Cited by 489Phytochemicals and Antioxidant ActivitiesPlant Gene Expression AnalysisPomegranate: compositions and health benefits

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Health benefits of anthocyanins and molecular mechanisms: Update from recent decade

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Li, Daotong, Wang, Pengpu, Luo, Yinghua, Zhao, Mengyao, Chen, Fang·2017·Critical Reviews in Food Science and Nutrition

DOI 10.1080/10408398.2015.1030064

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Abstract

Anthocyanins are one of the most widespread families of natural pigments in the plant kingdom. Their health beneficial effects have been documented in many in vivo and in vitro studies. This review summarizes the most recent literature regarding the health benefits of anthocyanins and their molecular mechanisms. It appears that several signaling pathways, including mitogen-activated protein kinase, nuclear factor κB, AMP-activated protein kinase, and Wnt/β-catenin, as well as some crucial cellular processes, such as cell cycle, apoptosis, autophagy, and biochemical metabolism, are involved in these beneficial effects and may provide potential therapeutic targets and strategies for the improvement of a wide range of diseases in future. In addition, specific anthocyanin metabolites contributing to the observed in vivo biological activities, structure-activity relationships as well as additive and synergistic efficacy of anthocyanins are also discussed.

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“Additionally, anthocyanins have also been reported to display several potential benefits to human health, such as antioxidants, anti-inflammatory, anticancer, antitumour, and antibacterial (Li et al., 2017; Sandoval-Ramírez et al., 2018).”
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Ayub, H., Ahmad, H., Zehra, S. H., Ramzan, K., Arif, M. A., Tariq, N., Capucchio, M. T., Mugabi, R., Sharma, A., & Nayik, G. A. (2026) · Food Chemistry X · doi:10.1016/j.fochx.2026.103614 · Cited by 2
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Advances in non-pharmacological therapies for depressive disorders: A systematic review
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Leather bergenia as an alternative to synthetic colorants for food systems
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Antioxidant components and health benefits of pigmented pseudocereals
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Genetic Dissection of Anthocyanin Accumulation in Tomato Using GWAS and Hybridization Probe Melting (HPM) for Marker-Assisted Breeding
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Development and Optimization of Black Rice-Based Instant Idli Mix Powder
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Eisen und besondere Ernährungsformen
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The Effect of Lycium ruthenicum Murry Anthocyanins on the Apoptosis and Proliferation of H9c2 Cell Induced by Hypoxia
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Anthocyanin attenuates oxygen-glucose deprivation/reperfusion-induced apoptosis of PC12 cells via inactivation of ASK1/JNK/p38 signaling pathway
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“Anthocyanin (Anc), one of the most widespread families of natural pigments, exerts cytoprotective roles in various pathological conditions [4], such as inflammation and cancer [5].”
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Food Polyphenols
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Authors: Li, D., Wang, P., Luo, Y., Zhao, M., & Chen, F.
Affiliations: Ministry of Education of the People's Republic of China (CN)
University of Maryland, College Park (US)
Corresponding author: Chen, Fang
ORCID: Li, Daotong
Luo, Yinghua
Zhao, Mengyao
Venue: Critical Reviews in Food Science and Nutrition
Publisher: Informa UK Limited
Published: 2015-07-20
Volume: 57
Issue: 8
Pages: 1729-1741
ISSN: 1040-8398 (ISSN-L)
1549-7852
DOI: 10.1080/10408398.2015.1030064
OpenAlex: W1765735955
Cited by: 489
References: 103
Citations by year: 2026: 25 · 2025: 36 · 2024: 69 · 2023: 60 · 2022: 58 · 2021: 69 · 2020: 63 · 2019: 45 · 2018: 33 · 2017: 19 · 2016: 8 · 2015: 3
FWCI: 14.39
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Critical Reviews in Food Science and Nutrition (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Gene Expression Analysis
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords: anthocyanins, health benefits, molecular mechanisms, signaling pathways, mitogen-activated protein kinase, NF-κB, AMPK, Wnt/β-catenin signaling, apoptosis, autophagy, cell cycle, anthocyanin metabolites, structure-activity relationship, synergistic efficacy, disease prevention
MeSH terms: Anthocyanins, Anti-Inflammatory Agents, Antineoplastic Agents, Autophagy, Cardiovascular Diseases, Cell Cycle, Humans, Hypoglycemic Agents, Signal Transduction, Apoptosis, Neuroprotective Agents, Anti-Obesity Agents

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Health benefits of anthocyanins and molecular mechanisms: Update from recent decade

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