The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.
Autophagy promotes ferroptosis by degradation of ferritin
Open accessAbstract
Macroautophagy/autophagy is an evolutionarily conserved degradation pathway that maintains homeostasis. Ferroptosis, a novel form of regulated cell death, is characterized by a production of reactive oxygen species from accumulated iron and lipid peroxidation. However, the relationship between autophagy and ferroptosis at the genetic level remains unclear. Here, we demonstrated that autophagy contributes to ferroptosis by degradation of ferritin in fibroblasts and cancer cells. Knockout or knockdown of Atg5 (autophagy-related 5) and Atg7 limited erastin-induced ferroptosis with decreased intracellular ferrous iron levels, and lipid peroxidation. Remarkably, NCOA4 (nuclear receptor coactivator 4) was a selective cargo receptor for the selective autophagic turnover of ferritin (namely ferritinophagy) in ferroptosis. Consistently, genetic inhibition of NCOA4 inhibited ferritin degradation and suppressed ferroptosis. In contrast, overexpression of NCOA4 increased ferritin degradation and promoted ferroptosis. These findings provide novel insight into the interplay between autophagy and regulated cell death.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“ferroptosis, which is promoted by the autophagic degradation of ferritin (ferritinophagy) [573, 574]”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [573]
In the citing paper
“Ferritin is selectively targeted for autophagic/lysosomal degradation by the cargo receptor NCOA4 [53], a process required for liberating iron making it bioavailable to the cell [51], [53], [65].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [65]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Ferroptosis: process and function
Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.158 · Cited by 3,727
Self-citationAutophagy as a Regulated Pathway of Cellular Degradation
Klionsky, D. J., & Emr, S. D. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,630
Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
Moy, R. H., & Cherry, S. R. (2013) · Journal of Innate Immunity · doi:10.1159/000350326 · Cited by 3,551
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506
Flagged first, then by citations
1 of the 28 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–200 of 1,000
Zhang, Z., Guo, M. L., Li, Y., Shen, M., Kong, D., Shao, J., Ding, H., Tan, S., Chen, A., Zhang, F., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1687985 · Cited by 467
Masaldan, S., Clatworthy, S. A. S., Gamell, C., Meggyesy, P. M., Rigopoulos, A.-T., Haupt, S., Haupt, Y., Denoyer, D., Adlard, P. A., Bush, A. I., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2017.08.015 · Cited by 452
The Role of Ferroptosis in Cancer Development and Treatment Response
Lu, B., Chen, X. B., Ying, M. D., He, Q. J., Cao, J., & Yang, B. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00992 · Cited by 444
Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis
Anandhan, A., Dodson, M. B., Schmidlin, C. J., Liu, P., & Zhang, D. D. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.03.011 · Cited by 442
Qin, X., Zhang, J., Wang, B., Xu, G., Yang, X., Zou, Z., & Yu, C. (2021) · Autophagy · doi:10.1080/15548627.2021.1911016 · Cited by 439
The chemistry and biology of ferroptosis
Stockwell, B. R., & Jiang, X. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.03.013 · Cited by 429
FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson's Disease
Tian, Y., Lü, J., Hao, X., Li, H., Zhang, G., Liu, X., Li, X., Zhao, C., Kuang, W., Chen, D., et al. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00929-z · Cited by 436
Du, J., Wang, T., Li, Y., Zhou, Y., Wang, X., Yu, X., Ren, X., An, Y., Wu, Y., Sun, W., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.011 · Cited by 487
ROS induced lipid peroxidation and their role in ferroptosis
Endale, H. T., Tesfaye, W., & Mengstie, T. A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1226044 · Cited by 441
The application of Ferroptosis in diseases
Qiu, Y., Cao, Y., Cao, W., Jia, Y., & Lu, N. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104919 · Cited by 415
Chen, P., Wu, Q., Feng, J., Yan, L., Sun, Y., Liu, S., Yu, X., Zhang, M., Pan, T. S., Chen, X., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0149-3 · Cited by 419
The role of NCOA4-mediated ferritinophagy in health and disease
Santana-Codina, N., & Mancias, J. D. (2018) · Pharmaceuticals · doi:10.3390/ph11040114 · Cited by 410
Autophagy in tumour immunity and therapy
Xia, H., Green, D. R., & Zou, W. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00344-2 · Cited by 421
Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis
Fuhrmann, D. C., Mondorf, A. W., Beifuß, J., Jung, M., & Brüne, B. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101670 · Cited by 415
Organelle-specific regulation of ferroptosis
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00859-z · Cited by 415
Self-citationWei, S., Qiu, T., Yao, X., Wang, N., Jiang, L., Jia, X., Tao, Y., Wang, Z., Pei, P., Zhang, J., et al. (2019) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.121390 · Cited by 386
Self-citationMetformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer
Yang, J., Zhou, Y., Xie, S., Wang, J., Li, Z., Chen, L., Mao, M., Chen, C., Huang, A., Chen, Y., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02012-7 · Cited by 399
Overcoming cancer chemotherapy resistance by the induction of ferroptosis
Wang, Y., Wu, X., Zhao, R., Li, Y., Zou, W., Chen, J., & Wang, H. (2022) · Drug Resistance Updates · doi:10.1016/j.drup.2022.100916 · Cited by 370
Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway
Kong, Z., Liu, R., & Cheng, Y. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.030 · Cited by 364
Diversity and complexity of cell death: a historical review
Park, W., Wei, S., Kim, B., Kim, B., Bae, S., Chae, Y. C., Ryu, D., & Ha, K. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01078-x · Cited by 381
Ferroptosis in health and disease
Berndt, C., Alborzinia, H., Skafar, V., Ayton, S., Barayeu, U., Bartelt, A., Bayır, H., Bebber, C. M., Birsoy, K., Böttcher, J. P., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103211 · Cited by 372
The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression
Wu, Y., Zhang, S.-W., Gong, X., Tam, S., Xiao, D., Liu, S., & Tao, Y. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01157-x · Cited by 343
Beclin 1 Phosphorylation – at the Center of Autophagy Regulation
Menon, M., & Dhamija, S. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00137 · Cited by 350
Ferroptosis and cell death mechanisms in Parkinson's disease
Guiney, S. J., Adlard, P. A., Bush, A. I., Finkelstein, D. I., & Ayton, S. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.01.004 · Cited by 353
Zhang, H., Liu, J., Zhou, Y., Qu, M., Wang, Y., Guo, K., Shen, R., Sun, Z., Cata, J. P., Yang, S., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.69141 · Cited by 341
Ferritinophagy and ferroptosis in the management of metabolic diseases
Ajoolabady, A., Aslkhodapasandhokmabad, H., Libby, P., Tuomilehto, J. O., Lip, G. Y. H., Penninger, J. M., Richardson, D. R., Tang, D., Zhou, H., Wang, S., et al. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.04.010 · Cited by 341
Self-citationCell death in pancreatic cancer: from pathogenesis to therapy
Chen, X., Zeh, H. J., Kang, R., Kroemer, G., & Tang, D. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00486-6 · Cited by 344
Self-citationBayır, H., Dixon, S. J., Tyurina, Y. Y., Kellum, J. A., & Kagan, V. E. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00689-x · Cited by 355
Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications
Zheng, Y., Sun, J., Luo, Z., Li, Y., & Huang, Y. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07244-x · Cited by 378
Recent progress in ferroptosis: inducers and inhibitors
Du, Y., & Guo, Z. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01297-7 · Cited by 342
Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy
Lv, H., Zhen, C., Liu, J., Yang, P., Hu, L., & Shang, P. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3150145 · Cited by 320
Dixon, S. J. (2017) · Immunological Reviews · doi:10.1111/imr.12533 · Cited by 314
Emerging mechanisms and targeted therapy of ferroptosis in cancer
Wang, H., Cheng, Y., Mao, C., Liu, S., Xiao, D., Huang, J. X., & Tao, Y. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.03.022 · Cited by 326
Ferroptosis Detection: From Approaches to Applications
Zeng, F., Nijiati, S., Tang, L., Ye, J., Zhou, Z., & Chen, X. S. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202300379 · Cited by 324
Superoxide Radicals in the Execution of Cell Death
Fujii, J., Homma, T., & Osaki, T. (2022) · Antioxidants · doi:10.3390/antiox11030501 · Cited by 337
The Role of NCOA4-Mediated Ferritinophagy in Ferroptosis
Santana-Codina, N., Gikandi, A., & Mancias, J. D. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-62026-4_4 · Cited by 329
Sun, Y., Berleth, N., Wu, W., Schlütermann, D., Deitersen, J., Stuhldreier, F., Berning, L., Friedrich, A., Akgün, S., Mendiburo, M. J., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04306-2 · Cited by 308
Ferroptosis: principles and significance in health and disease
Chen, F., Kang, R., Tang, D., & Liu, J. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01564-3 · Cited by 341
Self-citationFull-coverage regulations of autophagy by ROS: from induction to maturation
Zhou, J., Li, X., Liu, Y. J., Ji, F., Wu, Y., Shen, H., & Lu, G. (2021) · Autophagy · doi:10.1080/15548627.2021.1984656 · Cited by 304
A guideline on the molecular ecosystem regulating ferroptosis
Dai, E., Chen, X., Linkermann, A., Jiang, X., Kang, R., Kagan, V. E., Bayır, H., Yang, W. S., García‐Sáez, A. J., Ioannou, M. S., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01360-8 · Cited by 327
Self-citationAutophagy-dependent cell death—where.; how and why a cell eats itself to death
Bialik, S., Dasari, S. K., & Kimchi, A. (2018) · Journal of Cell Science · doi:10.1242/jcs.215152 · Cited by 295
Cell Death in Liver Diseases: A Review
Shojaie, L., Iorga, A., & Dara, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249682 · Cited by 309
Ferritinophagy/ferroptosis: Iron‐related newcomers in human diseases
Tang, M., Chen, Z., Wu, D., & Chen, L. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26954 · Cited by 292
Li, J., Liu, J., Zhou, Z., Wu, R., Chen, X., Yu, C., Stockwell, B. R., Kroemer, G., Kang, R., & Tang, D. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adg3049 · Cited by 305
Self-citationFerroptosis in liver disease: new insights into disease mechanisms
Wu, J., Wang, Y., Jiang, R., Xue, R., Yin, X., Wu, M., & Meng, Q. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00660-4 · Cited by 291
Subchronic and chronic toxicity evaluation of inorganic nanoparticles for delivery applications
Mohammadpour, R., Dobrovolskaia, M. A., Cheney, D. L., Greish, K. F., & Ghandehari, H. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.07.006 · Cited by 299
Yamada, N., Karasawa, T., Wakiya, T., Sadatomo, A., Ito, H., Kamata, R., Watanabe, S., Komada, T., Kimura, H. J., Sanada, Y., et al. (2020) · American Journal of Transplantation · doi:10.1111/ajt.15773 · Cited by 280
Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis
Yu, F. D., Zhang, Q., Liu, H., Liu, J., Yang, S., Luo, X., Liu, W., Zheng, H., Liu, Q., Cui, Y., et al. (2022) · Cell Discovery · doi:10.1038/s41421-022-00390-6 · Cited by 289
ESCRT-III–dependent membrane repair blocks ferroptosis
Dai, E., Meng, L., Kang, R., Wang, X., & Tang, D. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.110 · Cited by 283
Self-citationLewerenz, J., Ates, G., Methner, A., Conrad, M., & Maher, P. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00214 · Cited by 276
Ferroptosis and Its Potential Role in Human Diseases
Han, C., Liu, Y., Dai, R., Ismail, N., Su, W., & Li, B. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00239 · Cited by 283
Wiernicki, B., Dubois, H., Tyurina, Y. Y., Hassannia, B., Bayır, H., Kagan, V. E., Vandenabeele, P., Wullaert, A., & Berghe, T. V. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03118-0 · Cited by 280
The role of lipid metabolic reprogramming in tumor microenvironment
Yang, K., Wang, X., Song, C., Zhao, H., Wang, R., Xu, Y., Jiang, G., Wan, Y., Mei, J., & Mao, W. (2023) · Theranostics · doi:10.7150/thno.82920 · Cited by 311
GPX4-independent ferroptosis—a new strategy in disease’s therapy
Ma, T., Du, J., Zhang, Y., Wang, Y., Wang, B., & Zhang, T. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01212-0 · Cited by 291
Nishizawa, H., Matsumoto, M., Shindo, T., Saigusa, D., Kato, H., Suzuki, K., Sato, M., Ishii, Y., Shimokawa, H., & Igarashi, K. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009548 · Cited by 276
Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus
Sha, W., Hu, F., Yang, X., Chu, Y., & Bu, S. (2021) · Journal of Diabetes Research · doi:10.1155/2021/9999612 · Cited by 276
Persister cancer cells: Iron addiction and vulnerability to ferroptosis
Rodriguez, R., Schreiber, S. L., & Conrad, M. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.12.001 · Cited by 280
The function and mechanism of ferroptosis in cancer
Wang, Y., Wei, Z., Pan, K., Li, J., & Chen, Q. (2020) · APOPTOSIS · doi:10.1007/s10495-020-01638-w · Cited by 262
Song, X., Liu, J., Kuang, F., Chen, X., Zeh, H. J., Kang, R., Kroemer, G., Xie, Y., & Tang, D. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108767 · Cited by 262
Self-citationKim, E. H., Shin, D., Lee, J., Jung, A. R., & Roh, J. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.06.018 · Cited by 265
Guo, H., Ouyang, Y., Yin, H., Cui, H., Deng, H., Liu, H., Jian, Z., Fang, J. S., Zuo, Z., Wang, X., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102227 · Cited by 261
Ferroptosis: when metabolism meets cell death
Zheng, J., & Conrad, M. (2024) · Physiological Reviews · doi:10.1152/physrev.00031.2024 · Cited by 286
The emerging role of ferroptosis in intestinal disease
Xu, S., He, Y., Lin, L., Chen, P., Chen, M., & Zhang, S. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03559-1 · Cited by 265
Buccarelli, M., Marconi, M., Pacioni, S., Pascalis, I. D., D’Alessandris, Q. G., Martini, M., Ascione, B., Malorni, W., Larocca, L. M., Pallini, R., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0864-7 · Cited by 262
Chen, X., Xu, S., Zhao, C., & Liu, B. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.06.015 · Cited by 263
ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4
Wu, H., Liu, Q., Shan, X., Gao, W., & Chen, Q. (2023) · Autophagy · doi:10.1080/15548627.2023.2170960 · Cited by 267
Curcumin induces ferroptosis in non‐small‐cell lung cancer via activating autophagy
Tang, X., Ding, H., Liang, M., Chen, X., Yan, Y., Wan, N., Chen, Q., Zhang, J., & Cao, J. (2021) · Thoracic Cancer · doi:10.1111/1759-7714.13904 · Cited by 266
Li, C., Sun, G., Chen, B., Xu, L., Ye, Y., He, J., Bao, Z., Zhao, P., Miao, Z., Zhao, L., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105933 · Cited by 264
Iron Metabolism, Ferroptosis, and the Links With Alzheimer’s Disease
Yan, N., & Zhang, J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01443 · Cited by 256
The STING1 network regulates autophagy and cell death
Zhang, R., Kang, R., & Tang, D. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00613-4 · Cited by 266
Self-citationLin, Q., Li, S., Jin, H., Cai, H., Zhu, X., Yang, Y., Wu, J., Qi, C., Shao, X., Li, J., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.80775 · Cited by 254
Ferroptosis and its emerging roles in cardiovascular diseases
Li, N., Jiang, W., Wang, W., Xiong, R., Wu, X., & Geng, Q. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105466 · Cited by 256
Targeting iron metabolism in cancer therapy
Morales, M., & Xue, X. (2021) · Theranostics · doi:10.7150/thno.59092 · Cited by 262
Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases
Chen, L., Shen, Q., Liu, Y., Zhang, Y., Sun, L., Ma, X., Song, N., & Xie, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02071-0 · Cited by 279
The pathological role of ferroptosis in ischemia/reperfusion-related injury
Yan, H.-F., Tuo, Q., Yin, Q., & Lei, P. (2020) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2020.042 · Cited by 251
Ferroptosis is a lysosomal cell death process
Gao, H., Bai, Y., Jia, Y., Zhao, Y., Kang, R., Tang, D., & Dai, E. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.078 · Cited by 251
Self-citationTumor heterogeneity in autophagy-dependent ferroptosis
Li, J., Liu, J., Xu, Y., Wu, R., Chen, X., Song, X., Zeh, H. J., Kang, R., Klionsky, D. J., Wang, X., et al. (2021) · Autophagy · doi:10.1080/15548627.2021.1872241 · Cited by 246
Self-citationIdentification of Frataxin as a regulator of ferroptosis
Du, J., Zhou, Y., Li, Y., Xia, J., Chen, Y., Chen, S., Wang, X., Sun, W., Wang, T., Ren, X., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101483 · Cited by 243
Double-edge sword roles of iron in driving energy production versus instigating ferroptosis
Zhang, S., Xin, W., Anderson, G. J., Li, R., Gao, L., Chen, S., Zhao, J., & Liu, S. (2022) · Cell Death and Disease · doi:10.1038/s41419-021-04490-1 · Cited by 250
Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action
Wong, Y. K., Xu, C., Kalesh, K., He, Y., Lin, Q., Wong, W. S. F., Shen, H., & Wang, J. (2017) · Medicinal Research Reviews · doi:10.1002/med.21446 · Cited by 244
Transcription factors in ferroptotic cell death
Dai, C., Chen, X., Li, J., Comish, P. B., Kang, R., & Tang, D. (2020) · Cancer Gene Therapy · doi:10.1038/s41417-020-0170-2 · Cited by 244
Self-citationGuidelines for evaluating myocardial cell death
Mishra, P. K., Adameová, A., Hill, J. A., Baines, C. P., Kang, P. M., Downey, J. M., Narula, J., Takahashi, M., Abbate, A., Piristine, H. C., et al. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00259.2019 · Cited by 246
Han, D., Jiang, L., Gu, X., Huang, S., Pang, J., Wu, Y., Yin, J., & Wang, J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29727 · Cited by 239
Wang, Z., Ma, J., Li, X., Wu, Y., Shi, H., Chen, Y., Lu, G. X., Shen, H., Lu, G., & Zhou, J. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15350 · Cited by 236
Autophagy mediates an amplification loop during ferroptosis
Lee, S., Hwang, N., Seok, B. G., Lee, S., Lee, S., & Chung, S. W. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05978-8 · Cited by 253
AIFM2 blocks ferroptosis independent of ubiquinol metabolism
Dai, E., Zhang, W., Cong, D., Kang, R., Wang, J., & Tang, D. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.01.066 · Cited by 238
Self-citationThe lysosome as a master regulator of iron metabolism
Rizzollo, F., More, S., Vangheluwe, P., & Agostinis, P. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2021.07.003 · Cited by 243
Role of ferroptosis in hepatocellular carcinoma
Nie, J., Lin, B., Zhou, M., Wu, L. J., & Zheng, T. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2740-3 · Cited by 234
Zhou, H., Zhou, Y., Mao, J.-A., Tang, L., Xu, J., Wang, Z., He, Y., & Li, M. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102413 · Cited by 239
Shen, M., Li, Y., Wang, Y., Shao, J., Zhang, F., Yin, G., Chen, A., Zhang, Z., & Zheng, S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102151 · Cited by 230
Chemistry and biology of ferritin
Plays, M., Müller, S., & Rodriguez, R. (2021) · Metallomics · doi:10.1093/mtomcs/mfab021 · Cited by 232
Yang, R., Xu, W., Zheng, H., Zheng, X., Li, B., Jiang, L., & Jiang, S. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30039 · Cited by 228
Zhao, C., Yu, D. N., He, Z., Bao, L., Feng, L., Chen, L., Liu, Z., Hu, X., Zhang, N., Wang, T., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.09.008 · Cited by 229
NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration
Quiles del Rey, M., & Mancias, J. D. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00238 · Cited by 227
Liu, Y., Wang, Y., Liu, J., Kang, R., & Tang, D. (2020) · Cancer Gene Therapy · doi:10.1038/s41417-020-0182-y · Cited by 227
Self-citationProgrammed cell death in atherosclerosis and vascular calcification
Li, M., Wang, Z., Fang, L., Cheng, S.-Q., Wang, X., & Liu, N. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04923-5 · Cited by 243
Targeting lysosomes in human disease: from basic research to clinical applications
Cao, M., Luo, X., Wu, K., & He, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00778-y · Cited by 225
Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress
Imam, M. U., Zhang, S., Ma, J., Wang, H., & Wang, F. (2017) · Nutrients · doi:10.3390/nu9070671 · Cited by 239
Deng, F., Sharma, I., Dai, Y., Yang, M., & Kanwar, Y. S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129903 · Cited by 221
Heme Oxgenase-1, a Cardinal Modulator of Regulated Cell Death and Inflammation
Ryter, S. W. (2021) · Cells · doi:10.3390/cells10030515 · Cited by 228
Metadata
- Authors
- Hou, W., Xie, Y., Song, X., Sun, X., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D.
- Affiliations
- University of Pittsburgh (US)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Corresponding author
- Tang, Daolin
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2016-06-24
- Volume
- 12
- Issue
- 8
- Pages
- 1425-1428
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- PMC
- PMC4968231
- OpenAlex
- W2414659015
- Cited by
- 2,332
- References
- 28
- Citations by year
- 2026: 278 · 2025: 361 · 2024: 383 · 2023: 412 · 2022: 320 · 2021: 265 · 2020: 145 · 2019: 85 · 2018: 45 · 2017: 29 · 2016: 7
- FWCI
- 49.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Autophagy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pittsburgh (P30 CA047904)
- National Natural Science Foundation of China (201508020258, R01GM115366, 201400000004-4, RSG-16-014-01-CDD, P30CA047904, 201400000003, R01CA160417, 31171229, 201400000003-4, U1132005)
- Natural Science Foundation of Guangdong Province (31171229, RSG-16-014-01-CDD, 201400000003-4, R01CA160417, U1132005, P30CA047904, 201400000004-4, R01GM115366, 201508020258)
- National Institutes of Health (RSG-16-014-01-CDD)
- Cancer Institute, University of Pittsburgh (RSG-16-014-01-CDD, R01GM115366, R01CA160417, P30CA047904)
- National Cancer Institute (R01CA160417, R01CA181450, P30CA047904)
- National Institute of General Medical Sciences (R01GM115366)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- ferroptosis, ferritinophagy, ferritin degradation, NCOA4, ATG5, ATG7, lipid peroxidation, iron homeostasis, selective autophagy, regulated cell death, erastin
- MeSH terms
- Autophagy-Related Protein 5, Autophagy-Related Protein 7, Animals, Autophagy, Ferritins, Fibroblasts, Homeostasis, Humans, Iron, Pancreatic Neoplasms, Piperazines, Lipid Peroxidation, Apoptosis, Reactive Oxygen Species, Mice, Knockout, Mice, Nuclear Receptor Coactivators
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
