Autophagy promotes ferroptosis by degradation of ferritin

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

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Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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Ferroptosis: process and function

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Autophagy as a Regulated Pathway of Cellular Degradation

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Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila

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Autophagy and the Integrated Stress Response

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Induction and application of ferroptosis in cancer therapy

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STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury

Jin, L., Yu, B., Wang, H., Shi, L., Yang, J., Wu, L., Gao, C., Pan, H., Han, F., Lin, W., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.08.025 · Cited by 140

JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy

Sun, K., Hou, L., Guo, Z., Wang, G., Guo, J., Xu, J., Zhang, X., & Guo, F. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.03.008 · Cited by 136

Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer

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Implication of ferroptosis in aging

Mazhar, M., Din, A. U., Ali, H., Yang, G., Ren, W., Wang, L., Fan, X., & Yang, S. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00553-6 · Cited by 138

Ferroptosis: A Novel Therapeutic Target for Ischemia-Reperfusion Injury

Chen, Y., Fan, H., Wang, S., Tang, G., Zhai, C., & Shen, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.688605 · Cited by 139

Ferroptosis Signaling and Regulators in Atherosclerosis

Wang, Y., Zhao, Y., Ye, T., Yang, L. M., Shen, Y., & Li, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.809457 · Cited by 136

Ferroptosis: An emerging approach for targeting cancer stem cells and drug resistance

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FTH promotes the proliferation and renders the HCC cells specifically resist to ferroptosis by maintaining iron homeostasis

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Ferritin‐Hijacking Nanoparticles Spatiotemporally Directing Endogenous Ferroptosis for Synergistic Anticancer Therapy

Zhu, L., You, Y., Zhu, M., Song, Y., Zhang, J., Hu, J., Xu, X., Du, Y., Du, Y., & Ji, J. (2022) · Advanced Materials · doi:10.1002/adma.202207174 · Cited by 132

STAT3 signaling promotes cardiac injury by upregulating NCOA4-mediated ferritinophagy and ferroptosis in high-fat-diet fed mice

Zhu, M., Peng, L., Huo, S., Peng, D., Gou, J., Shi, W., Tao, J., Jiang, T., Jiang, Y., Wang, Q., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.03.003 · Cited by 137

Ferroptosis of immune cells in the tumor microenvironment

Kim, R., Taylor, D. K., Vonderheide, R. H., & Gabrilovich, D. I. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.06.005 · Cited by 143

Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis

Cheng, H., Feng, D., Li, X., Gao, L., Tang, S., Liu, W. Q., Wu, X., Yue, S., Li, C., & Luo, Z. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166204 · Cited by 132

The role of ferroptosis in lung cancer

Wu, S., Zhu, C., Tang, D., Dou, Q. P., Shen, J., & Chen, X. (2021) · Biomarker Research · doi:10.1186/s40364-021-00338-0 · Cited by 137

Insights on the crosstalk among different cell death mechanisms

Eskander, G., AbdelHamid, S. G., Wahdan, S. A., & Radwan, S. M. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02328-9 · Cited by 150

Molecular Interactions Between Reactive Oxygen Species and Autophagy in Kidney Disease

Kaushal, G. P., Chandrashekar, K., & Juncos, L. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153791 · Cited by 130

Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis

Zhou, Z., Ye, T. J., DeCaro, E., Buehler, B., Stahl, Z., Bonavita, G. J., Daniels, M. J., & You, M. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.09.012 · Cited by 132

Emerging and established modes of cell death during acetaminophen-induced liver injury

Jaeschke, H., Ramachandran, A., Chao, X., & Ding, W. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02597-1 · Cited by 135

Mechanisms of Regulated Cell Death: Current Perspectives

Santagostino, S. F., Assenmacher, C., Tarrant, J. C., Adedeji, A. O., & Radaelli, E. (2021) · Veterinary Pathology · doi:10.1177/03009858211005537 · Cited by 137

Interferon‐γ induces retinal pigment epithelial cell Ferroptosis by a JAK1‐2/STAT1/SLC7A11 signaling pathway in Age‐related Macular Degeneration

Wei, T., Zhang, M., Zheng, X., Xie, T., Wang, W., Zou, J., Li, Y., Li, H., Cai, J., Wang, X., et al. (2021) · FEBS Journal · doi:10.1111/febs.16272 · Cited by 129

Ferritinophagy Mediated by Oxidative Stress-Driven Mitochondrial Damage Is Involved in the Polystyrene Nanoparticles-Induced Ferroptosis of Lung Injury

Yang, S., Zhang, T., Ge, Y., Cheng, Y., Yin, L., Pu, Y., Chen, Z., & Liang, G. (2023) · ACS Nano · doi:10.1021/acsnano.3c07255 · Cited by 136

Ferroptosis: Mechanisms and role in diabetes mellitus and its complications

Liu, P., Zhang, Z., Cai, Y., Li, Z., Zhou, Q., & Chen, Q. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102201 · Cited by 137

Saponin Formosanin C-Induced Ferritinophagy and Ferroptosis in Human Hepatocellular Carcinoma Cells

Lin, P.-L., Tang, H. F., Wu, S., Shaw, N.-S., & Su, C. (2020) · Antioxidants · doi:10.3390/antiox9080682 · Cited by 129

Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine

Wang, X., Hua, P., He, C., & Chen, M. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.03.020 · Cited by 131

Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis

Chen, X., Song, X., Li, J., Zhang, R., Yu, C., Zhou, Z., Liu, J., Liao, S., Klionsky, D. J., Kroemer, G., et al. (2022) · Autophagy · doi:10.1080/15548627.2022.2059170 · Cited by 128

Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection

Li, N., Yi, X., He, Y., Huo, B., Chen, Y., Zhang, Z., Wang, Q., Li, Y., Zhong, X., Li, R., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.72528 · Cited by 127

Targeting Ferroptosis as a Promising Therapeutic Strategy for Ischemia-Reperfusion Injury

Pan, Y., Wang, X., Liu, X., Shen, L., Chen, Q., & Shu, Q. (2022) · Antioxidants · doi:10.3390/antiox11112196 · Cited by 129

The Interplay between Intracellular Iron Homeostasis and Neuroinflammation in Neurodegenerative Diseases

Lee, J., & Hyun, D. (2023) · Antioxidants · doi:10.3390/antiox12040918 · Cited by 142

PPARG-mediated ferroptosis in dendritic cells limits antitumor immunity

Han, L., Bai, L., Qu, C., Dai, E., Liu, J., Kang, R., Zhou, D., Tang, D., & Zhao, Y. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.08.082 · Cited by 128

Zinc transporter ZIP7 is a novel determinant of ferroptosis

Chen, P., Wu, J., Xu, Y., Ding, C. C., Mestre, A. A., Lin, C., Yang, W., & Chi, J. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03482-5 · Cited by 128

Ferroptosis in immunostimulation and immunosuppression

Tang, D., Kroemer, G., & Kang, R. (2023) · Immunological Reviews · doi:10.1111/imr.13235 · Cited by 129

Mechanisms and regulations of ferroptosis

Zhang, X.-D., Liu, Z., Wang, M.-S., Guo, Y.-X., Wang, X., Luo, K., Huang, S., & Li, R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1269451 · Cited by 138

Ferritinophagy: research advance and clinical significance in cancers

Wang, J., Wu, N., Peng, M., Oyang, L., Jiang, X., Peng, Q., Zhou, Y., He, Z., & Liao, Q. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01753-y · Cited by 128

Crosstalk between ferroptosis and cuproptosis: From mechanism to potential clinical application

Liu, N., & Chen, M. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116115 · Cited by 139

Ferroptotic therapy in cancer: benefits, side effects, and risks

Diao, J., Jia, Y., Dai, E., Liu, J., Kang, R., Tang, D., Han, L., Zhong, Y., & Meng, L. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01999-9 · Cited by 135

Recent progress on targeting ferroptosis for cancer therapy

Xu, G., Wang, H., Li, X., Huang, R., & Luo, L. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114584 · Cited by 121

Regulatory pathways and drugs associated with ferroptosis in tumors

Wang, D., Tang, L. M., Zhang, Y., Ge, G., Jiang, X., Mo, Y., Wu, P., Deng, X., Li, L., Zuo, S., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04927-1 · Cited by 131

The Role of Ferritin in Health and Disease: Recent Advances and Understandings

Kotla, N. K., Dutta, P., Parimi, S., & Das, N. K. (2022) · Metabolites · doi:10.3390/metabo12070609 · Cited by 141

The significance, trafficking and determination of labile iron in cytosol, mitochondria and lysosomes

Lv, H., & Shang, P. (2018) · Metallomics · doi:10.1039/c8mt00048d · Cited by 127

The V-ATPases in cancer and cell death

Chen, F., Kang, R., Liu, J., & Tang, D. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-022-00477-y · Cited by 138

The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro

Tsai, Y., Xia, C., & Sun, Z. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.598555 · Cited by 124

Regulated cell death: discovery, features and implications for neurodegenerative diseases

Cui, J., Zhao, S., Li, Y., Zhang, D., Wang, B., Xie, J., & Wang, J. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00799-8 · Cited by 130

Ferroptosis Suppressor Protein 1 Inhibition Promotes Tumor Ferroptosis and Anti-tumor Immune Responses in Liver Cancer

Cheu, J. W., Lee, D. P. H., Li, Q., Goh, C. C., Bao, M. H., Yuen, V. W., Zhang, M. S., Yang, C., Chan, C. Y., Tse, A. P., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.03.001 · Cited by 126

Iron Metabolism and Ferroptosis in Epilepsy

Chen, S., Chen, Y., Zhang, Y., Kuang, X., Liu, Y., Guo, M., Ma, L., Zhang, D., & Li, Q. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.601193 · Cited by 122

Low expression of ferritinophagy-related NCOA4 gene in relation to unfavorable outcome and defective immune cells infiltration in clear cell renal carcinoma

Mou, Y., Wu, J., Zhang, Y., Abdihamid, O., Duan, C., & Li, B. (2021) · BMC Cancer · doi:10.1186/s12885-020-07726-z · Cited by 122

Intersections between Regulated Cell Death and Autophagy

Napoletano, F., Baron, O., Vandenabeele, P., Mollereau, B., & Fanto, M. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.12.007 · Cited by 120

PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells

Zhao, J., Dar, H. H., Deng, Y., Croix, C. M. S., Li, Z., Minami, Y., Shrivastava, I. H., Tyurina, Y. Y., Etling, E. B., Rosenbaum, J. C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921618117 · Cited by 121

Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke

Liu, J., Guo, Z., Yan, X., Huang, S., Ren, J., Luo, Y., & Yang, Y. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.577403 · Cited by 120

Ferroptosis Nanomedicine: Clinical Challenges and Opportunities for Modulating Tumor Metabolic and Immunological Landscape

Yang, H., Yao, X., Liu, Y., Shen, X., Li, M., & Luo, Z. Y. (2023) · ACS Nano · doi:10.1021/acsnano.3c04632 · Cited by 122

Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis

Wei, X.-B., Jiang, W.-Q., Zeng, J.-H., Huang, L.-Q., Ding, H.-G., Jing, Y.-W., Han, Y.-L., Li, Y.-C., & Chen, S.-L. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02738-1 · Cited by 123

Iron and magnetic: new research direction of the ferroptosis-based cancer therapy.

Wang, S., Luo, J., Zhang, Z., Dong, D., Shen, Y., Fang, Y., Hu, L., Liu, M., Dai, C., Peng, S., et al. (2018) · Europe PMC (PubMed Central) · Cited by 117

Poly(rC)-binding protein 1 represses ferritinophagy-mediated ferroptosis in head and neck cancer

Lee, J., You, J. H., & Roh, J. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102276 · Cited by 118

Ferroptosis and Acute Kidney Injury (AKI): Molecular Mechanisms and Therapeutic Potentials

Feng, Q., Yu, X., Qiao, Y., Pan, S., Wang, R., Zheng, B., Wang, H., Ren, K., Liu, H., & Yang, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.858676 · Cited by 118

When ferroptosis meets pathogenic infections

Gao, J., Wang, Q., Tang, Y.-D., Zhai, J., Hu, W., & Zheng, C. (2022) · Trends in Microbiology · doi:10.1016/j.tim.2022.11.006 · Cited by 118

High Level of Uric Acid Promotes Atherosclerosis by Targeting NRF2‐Mediated Autophagy Dysfunction and Ferroptosis

Yu, W., Liu, W., Xie, D., Wang, Q., Xu, C., Zhao, H., Lv, J., He, F., Chen, B., Yamamoto, T., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9304383 · Cited by 117

Anti-Ferroptotic Effects of Nrf2: Beyond the Antioxidant Response

Shakya, A., McKee, N. W., Dodson, M. B., Chapman, E., & Zhang, D. D. (2023) · Molecules and Cells · doi:10.14348/molcells.2023.0005 · Cited by 120

Diverse Functions of Autophagy in Liver Physiology and Liver Diseases

Ke, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020300 · Cited by 117

Cathepsin B is a mediator of organelle-specific initiation of ferroptosis

Kuang, F., Liu, J., Li, C., Kang, R., & Tang, D. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.10.035 · Cited by 115

Ferroptosis in mitochondrial cardiomyopathy

Ahola, S., & Langer, T. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.06.002 · Cited by 118

Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy

Zheng, X., Jin, X., Ye, F., Liu, X., Yu, B., Li, Z., Zhao, T., Chen, W., Liu, X., Di, C., et al. (2023) · Experimental Hematology and Oncology · doi:10.1186/s40164-023-00427-w · Cited by 125

Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy

Huang, G., Cai, Y., Ren, M., Zhang, X., Fu, Y., Cheng, R., Wang, Y., Miao, M., Zhu, L., & Yan, T. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.09.027 · Cited by 124

Reclassifying Hepatic Cell Death during Liver Damage: Ferroptosis—A Novel Form of Non-Apoptotic Cell Death?

Macías‐Rodríguez, R. U., Inzaugarat, M. E., Ruiz‐Margáin, A., Nelson, L. J., Trautwein, C., & Cubero, F. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051651 · Cited by 116

Ferroptosis‐related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma

Lei, T., Hu, Q., Lei, P., & Hu, Y. (2021) · Cancer Science · doi:10.1111/cas.15131 · Cited by 114

Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis

Yi, J., Wu, S., Tan, S., Qin, Y., Wang, X., Jiang, J., Liu, H., & Wu, B. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00768-7 · Cited by 117

New Target for Prevention and Treatment of Neuroinflammation: Microglia Iron Accumulation and Ferroptosis

Liu, S., Gao, X., & Zhou, S. (2022) · ASN NEURO · doi:10.1177/17590914221133236 · Cited by 119

Ferroptosis: Final destination for cancer?

Zeng, Y., Liu, W., Zhuo, Q., Hu, Q., Liu, M., Sun, Q., Zhang, Z., Fan, G., Xu, W., Ji, S., et al. (2020) · Cell Proliferation · doi:10.1111/cpr.12761 · Cited by 116

The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors

Zhu, J., Xiong, Y., Zhang, Y., Wen, J., Cai, N., Cheng, K., Liang, H., & Zhang, W. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8810785 · Cited by 116

Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression

Sui, S., Xu, S., & Pang, D. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107992 · Cited by 117

Extracellular SQSTM1 exacerbates acute pancreatitis by activating autophagy-dependent ferroptosis

Yang, L., Ye, F., Liu, J., Klionsky, D. J., Tang, D., & Kang, R. (2022) · Autophagy · doi:10.1080/15548627.2022.2152209 · Cited by 114

Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling

Koeberle, S. C., Kipp, A. P., Stuppner, H., & Koeberle, A. (2023) · Medicinal Research Reviews · doi:10.1002/med.21933 · Cited by 117

Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro

Homma, T., Kobayashi, S., Sato, H., & Fujii, J. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.111592 · Cited by 113

Ionizing radiation-induced mitophagy promotes ferroptosis by increasing intracellular free fatty acids

Yang, P., Li, J., Zhang, T., Ren, Y., Zhang, Q., Liu, R., Li, H., Hua, J., Wang, W., Wang, J., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01230-0 · Cited by 126

Global organelle profiling reveals subcellular localization and remodeling at proteome scale

Hein, M. Y., Peng, D., Todorova, V., McCarthy, F., Kim, K., Liu, C., Savy, L., Januel, C., Baltazar-Nunez, R., Sekhar, M., et al. (2024) · Cell · doi:10.1016/j.cell.2024.11.028 · Cited by 130

Ferritinophagy activation and sideroflexin1-dependent mitochondria iron overload is involved in apelin-13-induced cardiomyocytes hypertrophy

Tang, M., Huang, Z., Luo, X., Liu, M., Wang, L., Qi, Z., Huang, S., Zhong, J., Chen, J., Li, L., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.052 · Cited by 111

Autophagy Function and Regulation in Kidney Disease

Kaushal, G. P., Chandrashekar, K., Juncos, L. A., & Shah, S. V. (2020) · Biomolecules · doi:10.3390/biom10010100 · Cited by 112

A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis

Hu, Z., Mi, Y., Qian, H., Guo, N., Yan, A., Zhang, Y., & Gao, X. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00897 · Cited by 112

The Multifaceted Regulation of Mitochondria in Ferroptosis

Wu, H., Wang, F., Ta, N., Zhang, T., & Gao, W. (2021) · Life · doi:10.3390/life11030222 · Cited by 111

Emerging roles of ferroptosis in cardiovascular diseases

Wang, K., Chen, X., Wang, Y.-H., Cheng, X., Zhao, Y., Zhou, L., & Wang, K. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01183-2 · Cited by 117

Redox biology of regulated cell death in cancer: A focus on necroptosis and ferroptosis

Florean, C., Song, S., Dicato, M. A., & Diederich, M. F. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.008 · Cited by 110

Regulation of ferroptosis in cancer cells by YAP/TAZ and Hippo pathways: The therapeutic implications

Sun, T., & Chi, J. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.05.004 · Cited by 111

Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence

Sun, D.-Y., Wu, W., Wu, J., Shi, Y. L., Xu, J., Ouyang, S.-X., Chi, C., Shi, Y., Ji, Q., Miao, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45823-w · Cited by 114

Metabolic networks in ferroptosis (Review)

Hao, S., Liang, B., Huang, Q., Dong, S., Wu, Z., He, W., & Shi, M. (2018) · Oncology Letters · doi:10.3892/ol.2018.8066 · Cited by 109

Iron homeostasis in arthropathies: From pathogenesis to therapeutic potential

Sun, K., Guo, Z., Hou, L., Xu, J., Du, T., Xu, T., & Guo, F. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101481 · Cited by 112

Cellular Senescence and Regulated Cell Death of Tubular Epithelial Cells in Diabetic Kidney Disease

Shen, S., Ji, C., & Wei, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.924299 · Cited by 111

Tubular injury in diabetic kidney disease: molecular mechanisms and potential therapeutic perspectives

Wang, Y., Jin, M., Cheng, C. K., & Li, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1238927 · Cited by 117

Metabolic regulation of ferroptosis in the tumor microenvironment

Mbah, N. E., & Lyssiotis, C. A. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101617 · Cited by 113

An overview of ferroptosis in non-alcoholic fatty liver disease

Wang, S., Liu, Z., Geng, J., Li, L., & Feng, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113374 · Cited by 107

A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis

Chen, X., Huang, J. X., Yu, C., Liu, J., Gao, W., Li, J., Song, X., Zhou, Z., Li, C., Xie, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34096-w · Cited by 105

The role of lysosome in regulated necrosis

Alu, A., Han, X., Ma, X., Wu, M., Wei, Y., & Wei, X. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.07.003 · Cited by 109

The Mechanism of Ferroptosis and Applications in Tumor Treatment

Lin, X., Ping, J., Wen, Y., & Wu, Y. R. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01061 · Cited by 107

Nutritional and Metabolic Control of Ferroptosis

Mishima, E., & Conrad, M. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062320-114541 · Cited by 107

The Road from AKI to CKD: Molecular Mechanisms and Therapeutic Targets of Ferroptosis

Guo, R., Duan, J., Pan, S., Cheng, F., Qiao, Y., Feng, Q., Liu, D., & Liu, Z. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05969-9 · Cited by 108

Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis

Thayyullathil, F., Cheratta, A. R., Alakkal, A., Subburayan, K., Pallichankandy, S., Hannun, Y. A., & Galadari, S. (2021) · Cell Death and Disease · doi:10.1038/s41419-020-03297-w · Cited by 104

Role of Ferroptosis in Non-Alcoholic Fatty Liver Disease and Its Implications for Therapeutic Strategies

Zhang, H., Zhang, E., & Hu, H. (2021) · Biomedicines · doi:10.3390/biomedicines9111660 · Cited by 104

Nrf2 and its dependent autophagy activation cooperatively counteract ferroptosis to alleviate acute liver injury

Liu, J., Huang, C., Liu, J., Meng, C., Gu, Q., Du, X., Yan, M., Yu, Y., Liu, F., & Xia, C. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106563 · Cited by 104

ACSL4 and the lipoxygenases 15/15B are pivotal for ferroptosis induced by iron and PUFA dyshomeostasis in dopaminergic neurons

Bouchaoui, H., Mahoney‐Sanchez, L., Garçon, G., Berdeaux, O., Alleman, L., Devos, D., Duce, J. A., & Devedjian, J.-C. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.12.086 · Cited by 112

Trypsin-Mediated Sensitization to Ferroptosis Increases the Severity of Pancreatitis in Mice

Liu, K., Liu, J., Zou, B., Li, C., Zeh, H. J., Kang, R., Kroemer, G., Huang, J. X., & Tang, D. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.09.008 · Cited by 107

Understanding sorafenib-induced ferroptosis and resistance mechanisms: Implications for cancer therapy

Li, Q., Chen, K., Zhang, T., Jiang, D., Chen, L., Jiang, J., Zhang, C., & Li, S. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175913 · Cited by 106

Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases

Xiang, Y., Song, X., & Long, D. (2024) · Archives of Toxicology · doi:10.1007/s00204-023-03660-8 · Cited by 116

Nanoparticle ferritin-bound erastin and rapamycin: a nanodrug combining autophagy and ferroptosis for anticancer therapy

Li, Y., Wang, X., Yan, J., Liu, Y., Yang, R., Pan, D., Wang, L., Xu, Y., Li, X., & Yang, M. (2019) · Biomaterials Science · doi:10.1039/c9bm00653b · Cited by 103

Ferroptosis is an autophagic cell death process

Gao, M., Monian, P., Pan, Q., Zhang, W., Xiang, J., & Jiang, X. (2016) · Cell Research · doi:10.1038/cr.2016.95 · Cited by 1,899

Ferroptosis is a type of autophagy-dependent cell death

Zhou, B., Liu, J., Kang, R., Klionsky, D. J., Kroemer, G., & Tang, D. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.03.002 · Cited by 1,094

ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

Park, E., & Chung, S. W. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2064-5 · Cited by 902

Autophagy-Dependent Ferroptosis: Machinery and Regulation

Liu, J., Kuang, F., Kroemer, G., Klionsky, D. J., Kang, R., & Tang, D. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.02.005 · Cited by 819

Autophagy mediates an amplification loop during ferroptosis

Lee, S., Hwang, N., Seok, B. G., Lee, S., Lee, S., & Chung, S. W. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05978-8 · Cited by 253