Apathy is associated with white matter abnormalities in anterior, medial brain regions in persons with HIV infection
Open accessAbstract
Apathy is a relatively common psychiatric syndrome in HIV infection, but little is known about its neural correlates. In the present study, we examined the associations between apathy and diffusion tensor imaging (DTI) indices in key frontal white matter regions in the thalamocorticostriatal circuit, which has been implicated in the expression of apathy. Nineteen participants with HIV infection and 19 demographically comparable seronegative comparison subjects completed the Apathy subscale of the Frontal Systems Behavioral Scale as a part of a comprehensive neuropsychiatric research evaluation. When compared to the seronegative participants, the HIV+ group had significantly more frontal white matter abnormalities. Within HIV+ persons, and as predicted, higher ratings of apathy were associated with greater white matter alterations in the anterior corona radiata, genu, and orbital medial prefrontal cortex. The associations between white matter alterations and apathy were independent of depression and were stronger among participants with lower current cluster of differentiation 4 (CD4) counts. All told, these findings indicate that apathy is independently associated with white matter abnormalities in anterior, medial brain regions in persons infected with HIV, particularly in the setting of lower current immune functioning, which may have implications for antiretroviral therapy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
White matter hyperintensities are strongly and independently associated with symptoms of apathy.
“WMH are also strongly and independently associated with symptoms of apathy241–245.”
From Psychobiological factors of resilience and depression in late life (2019) · cites this paper as [241]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527 · see citing works
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568 · see citing works
Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water
Song, S.-K., Sun, S.-W., Ramsbottom, M. J., Chang, C., Russell, J., & Cross, A. H. (2002) · NeuroImage · doi:10.1006/nimg.2002.1267 · Cited by 2,582 · see citing works
American Journal of Neuroradiology
(2020) · American Journal of Neuroradiology · doi:10.3174/ajnr · Cited by 2,468 · see citing works
Frontal-subcortical circuits and human behavior
Cummings, J. L. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540080076020 · Cited by 2,262 · see citing works
KRINGELBACH, M. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.006 · Cited by 1,977 · see citing works
Apathy and the Functional Anatomy of the Prefrontal Cortex–Basal Ganglia Circuits
Levy, R., & Dubois, B. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj043 · Cited by 1,285 · see citing works
The AIDS dementia complex: II. Neuropathology
NAVIA, B. A., Cho, E., Petito, C. K., & Price, R. W. (1986) · Annals of Neurology · doi:10.1002/ana.410190603 · Cited by 1,268 · see citing works
Frontal–subcortical neuronal circuits and clinical neuropsychiatry
Tekin, S., & Cummings, J. L. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00428-2 · Cited by 1,240 · see citing works
About “axial” and “radial” diffusivities
Wheeler‐Kingshott, C. A. M., & Cercignani, M. (2009) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21965 · Cited by 885 · see citing works
Wittchen, H.-U., Robins, L. N., Cottler, L. B., Sartorius, N., Burke, J. D., Regier, D., & Trials, P. I. T. M. W. F. (1991) · British Journal of Psychiatry · doi:10.1192/bjp.159.5.645 · Cited by 833 · see citing works
The impact of HIV-associated neuropsychological impairment on everyday functioning
Heaton, R. K., Marcotte, T. D., Mindt, M. R., Sadek, J. R., Moore, D. J., Bentley, H. A., McCutchan, J. A., REICKS, C., Grant, I., & THE HNRC GROUP (2004) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617704102130 · Cited by 726 · see citing works
Self-citationPrinciples of Frontal Lobe Function
(2013) · Oxford University Press eBooks · doi:10.1093/med/9780199837755.001.0001 · Cited by 719 · see citing works
Levy, M. L., Cummings, J. L., Fairbanks, L. A., Masterman, D. L., Miller, B. L., Craig, A., Paulsen, J. S., & Litvan, I. (1998) · Journal of Neuropsychiatry · doi:10.1176/jnp.10.3.314 · Cited by 678 · see citing works
Frontal-subcortical circuitry and behavior
Bonelli, R. M., & Cummings, J. L. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.2/rbonelli · Cited by 613 · see citing works
Carey, C. L., Woods, S. P., González, R., Conover, E., Marcotte, T. D., Grant, I., & Heaton, R. K. (2004) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390490510031 · Cited by 544 · see citing works
Self-citationSousa, A. E., Carneiro, J., Meier‐Schellersheim, M., Grossman, Z., & Victorino, R. M. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.3400 · Cited by 506 · see citing works
Atlas of Human Brain Connections
Catani, M., & Thiebaut de Schotten, M. (2012) · doi:10.1093/med/9780199541164.001.0001 · Cited by 467 · see citing works
A new method for improving functional-to-structural MRI alignment using local Pearson correlation
Saad, Z. S., Glen, D. R., Chen, G., Beauchamp, M. S., Desai, R., & Cox, R. W. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.09.037 · Cited by 405 · see citing works
Diffusion tensor imaging of post mortem multiple sclerosis brain
Schmierer, K., Wheeler-Kingshott, C. A. M., Boulby, P. A., Scaravilli, F., Altmann, D. R., Barker, G. J., Tofts, P. S., & Miller, D. H. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.010 · Cited by 395 · see citing works
Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease
Bruen, P. D., McGeown, W. J., Shanks, M. F., & Venneri, A. (2008) · Brain · doi:10.1093/brain/awn151 · Cited by 374 · see citing works
Cognitive Neuroscience of Attention
(1998) · Psychology Press eBooks · doi:10.4324/9781410603906 · Cited by 354 · see citing works
A prospective longitudinal study of apathy in Alzheimer's disease
STARKSTEIN, S. E. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.069575 · Cited by 339 · see citing works
Reduced basal ganglia volume in HIV‐1‐associated dementia
Aylward, E., Henderer, J. D., McArthur, J. C., Brettschneider, P. D., Harris, G. J., Barta, P. E., & Pearlson, G. D. (1993) · Neurology · doi:10.1212/wnl.43.10.2099 · Cited by 317 · see citing works
Frontal systems behavior scale : professional manual
Grace, J. (2001) · Medical Entomology and Zoology · Cited by 316 · see citing works
Barclay, T. R., Hinkin, C. H., Castellon, S. A., Mason, K. I., Reinhard, M. J., Marion, S., Levine, A. J., & Durvasula, R. (2007) · Health Psychology · doi:10.1037/0278-6133.26.1.40 · Cited by 303 · see citing works
The Antiretroviral Therapy (ART) Cohort Collaboration (2007) · AIDS · doi:10.1097/qad.0b013e328133f285 · Cited by 292 · see citing works
MRI atlas of human white matter
Oishi, K., & Crain, B. J. (2010) · Cited by 272 · see citing works
Marin, R. S., Fogel, B. S., Hawkins, J. W., Duffy, J., & Krupp, B. H. (1995) · Journal of Neuropsychiatry · doi:10.1176/jnp.7.1.23 · Cited by 229 · see citing works
White matter abnormalities in HIV-1 infection: A diffusion tensor imaging study
Pomara, N., CRANDALL, D. T., Choi, S. J., Johnson, G., & Lim, K. O. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(00)00082-2 · Cited by 201 · see citing works
Filippi, C. G., Uluğ, A. M., Ryan, E., Ferrando, S. J., & van Gorp, W. G. (2001) · PubMed Central · Cited by 195 · see citing works
Reijnders, J., Scholtissen, B., Weber, W., Aalten, P., Verhey, F., & Leentjens, A. (2010) · Movement Disorders · doi:10.1002/mds.23268 · Cited by 192 · see citing works
Cohen, R. A., Harezlak, J., Schifitto, G., Hana, G., Clark, U. S., Gongvatana, A., Paul, R. H., Taylor, M. J., Thompson, P. M., Alger, J. R., et al. (2010) · Journal of NeuroVirology · doi:10.3109/13550280903552420 · Cited by 191 · see citing works
Structural correlates of apathy in Alzheimer's disease
Apostolova, L. G., Akopyan, G. G., Partiali, N., Steiner, C. A., Dutton, R. A., Hayashi, K. M., Dinov, I. D., Toga, A. W., Cummings, J. L., & Thompson, P. M. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000103914 · Cited by 190 · see citing works
How psychotic are individuals with non-psychotic disorders?
Hanssen, M., Peeters, F. P. M. L., A, L. K. M., Radstake, S., Verdoux, H., & van Os, J. (2003) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-003-0622-7 · Cited by 185 · see citing works
Everall, I., Vaida, F., Khanlou, N., Lazzaretto, D., Achim, C. L., Letendre, S. L., Moore, D. J., Ellis, R. J., Cherner, M., Gelman, B. B., et al. (2009) · Journal of NeuroVirology · doi:10.3109/13550280903131915 · Cited by 183 · see citing works
Self-citation3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometry
Chiang, M.-C., Dutton, R. A., Hayashi, K. M., López, O. L., Aizenstein, H. J., Toga, A. W., Becker, J. T., & Thompson, P. M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.08.030 · Cited by 178 · see citing works
Pfefferbaum, A., Rosenbloom, M. J., Elfar Adalsteinsson, A., & Sullivan, E. V. (2006) · Brain · doi:10.1093/brain/awl242 · Cited by 171 · see citing works
Clinical factors related to brain structure in HIV: the CHARTER study
for the CHARTER Group, Jernigan, T. L., Archibald, S. L., Fennema‐Notestine, C., Taylor, M. J., Theilmann, R. J., Julaton, M. D., Notestine, R. J., Wolfson, T. J., Letendre, S. L., et al. (2011) · Journal of NeuroVirology · doi:10.1007/s13365-011-0032-7 · Cited by 167 · see citing works
Self-citationChoi, S. J., Lim, K. O., Monteiro, I. M., & Reisberg, . (2005) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988704271763 · Cited by 153 · see citing works
Lavretsky, H., Ballmaier, M., Pham, D., Toga, A., & Kumar, A. (2007) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3180325a16 · Cited by 143 · see citing works
Gongvatana, A., Schweinsburg, B. C., Taylor, M. J., Theilmann, R. J., Letendre, S. L., Alhassoon, O. M., Jacobus, J., Woods, S. P., Jernigan, T. L., Ellis, R. J., et al. (2009) · Journal of NeuroVirology · doi:10.1080/13550280902769756 · Cited by 139 · see citing works
Self-citationDiffusion alterations in corpus callosum of patients with HIV.
Wu, Y. G., Storey, P., Cohen, B. A., Epstein, L. G., Edelman, R. R., & Ragin, A. B. (2006) · PubMed Central · Cited by 139 · see citing works
Differentiation of States and Causes of Apathy
Stuss, D. T., van Reekum, R., & Murphy, K. J. (2000) · doi:10.1093/oso/9780195114645.003.0014 · Cited by 134 · see citing works
Neuroimaging Correlates of Apathy and Depression in Alzheimer's Disease
STARKSTEIN, S. E., Mizrahi, R., Capizzano, A. A., Ación, L., Brockman, S., & Power, B. (2009) · Journal of Neuropsychiatry · doi:10.1176/jnp.2009.21.3.259 · Cited by 132 · see citing works
Chen, Y., An, H., Hongtu Zhu, B., Stone, T. J., Smith, J. K., Hall, C. D., Bullitt, E., Shen, D. G., & Lin, W. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.04.030 · Cited by 123 · see citing works
Basal forebrain infarction. A clinicopathologic correlation.
Phillips, S., Sangalang, V., & Sterns, G. L. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520230024008 · Cited by 121 · see citing works
The Impact of Apathy and Depression on Quality of Life in Patients Infected with HIV
Tate, D. F., Paul, R. H., Flanigan, T., Tashima, K. T., Nash, J. M., Adair, C., BOLAND, R. J., & Cohen, R. A. (2003) · AIDS Patient Care and STDs · doi:10.1089/108729103763807936 · Cited by 119 · see citing works
Lévy, R. (2012) · Revue Neurologique · doi:10.1016/j.neurol.2012.05.003 · Cited by 116 · see citing works
Archibald, S. L., Masliah, E., Fennema‐Notestine, C., Marcotte, T. D., Ellis, R. J., McCutchan, J. A., Heaton, R. K., Grant, I., Mallory, M. E., Miller, A. L., et al. (2004) · Archives of Neurology · doi:10.1001/archneur.61.3.369 · Cited by 111 · see citing works
Self-citationRagin, A. B., Wu, Y. G., Storey, P., Cohen, B. A., Edelman, R. R., & Epstein, L. G. (2005) · Journal of NeuroVirology · doi:10.1080/13550280590953799 · Cited by 104 · see citing works
Apathy, Depression, and Cognitive Performance in HIV-1 Infection
Castellon, S. A., Hinkin, C. H., Wood, S. A., & Yarema, K. T. (1998) · Journal of Neuropsychiatry · doi:10.1176/jnp.10.3.320 · Cited by 104 · see citing works
Testing the equality of dependent intraclass correlation coefficients
Donner, A. P., & Zou, G. (2002) · Journal of the Royal Statistical Society Series D (The Statistician) · doi:10.1111/1467-9884.00324 · Cited by 103 · see citing works
Apathy is Associated With Volume of the Nucleus Accumbens in Patients Infected With HIV
Paul, R. H., Brickman, A. M., Navia, B., Hinkin, C., Malloy, P. F., Jefferson, A. L., Cohen, R. A., Tate, D. F., & Flanigan, T. (2005) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.17.2.167 · Cited by 102 · see citing works
Neurocognitive deficits are associated with unemployment in chronic methamphetamine users
Weber, E., Blackstone, K., Iudicello, J., Morgan, E. E., Grant, I., Moore, D. J., & Woods, S. P. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.04.002 · Cited by 102 · see citing works
Self-citationDiffusion-tensor MR imaging of the brain in human immunodeficiency virus-positive patients.
Thurnher, M. M., Castillo, M., Stadler, A., Rieger, A., Schmid, B., & Sundgren, P. C. (2005) · PubMed Central · Cited by 97 · see citing works
Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging
Tsujimoto, M., Senda, J., Ishihara, T., Niimi, Y., Kawai, Y., Atsuta, N., Watanabe, H., Tanaka, F., Naganawa, S., & Sobue, G. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.05.025 · Cited by 93 · see citing works
Relationships Among Apathy, Depression, and Cognitive Impairment in HIV/AIDS
Rabkin, J. G., Ferrando, S. J., van Gorp, W. G., Rieppi, R., McElhiney, M. C., & Sewell, M. C. (2000) · Journal of Neuropsychiatry · doi:10.1176/jnp.12.4.451 · Cited by 92 · see citing works
HIV-Associated Alterations in Normal-Appearing White Matter
Stebbins, G. T., Smith, C. A., Bartt, R. E., Kessler, H. A., Adeyemi, O. M., Martin, E. M., Cox, J. L., Bammer, R., & Moseley, M. E. (2007) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318159d807 · Cited by 76 · see citing works
Implications of Apathy for Everyday Functioning Outcomes in Persons Living with HIV Infection
Kamat, R., Woods, S. P., Marcotte, T. D., Ellis, R. J., & Grant, I. (2012) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acs055 · Cited by 72 · see citing works
Self-citationBrown, C., Campbell, M. C., Karimi, M., Tabbal, S. D., Loftin, S. K., Tian, L., Moerlein, S. M., & Perlmutter, J. S. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.04.025 · Cited by 68 · see citing works
Molecular mechanisms of HIV-1 associated neurodegeneration
Özdener, M. H. (2005) · Journal of Biosciences · doi:10.1007/bf02703676 · Cited by 64 · see citing works
Stata Multivariate Statistics Reference Manual
StataCorp (2008) · Medical Entomology and Zoology · Cited by 63 · see citing works
Preventing HIV transmission with antiretrovirals
Crowley, S. (2009) · Bulletin of the World Health Organization · doi:10.2471/blt.09.067330 · Cited by 56 · see citing works
White Matter Correlates of Apathy in HIV-Positive Subjects: A Diffusion Tensor Imaging Study
Hoare, J., Fouché, J., Spottiswoode, B. S., Joska, J. A., Schoeman, R., Stein, D. J., & Carey, P. D. (2010) · Journal of Neuropsychiatry · doi:10.1176/jnp.2010.22.3.313 · Cited by 54 · see citing works
Paul, R. H., Flanigan, T., Tashima, K. T., Cohen, R. A., Lawrence, J., Alt, E., Tate, D. F., Ritchie, C., & Hinkin, C. H. (2005) · Journal of Neuropsychiatry · doi:10.1176/jnp.17.1.114 · Cited by 47 · see citing works
Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120
Langford, D., Rosemary, H., Hashimoto, M., Digicaylioglu, M. H., & Masliah, E. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-8 · Cited by 46 · see citing works
Tengvar, C., Johansson, B., & Sørensen, J. C. H. (2004) · Brain Injury · doi:10.1080/02699050310001622806 · Cited by 40 · see citing works
Grunsfeld, A., & Login, I. S. (2006) · BMC Neurology · doi:10.1186/1471-2377-6-4 · Cited by 22 · see citing works
Akinetic Mutism Without a Structural Prefrontal Lesion
Demirtaş-Tatlıdede, A., Bahar, S., & Gurvit, H. I. (2013) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0b013e31829bd4f5 · Cited by 7 · see citing works
Castellon, S. A., Hinkin, C. H., & Myers, H. F. (2001) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617701766143 · Cited by 6 · see citing works
Functional Division among Monkey Prefrontal Areas in Goal-directed Behavior
Tanaka, K., Matsumoto, K., Mansouri, F. A., & Buckley, M. J. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199837755.003.0019 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Heaton RK Taylor MJ Manly J 2003 Demographic effects and use of demographically corrected norms with the WAIS-III and WMS-III Tulsky D Saklofske D Heaton RK Chelune GJ Ivnik RA Bornstein RA Prifitera A Ledbetter M Clinical interpretation of the WAIS-III and WMS-III 181 San Diego, CA Academic Press
Cited by
Sorted by citations
HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment
Saylor, D. R., Dickens, A. M., Sacktor, N. C., Haughey, N. J., Slusher, B. S., Pletnikov, M. V., Mankowski, J. L., Brown, A. M., Volsky, D. J., & McArthur, J. C. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.27 · Cited by 1,037 · see citing works
The anatomy of apathy: a neurocognitive framework for amotivated behaviour
Le Heron, C., Apps., M. A. J., & Husain, M. (2018) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.07.003 · Cited by 380 · see citing works
Psychobiological factors of resilience and depression in late life
Laird, K. T., Krause, B., Funes, C., & Lavretsky, H. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0424-7 · Cited by 229 · see citing works
Walker, K. A., & Brown, G. G. (2017) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2017.1349879 · Cited by 107 · see citing works
Self-citationNeuroimaging as a biomarker in symptom validity and performance validity testing
Bigler, E. D. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9409-1 · Cited by 69 · see citing works
Shollenbarger, S. G., Price, J., Wieser, J., & Lisdahl, K. (2015) · NeuroImage: Clinical · doi:10.1016/j.nicl.2015.03.024 · Cited by 64 · see citing works
Imaging studies of the HIV-infected brain
Chang, L., & Shukla, D. K. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63849-6.00018-9 · Cited by 56 · see citing works
Onoda, K., & Yamaguchi, S. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.07.030 · Cited by 47 · see citing works
Tierney, S. M., Woods, S. P., Weinborn, M., & Bucks, R. S. (2018) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2018.1444736 · Cited by 42 · see citing works
Self-citationTang, Z., Liu, Z., Li, R., Yang, X., Cui, X., Wang, S., Yu, D., Li, H., Dong, E., & Tian, J. (2017) · European Radiology · doi:10.1007/s00330-017-4820-1 · Cited by 42 · see citing works
Reliability of White Matter Microstructural Changes in HIV Infection: Meta-Analysis and Confirmation
O’Connor, E. E., Jaillard, A. S., Renard, F., & Zeffiro, T. A. (2017) · American Journal of Neuroradiology · doi:10.3174/ajnr.a5229 · Cited by 37 · see citing works
Novel Neuroimaging Methods to Understand How HIV Affects the Brain
Thompson, P. M., & Jahanshad, N. (2015) · Current HIV/AIDS Reports · doi:10.1007/s11904-015-0268-6 · Cited by 35 · see citing works
Apathy is associated with lower mental and physical quality of life in persons infected with HIV
Kamat, R., Woods, S. P., Cameron, M. V., Iudicello, J. E., & The HIV Neurobehavioral Research Program (HNRP) Group (2016) · Psychology Health & Medicine · doi:10.1080/13548506.2015.1131998 · Cited by 32 · see citing works
Self-citationNeurobehavioral Disturbances During Acute and Early HIV Infection
Kamat, R., Doyle, K. L., Iudicello, J. E., Morgan, E. E., Morris, S., Smith, D. M., Little, S. J., Grant, I., & Woods, S. P. (2016) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0000000000000084 · Cited by 29 · see citing works
Self-citationReduction of white matter integrity correlates with apathy in Parkinson's disease
Zhang, Y., Wu, J., Wu, W., Liu, R., Pang, L., Guan, D., & Xu, Y. (2017) · International Journal of Neuroscience · doi:10.1080/00207454.2017.1347170 · Cited by 28 · see citing works
Illenberger, J. M., Harrod, S. B., Mactutus, C. F., McLaurin, K. A., Kallianpur, A. R., & Booze, R. M. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09928-5 · Cited by 26 · see citing works
Cysique, L. A., & Brew, B. J. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64012-3.00006-x · Cited by 26 · see citing works
Tang, V. M., Lang, D. J., Giesbrecht, C. J., Panenka, W. J., Willi, T. S., Procyshyn, R. M., Vila‐Rodriguez, F., Jenkins, W., Lecomte, T., Boyda, H. N., et al. (2015) · BMC Research Notes · doi:10.1186/s13104-015-1501-5 · Cited by 26 · see citing works
Apathy is Associated with Critical Psychological Determinants of Medication Adherence in HIV Disease
Babicz, M. A., Woods, S. P., Fazeli, P. L., & Morgan, E. E. (2020) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-020-09715-7 · Cited by 26 · see citing works
Self-citationSetiadi, T. M., Martens, S., Opmeer, E. M., Marsman, J.-B. C., Tumati, S., Reesink, F. E., Deyn, P. P. D., Aleman, A., & Ćurĉić‐Blake, B. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102567 · Cited by 23 · see citing works
Microbes and Mental Illness: Past, Present, and Future
Bransfield, R. C., Mao, C., & Greenberg, R. (2023) · Healthcare · doi:10.3390/healthcare12010083 · Cited by 23 · see citing works
The neurobiology of brain recovery from traumatic stress: A longitudinal DTI study
Meng, L., Chen, Y., Xu, X. Y., Chen, T., Lui, S., Huang, X., Sweeney, J. A., Li, K., & Gong, Q. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.08.075 · Cited by 17 · see citing works
Muñoz-Moreno, J. A., Cysique, L. A., & Rourke, S. B. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_233 · Cited by 16 · see citing works
Finkelstein, A., Faiyaz, A., Weber, M. T., Qiu, X., Uddin, M. N., Zhong, J., & Schifitto, G. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.725059 · Cited by 15 · see citing works
Effect of human immunodeficiency virus on the brain: A review
Cilliers, K., & Muller, C. J. F. (2020) · The Anatomical Record · doi:10.1002/ar.24573 · Cited by 13 · see citing works
Incident major depressive episodes increase the severity and risk of apathy in HIV infection
Kamat, R., Cattie, J. E., Marcotte, T. D., Woods, S. P., Franklin, D. R., Corkran, S. H., Ellis, R. J., Grant, I., & Heaton, R. K. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.01.010 · Cited by 13 · see citing works
Self-citationUddin, M. N., Singh, M. V., Faiyaz, A., Szczepankiewicz, F., Nilsson, M., Boodoo, Z. D., Sutton, K. R., Tivarus, M. E., Zhong, J., Wang, L., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-80372-8 · Cited by 13 · see citing works
Ridgely, N. C., Woods, S. P., Webber, T. A., Mustafa, A. I., & Evans, D. (2023) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0000000000000358 · Cited by 12 · see citing works
Self-citationA longitudinal analysis of brain extracellular free water in HIV infected individuals
Uddin, M. N., Faiyaz, A., Wang, L., Zhuang, Y., Murray, K. D., Descoteaux, M., Tivarus, M. E., Weber, M. T., Zhong, J., Qiu, X., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-87801-y · Cited by 11 · see citing works
Carlier, A., van Exel, E. R., Dols, A., Bouckaert, F., Sienaert, P. A., ten Kate, M., Wattjes, M. P., Vandenbulcke, M., Stek, M. L., & Rhebergen, D. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4917 · Cited by 11 · see citing works
Apathy in persons living with HIV disease: A systematic narrative review
Thompson, J. L., Woods, S. P., Medina, L. D., Garcia, J. M., & Teixeira, A. L. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.016 · Cited by 10 · see citing works
Self-citationDisrupted Decision-Making: EcoHIV Inoculation in Cocaine Dependent Rats
McLaurin, K. A., Li, H., Mactutus, C. F., Harrod, S. B., & Booze, R. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169100 · Cited by 9 · see citing works
Apathy is not associated with a panel of biomarkers in older adults with HIV disease
Woods, S. P., Thompson, J. L., Babicz, M. A., Shahani, L., Colpo, G. D., Rocha, N. P., Morgan, E. E., & Teixeira, A. L. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110666 · Cited by 7 · see citing works
Self-citationMoschopoulos, C. D., Stanitsa, E., Protopapas, K., Kavatha, D., Papageorgiou, S. G., Antoniadou, A., & Papadopoulos, A. (2024) · Life · doi:10.3390/life14040508 · Cited by 6 · see citing works
Tavano, B., Tsipouri, V., Hardy, G. A. D., Royle, C. M., Keegan, M. R., Fuchs, D., Patterson, S., Almond, N. M., Berry, N. J., Ham, C., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00361 · Cited by 6 · see citing works
Riggs, P. K., Anderson, A. M. L., Tang, B., Rubin, L. H., Morgello, S., Marra, C. M., Gelman, B. B., Clifford, D. B., Franklin, D. R., Heaton, R. K., et al. (2023) · Viruses · doi:10.3390/v15122410 · Cited by 6 · see citing works
Self-citationApathetic symptoms and white matter integrity after traumatic brain injury
Navarro-Main, B., Castaño-Leon, A., Hilario, A., Lagares, A., Rubio, G., Periañez, J., Ríos-Lago, M., & Inertia Group Collaborators (2021) · Brain Injury · doi:10.1080/02699052.2021.1953145 · Cited by 5 · see citing works
Zhao, J., Jing, B., Liu, J., Chen, F., Wu, Y., & Li, H. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002829 · Cited by 3 · see citing works
McLaurin, K. A., Cranston, M. N., Li, H., Mactutus, C. F., Harrod, S. B., & Booze, R. M. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114174 · Cited by 2 · see citing works
Babicz, M. A., Matchanova, A., & Woods, S. P. (2023) · Journal of the Association of Nurses in AIDS Care · doi:10.1097/jnc.0000000000000413 · Cited by 2 · see citing works
Self-citationMotivation levels and white matter microstructure in children living with HIV
Wedderburn, C. J., Sevenoaks, T., Fouché, J., Phillips, N. J., Lawn, S. D., Stein, D. J., & Hoare, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-54411-3 · Cited by 1 · see citing works
Disrupted Decision-Making: EcoHIV Inoculation Following a History of Cocaine UsePreprint
McLaurin, K. A., Li, H., Mactutus, C. F., Harrod, S. B., & Booze, R. M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.13.491868 · Cited by 1 · see citing works
Linking Neuroinflammation and Extracellular Free Water in HIV Infection: A Longitudinal StudyPreprint
Uddin, M. N., Faiyaz, A., Wang, L., Zhuang, Y., Murray, K. D., Descoteaux, M., Tivarus, M. E., Weber, M. T., Zhong, J., Qiu, X., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-121836/v2
McLaurin, K. A., Cranston, M. N., Li, H., Mactutus, C. F., Harrod, S. B., & Booze, R. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.02.458761
Linking Neuroinflammation and Extracellular Free Water in HIV Infection: A Longitudinal StudyPreprint
Uddin, M. N., Faiyaz, A., Wang, L., Zhuang, Y., Murray, K. D., Descoteaux, M., Tivarus, M. E., Weber, M. T., Zhong, J., Qiu, X., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-121836/v1
Nweke, M., Hedges, D. W., & Gale, S. D. (2024) · doi:10.1093/oso/9780192870414.003.0007
HIV and vascular disease confer additive effects on apathy.
Woods, S., Mustafa, A., Kamar, J. L. T., Teixeira, A. L., Dotson, V. M., & Beltran-Najera, I. (2026) · AIDS Care · doi:10.1080/09540121.2026.2717449
Self-citation
- Authors
- Kamat, R., Brown, G. G., Bolden, K., Fennema-Notestein, C., Archibald, S., Marcotte, T. D., Letendre, S. L., Ellis, R. J., Woods, S. P., Grant, I., Heaton, R. K., & the TMARC Group
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Brown, Gregory G.
- ORCID
- Venue
- Journal of Clinical and Experimental Neuropsychology
- Publisher
- Informa UK Limited
- Published
- 2014-09-14
- Volume
- 36
- Issue
- 8
- Pages
- 854-866
- ISSN
- 0165-0475 (ISSN-L)
- 1380-3395
- 1744-411X
- PMC
- PMC4303236
- OpenAlex
- W2076540003
- Cited by
- 47
- References
- 68
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 7 · 2016: 3 · 2015: 6
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical and Experimental Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (R25MH081482, P30MH062512)
- National Institute on Drug Abuse (P50DA026306)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- apathy, HIV infection, white matter abnormalities, frontal white matter, corona radiata, genu, medial prefrontal cortex, CD4 count, depression, antiretroviral therapy
- MeSH terms
- Adult, Female, Frontal Lobe, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Regression Analysis, Cohort Studies, HIV Infections, Statistics, Nonparametric, Diffusion Tensor Imaging, Leukoencephalopathies, Apathy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review