The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man
Open accessAbstract
Flavonoids are antioxidants present in plant foods. They occur mainly as glycosides, i.e. linked with various sugars. It is uncertain to what extent dietary flavonoid glycosides are absorbed from the gut. We investigated how the nature of the sugar group affected absorption of one major flavonoid, quercetin. Quercetin linked with glucose, i.e. quercetin glucoside and quercetin linked with rutinose, i.e. quercetin rutinoside, both occur widely in foods. When we fed these compounds to nine volunteers, the peak concentration of quercetin (Cmax) in plasma was 20 times higher and was reached (Tmax) more than ten times faster after intake of the glucoside (Cmax = 3.5+/-0.6 microM (mean +/- SE); Tmax < 0.5 h) than after the rutinoside (Cmax = 0.18+/-0.04 microM; Tmax = 6.0+/-1.2 h). The bioavailability of the rutinoside was only 20% of that of the glucoside. We suggest that quercetin glucoside is actively absorbed from the small intestine, whereas quercetin rutinoside is absorbed from the colon after deglycosylation. Absorption of other food components might also be enhanced by attachment of a glucose group.
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Cites
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
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Self-citationFree radicals, antioxidants, and human disease: curiosity, cause, or consequence?
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The Flavonoids. A Class of Semi-Essential Food Components: Their Role in Human Nutrition
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Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
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Self-citationRelative bioavailability of the antioxidant flavonoid quercetin from various foods in man
Hollman, P. C. H., van Trijp, J. M. P., Buysman, M. N. C. P., v.d. Gaag, M. S., Mengelers, M. J. B., de Vries, J. H. M., & Katan, M. B. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01367-7 · Cited by 782
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Cited by
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219
Advances in flavonoid research since 1992
Harborne, J. B., & Williams, C. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00235-1 · Cited by 3,956
Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658
The biochemistry and medical significance of the flavonoids
Havsteen, B. H. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00298-x · Cited by 2,672
Metadata
- Authors
- Hollman, P. C. H., Bijsman, M. N. C. P., van Gameren, Y., Cnossen, E. P. J., de Vries, J. H. M., & Katan, M. B.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 1999-01
- Volume
- 31
- Issue
- 6
- Pages
- 569-573
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2120929516
- Cited by
- 554
- References
- 25
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Hollman, P. C. H., Bijsman, M. N. C. P., van Gameren, Y., Cnossen, E. P. J., de Vries, J. H. M., & Katan, M. B. (1999). The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Radical Research. https://doi.org/10.1080/10715769900301141
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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