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Cited by 217Retinoids in leukemia and cellular processesAcne and Rosacea Treatments and EffectsSkin Protection and Aging

The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.

Retinoids: a journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effects

Khalil, Samar, Bardawil, Tara, Stephan, Carla, Darwiche, Nadine, Abbas, Ossama, Kibbi, Abdul Ghani, Nemer, Georges, Kurban, Mazen·2017·Journal of Dermatological Treatment
DOI 10.1080/09546634.2017.1309349
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Abstract

Retinoids are a class of compounds derived from vitamin A or having structural and/or functional similarities with vitamin A. They are classified into three generations based on their molecular structures. Inside the body, retinoids bind to several classes of proteins including retinoid-binding proteins and retinoid nuclear receptors. This eventually leads to the activation of specific regulatory regions of DNA - called the retinoic acid response elements - involved in regulating cell growth, differentiation and apoptosis. Several clinical trials have studied the role of topical and systemic retinoids in disease, and research is still ongoing. Currently, retinoids are used in several fields of medicine. This paper aims to review the structure, mechanisms of action, and adverse effects of retinoids, as well as some of their current uses in Dermatology.

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Crossref · 10.1080/09546634.2017.1309349

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103 of 103 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 19

  1. unningham FG., 2014, Williams Obstetrics
  2. Leyden JJ, 2002, Cutis, 69, 12
  3. Webster GF, 2001, Cutis, 67, 4
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  19. 10.1097/00042560-199911010-00004 · DOI

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Metadata

Authors
Khalil, S., Bardawil, T., Stephan, C., Darwiche, N., Abbas, O., Kibbi, A. G., Nemer, G., & Kurban, M.
Affiliations
  • American University of Beirut (LB)
  • Columbia University Irving Medical Center (US)
Corresponding author
Kurban, Mazen
ORCID
Venue
Journal of Dermatological Treatment
Publisher
Informa UK Limited
Published
2017-04-02
Volume
28
Issue
8
Pages
684-696
ISSN
  • 0954-6634 (ISSN-L)
  • 1471-1753
DOI
10.1080/09546634.2017.1309349
OpenAlex
W2603105847
Cited by
217
References
102
Citations by year
2026: 21 · 2025: 14 · 2024: 36 · 2023: 23 · 2022: 25 · 2021: 38 · 2020: 31 · 2019: 20 · 2018: 8
FWCI
1.51
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Dermatological Treatment (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
  • Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
retinoids, vitamin A derivatives, retinoid-binding proteins, retinoic acid response element, cell differentiation, apoptosis, topical retinoids, systemic retinoids, adverse effects, dermatological applications
MeSH terms
Acne Vulgaris, Administration, Topical, Bacterial Infections, Humans, Psoriasis, Retinoids, Retinol-Binding Proteins, Skin Diseases, Vitamin A, Xerophthalmia, Receptors, Retinoic Acid, Retinoid X Receptors

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