Autophagy promotes ferroptosis by degradation of ferritin

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691

Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732

Ferroptosis: process and function

Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.158 · Cited by 3,727

Autophagy as a Regulated Pathway of Cellular Degradation

Klionsky, D. J., & Emr, S. D. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,630

Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila

Moy, R. H., & Cherry, S. R. (2013) · Journal of Innate Immunity · doi:10.1159/000350326 · Cited by 3,551

Autophagy and the Integrated Stress Response

Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506

New Insights into the Role of Ferritin in Iron Homeostasis and Neurodegenerative Diseases

Zhang, N., Yu, X., Xie, J., & Xu, H. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02277-7 · Cited by 223

Targeting ferroptosis in acute kidney injury

Ni, L., Cheng, Y., & Wu, X. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04628-9 · Cited by 228

The critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review

Liu, M., Kong, X., Yao, Y., Wang, X., Yang, W. P., Wu, H. M., Li, S., Ding, J., & Yang, J. (2022) · Annals of Translational Medicine · doi:10.21037/atm-21-6942 · Cited by 231

The mechanism of ferroptosis and its related diseases

Feng, S., Tang, D., Wang, Y., Li, X., Bao, H., Tang, C., Dong, X., Li, X., Yang, Q., Yan, Y., et al. (2023) · Molecular Biomedicine · doi:10.1186/s43556-023-00142-2 · Cited by 241

Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond

Mao, C., Wang, M., Zhuang, L., & Gan, B. (2024) · Protein & Cell · doi:10.1093/procel/pwae003 · Cited by 237

USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1

Rong, Y., Fan, J., Ji, C., Wang, Z., Ge, X., Wang, J., Wu, Y., Yin, G., Cai, W., & Liu, W. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00907-8 · Cited by 220

International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis

Chen, X., Tsvetkov, A. S., Shen, H., Isidoro, C., Ktistakis, N. T., Linkermann, A., Koopman, W. J. H., Simon, H., Galluzzi, L., Luo, S., et al. (2024) · Autophagy · doi:10.1080/15548627.2024.2319901 · Cited by 240

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Wang, Y., Hu, J., Wu, S., Fleishman, J. S., Li, Y., Xu, Y.-S., Zou, W., Wang, J., Feng, Y., Chen, J., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01720-0 · Cited by 225

Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death

Li, Y., Du, Y., Zhou, Y., Chen, Q., Luo, Z., Ren, Y., Chen, X., & Chen, G. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01267-1 · Cited by 225

Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

Jakaria, M., Belaidi, A. A., Bush, A. I., & Ayton, S. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15519 · Cited by 212

Ferroptosis: A flexible constellation of related biochemical mechanisms

Dixon, S. J., & Pratt, D. A. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.03.005 · Cited by 219

Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT

Wang, Z., Ding, Y., Wang, X., Lu, S., Wang, C., He, C. H., Wang, L., Piao, M., Chi, G., Luo, Y., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.04.021 · Cited by 211

The Effect of Oxidative Stress-Induced Autophagy by Cadmium Exposure in Kidney, Liver, and Bone Damage, and Neurotoxicity

Ma, Y., Su, Q., Yue, C., Zou, H., Zhu, J., Zhao, H., Song, R., & Liu, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113491 · Cited by 214

Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia‐Reperfusion Injury

Li, X., Ma, N., Xu, J., Zhang, Y., Yang, P., Su, X., Xing, Y., Yang, F., Yang, F., Zhang, L., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1587922 · Cited by 214

Autophagy in cancer development, immune evasion, and drug resistance

Niu, X., You, Q., Hou, K., Tian, Y., Wei, P., Zhu, Y., Gao, B., Ashrafizadeh, M., Aref, A. R., Kalbasi, A., et al. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101170 · Cited by 244

Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells

Wang, K., Zhang, Z., Tsai, H., Liu, Y., Gao, J., Wang, M., Song, L., Cao, X., Xu, Z., Chen, H., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00644-4 · Cited by 209

Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells

Ma, S., Dielschneider, R. F., Henson, E. S., Xiao, W., Choquette, T., Blankstein, A. R., Chen, Y., & Gibson, S. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182921 · Cited by 204

Targeting ferroptosis in breast cancer

Li, Z., Chen, L., Chen, C., Zhou, Y., Hu, D., Yang, J., Chen, Y., Zhuo, W., Mao, M., Zhang, X., et al. (2020) · Biomarker Research · doi:10.1186/s40364-020-00230-3 · Cited by 208

YAP1 alleviates sepsis-induced acute lung injury via inhibiting ferritinophagy-mediated ferroptosis

Zhang, J., Zheng, Y., Wang, Y., Wang, J., Sang, A., Song, X., & Li, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.884362 · Cited by 206

FANCD2 protects against bone marrow injury from ferroptosis

Song, X., Xie, Y., Kang, R., Hou, W., Sun, X., Epperly, M. W., Greenberger, J. S., & Tang, D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.068 · Cited by 203

Ferroptosis as an emerging target in inflammatory diseases

Mao, H., Zhao, Y., Li, H., & Lei, L. (2020) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2020.04.001 · Cited by 203

Interplay Between Lipid Metabolism and Autophagy

Xie, Y., Li, J., Kang, R., & Tang, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00431 · Cited by 205

Fighting age-related orthopedic diseases: focusing on ferroptosis

Ru, Q., Li, Y., Xie, W., Ding, Y., Chen, L., Xu, G., Wu, Y., & Wang, F. (2023) · Bone Research · doi:10.1038/s41413-023-00247-y · Cited by 211

Polystyrene microplastics up-regulates liver glutamine and glutamate synthesis and promotes autophagy-dependent ferroptosis and apoptosis in the cerebellum through the liver-brain axis

Yin, K., Wang, D., Zhao, H., Wang, Y., Zhang, Y., Liu, Y., Li, B., & Xing, M. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119449 · Cited by 205

MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells

Kuang, F., Liu, J., Xie, Y., Tang, D., & Kang, R. (2021) · Cell Chemical Biology · doi:10.1016/j.chembiol.2021.01.006 · Cited by 199

Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential

Ding, X.-S., Gao, L., Han, Z., Eleuteri, S., Shi, W., Shen, Y., Song, Z.-Y., Su, M., Yang, Q., Qu, Y., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102077 · Cited by 211

Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells

Wu, C., Zhao, W., Yu, J. Z., Li, S., Lin, L., & Chen, X. (2018) · Scientific Reports · doi:10.1038/s41598-017-18935-1 · Cited by 195

Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines

Zhang, Y., Kong, Y., Ma, Y., Ni, S., Wikerholmen, T., Xi, K., Zhao, F., Zhao, Z., Wang, J., Huang, B., et al. (2021) · Oncogene · doi:10.1038/s41388-020-01622-3 · Cited by 193

Interactions between reactive oxygen species and autophagy

Redza-Dutordoir, M., & Averill‐Bates, D. A. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119041 · Cited by 199

TMEM164 is a new determinant of autophagy-dependent ferroptosis

Liu, J., Liu, Y., Wang, Y., Li, C., Xie, Y., Klionsky, D. J., Kang, R., & Tang, D. (2022) · Autophagy · doi:10.1080/15548627.2022.2111635 · Cited by 195

The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells

Zhang, Z., Guo, M. L., Shen, M., Kong, D., Zhang, F., Shao, J., Tan, S., Wang, S., Chen, A., Cao, P., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101619 · Cited by 190

Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis

Wang, T., Tomas, D., Perera, N. D., Cuic, B., Luikinga, S. J., Viden, A., Barton, S. K., McLean, C., Samson, A. L., Southon, A. G., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00910-z · Cited by 193

Blockade of GCH1/BH4 Axis Activates Ferritinophagy to Mitigate the Resistance of Colorectal Cancer to Erastin-Induced Ferroptosis

Hu, Q., Wei, W., Wu, D., Huang, F., Li, M., Li, W., Yin, J., Peng, Y., Lu, Y., Zhao, Q., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.810327 · Cited by 194

In defence of ferroptosis

Alves, F. M., Lane, D. J. R., Nguyen, T. P. M., Bush, A. I., & Ayton, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02088-5 · Cited by 212

STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway

Yang, Y., Ma, Y., Li, Q., Ling, Y., Zhou, Y., Chu, K., Xue, L., & Tao, S. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04971-x · Cited by 191

Autophagy and Ferroptosis—What Is the Connection?

Kang, R., & Tang, D. (2017) · Current Pathobiology Reports · doi:10.1007/s40139-017-0139-5 · Cited by 186

Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer

Chaudhary, N., Choudhary, B. S., Shah, S. G., Khapare, N., Dwivedi, N., Gaikwad, A., Joshi, N., Raichanna, J., Basu, S., Gurjar, M., et al. (2021) · International Journal of Cancer · doi:10.1002/ijc.33711 · Cited by 185

Circular RNA cIARS regulates ferroptosis in HCC cells through interacting with RNA binding protein ALKBH5

Liu, Z., Wang, Q., Wang, X., Xu, Z., Wei, X., & Li, J. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00306-x · Cited by 187

Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity

Ni, Z., Li, Y., Song, D., Ding, J., Mei, S., Sun, S., Cheng, W., Yu, J., Zhou, L., Kuang, Y., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05037-8 · Cited by 187

Iron Overload, Oxidative Stress, and Ferroptosis in the Failing Heart and Liver

Mancardi, D., Mezzanotte, M., Arrigo, E., Barinotti, A., & Roetto, A. (2021) · Antioxidants · doi:10.3390/antiox10121864 · Cited by 188

Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis

Ding, H., Chen, S., Pan, X., Dai, X., Pan, G., Li, Z., Mai, X., Tian, Y., Zhang, S., Liu, B., et al. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12700 · Cited by 187

Ferroptosis and ferritinophagy in diabetes complications

He, J., Li, Z., Xia, P., Shi, A., FuChen, X., Zhang, J., & Yu, P. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101470 · Cited by 187

STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion

Li, C., Liu, J., Hou, W., Kang, R., & Tang, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.698679 · Cited by 185

Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer

Shin, D., Lee, J., You, J. H., Kim, D., & Roh, J. (2020) · Redox Biology · doi:10.1016/j.redox.2019.101418 · Cited by 179

Ferroptosis: Emerging mechanisms, biological function, and therapeutic potential in cancer and inflammation

Jin, X., Tang, J., Qiu, X., Nie, X., Ou, S., Wu, G., Zhang, R., & Zhu, J. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01825-7 · Cited by 188

Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma

Zhang, X., Yu, K., Ma, L., Qian, Z., Tian, X., Miao, Y., Niu, Y., Xu, X., Guo, S., Yang, Y., et al. (2021) · Theranostics · doi:10.7150/thno.55482 · Cited by 176

Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation

Kim, E. H., Wong, S., & Martinez, J. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0179-3 · Cited by 181

Iron Accumulation and Lipid Peroxidation in the Aging Retina: Implication of Ferroptosis in Age-Related Macular Degeneration

Zhao, T., Guo, X., & Sun, Y. (2021) · Aging and Disease · doi:10.14336/ad.2020.0912 · Cited by 180

Ferroptosis in Cancer Treatment: Another Way to Rome

Wu, Y., Yu, C., Luo, M., Chen, C., Qiu, J., Zhang, S., & Hu, K. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.571127 · Cited by 183

NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron–Sulfur Cluster Proteins

Santana-Codina, N., del Rey, M. Q., Kapner, K. S., Zhang, H., Gikandi, A., Malcolm, C., Poupault, C. L., Kuljanin, M., John, K. M., Biancur, D. E., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0043 · Cited by 182

NCOA4-mediated ferritinophagy promotes ferroptosis induced by erastin, but not by RSL3 in HeLa cells

Gryzik, M., Asperti, M., Denardo, A., Arosio, P., & Poli, M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118913 · Cited by 177

Iron and Cancer: 2020 Vision

Torti, S. V., & Torti, F. M. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-2017 · Cited by 183

The molecular mechanisms of ferroptosis and its role in cardiovascular disease

Zhang, Y., Xin, L., Xiang, M., Shang, C., Wang, Y., Wang, Y., Cui, X., & Lu, Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112423 · Cited by 175

Molecular Engineering of pH-Responsive NIR Oxazine Assemblies for Evoking Tumor Ferroptosis via Triggering Lysosomal Dysfunction

Li, W., Yin, S., Shen, Y., Li, H., Yuan, L., & Zhang, X. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c13222 · Cited by 170

Non-coding RNAs and ferroptosis: potential implications for cancer therapy

Balihodzic, A., Prinz, F., Dengler, M. A., Călin, G. A., Jost, P. J., & Pichler, M. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00998-x · Cited by 175

The emerging roles of MAPK-AMPK in ferroptosis regulatory network

Wang, X., Tan, X., Zhang, J., Wu, J., & Shi, H. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01170-9 · Cited by 178

Iron and leukemia: new insights for future treatments

Wang, F., Lv, H., Zhao, B., Zhou, L., Wang, S., Luo, J., Liu, J., & Shang, P. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1397-3 · Cited by 172

Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway

Wang, X., Shen, T., Lian, J., Deng, K., Qu, C., Li, E., Gan, L., Ren, Y., Wang, Z., Jiang, Z., et al. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00730-6 · Cited by 172

Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia

Li, Z., Jiang, L., Chew, S. H., Hirayama, T., Sekido, Y., & Toyokuni, S. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101297 · Cited by 167

Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis

Lin, L., Zhang, M.-X., Zhang, L., Zhang, D., Li, C., & Li, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.809955 · Cited by 166

Quercetin Protects against MPP + /MPTP‐Induced Dopaminergic Neuron Death in Parkinson’s Disease by Inhibiting Ferroptosis

Lin, Z., Liu, Y., Xue, N., Zheng, R., Yan, Y., Wang, Z., Li, Y., Ying, C.-Z., Song, Z., Tian, J., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7769355 · Cited by 173

Ferritin: An Inflammatory Player Keeping Iron at the Core of Pathogen-Host Interactions

Moreira, A. C., Mesquita, G., & Gomes, M. S. (2020) · Microorganisms · doi:10.3390/microorganisms8040589 · Cited by 172

Ferroptosis in Cancer Progression: Role of Noncoding RNAs

Zuo, Y.-B., Zhang, Y., Zhang, R., Tian, J., Lv, X., Li, R., Li, S., Cheng, M.-D., Shan, J., Zhao, Z., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.66917 · Cited by 171

Regulation and function of autophagy in pancreatic cancer

Li, J., Chen, X., Kang, R., Zeh, H. J., Klionsky, D. J., & Tang, D. (2020) · Autophagy · doi:10.1080/15548627.2020.1847462 · Cited by 167

Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal

Nishizawa, H., Yamanaka, M., & Igarashi, K. (2022) · FEBS Journal · doi:10.1111/febs.16382 · Cited by 164

The Aging of Iron Man

Ashraf, A., Clark, M., & So, P. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00065 · Cited by 163

Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes

Wang, Y., Wu, S., Li, Q., Sun, H., & Wang, H. (2023) · Advanced Science · doi:10.1002/advs.202300325 · Cited by 171

To eat or not to eat — the metabolic flavor of ferroptosis

Gao, M., & Jiang, X. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.11.001 · Cited by 160

Targeting ferroptosis for cancer therapy: exploring novel strategies from its mechanisms and role in cancers

Jiang, M., Qiao, M., Zhao, C., Deng, J., Li, X., & Zhou, C. (2020) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-341 · Cited by 158

Role of ferroptosis on tumor progression and immunotherapy

Gong, D., Chen, M., Wang, Y., Shi, J., & Hou, Y. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01218-8 · Cited by 162

Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases

Morris, G., Berk, M., Carvalho, A. F., Maes, M. H. J., Walker, A. J., & Puri, B. K. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.036 · Cited by 155

Ferroptosis in Neurological Diseases

Ren, J., Sun, X., Yan, X., Guo, Z., & Yang, Y. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00218 · Cited by 163

Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway

Shui, S., Zhao, Z., Wang, H., Conrad, M., & Liu, G. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102056 · Cited by 163

Ferroptosis: a double-edged sword mediating immune tolerance of cancer

Dang, Q., Sun, Z., Wang, Y., Wang, L., Liu, Z., & Han, X. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05384-6 · Cited by 155

Ferroptosis and the bidirectional regulatory factor p53

Xu, R., Wang, W., & Zhang, W. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01517-8 · Cited by 163

Immunological effects of iron oxide nanoparticles and iron-based complex drug formulations: Therapeutic benefits, toxicity, mechanistic insights, and translational considerations

Shah, A. B., & Dobrovolskaia, M. A. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2018.01.014 · Cited by 163

BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection

Chen, Y., Yi, X., Huo, B., He, Y., Guo, X., Zhang, Z., Zhong, X., Feng, X., Fang, Z., Zhu, X., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106122 · Cited by 155

The crosstalk between autophagy and ferroptosis: what can we learn to target drug resistance in cancer?

Zhou, Y., Shen, Y., Chen, C., Sui, X., Yang, J., Wang, L., & Zhou, J. (2019) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0158 · Cited by 157

Nuciferine protects against folic acid‐induced acute kidney injury by inhibiting ferroptosis

Li, D., Liu, B., Fan, Y., Liu, M. R., Han, B., Meng, Y., Xu, X. L., Song, Z., Liu, X., Hao, Q., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15364 · Cited by 153

Role of Ferroptosis in Lung Diseases

Xu, W., Deng, H., Hu, S., Zhang, Y., Li, Z., Liu, M., Chen, Y., Wei, J., Yang, H., & Lv, X. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s307081 · Cited by 155

NEDD4L-mediated LTF protein degradation limits ferroptosis

Wang, Y., Liu, Y., Liu, J., Kang, R., & Tang, D. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.07.032 · Cited by 152

Sigma‐1 receptor protects against ferroptosis in hepatocellular carcinoma cells

Bai, T., Lei, P., Zhou, H., Liang, R., Zhu, R., Wang, W., Zhou, L., & Sun, Y. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14594 · Cited by 152

The role of glutathione redox imbalance in autism spectrum disorder: A review

Bjørklund, G., Tinkov, A. A., Hosnedlová, B., Kizek, R., Ajsuvakova, O. P., Chirumbolo, S., Геннадиевна, С. М., Peana, M., Dadar, M., El-Ansary, A. K., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.017 · Cited by 156

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Conrad, M., Lorenz, S., & Proneth, B. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.08.010 · Cited by 155

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Xu, Y., Li, K., Zhao, Y., Zhou, L., Liu, Y., & Zhao, J. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01196-6 · Cited by 151

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Yue, D., Zhang, Q., Zhang, J., Liu, W., Chen, L., Wang, M., Li, R., Qin, S., Song, X., & Ji, Y. (2022) · Environment International · doi:10.1016/j.envint.2022.107706 · Cited by 147

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Lu, S., Wang, X., He, C., Wang, L., Liang, S.-P., Wang, C., Li, C., Luo, T., Feng, C., Wang, Z.-C., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00700-w · Cited by 142

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Zhang, X., Tang, B., Luo, J., Yang, Y., Weng, Q., Fang, S., Zhao, Z., Tu, J., Chen, M., & Ji, J. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02130-8 · Cited by 148

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Li, Y., Liu, Y., Wu, P., Tian, Y., Liu, B., Wang, J., Bihl, J. C., & Shi, H. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00850-1 · Cited by 142

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Ascenzi, F., Vitis, C. D., Maugeri‐Saccà, M., Napoli, C., Ciliberto, G., & Mancini, R. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02067-6 · Cited by 143

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Gao, M., Monian, P., Pan, Q., Zhang, W., Xiang, J., & Jiang, X. (2016) · Cell Research · doi:10.1038/cr.2016.95 · Cited by 1,899

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Liu, J., Kuang, F., Kroemer, G., Klionsky, D. J., Kang, R., & Tang, D. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.02.005 · Cited by 819

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