Cited by 152Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementGynecological conditions and treatments

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Current and emerging treatment options for endometriosis

Ferrero, Simone, Evangelisti, Giulio, Barra, Fabio·2018·Expert Opinion on Pharmacotherapy

DOI 10.1080/14656566.2018.1494154

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Abstract

INTRODUCTION: Pharmacotherapy has a pivotal role in the management of endometriosis with long-term treatments balancing clinical efficacy (control of pain symptoms and prevention of recurrence of the disease after surgery) with an acceptable safety profile. Treatment choice is based on several factors including age and patient preference, reproductive plans, intensity of pain, severity of disease and incidence of adverse effects. AREAS COVERED: The aim of this review is to provide the reader with a complete overview of drugs that are currently available or are under investigation for the treatment of endometriosis highlighting on-going clinical trials. EXPERT OPINION: Almost all of the available treatment options for endometriosis suppress ovarian function and are not curative. Combined oral contraceptives and progestins are commonly administered to these patients in order to ameliorate pain symptoms. Gonadotropin-releasing hormone-agonists are prescribed when first-line therapies are ineffective, not tolerated or contraindicated. Aromatase inhibitors should be reserved only for women who are refractory to other treatments. Amongst the drugs under development, gonadotropin-releasing hormone antagonists have shown the most promising results. Presently, are a number of potential therapies currently in pre-clinical or early clinical studies which may alter treatment strategies in the future although further studies are necessary.

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Authors: Ferrero, S., Evangelisti, G., & Barra, F.
Affiliations: Ospedale Policlinico San Martino (IT)
Corresponding author: Ferrero, Simone
ORCID: Ferrero, Simone
Evangelisti, Giulio
Barra, Fabio
Venue: Expert Opinion on Pharmacotherapy
Publisher: Informa UK Limited
Published: 2018-07-03
Volume: 19
Issue: 10
Pages: 1109-1125
ISSN: 1465-6566 (ISSN-L)
1744-7666
DOI: 10.1080/14656566.2018.1494154
OpenAlex: W2872842744
Cited by: 152
References: 201
Citations by year: 2026: 9 · 2025: 14 · 2024: 17 · 2023: 21 · 2022: 19 · 2021: 30 · 2020: 19 · 2019: 16 · 2018: 7
FWCI: 2.76
Type: journal article
Language: en
Open access: closed
Locations: Expert Opinion on Pharmacotherapy (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords: endometriosis, pharmacotherapy, ovarian suppression, combined oral contraceptives, progestins, GnRH agonist, GnRH antagonist, aromatase inhibitors, pain management, drug development, clinical trials
MeSH terms: Anti-Inflammatory Agents, Non-Steroidal, Drug Combinations, Endometriosis, Ethinyl Estradiol, Female, Hormone Antagonists, Humans, Gonadotropin-Releasing Hormone, Norpregnenes, Progestins, Aromatase Inhibitors, Pain Management

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