Superoxide dismutase: An updated review on its health benefits and industrial applications
Abstract
), are toxic or can create oxidative stress in cells, a response involved in the pathogenesis of numerous diseases depending on their concentration, location, and cellular conditions. Superoxide dismutase (SOD) activities as an endogenous and exogenous cell defense mechanism include the potential use in treating various diseases, improving the potential use in treating various diseases, and improving food-stuffs preparation dietary supplements human nutrition. Published work indicates that SOD regulates oxidative stress, lipid metabolism, inflammation, and oxidation in cells. It can prevent lipid peroxidation, the oxidation of low-density lipoprotein in macrophages, lipid droplets' formation, and the adhesion of inflammatory cells into endothelial monolayers. It also expresses antioxidant effects in numerous cancer-related processes. Additionally, different forms of SOD may also augment food processing and pharmaceutical applications, exhibit anticancer, antioxidant, and anti-inflammatory effects, and prevent arterial problems by protecting the proliferation of vascular smooth muscle cells. Many investigations in this review have reported the therapeutic ability and physiological importance of SOD. Because of their antioxidative effects, SODs are of great potential in the medicinal, cosmetic, food, farming and chemical industries. This review discusses the findings of human and animal studies that support the advantages of SOD enzyme regulations to reduce the formation of oxidative stress in various ways.
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The most used methods for measuring SOD activity require a superoxide radical generator and a detector of the superoxide radical.
“The most used methods require two components: (a) a superoxide radical generator and (b) a detector of the superoxide radical [103].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [103]
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Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity
Andrés, C. M. C., Pérez de la Lastra, J. M., Andrés Juan, C., Plou, F. J., & Pérez-Lebeña, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031841 · Cited by 342 · see citing works
- Authors
- Islam, M. N., Rauf, A., Fahad, F. I., Emran, T. B., Mitra, S., Olatunde, A., Shariati, M. A., Rebezov, M., Rengasamy, K. R. R., & Mubarak, M. S.
- Affiliations
- International Islamic University Chittagong (BD)
- University of Swabi (PK)
- BGC Trust University Bangladesh (BD)
- University of Dhaka (BD)
- Abubakar Tafawa Balewa University (NG)
- Moscow State University of Technologies and Management named after K.G. Razumovskiy (RU)
- V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russian Federation
- University of Limpopo (ZA)
- University of Jordan (JO)
- Corresponding author
- Rauf, Abdur
- Rengasamy, Kannan R. R.
- Mubarak, Mohammad S.
- ORCID
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2021-04-27
- Volume
- 62
- Issue
- 26
- Pages
- 7282-7300
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W3158496923
- Cited by
- 307
- References
- 165
- Citations by year
- 2026: 62 · 2025: 96 · 2024: 74 · 2023: 44 · 2022: 25 · 2021: 6
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- superoxide dismutase, oxidative stress, antioxidant enzymes, lipid peroxidation, LDL oxidation, inflammation, cancer, dietary supplements, food processing, pharmaceutical applications, vascular smooth muscle cells, cosmetic applications, industrial applications
- MeSH terms
- Animals, Antioxidants, Humans, Hydrogen Peroxide, Superoxides, Superoxide Dismutase, Reactive Oxygen Species, Oxidative Stress
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