The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
The emerging landscape of circular RNA in life processes
Open accessAbstract
Circular RNAs (circRNAs) are a novel class of non-coding RNA that assumes a covalently closed continuous conformation. CircRNAs were previously thought to be the byproducts of splicing errors caused by low abundance and the technological limitations. With the recent development of high-throughput sequencing technology, numerous circRNAs have been discovered in many species. Recent studies have revealed that circRNAs are stable and widely expressed, and often exhibit cell type-specific or tissue-specific expression. Most circRNAs can be generated from exons, introns, or both. Remarkably, emerging evidence indicates that some circRNAs can serve as microRNA (miRNA) sponges, regulate transcription or splicing, and can interact with RNA binding proteins (RBPs). Moreover, circRNAs have been reported to play essential roles in myriad life processes, such as aging, insulin secretion, tissue development, atherosclerotic vascular disease risk, cardiac hypertrophy and cancer. Although circRNAs are ancient molecules, they represent a newly appreciated form of noncoding RNA and as such have great potential implications in clinical and research fields. Here, we review the current understanding of circRNA classification, function and significance in physiological and pathological processes. We believe that future research will increase our understanding of the regulation and function of these novel molecules.
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Cites
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Natural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985
Self-citationLong non-coding RNAs: insights into functions
Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2521 · Cited by 5,654
Circular RNAs are abundant, conserved, and associated with ALU repeats
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed
Rybak-Wolf, A., Stottmeister, C., Glažar, P., Jens, M., Pino, N., Giusti, S., Hanan, M., Behm, M., Bartok, O., Ashwal-Fluss, R., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.027 · Cited by 2,423 · cited 1×
“CircRNAs can be generated from any region of the genome, and all result in a great diversity of lengths.(17-20,30,35,45,46) The”
BackgroundSanger, H. L., Klotz, G., Riesner, D., Gross, H. J., & Kleinschmidt, A. K. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.3852 · Cited by 2,296
Circular intronic long noncoding RNAs
Zhang, Y., Zhang, X.-O., Chen, T., Xiang, J.-F., Yin, Q.-F., Xing, Y.-H., Zhu, S., Yang, L., & Chen, L.-L. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.017 · Cited by 2,221
Self-citationComplementary Sequence-Mediated Exon Circularization
Zhang, X.-O., Wang, H.-B., Zhang, Y., Lu, X., Chen, L.-L., & Yang, L. (2014) · Cell · doi:10.1016/j.cell.2014.09.001 · Cited by 1,999
Self-citationCircular RNA: a new star of noncoding RNAs
Qu, S., Yang, X., Li, X., Wang, J., Gao, Y., Shang, R., Sun, W., Dou, K., & Li, H. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.06.003 · Cited by 1,808 · cited 1×
“Unlike traditionally linear RNA molecules, circRNA is a covalently closed circular molecule without 5’–3’ polarities or a polyadenylated tail.(1)”
BackgroundThe biogenesis and emerging roles of circular RNAs
Chen, L.-L. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.32 · Cited by 1,743
Cited by
Ding, L., Zhao, Y., Dang, S., Wang, Y., Li, X., Yu, X., Li, Z., Wei, J., Liu, M., & Li, G. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1006-2 · Cited by 298
Chen, X., Jiang, C., Sun, R., Yang, D., & Liu, Q. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.01.010 · Cited by 66
Metadata
- Authors
- Qu, S., Zhong, Y., Shang, R., Zhang, X., Song, W., Kjems, J., & Li, H.
- Venue
- RNA Biology
- Publisher
- Informa UK Limited
- Published
- 2016-09-12
- Volume
- 14
- Issue
- 8
- Pages
- 992-999
- ISSN
- 1547-6286 (ISSN-L)
- 1555-8584
- OpenAlex
- W2510950741
- Cited by
- 421
- References
- 14
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Qu, S., Zhong, Y., Shang, R., Zhang, X., Song, W., Kjems, J., & Li, H. (2017). The emerging landscape of circular RNA in life processes. RNA Biology. https://doi.org/10.1080/15476286.2016.1220473
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