Cited by 197Antioxidant Activity and Oxidative StressTryptophan and brain disordersRedox biology and oxidative stress

Antioxidative enzymes and increased oxidative stress in depressive women

Kodydková, Jana, Vávrová, Lucie, Zeman, Miroslav, Jirák, Roman, Macášek, Jaroslav, Staňková, Barbora, Tvrzická, Eva, Žák, Aleš·2009·Clinical Biochemistry

Abstract

Objectives To investigate the activities of the main antioxidative enzymes and oxidative stress in women with depressive disorder (DD).Methods In 35 drug-naive women with DD and 35 age matched healthy women enzymes superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPX1), glutathione reductase (GR) and paraoxonase (PON1), concentrations of conjugated dienes (CD), reduced glutathione (GSH) and anthropometric and clinical data were investigated.Results Women with DD were found to have decreased activities of GPX1 (p<0.05), decreased concentrations of GSH (p<0.05), and increased activities of GR (p<0.05), CuZnSOD (p<0.001), and concentrations of CD (p<0.05). Activity of GPX1 was positively correlated with concentration of GSH (p<0.05). Concentrations of CD were positively correlated with TG (p<0.01).Conclusion Our set of depressive women was characterized by changes indicating an increased oxidative stress, as well as by certain features of metabolic syndrome.

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Crossref · 10.1016/j.clinbiochem.2009.06.006

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Authors
Kodydková, J., Vávrová, L., Zeman, M., Jirák, R., Macášek, J., Staňková, B., Tvrzická, E., & Žák, A.
Affiliations
Charles University (CZ)
Corresponding author
Kodydková, Jana
Venue
Clinical Biochemistry
Publisher
Elsevier BV
Published
2009-09
Volume
42
Issue
13-14
Pages
1368-1374
ISSN
0009-9120 (ISSN-L)
OpenAlex
W2037761163
Cited by
197
References
61
Citations by year
2026: 4 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 8 · 2021: 8 · 2020: 19 · 2019: 6 · 2018: 13 · 2017: 16 · 2016: 11 · 2015: 14 · 2014: 22 · 2013: 14 · 2012: 19
FWCI
7.73
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Health (MSM0021620820)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
depressive disorders, oxidative stress, antioxidant enzymes, women, glutathione peroxidase 1, superoxide dismutase, catalase, glutathione reductase, paraoxonase 1, reduced glutathione, conjugated dienes, metabolic syndrome, triglycerides
MeSH terms
Aged, Alkadienes, Catalase, Depressive Disorder, Enzymes, Female, Glutathione, Glutathione Peroxidase, Glutathione Reductase, Humans, Middle Aged, Oxidation-Reduction, Spectrophotometry, Superoxide Dismutase, Triglycerides, Oxidative Stress, Aryldialkylphosphatase

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