The DOI matches its Crossref record, with a small difference in title or year; 103 of the 103 references it cites were found in a registry or an index.
Health benefits of anthocyanins and molecular mechanisms: Update from recent decade
Open accessAbstract
Anthocyanins are one of the most widespread families of natural pigments in the plant kingdom. Their health beneficial effects have been documented in many in vivo and in vitro studies. This review summarizes the most recent literature regarding the health benefits of anthocyanins and their molecular mechanisms. It appears that several signaling pathways, including mitogen-activated protein kinase, nuclear factor κB, AMP-activated protein kinase, and Wnt/β-catenin, as well as some crucial cellular processes, such as cell cycle, apoptosis, autophagy, and biochemical metabolism, are involved in these beneficial effects and may provide potential therapeutic targets and strategies for the improvement of a wide range of diseases in future. In addition, specific anthocyanin metabolites contributing to the observed in vivo biological activities, structure-activity relationships as well as additive and synergistic efficacy of anthocyanins are also discussed.
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“These molecules reduce oxidative stress, by lowering the number of free radicals.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [116]
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Bordoloi, S., Pathak, K., Devi, M., Saikia, R., Das, J., Kashyap, V. H., Das, D., Ahmad, M. Z., & Abdel‐Wahab, B. A. (2024) · Discover Applied Sciences · doi:10.1007/s42452-024-05811-7 · Cited by 54
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Diaconeasa, Z. M., Ayvaz, H., Rugină, D. O., LEOPOLD, L. F., Stănilă, A., Socaciu, C., Tăbăran, F., Lupuţ, L., Mada, D. C., Pintea, A., et al. (2017) · Plant Foods for Human Nutrition · doi:10.1007/s11130-017-0638-x · Cited by 48
“Anthocyanins and anthocyanidins are known to exhibit various biological effects, such as antioxidant activity [3–5], antidiabetic [6, 7] or anticarcinogenic potential [8, 9].”
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“There exists a growing interest in the therapeutic effects of polyphenolic compounds known as anthocyanins, which are water-soluble pigments, found in colored berries, fruits, and vegetables [96].”
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Gonçalves, A. C., Bento, C., Jesus, F., Alves, G., & Silva, L. R. (2018) · Studies in natural products chemistry · doi:10.1016/b978-0-444-64179-3.00002-5 · Cited by 47
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“Amongst the existing classes of phytochemicals, anthocyanins represent one of the most attractive, owing to their simultaneous acknowledged bioactivity repertoire and visually attractive colors [11].”
BackgroundPbMYB120 Negatively Regulates Anthocyanin Accumulation in Pear
Song, L., Wang, X., Han, W., Qu, Y., Wang, Z., Zhai, R., Yang, C., Ma, F., & Xu, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041528 · Cited by 43
“anthocyanin-rich foods contributes to the prevention or alleviation of various diseases, including inflammations, cardiovascular diseases, neurogenic diseases, and cancers [11,12].”
BackgroundRamezan, Y., Kamkari, A., Lashkari, A., Moradi, D., & Tabrizi, A. N. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3897 · Cited by 43
“The greatest intensity in the blue color (hydroxyl group) and red color most sensitive pigment), light, oxygen, solvents, and the presence of enzymes, proteins, and metallic ions (Jackman & Smith, 1996; Li et al., 2017; Smeriglio et al., 2016).”
Clark, J. L., Taylor, C. G., & Zahradka, P. C. (2018) · Nutrients · doi:10.3390/nu10040434 · Cited by 44
“Studies have shown AMPK is activated by anthocyanins [99,100], which then increases GLUT4 translocation leading to increased glucose uptake and improved insulin sensitivity [99,101].”
BackgroundHabibi, F., García-Pastor, M. E., Puente-Moreno, J., Garrido-Auñón, F., Serrano, M., & Valero, D. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2098250 · Cited by 41
“At molecular level, the health-beneficial effects of antho-cyanins involve a wide range of signaling pathways, such as protein kinase (AMP or N activated), cell autophagy, and apoptosis, that could be used as new therapeutic targets to reduce some diseases (Li et al. 2017).”
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Blando, F., Gerardi, C., Renna, M., Castellano, S., & Serio, F. (2018) · Journal of Berry Research · doi:10.3233/jbr-170258 · Cited by 41
Jia, D., Li, Z., Dang, Q., Shang, L., Shen, J., Leng, X., Wang, Y., & Yuan, Y. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b07098 · Cited by 41
Cai, Y., Li, X., Pan, Z., Zhu, K. Y., Tuo, J., Meng, Q., Dai, G., Yang, G., & Pan, Y. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173360 · Cited by 41
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“Although anthocyanins were revealed to affect the fat and carbohydrate metabolism [9,48,49], here we did not observe further loss of body mass in mice fed with the grain with high content of anthocyanins in comparison with the effect of the control grain diet.”
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Recent advances in the extraction of polyphenols from eggplant and their application in foods
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“The increased consumption of fruits and vegetables has shown to improve different parameters of MetS, which i attributed in large part to the polyphenolic compounds present in these foods with antioxidant, anti-inflammatory, and anticancer activities (reviewed previously [50]).”
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Anthocyanins as functional food components
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“Moreover, PAs and anthocyanins show different health effects in vitro, such as anticancer and antiinflammatory activities, as well as antioxidation [4,5].”
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Comparative Study on Grape Berry Anthocyanins of Various Teinturier Varieties
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Red orange and lemon extract prevents the renal toxicity induced by ochratoxin A in rats
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“As a class of widespread flavonoids in fruits and vegetables, anthocyanins are easily available in people’s daily diet (50mg/day recommended by China Nutrition Society) and are well known for their dramatic free radical scavenging and anti-inflammatory efficacies [16, 17].”
Aprile, A., Negro, C., Sabella, E., Luvisi, A., Nicolì, F., Nutricati, E., Vergine, M., Miceli, A., Blando, F., & Bellis, L. D. (2019) · Antioxidants · doi:10.3390/antiox8050138 · Cited by 36
“They have good antioxidant, anti-inflammatory, and preventive effects against various pathological states, such as cardiovascular diseases and tumors [29].”
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Gamage, G. C. V., Lim, Y. Y., & Choo, W. S. (2021) · ACS Food Science & Technology · doi:10.1021/acsfoodscitech.1c00203 · Cited by 38
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Chronological development of functional fluorophores for bio-imaging
Munan, S., Chang, Y., & Samanta, A. (2023) · Chemical Communications · doi:10.1039/d3cc04895k · Cited by 35
Antiproliferative and Apoptotic Potential of Cyanidin-Based Anthocyanins on Melanoma Cells
Rugină, D. O., Hanganu, D., Diaconeasa, Z. M., Tăbăran, F., Coman, C., LEOPOLD, L. F., Bunea, A., & Pintea, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050949 · Cited by 35
“The structure-function relationships of anthocyanins were recently reviewed [23].”
Backgrounddos Santos, F. N., de Souza, E. J. D., de Souza, J. F., Pires, J. B., Siebeneichler, T. J., Kringel, D. H., Fajardo, A. R., Rombaldi, C. V., Dias, Á. R. G., & Zavareze, E. D. R. (2022) · Food Biophysics · doi:10.1007/s11483-022-09758-3 · Cited by 34
Çatalkaya, G., Güldiken, B., & Çapanoğlu, E. (2022) · Food & Function · doi:10.1039/d2fo02569h · Cited by 34
Nanoencapsulation of Cyanidin 3-O-Glucoside: Purpose, Technique, Bioavailability, and Stability
Zannou, O., Oussou, K. F., Chabı, I. B., Awad, N. M. H., Aïssi, M. V., Gökşen, G., Mortaş, M., Öz, F., Proestos, C., & Kayodé, A. P. P. (2023) · Nanomaterials · doi:10.3390/nano13030617 · Cited by 34
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“2 A,9 [5,63,64] Dendranthema p D p D p D 168–182 B [56,65,66] Phaseolus coccineus no data”
BackgroundAnthocyanins’ effects on diabetes mellitus and islet transplantation
Liu, Y., Wang, Q., Wu, K., Sun, Z., Tang, Z., Li, X., & Zhang, B. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2098464 · Cited by 37
“The main risk factor for cardiovascular disease in T2DM is Dyslipidemia, which is characterized by low HDL-cholesterol concentrations, and high LDL-cholesterol concentrations and TGs concentrations(Li et al. 2015).”
BackgroundMethodInfluentialFunctional Activities and Mechanisms of Aronia melanocarpa in Our Health
Go, M. Y., Kim, J., Jeon, C. Y., & Shin, D. W. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46080477 · Cited by 32
“Another study suggested that Aronia juice inhibited the increase in postprandial blood glucose levels by suppressing dipeptidyl peptidase IV, α - glucosidase, and angiotensin-converting enzymes, which play important roles in regulating carbohydrate metabolism and the onset of diabetes, respectively…”
BackgroundFerruzza, S., Natella, F., Ranaldi, G., Murgia, C., Rossi, C., Trôst, K., Mattivi, F., Nardini, M., Maldini, M., Giusti, A. M., et al. (2016) · Pharmaceuticals · doi:10.3390/ph9030048 · Cited by 32
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“They possess antioxidant, anti-inflammatory, hypoglycemic, antimutagenic, and neuroprotective activities; they can prevent cardiovascular disease, metabolic syndrome, different types of cancer, as well as they are beneficial for eye vision [5,6].”
BackgroundStarch-Based Materials Encapsulating Anthocyanins: A Review
Schlindweinn, E. B., Chacon, W. D. C., Koop, B. L., Fonseca, J. D. M., Monteiro, A. R., & Valencia, G. A. (2022) · Journal of Polymers and the Environment · doi:10.1007/s10924-022-02474-6 · Cited by 32
“The anthocyanidin groups most commonly found in plants are cyanidin, delphinidin, and pelargonidin [21, 24], followed by peonidin, malvidin, and petunidin [25].”
BackgroundTherapeutic and Preventive Potential of Plant-Derived Antioxidant Nutraceuticals
Pereira, A. G., Echave, J., Jorge, A. O. S., Nogueira‐Marques, R., Yuksek, E. N., Barciela, P., Perez-Vazquez, A., Chamorro, F., Oliveira, M. B. P. P., Carpena, M., et al. (2025) · Foods · doi:10.3390/foods14101749 · Cited by 40
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Yield and Quality in Purple-Grained Wheat Isogenic Lines
Morgounov, A. I., Karaduman, Y., Akın, B., Aydoğan, S., Baenziger, P. S., Bhatta, M., Chudinov, V., Dreisigacker, S., Govindan, V., Güler, S., et al. (2020) · Agronomy · doi:10.3390/agronomy10010086 · Cited by 30
“The number of research publications devoted to wheat with blue and purple grain have increased dramatically over the last two years, indicating the priority and potential of these genotypes in developing wheat cultivars with specific benefits for human health [1,2].”
BackgroundJing, N., Song, J., Liu, Z., Wang, L., & Jiang, G. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-03096-y · Cited by 30
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Flavonoid-based nanomedicines to target tumor microenvironment
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“Evidence suggests that anthocyanins can have antioxidative, antiatherogenic, anticancer, antidiabetic, anti-obesity, anti-inflammatory, and neuroprotective activity (Li et al. 2017; Khoo et al. 2017; Krga and Milenkovic 2019).”
Anti-Apoptotic Activity of Anthocyanins has Potential to inhibit Caspase-3 Signaling
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“Black rice anthocyanins have been reported promoting some health benefits as anti-obesity [17, 18], antioxidant [19, 20], anti-inflammatory [21] and antiapoptosis [22, 23].”
BackgroundLeonardou, V. K., Doudoumis, E., Tsormpatsidis, E., Vysini, E., Papanikolopoulos, T., Papasotiropoulos, V., & Lamari, F. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413499 · Cited by 28
“themselves, but more importantly because they interact with cellular signaling cascades regulating the activity of transcription factors and influencing the expression of genes essential in cellular metabolism and survival [17,18].”
BackgroundLi, B., Zhao, Y., Wang, M., Guan, W., Liu, J., Zhao, H., & Brennan, C. S. (2022) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.16612 · Cited by 28
Yang, S., Mi, L., Wu, J., Liao, X., & Xu, Z. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2067117 · Cited by 28
“…such as antidiabetic and anti-obesity effects (Gowd, Jia, and Chen 2017), antiangiogenic and anti-thrombotic effects (Krga and Milenkovic 2019), and anticancer (Lin et al. 2017), neuroprotective (Li et al. 2017), and vision-protective effects (Miyake et al. 2012), have been demonstrated.”
BackgroundJiang, L., Li, Z., Xie, Y., Liu, L., & Cao, Y. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.03.047 · Cited by 27
Yousefnia, S., Naseri, D., Forootan, F. S., Tabatabaeian, M., Moattar, F. S., Ghafghazi, T., Nasr‐Esfahani, M. H., & Ghaedi, K. (2020) · Clinical & Translational Oncology · doi:10.1007/s12094-020-02307-9 · Cited by 27
“It also inhibits the growth and progression of cancer through cell cycle arrest in G0/G1 and G2/M with increasing p21WAF1 and P27KIP1 expression and decreasing the expression of cyclin A and B [32].”
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Cyanidin‐3‐o‐glucoside inhibits UVA‐induced human dermal fibroblast injury by upregulating autophagy
Wu, S., Hu, Y., Bai, W., Zhao, J., Huang, C., Wen, C., Deng, L., & Lu, D. (2019) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12493 · Cited by 26
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“Although they are valuable medicinally, due to anticancer, antioxidant, and other health-promoting properties [35], not enough attention has been focused on the synthesis of anthocyanins after cryopreservation [36,37].”
BackgroundTan, L., Yang, C., Zhou, B., Wang, L., Zou, Y., Chen, W., Xia, T., & Tang, Q. (2020) · Physiologia Plantarum · doi:10.1111/ppl.13114 · Cited by 25
Phenolic composition of 91 Australian apple varieties: towards understanding their health attributes
Bondonno, C. P., Bondonno, N. P., Shinde, S., Shafaei, A., Boyce, M. C., Swinny, E. E., Jacob, S. R., Lacey, K., Woodman, R. J., Croft, K. D., et al. (2020) · Food & Function · doi:10.1039/d0fo01130d · Cited by 26
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“Rahimlou, Ahmadnia, & Hekmatdoost, 2015) via various ways such as inhibition of NF-κB signaling pathways (Li, Wang, Luo, Zhao, & Chen, 2017), and down regulation of inflammatory genes including TNF-α and IL-6 (Guo et al., 2014; Li et al., 2017).”
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“A considerable amount of interest has recently focused on the use of nutraceutical supplements for health, particularly those containing polyphenols such as anthocyanins and flavonols, in part because they are potent antioxidants and possess strong anti-inflammatory properties [1, 2].”
BackgroundResearch Progress of the Role of Anthocyanins on Bone Regeneration
Mao, W., Huang, G., Chen, H., Xu, L., Qin, S., & Li, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.773660 · Cited by 24
“More than 635 ACNs have been identified based on the number and location of hydroxyl and methoxy groups (Wu and Prior, 2005; Mulabagal and Calderón, 2012; Sehitoglu et al., 2014; Wallace and Giusti, 2015; Smeriglio et al., 2016; Cerletti et al., 2017; Khoo and Azlan, 2017; Li et al., 2017).”
BackgroundLingonberry Improves Hepatic Lipid Metabolism by Targeting Notch1 Signaling
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“Anthocyanins are a group of water-soluble polyphenols that have been shown to have beneficial health effects against oxidative stress, inflammation and obesity [40].”
BackgroundA mechanistic review of chinese medicine polyphenols on bone formation and resorption
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“The effects of anthocyanins have been reported on antiproliferative activity, anti-inflammation, neuroprotective activity, anti-obesity, and antidiabetic activity [32], and prevention of cardiovascular disease [32,33].”
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“Anthocyanins are secondary metabolites determining the pink, purple, and blue color of plant organs, valuable in medicine due to anticancer, antioxidant, and other health-promoting properties [40].”
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“In recent decades, anthocyanin-related research has proved its beneficial health effects [4].”
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“Anthocyanins also have roles in fighting other diseases with their antibacterial [15] and antitumor [11,16] activities.”
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Metadata
- Authors
- Li, D., Wang, P., Luo, Y., Zhao, M., & Chen, F.
- Affiliations
- Ministry of Education of the People's Republic of China (CN)
- University of Maryland, College Park (US)
- Corresponding author
- Chen, Fang
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2015-07-20
- Volume
- 57
- Issue
- 8
- Pages
- 1729-1741
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W1765735955
- Cited by
- 489
- References
- 103
- Citations by year
- 2026: 25 · 2025: 36 · 2024: 69 · 2023: 60 · 2022: 58 · 2021: 69 · 2020: 63 · 2019: 45 · 2018: 33 · 2017: 19 · 2016: 8 · 2015: 3
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Gene Expression Analysis
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- anthocyanins, health benefits, molecular mechanisms, signaling pathways, mitogen-activated protein kinase, NF-κB, AMPK, Wnt/β-catenin signaling, apoptosis, autophagy, cell cycle, anthocyanin metabolites, structure-activity relationship, synergistic efficacy, disease prevention
- MeSH terms
- Anthocyanins, Anti-Inflammatory Agents, Antineoplastic Agents, Autophagy, Cardiovascular Diseases, Cell Cycle, Humans, Hypoglycemic Agents, Signal Transduction, Apoptosis, Neuroprotective Agents, Anti-Obesity Agents
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