CoChat
Sign Up
Cited by 61Attention Deficit Hyperactivity DisorderAntioxidant Activity and Oxidative StressParaoxonase enzyme and polymorphisms

Increased oxidative stress in children with attention deficit hyperactivity disorder

Open access
Sezen, Hatice, Kandemir, Hasan, Savik, Emin, Basmacı Kandemir, Sultan, Kilicaslan, Fethiye, Bilinc, Hasan, Aksoy, Nurten·2016·Redox Report
DOI 10.1080/13510002.2015.1116729PMC PMC6837712
Open this paper in CoChat — free accountOpen PDF

Abstract

OBJECTIVES: The purpose of this study was to investigate oxidative stress in children with attention deficit hyperactivity disorder (ADHD). METHODS: Total oxidant status (TOS), total antioxidant status (TAS), paraxonase-1 (PON-1) and arylesterase (ARE) activity were measured in 76 children (44 boys, 32 girls) diagnosed with ADHD according to the DSM-IV and 78 healthy children (46 boys, 32 girls). RESULTS: Age and sex were similar between the groups (P > 0.05). TOS and the oxidative stress index (OSI) were higher in the patient group than the control group (P < 0.001). PON-1 (P = 0.002), ARE (P = 0.010) activity and TAS (P < 0.001) were lower in the patient group than the control group. DISCUSSION: We found decreased PON-1, ARE activity and TAS, and increased TOS and OSI in children with ADHD. Our study showed that there is significantly increased oxidative stress in children with ADHD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1080/13510002.2015.1116729

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 37

  1. Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 2007;164(6):942-8. doi:10.1176/ajp.2007.164.6.942 · DOI · Paper page
  2. Cheng K, Myers MK. Attention deficit hyperactivity disorder. In: Stubbe ED, (ed.) Child and adolescent psychiatry. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 53-73.
  3. Harpin VA. The effect of ADHD on the life of an individual, their family, and community from preschool to adult life. Arch Dis Child 2005;90(Suppl 1):2-7. doi:10.1136/adc.2004.059006 · DOI · Paper page
  4. Kandemir H, Kılıç BG, Ekinci S, Yüce M. An evaluation of the quality of life of children with attention-deficit/hyperactivity dis- order (ADHD) and their families. Anadolu Psikiyatri Derg 2014;15(3):265-71.
  5. Kurman J, Rothschild-Yakar L, Angel R, Katz M. How good am i? Implicit and explicit self-esteem as a function of perceived parenting styles among children with ADHD. J Atten Disord 2015. doi:10.1177/1087054715569599. · DOI
  6. Takon I. Clinical use of a modified release methylphenidate in the treatment of childhood attention deficit hyperactivity dis- order. Ann Gen Psychiatry 2011;10:25. doi:10.1186/1744- 859X-10-25 · DOI
  7. Sharp SI, McQuillin A, Gurling HM. Genetics of attention- deficit hyperactivity disorder (ADHD). Neuropharmacology 2009;57(7-8):590-600. doi:10.1016/j.neuropharm.2009.08.011 · DOI
  8. Tripp G, Wickens JR. Neurobiology of ADHD. Neuropharmacology 2009;57(7-8):579-89. doi:10.1016/j.neuro pharm.2009.07.026 · DOI · Paper page
  9. Kandemir H, Erdal ME, Selek S, Ay ÖI ˙, Karababa IF, Kandemir SB, et al. Evaluation of several micro RNA (miRNA) levels in children and adolescents with attention deficit hyperactivity disorder. Neurosci Lett 2014;580:158-62. doi:10.1016/j.neulet.2014.07.060 · DOI
  10. Young J, McKinney SB, Ross BM, Wahle KW, Boyle SP. Biomarkers of oxidative stress in schizophrenic and control sub- jects. Prostaglandins Leukot Essent Fatty Acids 2007;76(2): 73-85. doi:10.1016/j.plefa.2006.11.003 · DOI
  11. Selek S, Herken H, Bulut M, Ceylan MF, Celik H, Savas HA, et al. Oxidative imbalance in obsessive compulsive disorder patients: a total evaluation of oxidant-antioxidant status. Prog Neuropsychopharmacol Biol Psychiatry 2008;32(2):487-91. doi :10.1016/j.pnpbp.2007.10.002 · DOI
  12. Yumru M, Savas HA, Kalenderoglu A, Bulut M, Celik H, Erel O. Oxidative imbalance in bipolar disorder subtypes: a compara- tive study. Prog Neuropsychopharmacol Biol Psychiatry 2009;33(6):1070-4. doi:10.1016/j.pnpbp.2009.06.005 · DOI
  13. Tsaluchidu S, Cocchi M, Tonello L, Puri BK. Fatty acids and oxidative stress in psychiatric disorders. BMC Psychiatry 2008;8(Suppl 1):5. doi:10.1186/1471-244X-8-S1-S5 19 · DOI
  14. Spahis S, Vanasse M, Bélanger SA, Ghadirian P, Grenier E, Levy E. Lipid profile, fatty acid composition and pro-and anti-oxidant status in pediatric patients with attention-deficit/ hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 2008;79(1-2):47-53. doi:10.1016/j.plefa.2008.07.005 · DOI
  15. Oztop D, Altun H, Baskol G, Ozsoy S. Oxidative stress in children with attention deficit hyperactivity disorder. Clin Biochem 2012;45(10-11):745-8. doi:10.1016/j.clinbiochem.2012.03.027 · DOI
  16. Dvoráková M, Sivonová M, Trebatická J, Skodácek I, Waczuliková I, Muchová J, et al. The effect of polyphenolic extract from pine bark, Pycnogenol on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD). Redox Rep 2006;11(4):163-72. doi:10.1179/ 135100006X116664 · DOI
  17. Varol TF, Guvenir T, Tas G, Cakaloz B, Ormen M. Nitric oxide levels in disruptive behavioral disorder. Neuropsychobiology 2006;53(4):176-80. doi:10.1159/000093781 · DOI
  18. Bulut M, Selek S, Gergerlioglu HS, Savas HA, Yilmaz HR, Yuce M, et al. Malondialdehyde levels in adult attention-deficit hyper- activity disorder. J Psychiatry Neurosci 2007;32(6):435-8.
  19. Selek S, Savas HA, Gergerlioglu HS, Bulut M, Yilmaz HR. Oxidative imbalance in adult attention deficit/hyperactivity dis- order. Biol Psychol 2008;79(2):256-9. doi:10.1016/j.biopsycho .2008.06.005 · DOI
  20. Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, et al. Structure and evolution of the serum paraox- onase family of detoxifying and anti-atherosclerotic enzymes. Nat Struct Mol Biol 2004;11(5):412-9. Epub 18 April 2004. Erratum in: Nat Struct Mol Biol 2004 Dec;11(12):1253. doi:10 .1038/nsmb767 · DOI
  21. Gur M, Aslan M, Yildiz A, Demirbag R, Yilmaz R, Selek S, et al. Paraoxonase and arylesterase activities in coronary artery disease. Eur J Clin Invest 2006;36(11):779-87. doi:10.1111/j .1365-2362.2006.01727.x · DOI
  22. Aslan M, Kosecik M, Horoz M, Selek S, Celik H, Erel O. Assessment of paraoxonase and arylesterase activities in patients with iron deficiency anemia. Atherosclerosis 2007;191(2): 397-402. doi:10.1016/j.atherosclerosis.2006.04.007 · DOI
  23. Mabrouk H, Mechria H, Mechri A, Azizi I, Neffati F, Douki W, et al. Paraoxonase 1 activity and lipid profile in schizophrenic patients. Asian J Psychiatr 2014;9:36-40. doi:10.1016/j.ajp.2013 .12.019 · DOI
  24. Calik M, Oguz E, Sarikaya S, Kocaturk O, Koca B, Gungor HE, et al. An evaluation of serum paraoxonase together with aryles- terase activities and oxidative stress in children with intractable epilepsy: a cross-sectional study. Epilepsy Res 2014;108(9): 1591-6. doi:10.1016/j.eplepsyres.2014.08.007 · DOI
  25. Eckerson HW, Wyte MC, La Du BN. The human serum paraox- onase/arylesterase polymorphism. Am J Hum Genet 1983;35: 1126-38.
  26. Haagen L, Brock A. A new automated method for phenotyping arylesterase (E.C.3.1.1.2.) based upon inhibition of enzymatic hydrolysis of 4-nitrophenyl acetate by phenyl acetate. Eur J Clin Chem Clim Biochem 1992;30:391-5.
  27. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 2004;37(2):112-9. doi:10.1016/j.clinbiochem.2003.10.014 · DOI
  28. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005;38(12):1103-11. doi:10 .1016/j.clinbiochem.2005.08.008 · DOI
  29. Kosecik M, Erel O, Sevinc E, Selek S. Increased oxidative stress in children exposed to passive smoking. Int J Cardiol 2005;100(1):61-4. doi:10.1016/j.ijcard.2004.05.069 · DOI
  30. Archana E, Pai P, Prabhu BK, Shenoy RP, Prabhu K, Rao A. Altered biochemical parameters in saliva of pediatric attention deficit hyperactivity disorder. Neurochem Res 2012;37(2): 330-4. doi:10.1007/s11064-011-0616-x · DOI
  31. Comim CM, Gomes KM, Réus GZ, Petronilho F, Ferreira GK, Streck EL, et al. Methylphenidate treatment causes oxidative stress and alters energetic metabolism in an animal model of attention-deficit hyperactivity disorder. Acta Neuropsychiatr 2014;26(2):96-103. doi:10.1017/neu.2013.35 · DOI
  32. Martins MR, Reinke A, Petronilho FC, Gomes KM, Dal-Pizzol F, Quevedo J. Methylphenidate treatment induces oxidative stress in young rat brain. Brain Res 2006;1078(1):189-97. doi :10.1016/j.brainres.2006.01.004 · DOI · Paper page
  33. Kawatani M, Tsukahara H, Mayumi M. Evaluation of oxidative stress status in children with pervasive developmental disorder and attention deficit hyperactivity disorder using urinary-specific biomarkers. Redox Rep 2011;16(1):45-6. doi:10.1179/ 174329211X12968219310873 · DOI
  34. Ceylan M, Sener S, Bayraktar AC, Kavutcu M. Oxidative imbalance in child and adolescent patients with attention- deficit/hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 2010;34(8):1491-4. doi:10.1016/j.pnpbp.2010. 08.010 · DOI
  35. Stoelting M, Geyer M, Reuter S, Reichelt R, Bek MJ, Pavenstädt H. Alpha/beta hydrolase 1 is upregulated in D5 dopamine receptor knockout mice and reduces O2-production of NADPH oxidase. Biochem Biophys Res Commun 2009;379(1):81-5. doi:10.1016/j.bbrc.2008.12.008 · DOI
  36. Wu J, Xiao H, Sun H, Zou L, Zhu LQ. Role of dopamine recep- tors in ADHD: a systematic meta-analysis. Mol Neurobiol 2012;45(3):605-20. doi:10.1007/s12035-012-8278-5 · DOI · Paper page
  37. Wiecek M, Maciejczyk M, Szymura J, Szygula Z. Changes in oxidative stress and acid-base balance in men and women fol- lowing maximal-intensity physical exercise. Physiol Res 2015;64(1):93-102.

Cited by

Sorted by citations

Authors
Sezen, H., Kandemir, H., Savik, E., Basmacı Kandemir, S., Kilicaslan, F., Bilinc, H., & Aksoy, N.
Affiliations
Harran University (TR)
Corresponding author
Sezen, Hatice
ORCID
Venue
Redox Report
Publisher
Informa UK Limited
Published
2016-02-18
Volume
21
Issue
6
Pages
248-253
ISSN
  • 1351-0002 (ISSN-L)
  • 1743-2928
DOI
10.1080/13510002.2015.1116729
PMC
PMC6837712
OpenAlex
W2274765199
Cited by
61
References
5
Citations by year
2026: 5 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 2
FWCI
5.04
Type
journal article
Language
en
Open access
Locations
  • Redox Report (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
No funding
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords
attention deficit hyperactivity disorder, oxidative stress, children, total oxidant status, total antioxidant status, paraoxonase 1, arylesterase, oxidative stress index, antioxidant activity
MeSH terms
Adolescent, Antioxidants, Attention Deficit Disorder with Hyperactivity, Carboxylic Ester Hydrolases, Child, Female, Humans, Male, Oxidation-Reduction, Oxidative Stress, Aryldialkylphosphatase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review