpin its rapid uptake into clinical medicine as a drug that increases the production of neutrophils in patients with chemotherapy-induced neutropenia. Ongoing research has uncovered initially unsuspected polyfunctionality for G-CSF. G-CSF is well recognised as a potent mobiliser of haemopoietic stem cells from the bone marrow into the blood, and now is being increasingly accepted as a regulator of immune responses. These two "new" actions of G-CSF first came to light through observations made during clinical trials of G-CSF. Subsequent investigations into the cellular and molecular basis for this polyfunctionality have generated exciting new knowledge about the biology of G-CSF. This review emphasises recent advances in knowledge about G-CSF signalling, mechanisms of G-CSF-induced stem cell mobilisation, and how G-CSF influences T-cell function and dendritic cell activation. An attempt is made to link the current issues about the biology of G-CSF with its clinical uses, both present a…
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Lower levels of GCSF are observed in THS-exposed mouse wounds.
“However, we observed lower levels of GCSF, which not only is a key regulator of neutrophil production [60] but also plays an essential role in neutrophil trafficking [61].”
From Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing (2016) · cites this paper as [60]
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“More recently, IL-17 has been implicated as a major upstream extracellular regulator of G-CSF production by tissues, particularly the bone marrow stroma (Fossiez et al. 1996).”
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- Authors
- Roberts, A. W.
- Affiliations
- Walter and Eliza Hall Institute of Medical Research (AU)
- Corresponding author
- Roberts, Andrew W.
- ORCID
- Roberts, Andrew W.
- Venue
- Growth Factors
- Publisher
- Informa UK Limited
- Published
- 2005-03
- Volume
- 23
- Issue
- 1
- Pages
- 33-41
- ISSN
- 0897-7194 (ISSN-L)
- 1029-2292
- OpenAlex
- W1981127449
- Cited by
- 335
- References
- 87
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 14 · 2023: 25 · 2022: 35 · 2021: 27 · 2020: 21 · 2019: 17 · 2018: 16 · 2017: 22 · 2016: 17 · 2015: 17 · 2014: 20 · 2013: 20 · 2012: 18
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Growth Factors (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- Cancer Council Victoria
- National Medical Research Council
- National Cancer Institute (CA22556)
- Topics
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Keywords
- granulocyte colony-stimulating factor, neutrophil production, hematopoiesis, T cell function, dendritic cell activation, innate immunity, chemotherapy-induced neutropenia, G-CSF therapy
- MeSH terms
- Animals, Dendritic Cells, Forecasting, Humans, Models, Biological, Neutropenia, Neutrophils, T-Lymphocytes, Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Mobilization
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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