Cited by 54Musculoskeletal pain and rehabilitationConnective tissue disorders researchFibromyalgia and Chronic Fatigue Syndrome Research

Low- and high-anxious hypermobile Ehlers–Danlos syndrome patients: comparison of psychosocial and health variables

Baeza-Velasco, Carolina, Bourdon, Caroline, Montalescot, Lucile, de Cazotte, Cécile, Pailhez, Guillem, Bulbena, Antonio, Hamonet, Claude·2018·Rheumatology International

Abstract

Despite the frequent co-ocurrence of hypermobile Ehler-Danlos syndrome (hEDS) and pathological anxiety, little is known about the psychosocial and health implications of such comorbidity. Our aim was to explore the association between high levels of anxiety and psychosocial (catastrophizing, kinesiophobia, somatosensory amplification, social support and functioning), health (pain, fatigue, BMI, tobacco/alcohol use, depression, diagnosis delay, general health), and sociodemographic factors in people with hEDS. In this cross-sectional study, 80 hEDS patients were divided into two groups according to self-reported anxiety levels: low and high. Psychosocial, sociodemographic and health variables were compared between the groups. Forty-one participants reported a high level of anxiety (51.2%). No differences were found in the sociodemographic variables between high-anxious and low-anxious patients. The percentage of participants with severe fatigue and high depressive symptomatology was significantly higher in the high-anxious group (80.5 vs 56.4; 26.8 vs 12.8%, respectively). High-anxious hEDS patients also showed significantly higher levels of pain catastrophizing, somatosensory amplification as well as a poorer social functioning and general health. Multivariate analyses showed that somatosensory amplification, pain catastrophizing and poor social functioning are variables that increase the probability of belonging to the high-anxious group. Despite limitations, this first stud…

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Crossref · 10.1007/s00296-018-4003-7

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  • In adult patients with hEDS, 67.1% reported experiencing pain of severe to very severe intensity.

    “However, 67.1% of adult patients with hEDS reported experiencing pain of severe to very severe intensity,29”
  • Adults with symptomatic GJH have increased kinesiophobia.

    “Adults with symptomatic GJH had increased overall scores of anxieties31,32,37,40,44,45, 46, 47,51,53 and kinesiophobia.29,30,38,44,48”
  • Highly anxious hEDS patients score significantly higher in pain catastrophizing and somatosensory amplification and lower in social functioning than those without high anxiety.

    “Highly anxious hEDS patients scored significantly higher in pain catastrophizing and somatosensory amplification and lower in social functioning than those without high anxiety.29”
  • In populations with symptomatic GJH, the presence of anxiety and pain complaints is accompanied by other psychosocial complaints such as pain catastrophizing, somatosensory amplification, and decreased social functioning.

    “In populations with symptomatic GJH, the presence of anxiety and pain complaints were accompanied by other psychosocial complaints such as pain catastrophizing, somatosensory amplification, and decreased social functioning.29”

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Authors
Baeza-Velasco, C., Bourdon, C., Montalescot, L., de Cazotte, C., Pailhez, G., Bulbena, A., & Hamonet, C.
Affiliations
  • Université Paris Cité (FR)
  • Universitat Autònoma de Barcelona (ES)
  • Université Paris-Est Créteil (FR)
Venue
Rheumatology International
Published
2018-03-01
Volume
38
Issue
5
Pages
871-878
ISSN
  • 0172-8172 (ISSN-L)
  • 1437-160X
OpenAlex
W2793786097
Cited by
54
References
62
Citations by year
2026: 3 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 5 · 2018: 1
FWCI
4.22
Type
journal article
Language
en
Open access
closed
Locations
  • Rheumatology International (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Keywords
hypermobile Ehlers-Danlos syndrome, anxiety, pain catastrophizing, kinesiophobia, somatosensory amplification, social functioning, social support, fatigue, depression, delayed diagnosis, chronic pain, biopsychosocial model
MeSH terms
Adolescent, Adult, Alcohol Drinking, Anxiety, Cross-Sectional Studies, Depression, Ehlers-Danlos Syndrome, Fatigue, Fear, Female, Health Status, Humans, Joint Instability, Joints, Male, Mental Health, Middle Aged, Pain Measurement, Paris, Phobic Disorders, Risk Factors, Severity of Illness Index, Smoking, Social Support, Body Mass Index, Prevalence, Multivariate Analysis, Range of Motion, Articular, Somatosensory Disorders, Young Adult, Self Report, Catastrophization

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