Norethisterone acetate in the treatment of colorectal endometriosis: a pilot study
Open accessAbstract
BACKGROUND: This pilot study evaluates the efficacy of norethisterone acetate in treating pain and gastrointestinal symptoms of women with colorectal endometriosis. METHODS: This prospective study included 40 women with colorectal endometriosis, who had pain and gastrointestinal symptoms. Patients received norethisterone acetate (2.5 mg/day) for 12 months; in case of breakthrough bleeding, the dose of norethisterone acetate was increased by 2.5 mg/day. The degree of patient satisfaction with treatment (primary end-point) and the changes in symptoms (secondary end-point) were evaluated. Side effects of treatment were recorded. RESULTS: Norethisterone acetate determined a significant improvement in the intensity of chronic pelvic pain, deep dyspareunia, dyschezia. Treatment determined the disappearance of symptoms related to the menstrual cycle (dysmenorrhea, constipation during the menstrual cycle, diarrhoea during the menstrual cycle and cyclical rectal bleeding). The severity of diarrhoea, intestinal cramping and passage of mucus significantly improved during treatment. On the contrary, the administration of norethisterone acetate did not determine a significant effect on constipation, abdominal bloating and feeling of incomplete evacuation after bowel movements. At the completion of treatment, 57% of the patients with diarrhoea or diarrhoea during the menstrual cycle continued the treatment with norethisterone acetate compared with 17% of the patients with constipation or constipation during the menstrual cycle. CONCLUSIONS: In some patients with bowel endometriosis, the administration of norethisterone acetate may determine a relief of pain and gastrointestinal symptoms. This therapy has greater benefits in patients with gastrointestinal symptoms related to the menstrual cycle, diarrhoea and intestinal cramping.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a pilot study of women with bowel endometriosis, low-dose oral NETA significantly improved chronic pelvic pain, deep dyspareunia, dyschezia, and eliminated menstrual cycle-related symptoms.
“A pilot study on women with bowel endometriosis showed that low dose oral NETA determined a significant improvement in the intensity of chronic pelvic pain, deep dyspareunia, dyschezia and the disappearance of symptoms related to the menstrual cycle (dysmenorrhea, constipation during the menstrual cycle, diarrhea during the menstrual cycle and cyclical rectal bleeding) [210].”
From Hormonal treatments for endometriosis: The endocrine background (2022) · cites this paper as [210]
In a prospective case series of 40 women with bowel endometriosis, norethisterone acetate 2.5 mg/day for 12 months significantly improved dysmenorrhea, dyspareunia, chronic pelvic pain, dyschezia, and diarrhea.
“Significant improvement of dysm, dysp, CPP, dyschezia and diarrhea.”
From Medical treatment in the management of deep endometriosis infiltrating the proximal rectum and sigmoid colon: a comprehensive literature review (2018) · cites this paper as [11]
Numerous studies demonstrated efficacy of a reduced daily NETA dose of 2.5 mg.
“numerous studies by independent groups demonstrated the efficacy of a reduced daily dose of 2.5 mg [13-16].”
From Oral and depot progestin therapy for endometriosis: towards a personalized medicine (2017) · cites this paper as [14]
In a pilot study of colorectal endometriosis, NETA 2.5 mg/d for 12 months achieved good satisfaction (60%) and more than half reported improvement in GI symptoms and amelioration of chronic pelvic pain and deep dyspareunia.
“The satisfaction rate was good (60%), more than half of the patients reported an improvement in gastrointestinal symptoms and an amelioration of chronic pelvic pain and deep dyspareunia.”
From Oral and depot progestin therapy for endometriosis: towards a personalized medicine (2017) · cites this paper as [14]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
THE JOURNAL OF REPRODUCTIVE MEDICINE
Reddy, D. M., & Wasserman, S. A. (1999) · AJN American Journal of Nursing · doi:10.1097/00000446-199901000-00024 · Cited by 2,483 · see citing works
NEW YORK STATE JOURNAL OF MEDICINE.
(1901) · JAMA · doi:10.1001/jama.1901.02470020041007 · Cited by 1,481 · see citing works
An Evidence-Based Position Statement on the Management of Irritable Bowel Syndrome
American College of Gastroenterology IBS Task Force (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.122 · Cited by 694 · see citing works
Deep Pelvic Endometriosis: MR Imaging for Diagnosis and Prediction of Extension of Disease
Bazot, M., Darai, E., Hourani, R., Thomassin, I., Cortez, A., Uzan, S., & Buy, J.-N. (2004) · Radiology · doi:10.1148/radiol.2322030762 · Cited by 580 · see citing works
Abrão, M., Gonçalves, M. O. D. C., Dias, J., Podgaec, S., Chamié, L., & Blasbalg, R. (2007) · Human Reproduction · doi:10.1093/humrep/dem187 · Cited by 520 · see citing works
Bazot, M., Lafont, C., Rouzier, R., Roseau, G., Thomassin-Naggara, I., & Daraï, E. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.09.005 · Cited by 434 · see citing works
Bowel Endometriosis: Presentation, Diagnosis, and Treatment
Remorgida, V., Ferrero, S., Fulcheri, E., Ragni, N., & Martin, D. C. (2007) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000268688.55653.5c · Cited by 329 · see citing works
Self-citationQuality of life after laparoscopic colorectal resection for endometriosis
Dubernard, G., Piketty, M., Rouzier, R., Houry, S., Bazot, M., & Darai, E. (2006) · Human Reproduction · doi:10.1093/humrep/dei491 · Cited by 272 · see citing works
Vercellini, P., Pietropaolo, G., De Giorgi, O., Pasin, R., Chiodini, A., & Crosignani, P. G. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.03.083 · Cited by 197 · see citing works
Remorgida, V., Ragni, N., Ferrero, S., Anserini, P., Torelli, P., & Fulcheri, E. (2005) · Human Reproduction · doi:10.1093/humrep/dei047 · Cited by 171 · see citing works
Self-citationMinelli, L. (2009) · Archives of Surgery · doi:10.1001/archsurg.2008.555 · Cited by 170 · see citing works
Bazot, M., Bornier, C., Dubernard, G., Roseau, G., Cortez, A., & Daraï, E. (2007) · Human Reproduction · doi:10.1093/humrep/dem008 · Cited by 160 · see citing works
Laparoscopic colorectal resection for deep infiltrating endometriosis: analysis of 436 cases
Ruffo, G., Scopelliti, F., Scioscia, M., Ceccaroni, M., Mainardi, P., & Minelli, L. (2010) · Surgical Endoscopy · doi:10.1007/s00464-009-0517-0 · Cited by 156 · see citing works
Thomassin‐Naggara, I., Bazot, M., Detchev, R., Barranger, E., Cortez, A., & Daraï, É. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2003.12.004 · Cited by 156 · see citing works
Chapron, C., Vieira, M., Chopin, N., Balleyguier, C., Barakat, H., Dumontier, I., Roseau, G., Fauconnier, A., Foulot, H., & Dousset, B. E. (2004) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.1107 · Cited by 156 · see citing works
Laparoscopic treatment of bowel endometriosis in infertile women
Stepniewska, A., Pomini, P., Bruni, F., Mereu, L., Ruffo, G., Ceccaroni, M., Scioscia, M., Guerriero, M., & Minelli, L. (2009) · Human Reproduction · doi:10.1093/humrep/dep083 · Cited by 146 · see citing works
Seracchioli, R., Poggioli, G., Pierangeli, F., Manuzzi, L., Gualerzi, B., Savelli, L., Remorgida, V, Mabrouk, M., & Venturoli, S. (2007) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2007.01363.x · Cited by 145 · see citing works
Self-citationFerrero, S., Camerini, G., Seracchioli, R., Ragni, N., Venturini, P., & Remorgida, V. (2009) · Human Reproduction · doi:10.1093/humrep/dep302 · Cited by 145 · see citing works
Self-citationMedical treatment for rectovaginal endometriosis: what is the evidence?
Vercellini, P., Crosignani, P. G., Somigliana, E., Berlanda, N., Barbara, G., & Fedele, L. (2009) · Human Reproduction · doi:10.1093/humrep/dep231 · Cited by 144 · cited 4× · see citing works
“Medical therapies (particularly progestogens and estro-progestogen combinations) have been repeatedly demonstrated to be safe, well tolerated and effective in the long-term treatment of women with symptomatic endometriosis (Vercellini et al., 2009).”
BackgroundInfluentialLaparoscopic segmental colorectal resection for endometriosis: limits and complications
Daraï, É., Ackerman, G., Bazot, M., Rouzier, R., & Dubernard, G. (2007) · Surgical Endoscopy · doi:10.1007/s00464-006-9160-1 · Cited by 143 · see citing works
Multislice CT enteroclysis in the diagnosis of bowel endometriosis
Biscaldi, E., Ferrero, S., Fulcheri, E., Ragni, N., Remorgida, V., & Rollandi, G. A. (2006) · European Radiology · doi:10.1007/s00330-006-0364-5 · Cited by 137 · see citing works
Self-citationChamié, L. P., Blasbalg, R., Gonçalves, M. O. C., Carvalho, F. M., Abrão, M. S., & de Oliveira, I. S. (2009) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2009.04.013 · Cited by 124 · see citing works
Fertility after bowel resection for endometriosis
Ferrero, S., Anserini, P., Abbamonte, L. H., Ragni, N., Camerini, G. B., & Remorgida, V. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.04.070 · Cited by 116 · see citing works
Self-citationFertility after laparoscopic colorectal resection for endometriosis: preliminary results
Daraï, É., Marpeau, O., Thomassin‐Naggara, I., Dubernard, G., Barranger, E., & Bazot, M. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.04.037 · Cited by 115 · see citing works
Remorgida, V., Ragni, N., Ferrero, S., Anserini, P., Torelli, P., & Fulcheri, E. (2004) · Human Reproduction · doi:10.1093/humrep/deh568 · Cited by 92 · see citing works
Self-citationBowel endometriosis: CT-enteroclysis
Biscaldi, E., Ferrero, S., Remorgida, V., & Rollandi, G. A. (2006) · Abdominal Imaging · doi:10.1007/s00261-006-9152-6 · Cited by 69 · see citing works
Self-citationDyschezia and Posterior Deep Infiltrating Endometriosis: Analysis of 360 Cases
Seracchioli, R., Mabrouk, M., Guerrini, M., Manuzzi, L., Savelli, L., Frascà, C., & Venturoli, S. (2008) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2008.07.005 · Cited by 69 · see citing works
Effect of norethindrone acetate in the treatment of symptomatic endometriosis.
Muneyyirci‐Delale, O., & Karacan, M. (1998) · PubMed · Cited by 67 · see citing works
Outcome after rectum or sigmoid resection: A review for gynecologists
Ret Dávalos, M. L., De Cicco, C., D’Hoore, A., De Decker, B., & Koninckx, P. R. (2007) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2006.07.015 · Cited by 66 · see citing works
Norethisterone acetate in combination with estrogen: Effects on the skeleton and other organs
Riis, B. J., Lehmann, H.-J., & Christiansen, C. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.122852 · Cited by 40 · see citing works
Ferrero, S., Camerini, G. B., Menada, M. V., Biscaldi, E., Ragni, N., & Remorgida, V. (2009) · PubMed · Cited by 32 · see citing works
Self-citationRectosigmoid endometriosis with unusual presentation at magnetic resonance imaging
Biscaldi, E., Ferrero, S., Remorgida, V., et al. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.02.131 · Cited by 22 · see citing works
Self-citationEndometriosis and irritable bowel syndrome: co‐morbidity or misdiagnosis?
Ferrero, S., Camerini, G. B., Ragni, N., et al. (2008) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2008.01998.x · Cited by 20 · see citing works
Self-citationAbdominal Pain, Bloating, and Urgency
Ferrero, S., Abbamonte, L. H., Remorgida, V., et al. (2005) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000169600.45875.b1 · Cited by 19 · see citing works
Self-citationPost-operative digestive symptoms after colorectal resection for endometriosis
Ferrero, S., Ragni, N., & Remorgida, V. (2006) · Human Reproduction · doi:10.1093/humrep/del101 · Cited by 14 · see citing works
Self-citationPorpora, M. G., Pallante, D., Ferro, A., Crobu, M., Cerenzia, P., & Panici, P. L. B. (2006) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2005.10.013 · Cited by 10 · cited 2× · see citing works
“Gonadotrophin-releasing hormone agonists (GnRH-a) have been used with success in selected cases (Markham et al., 1991; Porpora et al., 2006); however, the length of treatment with GnRH-a is limited by side effects and bowel symptoms recur when medical therapy is interrupted (Markham et al.”
MethodEndometriosis of the rectum treated with a long term GnRH agonist and surgery.
Markham, S. M., Welling, D.-R., Larsen, K. S., et al. (1991) · PubMed · Cited by 10 · see citing works
Endometriosis and irritable bowel syndrome: co‐morbidity or misdiagnosis?
Ballard, K., & Wright, J. (2008) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2008.01999.x · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Deep endometriosis infiltrating the recto-sigmoid: critical factors to consider before management
Abrao, M. S., Petraglia, F., Falcone, T., Keckstein, J., Osuga, Y., & Chapron, C. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv003 · Cited by 398 · see citing works
Hormonal treatments for endometriosis: The endocrine background
Vannuccini, S., Clemenza, S., Rossi, M., & Petraglia, F. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09666-w · Cited by 336 · see citing works
Bowel endometriosis: Diagnosis and management
Nezhat, C., Li, A., Falik, R., Copeland, D., Razavi, G., Shakib, A., Mihailide, C., Bamford, H., DiFrancesco, L., Tazuke, S., et al. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.09.023 · Cited by 205 · see citing works
Medical treatment of endometriosis-related pain
Vercellini, P., Buggio, L., Frattaruolo, M. P., Borghi, A., Dridi, D., & Somigliana, E. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.01.015 · Cited by 188 · see citing works
Leone Roberti Maggiore, U., Ferrero, S., Candiani, M., Somigliana, E., Viganò, P., & Vercellini, P. (2017) · European Urology · doi:10.1016/j.eururo.2016.12.015 · Cited by 187 · see citing works
Self-citation“Waiting for Godot”: a commonsense approach to the medical treatment of endometriosis
Vercellini, P., Crosignani, P., Somigliana, E., Vigano, P., Frattaruolo, M. P., & Fedele, L. (2011) · Human Reproduction · doi:10.1093/humrep/deq302 · Cited by 180 · see citing works
Current and emerging treatment options for endometriosis
Ferrero, S., Evangelisti, G., & Barra, F. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1494154 · Cited by 152 · see citing works
Self-citationVercellini, P., Somigliana, E., Consonni, D., Frattaruolo, M. P., De Giorgi, O., & Fedele, L. (2012) · Human Reproduction · doi:10.1093/humrep/des313 · Cited by 129 · see citing works
Vercellini, P., Bracco, B., Mosconi, P., Roberto, A., Alberico, D., Dhouha, D., & Somigliana, E. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.11.016 · Cited by 127 · see citing works
Barra, F., Scala, C., & Ferrero, S. (2018) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2018.1461840 · Cited by 100 · see citing works
Self-citationDienogest or Norethindrone acetate for the treatment of ovarian endometriomas: Can we avoid surgery?
Del Forno, S., Mabrouk, M., Arena, A., Mattioli, G., Giaquinto, I., Paradisi, R., & Seracchioli, R. (2019) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2019.04.010 · Cited by 88 · see citing works
Vercellini, P., Frattaruolo, M. P., Somigliana, E., Jones, G. L., Consonni, D., Alberico, D., & Fedele, L. (2013) · Human Reproduction · doi:10.1093/humrep/det041 · Cited by 97 · see citing works
Hormonal therapy for endometriosis: from molecular research to bedside
Tosti, C., Biscione, A., Morgante, G., Bifulco, G., Luisi, S., & Petraglia, F. (2017) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2016.05.032 · Cited by 96 · see citing works
Morotti, M., Sozzi, F., Remorgida, V., Venturini, P. L., & Ferrero, S. (2014) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2014.10.036 · Cited by 84 · see citing works
Self-citationLetrozole and norethisterone acetate in colorectal endometriosis
Ferrero, S., Camerini, G., Ragni, N., Venturini, P. L., Biscaldi, E., Seracchioli, R., & Remorgida, V. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2010.02.023 · Cited by 80 · see citing works
Self-citationLeone Roberti Maggiore, U., Remorgida, V., Scala, C., Tafi, E., Venturini, P. L., & Ferrero, S. (2014) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1111/aogs.12326 · Cited by 80 · see citing works
Self-citationSurgery versus hormonal therapy for deep endometriosis: is it a choice of the physician?
Berlanda, N., Somigliana, E., Frattaruolo, M. P., Buggio, L., Dridi, D., & Vercellini, P. (2017) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2016.07.513 · Cited by 74 · see citing works
A stepped-care approach to symptomatic endometriosis management: A participatory research initiative
Vercellini, P., Donati, A., Ottolini, F., Frassineti, A., Fiorini, J., Nebuloni, V., Frattaruolo, M. P., Roberto, A., Mosconi, P., & Somigliana, E. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.01.037 · Cited by 64 · see citing works
Dienogest in the treatment of endometriosis
Bizzarri, N., Remorgida, V., Leone Roberti Maggiore, U., Scala, C., Tafi, E., Ghirardi, V., Salvatore, S., Candiani, M., Venturini, P. L., & Ferrero, S. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.943734 · Cited by 63 · see citing works
Self-citationFerrero, S., Leone Roberti Maggiore, U., Scala, C., Di Luca, M., Venturini, P. L., & Remorgida, V. (2013) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2581-2 · Cited by 57 · see citing works
Self-citationOral and depot progestin therapy for endometriosis: towards a personalized medicine
Buggio, L., Somigliana, E., Barbara, G., Frattaruolo, M. P., & Vercellini, P. (2017) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2017.1381086 · Cited by 58 · see citing works
Vercellini, P., Frattaruolo, M. P., Rosati, R., Dridi, D., Roberto, A., Mosconi, P., De Giorgi, O., Cribiù, F. M., & Somigliana, E. (2018) · Human Reproduction · doi:10.1093/humrep/dex364 · Cited by 44 · see citing works
Morotti, M., Venturini, P. L., Biscaldi, E., Racca, A., Calanni, L., Vellone, V. G., Stabilini, C., & Ferrero, S. (2017) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2017.03.033 · Cited by 43 · see citing works
Self-citationUse of Norethindrone Acetate Alone for Postoperative Suppression of Endometriosis Symptoms
Kaser, D. J., Missmer, S. A., Berry, K. F., & Laufer, M. R. (2012) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2011.09.013 · Cited by 42 · see citing works
Vercellini, P., Buggio, L., Borghi, A., Monti, E., Gattei, U., & Frattaruolo, M. P. (2018) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1111/aogs.13328 · Cited by 39 · see citing works
Ileocecal endometriosis: clinical and pathogenetic implications of an underdiagnosed condition
Fedele, L., Berlanda, N., Corsi, C., Gazzano, G., Morini, M., & Vercellini, P. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.11.126 · Cited by 31 · see citing works
Roman, H., Saint Ghislain, M., Milles, M., Marty, N., Hennetier, C., Moatassim, S., Desnyder, E., & Abo, C. (2015) · Gynécologie Obstétrique & Fertilité · doi:10.1016/j.gyobfe.2015.07.001 · Cited by 10 · see citing works
Gurbuz, T. B., Aslan, K., Kasapoglu, I., Muzii, L., & Uncu, G. (2025) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2025.113940 · Cited by 10 · see citing works
- Authors
- Ferrero, S., Camerini, G., Ragni, N., Venturini, P. L., Biscaldi, E., & Remorgida, V.
- Affiliations
- Ospedale Policlinico San Martino (IT)
- Istituto Giannina Gaslini (IT)
- Ente Ospedaliero Ospedali Galliera (IT)
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-10-10
- Volume
- 25
- Issue
- 1
- Pages
- 94-100
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2152713755
- Cited by
- 107
- References
- 38
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 5 · 2020: 13 · 2019: 3 · 2018: 11 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 5 · 2013: 4 · 2012: 4
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (other-oa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- norethisterone acetate, colorectal endometriosis, bowel endometriosis, chronic pelvic pain, dyschezia, dysmenorrhea, deep dyspareunia, treatment efficacy, patient satisfaction, adverse effects
- MeSH terms
- Norethindrone Acetate, Adult, Colonic Diseases, Endometriosis, Female, Humans, Norethindrone, Pain, Pilot Projects, Prospective Studies, Rectal Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
