Impact of the Dash Diet on Endothelial Function, Exercise Capacity, and Quality of Life in Patients with Heart Failure
Open accessAbstract
Endothelial dysfunction has been recognized as a pathophysiologic mechanism in the progression of heart failure (HF). However, little attention has been given to the ability of dietary approaches to improve endothelial function. This study examined the effects of the Dietary Approaches to Stop Hypertension (DASH) diet on endothelial function, exercise capacity, and quality of life in patients with chronic symptomatic (stage C) HF. Forty-eight patients were randomized to follow the DASH diet (n = 24) or the general HF dietary recommendations (n = 24). Endothelial function was assessed by measuring large and small arterial elasticity (LAE and SAE) at rest. Exercise capacity (measured with the 6-minute walk test) and quality of life (measured with the Minnesota Living with Heart Failure Questionnaire) at baseline and 3 months were also evaluated. Patients were older adults with an average HF duration of 5 years. LAE at 1 month improved significantly in the DASH diet group (P < 0.01). Overall LAE and SAE scores at 3 months also improved; however, the net changes were not statistically significant. The DASH group had better exercise capacity (292 m vs 197 m; P = 0.018) and quality of life scores (21 vs 39; P = 0.006) over time, while sodium intake levels at 1, 2, and 3 months were comparable between the groups. Adhering to the DASH diet improved arterial compliance initially and improved exercise capacity and quality of life scores at 3 months. The DASH diet may be an important adjunctive therapy for patients with symptomatic HF.
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Lack of regulation across probiotic supplements could potentially raise the risk of probiotic translocation and associated sepsis.
“the lack of regulation across supplements could potentially raise the risk of probiotic translocation and associated sepsis212,213.”
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- Authors
- Rifai, L., Pisano, C., Hayden, J., Sulo, S., & Silver, M. A.
- Affiliations
- Advocate Lutheran General Hospital (US)
- Corresponding author
- Rifai, Luay
- Venue
- Baylor University Medical Center Proceedings
- Publisher
- Informa UK Limited
- Published
- 2015-04
- Volume
- 28
- Issue
- 2
- Pages
- 151-156
- ISSN
- 0899-8280 (ISSN-L)
- 1525-3252
- PMC
- PMC4365107
- OpenAlex
- W2411002979
- Cited by
- 82
- References
- 27
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 12 · 2023: 9 · 2022: 14 · 2021: 6 · 2020: 10 · 2019: 7 · 2018: 8 · 2017: 4 · 2016: 3 · 2015: 1
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Baylor University Medical Center Proceedings (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Aurora Health Care
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- DASH diet, heart failure, endothelial function, arterial elasticity, exercise capacity, quality of life, dietary intervention, arterial compliance, sodium intake, Minnesota Living with Heart Failure Questionnaire, 6-minute walk test
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