The DOI matches its Crossref record, with a small difference in title or year; 103 of the 103 references it cites were found in a registry or an index.
Health benefits of anthocyanins and molecular mechanisms: Update from recent decade
Open accessAbstract
Anthocyanins are one of the most widespread families of natural pigments in the plant kingdom. Their health beneficial effects have been documented in many in vivo and in vitro studies. This review summarizes the most recent literature regarding the health benefits of anthocyanins and their molecular mechanisms. It appears that several signaling pathways, including mitogen-activated protein kinase, nuclear factor κB, AMP-activated protein kinase, and Wnt/β-catenin, as well as some crucial cellular processes, such as cell cycle, apoptosis, autophagy, and biochemical metabolism, are involved in these beneficial effects and may provide potential therapeutic targets and strategies for the improvement of a wide range of diseases in future. In addition, specific anthocyanin metabolites contributing to the observed in vivo biological activities, structure-activity relationships as well as additive and synergistic efficacy of anthocyanins are also discussed.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These molecules reduce oxidative stress, by lowering the number of free radicals.”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [116]
Citations
Cites
FLAVONOIDS: Chemistry, Biochemistry and Applications
Andersen, Ø. M., & Markham, K. R. (2018) · Cited by 1,717
Anthocyanins: Natural Colorants with Health-Promoting Properties
He, J., & Giusti, M. M. (2010) · Annual Review of Food Science and Technology · doi:10.1146/annurev.food.080708.100754 · Cited by 1,698 · cited 2×
“…several excellent reviews have illustrated these natural dietary phytochemicals in terms of their absorption (McGhie and Walton, 2007), metabolism (He and Giusti, 2010), bioavailability (Fernandes et al., 2014), and pharmacokinetics (Kay, 2006) as well as their various analytical techniques…”
BackgroundProspective study of alcohol consumption and risk of coronary disease in men.
Rimm, E. B., Giovannucci, E. L., Willett, W. C., Colditz, G. A., Ascherio, A., Rosner, B., & Stampfer, M. J. (1991) · The Lancet · doi:10.1016/0140-6736(91)90542-w · Cited by 1,239 · cited 1×
“The relationship between anthocyanins intake and the reduced risk of developing cardiovascular disease has been indicated in several epidemiological studies (PrRimm et al., 1991; Wallace, 2011).”
BackgroundWu, X., Beecher, G. R., Holden, J. M., Haytowitz, D. B., Gebhardt, S. E., & Prior, R. L. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf060300l · Cited by 1,190 · cited 1×
“Table 1 shows the daily consumption of anthocyanins from fruits, vegetables, and beverages obtained from the National Health and Nutrition Examination Survey (NHANES, 2001; Wu et al., 2006).”
BackgroundAnthocyanins and their role in cancer prevention
Wang, L., & Stoner, G. D. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.05.020 · Cited by 1,045 · cited 1×
“However, convincing epidemiological evidence indicating a positive association between the intake of anthocyanins-rich food and other cancers is needed to be further determined (Wang and Stoner, 2008).”
BackgroundFlavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women
Mink, P. J., Scrafford, C. G., Barraj, L. M., Harnack, L., Hong, C.-P., Nettleton, J. A., & Jacobs, D. R. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.895 · Cited by 945 · cited 1×
“In addition, an Iowa Women’s Health Study with 34,489 women showed a significant reduction in cardiovascular disease mortality associated with anthocyanins-rich strawberry intake (Mink et al., 2007).”
BackgroundAnthocyanins in Fruits, Vegetables, and Grains
Mazza, G. A. (2018) · CRC Press eBooks · doi:10.1201/9781351069700 · Cited by 855 · cited 1×
“Anthocyanins belong to a large group of compounds, collectively known as flavonoids, which are a subgroup of an even larger group of compounds known as polyphenolics (Mazza and Miniati, 1993; Andersen, 2001; Andersen and Markham, 2006; McGhie and Walton, 2007).”
BackgroundAnthocyanins in fruits, vegetables and grains
Brouillard, R. (1993) · Food Research International · doi:10.1016/0963-9969(93)90093-x · Cited by 746
The bioavailability and absorption of anthocyanins: Towards a better understanding
McGhie, T. K., & Walton, M. C. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700092 · Cited by 617 · cited 3×
“Anthocyanins belong to a large group of compounds, collectively known as flavonoids, which are a subgroup of an even larger group of compounds known as polyphenolics (Mazza and Miniati, 1993; Andersen, 2001; Andersen and Markham, 2006; McGhie and Walton, 2007).”
BackgroundAnthocyanins: from plant to health
de Pascual‐Teresa, S., & Sánchez-Ballesta, M. T. (2007) · Phytochemistry Reviews · doi:10.1007/s11101-007-9074-0 · Cited by 548 · cited 1×
“Among them, the six most mentioned anthocyanidins in plants are pelargonidin, cyanidin, peonidin, delphinidin, petunidin, and malvidin (de Pascual-Teresa and Sanchez-Ballesta, 2008; CONTACT Fang Chen chenfangch@sina.com College of Food Science and Nutritional Engineering, China Agricultural…”
Background
Research works printed but not linked: 8
- Bishayee A., 2010, Nat. Prod. Commun., 5, 1613
- Devi P. S., 2011, Int. J. Breast Cancer., 891481
- Ghosh D., 2007, Asia. Pac. J. Clin. Nutr., 16, 200
- Hassimotto N. M., 2013, Biomed. Res. Int., 146716
- Kocic B., 2011, J. BUON., 16, 602
- Mpiana P. T., 2010, Blood Transfus., 8, 248
- NHANES, 2001, National Health and Nutrition Examination Survey Data
- Yoon B. I., 2013, Chin. J. Integr. Med., 14
Cited by
Sorted by citations
Items 201–300 of 489
Jafari, R. S., & Behrouz, V. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1215358 · Cited by 24
“Anthocyanins are organic water-soluble glycosidic pigments widely found in dark-colored vegetables, fruits, and grains with considerable inherent antioxidant properties (65).”
BackgroundMitharwal, S., Saini, A., Chauhan, K., Taneja, N. K., & Oberoi, H. S. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.70001 · Cited by 22
HPLC-Mass spectrometry analysis of phenolics comparing traditional bilberry and blueberry liqueurs
Medič, A., Smrke, T., Hudina, M., Veberič, R., & Zamljen, T. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113373 · Cited by 21
“…alez-Param ´ as, Barreiro, & Ferreira, 2017), with fewer anthocyanins, which are believed to have antidiabetic, anticancer, anti-inflammatory, anti-microbial and anti-obesity effects, and to protect against cardiovascular diseases (Khoo, Azlan, Tang, & Lim, 2017; Li, Wang, Luo, Zhao, & Chen, 2017).”
Yuan, K.-C., Chiang, Y.-C., Li, P., & Chiang, P.-Y. (2023) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2023.109674 · Cited by 21
Effect of anthocyanin-rich bilberry extract on bone metabolism in ovariectomized rats
Shimizu, S., Matsushita, H., Morii, Y., Ohyama, Y., Morita, N., Tachibana, R., Watanabe, K., & Wakatsuki, A. (2017) · Biomedical Reports · doi:10.3892/br.2017.1029 · Cited by 21
Beneficial effects of anthocyanins against diabetes mellitus associated consequences-A mini review
Chaiyasut, C., Sivamaruthi, B. S., Kesika, P., & Subasankari, K. (2018) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/2221-1691.244137 · Cited by 21
“Pelargonidin, cyanidin, delphinidin, malvidin, peonidin, and petunidin are commonly found and most described anthocyanidins in plants[3,4].”
BackgroundDing, Y., & Yu, Y. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13474 · Cited by 24
“The health benefits of anthocy‑ anidins are commonly known (106,107). anthocyanins can traverse the blood‑brain barrier and blood‑retinal barrier and are highly distributed in ocular tissue (108).”
Anthocyanins: Nutrition and Health
Fernandes, I., Marques, C., Évora, A. S., Faria, A., Calhau, C., Mateus, N. F. D. C. B., & de Freitas, V. A. P. (2019) · Reference series in phytochemistry · doi:10.1007/978-3-319-78030-6_79 · Cited by 21
Elvan, M., Baysal, A. H., & Harsa, Ş. (2021) · LWT · doi:10.1016/j.lwt.2021.112975 · Cited by 21
Khongthaw, B., Chauhan, P. K., Dulta, K., Kumar, V., & Ighalo, J. O. (2022) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-022-01697-4 · Cited by 23
Syeda, M. Z., Fasae, M. B., Yue, E., PRUDENCE, I. A., Jiang, Y., Du, Z., Yang, B., & Bai, Y. (2019) · Phytotherapy Research · doi:10.1002/ptr.6485 · Cited by 20
Li, X., Zhang, Z., Zhang, X., Cheng, J., Liu, D., Yan, Y., & Wang, H. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.01.015 · Cited by 20
“In recent years, anthocyanins have attracted scientific interest because of their healthpromoting properties in humans (Li et al., 2017).”
Adhikari, J., Araghi, L. R., Singh, R. K., Adhikari, K., & Patil, B. S. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c01289 · Cited by 20
Ionescu, C., Samide, A. P., & Tigae, C. (2025) · Antioxidants · doi:10.3390/antiox14020227 · Cited by 19
Structure-affinity relationship of dietary anthocyanin–HSA interaction
Zhang, J., Zuo, B., Ulrih, N. P., Sengupta, P. K., Zheng, X., & Xiao, J. (2017) · Journal of Berry Research · doi:10.3233/jbr-170167 · Cited by 19
Bratosin, B. C., Martău, G. A., Ciont, C., Ranga, F., Simon, E., Szabo, K., Dârjan, S., Teleky, B., & Vodnar, D. C. (2024) · Applied Sciences · doi:10.3390/app14062338 · Cited by 19
Cyboran-Mikołajczyk, S., Solarska‐Ściuk, K., Mieszała, K., Glatzel-Plucinska, N. M., Matczak, K., & Kleszczyńska, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081928 · Cited by 19
“The wide presence of anthocyanins in nature and thus in the daily human diet results in a huge amount of research that has been focused on their potential health benefits [6].”
Rubio, M. B., de Alba, Á. E. M., Nicolás, C., Monte, E., & Hermosa, R. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02444 · Cited by 19
Zaim, M., Kara, İ., & Kırmızıbekmez, A. M. (2021) · Cytotechnology · doi:10.1007/s10616-021-00500-4 · Cited by 18
Sangouni, A. A., Sangsefidi, Z. S., Yarhosseini, F., Hosseinzadeh, M., Akhondi‐Meybodi, M., Ranjbar, A., Madadizadeh, F., & Mozaffari–Khosravi, H. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.11.023 · Cited by 19
An Overview of Food Bioactive Compounds and Their Health-Promoting Features
Kamiloğlu, S., Çapanoğlu, E., & Jafari, S. M. (2022) · Food bioactive ingredients · doi:10.1007/978-3-030-96885-4_1 · Cited by 21
Molonia, M. S., Quesada‐López, T., Speciale, A., Muscarà, C., Saija, A., Villarroya, F., & Cimino, F. (2021) · Chemistry & Biodiversity · doi:10.1002/cbdv.202100607 · Cited by 17
“Evidences of the pleiotropic properties of anthocyanins, such as the suppressive effect on body fat accumulation and the anti-diabetic activity, continue to accumulate, and these effects seem to be due to their interaction with different cellular molecular pathways, thus modulating oxidative damage and the expression…”
BackgroundLi, F., Sun, Q., Chen, L., Zhang, R., & Zhang, Z. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2328176 · Cited by 20
“Studies have indicated that the chemical structures of anthocyanins have significant influences on its stability, antioxidant activities, absorption and metabolism, which, in turn, further determine their biological and health-promoting activities (Li et al. 2017).”
The mechanisms of wine phenolic compounds for preclinical anticancer therapeutics
Duan, J., Guo, H., Fang, Y., & Zhou, G. (2021) · Food & Nutrition Research · doi:10.29219/fnr.v65.6507 · Cited by 17
“The primary pathways targeted by anthocyanins by which it interferes with the growth of cancer cells include mitogen-activated protein kinase (MAPK), nuclear factor κB (NFκB ), AMP-activated protein kinase, and Wnt/β-catenin (88).”
BackgroundValencia-Llano, C. H., Solano, M. A., & Grande‐Tovar, C. D. (2021) · Polymers · doi:10.3390/polym13223877 · Cited by 17
“Anthocyanins have previously been show to benefit human health (anticancer activity, anti-infl mmatory activit , neuroprotective activity, prevention of cardiov scular disease, anti-obesity, and ti-diabetic activities) [44].”
BackgroundAnthocyanin as neuroprotector for methamphetamine-induced neurotoxicity
Primatanti, P. A., & Jawi, I. M. (2019) · International journal of health & medical sciences · doi:10.31295/ijhms.v3n1.101 · Cited by 19
“Mitochondrial dysfunction could be caused by oxidative stress and this might initiate further neuronal damage (Li et al, 2017).”
BackgroundInfluentialOsorio-Guarín, J. A., Gopaulchan, D., Quackenbush, C. R., Lennon, A. M., Umaharan, P., & Cornejo, O. E. (2021) · PLoS ONE · doi:10.1371/journal.pone.0261364 · Cited by 18
“Besides being directly beneficial to plants, anthocyanins have also been used as natural food colorants and display vital nutraceutical properties that could be advantageous for human health (Tanaka et al., 2008; Pojer et al., 2013; Li et al., 2017).”
Chen, J., Liu, F., Wu, R. A., Chen, J., Wang, W., Ye, X., Liu, D., & Cheng, H. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2137778 · Cited by 16
“Obesity results from excessive lipid accumulation in the body which is attributed to the imbalance of energy metabolism, leading to various metabolic disorders (Li et al. 2017).”
BackgroundMostafa, H. M. A., Meroño, T., Miñarro, A., Sánchez‐Pla, Á., Lanuza, F., Zamora‐Ros, R., Rostgaard‐Hansen, A. L., Estanyol-Torres, N., Cubedo, M., Tjønneland, A. M., et al. (2023) · Nutrients · doi:10.3390/nu15051208 · Cited by 18
“Dietary ACNs and their microbial metabolites are suggested to play roles in the prevention and treatment of cardiometabolic diseases [4,5].”
BackgroundSpontaneous and Microbiota‐Driven Degradation of Anthocyanins in an In Vitro Human Colon Model
Shehata, E., Day-Walsh, P. E., Kellingray, L., Narbad, A., & Kroon, P. A. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300036 · Cited by 16
Mairuae, N., Palachai, N., & Noisa, P. (2024) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-024-04458-6 · Cited by 16
Chemical and biological study of flavonoid-related plant pigment: current findings and beyond
Yoshida, K. (2024) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbae048 · Cited by 16
Li, Q., Zheng, Y., Zhao, J., Wei, X., Shi, Z., Fan, H., Ge, C., Xu, M., & Tan, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113385 · Cited by 17
Jin, S., & Hyun, T. K. (2020) · Antioxidants · doi:10.3390/antiox9100922 · Cited by 16
“Additionally, anthocyanins have attracted attention due to their known physiological activities and their applications in the food, cosmetic, and pharmaceutical industries, as well as their many benefits to human health [4].”
BackgroundSangsefidi, Z. S., Mozaffari–Khosravi, H., khorasani, S. S., & Hosseinzadeh, M. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2278 · Cited by 16
Li, R., Li, H., & Zhang, Q. (2021) · Environmental Toxicology · doi:10.1002/tox.23389 · Cited by 16
Intuyod, K., Priprem, A., Pairojkul, C., Hahnvajanawong, C., Vaeteewoottacharn, K., Pinlaor, P., & Pinlaor, S. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4306 · Cited by 16
“Anthocyanins exhibit anti-inflammatory, anti-angiogenesis, antioxidant and anti-proliferative effects, and thus have a number of medical applications (15-18).”
Arango-Varela, S. S., Torres-Camargo, D., Reyes‐Dieck, C., Londoño, M. B. Z., & Celis, M. E. M. (2021) · Journal of Berry Research · doi:10.3233/jbr-200684 · Cited by 15
“…sugars, and acylated acids, and the position and degree of glycosylation and acylation in the anthocyanin molecules considered the main factors influencing the anticancer property, however thestructure-activityrelationshipofanthocyaninsaschemoprotectiveagentsremainstobefurtherelucidated[40].”
Zhang, J., Trossat-Magnin, C., Bathany, K., Négroni, L., Delrot, S., & Chaudière, J. (2022) · Molecules · doi:10.3390/molecules27031047 · Cited by 15
Speciale, A., Molonia, M. S., Muscarà, C., Cristani, M., Salamone, F. L., Saija, A., & Cimino, F. (2024) · Fitoterapia · doi:10.1016/j.fitote.2024.105953 · Cited by 17
Yeung, A. W. K., Solka, M., Jóźwik, A., Ksepka, N., Matin, M., Wang, D., Zielińska, A., MohanaSundaram, A., Véjux, A., Zarrouk, A., et al. (2024) · Animal Science Papers and Reports · doi:10.2478/aspr-2023-0020 · Cited by 16
Chen, S.-Y., Islam, M. A., Johnson, J. B., Xu, C., Mazhar, M. S., & Naiker, M. (2024) · Horticulturae · doi:10.3390/horticulturae10101048 · Cited by 15
Antiproliferative and biochemical evaluation of rose extracts: impact on tumor and normal skin cells
Faur, C.-A., Zăhan, M., Bunea, C. I., Hărşan, E., Bora, F. D., & Bunea, A. (2024) · Frontiers in Plant Science · doi:10.3389/fpls.2024.1477243 · Cited by 15
Re-igniting the green revolution with wild crops
Gruber, K. F. (2016) · Nature Plants · doi:10.1038/nplants.2016.48 · Cited by 15
Zhang, Y., Zhang, T., Zhao, Q., Xie, X., Li, Y., Chen, Q., Cheng, F., Tian, J., Gu, H., & Huang, J. (2021) · Foods · doi:10.3390/foods10092180 · Cited by 15
Inhibitory effects of anthocyanins on α -glucosidase activity
Zhang, J., Xiao, J., Giampieri, F., Forbes-Hernández, T. Y., Gasparrini, M., Afrin, S., Cianciosi, D., Reboredo‐Rodríguez, P., Battino, M. A., & Zheng, X. (2018) · Journal of Berry Research · doi:10.3233/jbr-180335 · Cited by 16
Chemical Composition and Health Attributes of Agri-Foods: A Scientific Overview on Black Foods
Nguyen, D. H. H., El-Ramady, H. R., Llanaj, X., Törős, G., Hajdú, P., & Prokisch, J. (2023) · Sustainability · doi:10.3390/su15043852 · Cited by 14
Sangsefidi, Z. S., Zadeh, S. H., & Hosseinzadeh, M. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518002957 · Cited by 14
“In addition, some studies reported that the anti-inflammatory impact of anthocyanins might depend on different factors, including sources, doses and categories of anthocyanins used in the researches((31,35)).”
BackgroundInfluentialDenaro, M., Smeriglio, A., Francesco, C. D., Xiao, J., Cornara, L., & Trombetta, D. (2020) · Fitoterapia · doi:10.1016/j.fitote.2020.104723 · Cited by 14
Natural Food Pigments and Colorants
Rodriguez–Amaya, D. B. (2017) · Reference series in phytochemistry · doi:10.1007/978-3-319-54528-8_12-1 · Cited by 15
Lozada‐Ramírez, J. D., Guerrero-Moras, M. C., González-Peña, M. A., Pereira, T. S. S., de Parrodi, C. A., & Ortega-Regules, A. E. (2023) · Molecules · doi:10.3390/molecules28031353 · Cited by 16
da Silva-Maia, J. K., Nagalingam, A., Cazarin, C. B. B., Maróstica, M. R., & Sharma, D. (2023) · Food Chemistry Molecular Sciences · doi:10.1016/j.fochms.2023.100167 · Cited by 13
Darnal, A., Poggesi, S., Ceci, A. T., Mimmo, T., Boselli, E., & Longo, E. (2023) · European Food Research and Technology · doi:10.1007/s00217-023-04270-5 · Cited by 13
“The research in this field is currently investigating the molecular mechanisms of this bioactivity [4, 5].”
BackgroundSong, W., Yuan, Q., Wang, Y., Mai, M., Luo, M., & Guo, H. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.05.009 · Cited by 14
The Effects of an Acute Dose of New Zealand Blackcurrant Extract on 5-km Running Performance
Moss, S. L., Brindley, E., Enright, K. J., Highton, J. M., & Bott, R. P. (2023) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2023-0029 · Cited by 14
Multi-omics analysis reveals improvement of tomato quality by grafting on goji rootstock
Wang, R., Yang, Y., Xu, K., Wang, T., Elsadek, M. A., Yuan, L., Hu, Z., Lv, Y., Yuan, X., Chen, X., et al. (2024) · Food Quality and Safety · doi:10.1093/fqsafe/fyae023 · Cited by 13
Yang, Y., & Kilmartin, P. A. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.142648 · Cited by 14
Indian Berries and Their Active Compounds
Khan, M. S., Qais, F. A., & Ahmad, I. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814619-4.00008-2 · Cited by 16
Hu, J., Sun, X., Xiao, H., Yang, F., Liu, C., Wang, H., Zhang, H., & Zhang, W. (2022) · Plants · doi:10.3390/plants11212809 · Cited by 13
Sari, D. R. T., Paemanee, A., Roytrakul, S., Cairns, J. R. K., Safitri, A., & Fatchiyah, F. (2021) · Acta Biochimica Polonica · doi:10.18388/abp.2020_5386 · Cited by 13
Cai, X., Lin, L., Wang, X., Xu, C., & Wang, Q. (2018) · Genome · doi:10.1139/gen-2017-0261 · Cited by 13
Cheng, X., Zhu, J., Chen, Z., Wu, Z., Zhang, F., Wu, C., & Fan, G. (2023) · Food Science and Biotechnology · doi:10.1007/s10068-023-01271-8 · Cited by 12
Dudek, A., Strugała, P., Kral, T. E., Hof, M., & Pruchnik, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-39470-2 · Cited by 12
“Anthocyanins demonstrate anti-cancer 1 , anti-diabetic 2 , anti-neurodegenerative 3 , anti-inflammatory effects 4 and prevent cardiovascular diseases 5 .”
A review of pomegranate supplementation: A promising remedial avenue for Alzheimer's disease
Ullah, A., Khan, A., Ahmed, S., Irfan, H. M., Hafiz, A. A., Jabeen, K., Alruwaili, M., Alotaibi, M., Naeem, W. A., Khan, A., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22483 · Cited by 13
“In the last few decades, a number of studies have highlighted different biological activities like, antiobesity, anticancer [42,43], ROS [44], antidiabetic [45] and cardioprotective properties [46].”
BackgroundJiang, M., Jiang, Q., Yang, H., & Zhang, Y. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101195 · Cited by 12
Zhang, G., Cui, X., Niu, J., Ma, F., & Li, P. (2021) · Physiologia Plantarum · doi:10.1111/ppl.13383 · Cited by 12
Hansen, M. M., Hartel, R. W., & Roos, Y. H. (2021) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2021.110586 · Cited by 12
Jung, J., Simonsen, J., Wang, W., & Zhao, Y. (2018) · Food and Bioprocess Technology · doi:10.1007/s11947-018-2114-5 · Cited by 12
“Natural anthocyanin pigments represent attractive red, purple, and blue color in plants, fruits, and vegetables (Li et al. 2015; Yousuf et al. 2015).”
BackgroundPerri, M. R., Romano, C., Marrelli, M., Zicarelli, L., Toma, C.-C., Basta, D., Conforti, F., & Statti, G. A. (2021) · Plants · doi:10.3390/plants11010004 · Cited by 13
Regulation of platelet function by natural bioactive compounds
Fernandez-Rojas, M., Rodríguez, L., Trostchansky, A., & Eduardo Fuentes, Q. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101742 · Cited by 12
Pectin Based Colorimetric Film for Monitoring Food Freshness
Sudharsan, M. S., Mani, H., Kumar, L. S. D., Pazhamalai, V., & Hari, S. (2023) · Current Research in Nutrition and Food Science Journal · doi:10.12944/crnfsj.11.3.03 · Cited by 11
Extraction and food enrichment applications of black carrot phytocompounds: A review
Anandhi, E., Shams, R., Dash, K. K., Bhasin, J. K., Pandey, V. K., & Tripathi, A. (2024) · Applied Food Research · doi:10.1016/j.afres.2024.100420 · Cited by 14
Song, W., Yuan, Q., Xie, Y., Wang, Y., Deng, D., & Guo, H. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140446 · Cited by 11
Şahin, M., Bilgiç, P., Montanari, S., & Willems, M. E. T. (2020) · Journal of Dietary Supplements · doi:10.1080/19390211.2020.1841356 · Cited by 11
Sasaki, K., Geribaldi‐Doldán, N., Szele, F. G., & Isoda, H. (2021) · Aging · doi:10.18632/aging.203373 · Cited by 12
“Also, they were anti-inflammatory in several diseases [15, 16].”
BackgroundIntroduction of Phytonutrients
Nahar, L., Xiao, J., & Sarker, S. D. (2019) · Springer eBooks · doi:10.1007/978-981-13-1745-3_2-1 · Cited by 11
Responsible innovation: Its role in an era of technological and regulatory transformation
Tait, J., Brown, A., Lalinde, I. C., Barlow, D., Chiles, M., & Mason, P. (2021) · Engineering Biology · doi:10.1049/enb2.12005 · Cited by 11
Siatka, T. (2019) · Natural Product Communications · doi:10.1177/1934578x19857344 · Cited by 11
Lai, Y., Chiang, Y.-C., Jhan, Y.-S., Song, T., & Cheng, M. (2024) · Foods · doi:10.3390/foods13142172 · Cited by 10
“Antioxidants neutralize free radicals and reduce oxidative damage, thereby aiding in the prevention of inflammation, cellular aging, and the onset of chronic diseases [9,10].”
BackgroundO mundo colorido das antocianinas
de Freitas, V. A. P. (2019) · Revista de Ciência Elementar · doi:10.24927/rce2019.017 · Cited by 10
Biomarkers of Berry Intake: Systematic Review Update
Mostafa, H. M. A., Cheok, A., Meroño, T., Andrés‐Lacueva, C., & Rodriguez‐Mateos, A. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c01142 · Cited by 12
Oberlerchner, J. T., Fuchs, C., Grausgruber, H., Potthast, A., & Böhmdorfer, S. (2017) · Journal of Chromatography A · doi:10.1016/j.chroma.2017.12.016 · Cited by 10
Seasonal variations in group leaf characteristics in species with red young leaves
Zhang, T., Tian, X., Liu, X.-T., Huang, X.-D., & Peng, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-52753-x · Cited by 10
Role of Natural Flavonoid Products in Managing Osteoarthritis
Pal, R., Kumar, L., Anand, S., & Bharadvaja, N. (2023) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-023-00387-6 · Cited by 10
“CD-40-induced signaling is also inhibited by cyanidin-O-β-glucoside (3), referring to anthocyanins being actively involved in lipid-dependent regulators of inflammatory response (Li et al. 2017).”
BackgroundContreras, J., Alcázar-Valle, M., Lugo‐Cervantes, E., Luna‐Vital, D. A., & Mojica, L. (2023) · Pharmaceuticals · doi:10.3390/ph16060874 · Cited by 9
“Phenolic compounds and anthocyanin are molecules with a polar structure, showing more affinity to the lower phase [12,13].”
BackgroundAksoy, A. S. (2023) · Turkish Journal of Agriculture - Food Science and Technology · doi:10.24925/turjaf.v11i10.2027-2043.6305 · Cited by 12
“Cyclooxygenases and inducible nitric oxide synthase are pivotal enzymes with proinflammatory roles, accountable for generating lipid mediators and nitric oxide, respectively, which are associated with the progression of many inflammatory diseases (Li et al., 2017).”
BackgroundPatanè, G. T., Calderaro, A., Putaggio, S., Ginestra, G., Mandalari, G., Cirmi, S., Barreca, D., Russo, A., Gervasi, T., Neri, G., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189929 · Cited by 9
“Among these, the use of anthocyanins as molecules rich in numerous biological properties and as natural colorants has recently caught the attention of researchers [23,24].”
BackgroundCebulj, A., Vanzo, A., Hladnik, J., Kastelec, D., & Vrhovšek, U. (2021) · Plants · doi:10.3390/plants10071402 · Cited by 9
“Anthocyanins are known for their beneficial role in human health [35].”
BackgroundKaiser, M., Müller-Ehl, L., Passon, M., & Schieber, A. (2020) · Molecules · doi:10.3390/molecules25030518 · Cited by 9
“Accordingly, positive effects on the cardiovascular system and protection against neurodegenerative diseases like Alzheimer’s disease and dementia, via suppressing dopaminergic cell death by interfering with the microglial activation and amelioration of mitochondrial dysfunction, were reported [3,4].”
BackgroundInfluentialHershey, M. S., Sotos‐Prieto, M., Ruiz‐Canela, M., Martínez‐González, M. Á., Cassidy, A., Moffatt, S. M., & Kales, S. N. (2020) · Molecules · doi:10.3390/molecules25194398 · Cited by 9
“These protective effects have been explained by participation in different mechanisms and pathways, including the free-radical scavenging pathway, cyclooxygenase pathway, mitogen-activated protein kinase pathway, and inflammatory cytokines signaling, as well as some crucial cellular processes, including the cell cycle…”
BackgroundYücel, E. E., & Kaya, C. (2021) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.15820 · Cited by 9
Fruit juices as a carrier of probiotics to modulate gut phenolics and microbiota
Leonard, W., Liang, A., Ranadheera, C. S., Fang, Z., & Zhang, P. (2022) · Food & Function · doi:10.1039/d2fo01851a · Cited by 9
Santos, P. C. S., Teixeira, B. A., Queiróz, V. A. V., Vidigal, M. C. T. R., Stringheta, P. C., & de Barros, F. A. R. (2023) · Journal of Food Science · doi:10.1111/1750-3841.16826 · Cited by 8
Lv, S., Tang, X., Jiang, L., Zhang, J., Sun, B., Liu, Q., Mao, X., Yu, H., Chen, P., Chen, W., et al. (2024) · Rice · doi:10.1186/s12284-024-00713-z · Cited by 8
“Our study has demonstrated that OsLSC6 played a crucial role in regulating rice cold tolerance stress, which is different from other reported stress related UGTs, such as UGT76C2 and UGT71C5 (Li et al. 2015; Liu et al. 2015).”
El-Aziz, N. M. A., Mehany, T., & Shehata, M. G. (2024) · LWT · doi:10.1016/j.lwt.2024.116745 · Cited by 9
Ambroziewicz, Z. M., Siemiątkowski, R., Łata, M., Dowgiert, S., Sikorska, M., Kamiński, J., Więcław, K., Grabowska, H., Chruściel, J., & Mąsior, G. (2024) · Journal of Education Health and Sport · doi:10.12775/jehs.2024.76.56522 · Cited by 12
Li, Z., Gao, Z., Su, D., Su, Z., Fu, Y., Xiao, W., Fu, F., Li, G., Huang, L., Guo, J., et al. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.143449 · Cited by 8
Barciela, P., Rodrigues, D. B., Perez-Vazquez, A., da Silveira, T. F. F., Pires, T. C. S. P., Mandim, F., Carpena, M., Pereira, C., Ferreira, I. C. F. R., Barros, L., et al. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.144355 · Cited by 8
McIntyre, S. M., Ma, Q., Burritt, D. J., Oey, I., Gordon, K. C., & Fraser‐Miller, S. J. (2020) · Journal of Raman Spectroscopy · doi:10.1002/jrs.5867 · Cited by 8
Functional Food for Rabbits. Current Approaches and Trends to Increase Functionality
Hechavarría, E. A. D., Guevara-González, R. G., Ocampo-Velazquez, R. V., Soto, J. G. G., Vargas-Hernández, M., Parola-Contreras, I., & Torres‐Pacheco, I. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1939711 · Cited by 10
“On the industry, they have high demand because can be used as pigments, also have high absorption, bioavailability, and pharmacokinetics; besides, they have biological beneficial effects such as anticancer activity, antidiabetic activity, antiinflammatory activity, anti-obesity, the prevention of cardiovascular diseas…”
Background
Metadata
- Authors
- Li, D., Wang, P., Luo, Y., Zhao, M., & Chen, F.
- Affiliations
- Ministry of Education of the People's Republic of China (CN)
- University of Maryland, College Park (US)
- Corresponding author
- Chen, Fang
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2015-07-20
- Volume
- 57
- Issue
- 8
- Pages
- 1729-1741
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W1765735955
- Cited by
- 489
- References
- 103
- Citations by year
- 2026: 25 · 2025: 36 · 2024: 69 · 2023: 60 · 2022: 58 · 2021: 69 · 2020: 63 · 2019: 45 · 2018: 33 · 2017: 19 · 2016: 8 · 2015: 3
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Gene Expression Analysis
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- anthocyanins, health benefits, molecular mechanisms, signaling pathways, mitogen-activated protein kinase, NF-κB, AMPK, Wnt/β-catenin signaling, apoptosis, autophagy, cell cycle, anthocyanin metabolites, structure-activity relationship, synergistic efficacy, disease prevention
- MeSH terms
- Anthocyanins, Anti-Inflammatory Agents, Antineoplastic Agents, Autophagy, Cardiovascular Diseases, Cell Cycle, Humans, Hypoglycemic Agents, Signal Transduction, Apoptosis, Neuroprotective Agents, Anti-Obesity Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
