Cited by 47HIV Research and TreatmentHIV-related health complications and treatmentsAdvanced Neuroimaging Techniques and Applications

Apathy is associated with white matter abnormalities in anterior, medial brain regions in persons with HIV infection

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Kamat, Rujvi, Brown, Gregory G., Bolden, Khalima, Fennema-Notestein, Christine, Archibald, Sarah, Marcotte, Thomas D., Letendre, Scott L., Ellis, Ronald J. +4 more·2014·Journal of Clinical and Experimental Neuropsychology

Abstract

Apathy is a relatively common psychiatric syndrome in HIV infection, but little is known about its neural correlates. In the present study, we examined the associations between apathy and diffusion tensor imaging (DTI) indices in key frontal white matter regions in the thalamocorticostriatal circuit, which has been implicated in the expression of apathy. Nineteen participants with HIV infection and 19 demographically comparable seronegative comparison subjects completed the Apathy subscale of the Frontal Systems Behavioral Scale as a part of a comprehensive neuropsychiatric research evaluation. When compared to the seronegative participants, the HIV+ group had significantly more frontal white matter abnormalities. Within HIV+ persons, and as predicted, higher ratings of apathy were associated with greater white matter alterations in the anterior corona radiata, genu, and orbital medial prefrontal cortex. The associations between white matter alterations and apathy were independent of depression and were stronger among participants with lower current cluster of differentiation 4 (CD4) counts. All told, these findings indicate that apathy is independently associated with white matter abnormalities in anterior, medial brain regions in persons infected with HIV, particularly in the setting of lower current immune functioning, which may have implications for antiretroviral therapy.

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  1. Heaton RK Taylor MJ Manly J 2003 Demographic effects and use of demographically corrected norms with the WAIS-III and WMS-III Tulsky D Saklofske D Heaton RK Chelune GJ Ivnik RA Bornstein RA Prifitera A Ledbetter M Clinical interpretation of the WAIS-III and WMS-III 181 San Diego, CA Academic Press

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Authors
Kamat, R., Brown, G. G., Bolden, K., Fennema-Notestein, C., Archibald, S., Marcotte, T. D., Letendre, S. L., Ellis, R. J., Woods, S. P., Grant, I., Heaton, R. K., & the TMARC Group
Affiliations
University of California San Diego (US)
Corresponding author
Brown, Gregory G.
Venue
Journal of Clinical and Experimental Neuropsychology
Published
2014-09-14
Volume
36
Issue
8
Pages
854-866
ISSN
  • 0165-0475 (ISSN-L)
  • 1380-3395
  • 1744-411X
OpenAlex
W2076540003
Cited by
47
References
68
Citations by year
2026: 1 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 7 · 2016: 3 · 2015: 6
FWCI
2.38
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical and Experimental Neuropsychology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institute of Mental Health (R25MH081482, P30MH062512)
  • National Institute on Drug Abuse (P50DA026306)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
apathy, HIV infection, white matter abnormalities, frontal white matter, corona radiata, genu, medial prefrontal cortex, CD4 count, depression, antiretroviral therapy
MeSH terms
Adult, Female, Frontal Lobe, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Regression Analysis, Cohort Studies, HIV Infections, Statistics, Nonparametric, Diffusion Tensor Imaging, Leukoencephalopathies, Apathy

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